Attenuated Expression of DFFB is a Hallmark of Oligodendrogliomas with 1p-Allelic Loss View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-12

AUTHORS

J Matthew McDonald, Valerie Dunmire, Ellen Taylor, Raymond Sawaya, Janet Bruner, Gregory N Fuller, Kenneth Aldape, Wei Zhang

ABSTRACT

Allelic loss of chromosome 1p is frequently observed in oligodendroglioma. We screened 177 oligodendroglial tumors for 1p deletions and found 6 tumors with localized 1p36 deletions. Several apoptosis regulation genes have been mapped to this region, including Tumor Protein 73 (p73), DNA Fragmentation Factor subunits alpha (DFFA) and beta (DFFB), and Tumor Necrosis Factor Receptor Superfamily Members 9 and 25 (TNFRSF9, TNFRSF25). We compared expression levels of these 5 genes in pairs of 1p-loss and 1p-intact tumors using quantitative reverse-transcriptase PCR (QRTPCR) to test if 1p deletions had an effect on expression. Only the DFFB gene demonstrated decreased expression in all tumor pairs tested. Mutational analysis did not reveal DFFB mutations in 12 tested samples. However, it is possible that DFFB haploinsufficiency from 1p allelic loss is a contributing factor in oligodendroglioma development. More... »

PAGES

35

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1476-4598-4-35

DOI

http://dx.doi.org/10.1186/1476-4598-4-35

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043851532

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16156899


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