Rare human papillomavirus 16 E6 variants reveal significant oncogenic potential View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

Ingeborg Zehbe, Hava Lichtig, Ashley Westerback, Paul F Lambert, Massimo Tommasino, Levana Sherman

ABSTRACT

The aim of this study was to determine whether low prevalence human papillomavirus (HPV) 16 E6 variants differ from high prevalence types in their functional abilities. We evaluated functions relevant to carcinogenesis for the rarely-detected European variants R8Q, R10G and R48W as compared to the commonly detected L83V. Human immortalized keratinocytes (NIKS) stably transduced with the E6 variants were used in most functional assays. Low and high prevalence E6 variants displayed similar abilities in abrogation of growth arrest and inhibition of p53 elevation induced by actinomycin D. Differences were detected in the abilities to dysregulate stratification and differentiation of NIKS in organotypic raft cultures, modulate detachment induced apoptosis (anoikis) and hyperactivate Wnt signaling. No distinctive phenotype could be assigned to include all rare variants. Like L83V, raft cultures derived from variants R10G and R48W similarly induced hyperplasia and aberrantly expressed keratin 5 in the suprabasal compartment with significantly lower expression of keratin 10. Unlike L83V, both variants, and particularly R48W, induced increased levels of anoikis upon suspension in semisolid medium. R8Q induced a unique phenotype characterized by thin organotypic raft cultures, low expression of keratin 10, and high expression of keratins 5 and 14 throughout all raft layers. Interestingly, in a reporter based assay R8Q exhibited a higher ability to augment TCF/β-catenin transcription. The data suggests that differences in E6 variant prevalence in cervical carcinoma may not be related to the carcinogenic potential of the E6 protein. More... »

PAGES

77

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1476-4598-10-77

DOI

http://dx.doi.org/10.1186/1476-4598-10-77

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029995469

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21702904


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Frequency", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Variation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HEK293 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutant Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncogene Proteins, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Papillomavirus Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Repressor Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Uterine Cervical Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Thunder Bay Regional Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.452835.d", 
          "name": [
            "Thunder Bay Regional Research Institute, Probe Development & Biomarker Exploration, Thunder Bay, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zehbe", 
        "givenName": "Ingeborg", 
        "id": "sg:person.0773334543.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773334543.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tel Aviv University", 
          "id": "https://www.grid.ac/institutes/grid.12136.37", 
          "name": [
            "Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lichtig", 
        "givenName": "Hava", 
        "id": "sg:person.01266754375.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266754375.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Thunder Bay Regional Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.452835.d", 
          "name": [
            "Thunder Bay Regional Research Institute, Probe Development & Biomarker Exploration, Thunder Bay, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Westerback", 
        "givenName": "Ashley", 
        "id": "sg:person.01143017643.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143017643.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lambert", 
        "givenName": "Paul F", 
        "id": "sg:person.07673665117.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07673665117.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "International Agency For Research On Cancer", 
          "id": "https://www.grid.ac/institutes/grid.17703.32", 
          "name": [
            "International Agency for Research on Cancer, World Health Organization, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tommasino", 
        "givenName": "Massimo", 
        "id": "sg:person.01212326615.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212326615.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tel Aviv University", 
          "id": "https://www.grid.ac/institutes/grid.12136.37", 
          "name": [
            "Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sherman", 
        "givenName": "Levana", 
        "id": "sg:person.0713601777.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713601777.12"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/jnci/93.17.1325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001098923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1593/neo.07986", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002772293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbcan.2009.03.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004860486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.01148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005221853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djj297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006348604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19981005)78:2<166::aid-ijc8>3.0.co;2-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006408403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1747.2000.00869.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010696107", 
          "https://doi.org/10.1046/j.1523-1747.2000.00869.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.arcmed.2009.06.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011189867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2003.tb01424.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011682309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2003.tb01424.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011682309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jmv.20978", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013172134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2009.10.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017919191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bdrc.20055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018704605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bdrc.20055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018704605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.85.19.7169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019308704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.90.9.3988", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021004257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.1520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021083788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.01080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021379825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1750-9378-2-16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021667325", 
          "https://doi.org/10.1186/1750-9378-2-16"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2006.01.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021685229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2008.09.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022190744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19961021)69:5<364::aid-ijc2>3.0.co;2-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024155829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.21655", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025058893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6600024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027440646", 
          "https://doi.org/10.1038/sj.bjc.6600024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6600024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027440646", 
          "https://doi.org/10.1038/sj.bjc.6600024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virusres.2007.08.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029942878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1055-9965.epi-06-0670", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033785449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-3527(06)66003-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034410532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2008.07.045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035241070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06835", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035894274", 
          "https://doi.org/10.1038/nature06835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-419x(96)00020-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036152914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-0455", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037267241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(89)92329-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037632198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1055-9965.epi-05-0864", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038514200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.93", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039035650", 
          "https://doi.org/10.1038/onc.2010.93"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.93", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039035650", 
          "https://doi.org/10.1038/onc.2010.93"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.123.4.909", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039584892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0595-464", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040346268", 
          "https://doi.org/10.1038/nm0595-464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.78.11.5934-5945.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040726652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.10.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041684641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.01490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041737037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2008.11.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042200848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0707947104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049429793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049743007", 
          "https://doi.org/10.1038/nature08137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049743007", 
          "https://doi.org/10.1038/nature08137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(01)00617-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050493178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.cellbio.23.090506.123357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050750066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.22481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051209222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)61263-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051888489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/12.11.2063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059449698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/172.3.747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059705399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074673336", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074769890", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077649176", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082630443", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082957645", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083219810", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-12", 
    "datePublishedReg": "2011-12-01", 
    "description": "The aim of this study was to determine whether low prevalence human papillomavirus (HPV) 16 E6 variants differ from high prevalence types in their functional abilities. We evaluated functions relevant to carcinogenesis for the rarely-detected European variants R8Q, R10G and R48W as compared to the commonly detected L83V. Human immortalized keratinocytes (NIKS) stably transduced with the E6 variants were used in most functional assays. Low and high prevalence E6 variants displayed similar abilities in abrogation of growth arrest and inhibition of p53 elevation induced by actinomycin D. Differences were detected in the abilities to dysregulate stratification and differentiation of NIKS in organotypic raft cultures, modulate detachment induced apoptosis (anoikis) and hyperactivate Wnt signaling. No distinctive phenotype could be assigned to include all rare variants. Like L83V, raft cultures derived from variants R10G and R48W similarly induced hyperplasia and aberrantly expressed keratin 5 in the suprabasal compartment with significantly lower expression of keratin 10. Unlike L83V, both variants, and particularly R48W, induced increased levels of anoikis upon suspension in semisolid medium. R8Q induced a unique phenotype characterized by thin organotypic raft cultures, low expression of keratin 10, and high expression of keratins 5 and 14 throughout all raft layers. Interestingly, in a reporter based assay R8Q exhibited a higher ability to augment TCF/\u03b2-catenin transcription. The data suggests that differences in E6 variant prevalence in cervical carcinoma may not be related to the carcinogenic potential of the E6 protein.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1476-4598-10-77", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2476421", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2435413", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1031030", 
        "issn": [
          "1476-4598"
        ], 
        "name": "Molecular Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "Rare human papillomavirus 16 E6 variants reveal significant oncogenic potential", 
    "pagination": "77", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8ee52f4755a617ba649240d0be78eff4e503c7e120b95f16ca63aac233c31337"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21702904"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101147698"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1476-4598-10-77"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1029995469"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1476-4598-10-77", 
      "https://app.dimensions.ai/details/publication/pub.1029995469"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T02:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000513.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1476-4598-10-77"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1476-4598-10-77'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1476-4598-10-77'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1476-4598-10-77'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1476-4598-10-77'


 

This table displays all metadata directly associated to this object as RDF triples.

333 TRIPLES      21 PREDICATES      96 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1476-4598-10-77 schema:about N2271a013f242426199d2f70476d9212e
2 N33ba2a2929f84327a1036969bd520f11
3 N40cc657fc7cf4462a2066443a82d8065
4 N56b79b8595c6427eb5a75146e0fa39c4
5 N5c9c6e6ed9a04810ac9bb16b6ee2098a
6 N9dfc328f811341d7b3274848d4270f5d
7 Nb574a880a3244ca48b114b189111df1b
8 Nc000d9654ab744358ad4510ef73d9f7c
9 Nc0f23b102de640dbaeb5733d5d16a34d
10 Nc4bf560ec4204a1888643b38d1eece3a
11 Ndd4922f5cb2f4163a991b074ae6cd16b
12 Ne1e6cb68f3fb447db4f7a1686d1d8abe
13 Nebcfc9e8272449a6bd776629d40963a7
14 Nf45d794387ec4c8cbf08464e4741ca87
15 Nfb3f770fde9b4846829203fee4435d57
16 anzsrc-for:11
17 anzsrc-for:1103
18 schema:author Nbfbe66784e4d4e19a35be2463d480cb9
19 schema:citation sg:pub.10.1038/nature06835
20 sg:pub.10.1038/nature08137
21 sg:pub.10.1038/nm0595-464
22 sg:pub.10.1038/onc.2010.93
23 sg:pub.10.1038/sj.bjc.6600024
24 sg:pub.10.1046/j.1523-1747.2000.00869.x
25 sg:pub.10.1186/1750-9378-2-16
26 https://app.dimensions.ai/details/publication/pub.1074673336
27 https://app.dimensions.ai/details/publication/pub.1074769890
28 https://app.dimensions.ai/details/publication/pub.1077649176
29 https://app.dimensions.ai/details/publication/pub.1082630443
30 https://app.dimensions.ai/details/publication/pub.1082957645
31 https://app.dimensions.ai/details/publication/pub.1083219810
32 https://doi.org/10.1002/(sici)1097-0215(19961021)69:5<364::aid-ijc2>3.0.co;2-3
33 https://doi.org/10.1002/(sici)1097-0215(19981005)78:2<166::aid-ijc8>3.0.co;2-x
34 https://doi.org/10.1002/bdrc.20055
35 https://doi.org/10.1002/ijc.1520
36 https://doi.org/10.1002/ijc.21655
37 https://doi.org/10.1002/ijc.22481
38 https://doi.org/10.1002/jmv.20978
39 https://doi.org/10.1016/0304-419x(96)00020-0
40 https://doi.org/10.1016/j.arcmed.2009.06.001
41 https://doi.org/10.1016/j.bbcan.2009.03.005
42 https://doi.org/10.1016/j.cell.2006.10.018
43 https://doi.org/10.1016/j.virol.2006.01.038
44 https://doi.org/10.1016/j.virol.2008.09.036
45 https://doi.org/10.1016/j.virol.2008.11.017
46 https://doi.org/10.1016/j.virol.2009.10.011
47 https://doi.org/10.1016/j.virusres.2007.08.003
48 https://doi.org/10.1016/j.ygyno.2008.07.045
49 https://doi.org/10.1016/s0065-3527(06)66003-x
50 https://doi.org/10.1016/s0140-6736(05)61263-9
51 https://doi.org/10.1016/s0140-6736(89)92329-5
52 https://doi.org/10.1016/s1470-2045(01)00617-9
53 https://doi.org/10.1073/pnas.0707947104
54 https://doi.org/10.1073/pnas.85.19.7169
55 https://doi.org/10.1073/pnas.90.9.3988
56 https://doi.org/10.1083/jcb.123.4.909
57 https://doi.org/10.1093/carcin/12.11.2063
58 https://doi.org/10.1093/infdis/172.3.747
59 https://doi.org/10.1093/jnci/93.17.1325
60 https://doi.org/10.1093/jnci/djj297
61 https://doi.org/10.1111/j.1349-7006.2003.tb01424.x
62 https://doi.org/10.1128/jvi.78.11.5934-5945.2004
63 https://doi.org/10.1146/annurev.cellbio.23.090506.123357
64 https://doi.org/10.1158/0008-5472.can-05-0455
65 https://doi.org/10.1158/1055-9965.epi-05-0864
66 https://doi.org/10.1158/1055-9965.epi-06-0670
67 https://doi.org/10.1242/dev.01148
68 https://doi.org/10.1242/jcs.01080
69 https://doi.org/10.1242/jcs.01490
70 https://doi.org/10.1593/neo.07986
71 schema:datePublished 2011-12
72 schema:datePublishedReg 2011-12-01
73 schema:description The aim of this study was to determine whether low prevalence human papillomavirus (HPV) 16 E6 variants differ from high prevalence types in their functional abilities. We evaluated functions relevant to carcinogenesis for the rarely-detected European variants R8Q, R10G and R48W as compared to the commonly detected L83V. Human immortalized keratinocytes (NIKS) stably transduced with the E6 variants were used in most functional assays. Low and high prevalence E6 variants displayed similar abilities in abrogation of growth arrest and inhibition of p53 elevation induced by actinomycin D. Differences were detected in the abilities to dysregulate stratification and differentiation of NIKS in organotypic raft cultures, modulate detachment induced apoptosis (anoikis) and hyperactivate Wnt signaling. No distinctive phenotype could be assigned to include all rare variants. Like L83V, raft cultures derived from variants R10G and R48W similarly induced hyperplasia and aberrantly expressed keratin 5 in the suprabasal compartment with significantly lower expression of keratin 10. Unlike L83V, both variants, and particularly R48W, induced increased levels of anoikis upon suspension in semisolid medium. R8Q induced a unique phenotype characterized by thin organotypic raft cultures, low expression of keratin 10, and high expression of keratins 5 and 14 throughout all raft layers. Interestingly, in a reporter based assay R8Q exhibited a higher ability to augment TCF/β-catenin transcription. The data suggests that differences in E6 variant prevalence in cervical carcinoma may not be related to the carcinogenic potential of the E6 protein.
74 schema:genre research_article
75 schema:inLanguage en
76 schema:isAccessibleForFree true
77 schema:isPartOf N87e3b764273842a695623534dc104201
78 Nf73d6fc5bb0c47568a340f7590d10c12
79 sg:journal.1031030
80 schema:name Rare human papillomavirus 16 E6 variants reveal significant oncogenic potential
81 schema:pagination 77
82 schema:productId N24a4112b6997411ead9d9f31195a6011
83 N3b5366786640497c93d909481cbe23b5
84 N46ff94d0b24c4a0b94c1673970135b61
85 Nf46e245832dc46ee85cbd1af1c26e23e
86 Nfbd1f063a791421e8d875361cf0938ac
87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029995469
88 https://doi.org/10.1186/1476-4598-10-77
89 schema:sdDatePublished 2019-04-11T02:01
90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
91 schema:sdPublisher Nfdad0763540b47b9a48d6ef5a978d1b7
92 schema:url http://link.springer.com/10.1186%2F1476-4598-10-77
93 sgo:license sg:explorer/license/
94 sgo:sdDataset articles
95 rdf:type schema:ScholarlyArticle
96 N2271a013f242426199d2f70476d9212e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Mutant Proteins
98 rdf:type schema:DefinedTerm
99 N24a4112b6997411ead9d9f31195a6011 schema:name readcube_id
100 schema:value 8ee52f4755a617ba649240d0be78eff4e503c7e120b95f16ca63aac233c31337
101 rdf:type schema:PropertyValue
102 N33ba2a2929f84327a1036969bd520f11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Uterine Cervical Neoplasms
104 rdf:type schema:DefinedTerm
105 N3b5366786640497c93d909481cbe23b5 schema:name dimensions_id
106 schema:value pub.1029995469
107 rdf:type schema:PropertyValue
108 N40cc657fc7cf4462a2066443a82d8065 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Gene Frequency
110 rdf:type schema:DefinedTerm
111 N46ff94d0b24c4a0b94c1673970135b61 schema:name pubmed_id
112 schema:value 21702904
113 rdf:type schema:PropertyValue
114 N495fe977a04242c0822e52ddeeca43e1 rdf:first sg:person.0713601777.12
115 rdf:rest rdf:nil
116 N56b79b8595c6427eb5a75146e0fa39c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Genetic Variation
118 rdf:type schema:DefinedTerm
119 N5c9c6e6ed9a04810ac9bb16b6ee2098a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Female
121 rdf:type schema:DefinedTerm
122 N5ff3b38dcfbf4fa98e6cbcecaf080e5a rdf:first sg:person.01266754375.54
123 rdf:rest N9212a52590854ed0afac93e95501e405
124 N6eb4cca14fb7419eb37843c99f0b2329 rdf:first sg:person.01212326615.04
125 rdf:rest N495fe977a04242c0822e52ddeeca43e1
126 N87e3b764273842a695623534dc104201 schema:volumeNumber 10
127 rdf:type schema:PublicationVolume
128 N9212a52590854ed0afac93e95501e405 rdf:first sg:person.01143017643.53
129 rdf:rest Ned216129aaa547d1896e6569103903d2
130 N9dfc328f811341d7b3274848d4270f5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Polymorphism, Genetic
132 rdf:type schema:DefinedTerm
133 Nb574a880a3244ca48b114b189111df1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Genotype
135 rdf:type schema:DefinedTerm
136 Nbfbe66784e4d4e19a35be2463d480cb9 rdf:first sg:person.0773334543.17
137 rdf:rest N5ff3b38dcfbf4fa98e6cbcecaf080e5a
138 Nc000d9654ab744358ad4510ef73d9f7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Papillomavirus Infections
140 rdf:type schema:DefinedTerm
141 Nc0f23b102de640dbaeb5733d5d16a34d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Cell Transformation, Viral
143 rdf:type schema:DefinedTerm
144 Nc4bf560ec4204a1888643b38d1eece3a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name HEK293 Cells
146 rdf:type schema:DefinedTerm
147 Ndd4922f5cb2f4163a991b074ae6cd16b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Cells, Cultured
149 rdf:type schema:DefinedTerm
150 Ne1e6cb68f3fb447db4f7a1686d1d8abe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Humans
152 rdf:type schema:DefinedTerm
153 Nebcfc9e8272449a6bd776629d40963a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Carcinoma
155 rdf:type schema:DefinedTerm
156 Ned216129aaa547d1896e6569103903d2 rdf:first sg:person.07673665117.09
157 rdf:rest N6eb4cca14fb7419eb37843c99f0b2329
158 Nf45d794387ec4c8cbf08464e4741ca87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Repressor Proteins
160 rdf:type schema:DefinedTerm
161 Nf46e245832dc46ee85cbd1af1c26e23e schema:name nlm_unique_id
162 schema:value 101147698
163 rdf:type schema:PropertyValue
164 Nf73d6fc5bb0c47568a340f7590d10c12 schema:issueNumber 1
165 rdf:type schema:PublicationIssue
166 Nfb3f770fde9b4846829203fee4435d57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Oncogene Proteins, Viral
168 rdf:type schema:DefinedTerm
169 Nfbd1f063a791421e8d875361cf0938ac schema:name doi
170 schema:value 10.1186/1476-4598-10-77
171 rdf:type schema:PropertyValue
172 Nfdad0763540b47b9a48d6ef5a978d1b7 schema:name Springer Nature - SN SciGraph project
173 rdf:type schema:Organization
174 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
175 schema:name Medical and Health Sciences
176 rdf:type schema:DefinedTerm
177 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
178 schema:name Clinical Sciences
179 rdf:type schema:DefinedTerm
180 sg:grant.2435413 http://pending.schema.org/fundedItem sg:pub.10.1186/1476-4598-10-77
181 rdf:type schema:MonetaryGrant
182 sg:grant.2476421 http://pending.schema.org/fundedItem sg:pub.10.1186/1476-4598-10-77
183 rdf:type schema:MonetaryGrant
184 sg:journal.1031030 schema:issn 1476-4598
185 schema:name Molecular Cancer
186 rdf:type schema:Periodical
187 sg:person.01143017643.53 schema:affiliation https://www.grid.ac/institutes/grid.452835.d
188 schema:familyName Westerback
189 schema:givenName Ashley
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143017643.53
191 rdf:type schema:Person
192 sg:person.01212326615.04 schema:affiliation https://www.grid.ac/institutes/grid.17703.32
193 schema:familyName Tommasino
194 schema:givenName Massimo
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212326615.04
196 rdf:type schema:Person
197 sg:person.01266754375.54 schema:affiliation https://www.grid.ac/institutes/grid.12136.37
198 schema:familyName Lichtig
199 schema:givenName Hava
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266754375.54
201 rdf:type schema:Person
202 sg:person.0713601777.12 schema:affiliation https://www.grid.ac/institutes/grid.12136.37
203 schema:familyName Sherman
204 schema:givenName Levana
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713601777.12
206 rdf:type schema:Person
207 sg:person.07673665117.09 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
208 schema:familyName Lambert
209 schema:givenName Paul F
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07673665117.09
211 rdf:type schema:Person
212 sg:person.0773334543.17 schema:affiliation https://www.grid.ac/institutes/grid.452835.d
213 schema:familyName Zehbe
214 schema:givenName Ingeborg
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773334543.17
216 rdf:type schema:Person
217 sg:pub.10.1038/nature06835 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035894274
218 https://doi.org/10.1038/nature06835
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/nature08137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049743007
221 https://doi.org/10.1038/nature08137
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/nm0595-464 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040346268
224 https://doi.org/10.1038/nm0595-464
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/onc.2010.93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039035650
227 https://doi.org/10.1038/onc.2010.93
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/sj.bjc.6600024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027440646
230 https://doi.org/10.1038/sj.bjc.6600024
231 rdf:type schema:CreativeWork
232 sg:pub.10.1046/j.1523-1747.2000.00869.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010696107
233 https://doi.org/10.1046/j.1523-1747.2000.00869.x
234 rdf:type schema:CreativeWork
235 sg:pub.10.1186/1750-9378-2-16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021667325
236 https://doi.org/10.1186/1750-9378-2-16
237 rdf:type schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1074673336 schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1074769890 schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1077649176 schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1082630443 schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1082957645 schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1083219810 schema:CreativeWork
244 https://doi.org/10.1002/(sici)1097-0215(19961021)69:5<364::aid-ijc2>3.0.co;2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024155829
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1002/(sici)1097-0215(19981005)78:2<166::aid-ijc8>3.0.co;2-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006408403
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1002/bdrc.20055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018704605
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1002/ijc.1520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021083788
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1002/ijc.21655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025058893
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1002/ijc.22481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051209222
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1002/jmv.20978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013172134
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/0304-419x(96)00020-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036152914
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.arcmed.2009.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011189867
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.bbcan.2009.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004860486
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.cell.2006.10.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041684641
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.virol.2006.01.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021685229
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.virol.2008.09.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022190744
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/j.virol.2008.11.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042200848
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/j.virol.2009.10.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017919191
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/j.virusres.2007.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029942878
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/j.ygyno.2008.07.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035241070
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/s0065-3527(06)66003-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034410532
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/s0140-6736(05)61263-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051888489
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/s0140-6736(89)92329-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037632198
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/s1470-2045(01)00617-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050493178
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1073/pnas.0707947104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049429793
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1073/pnas.85.19.7169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019308704
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1073/pnas.90.9.3988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021004257
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1083/jcb.123.4.909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039584892
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1093/carcin/12.11.2063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059449698
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1093/infdis/172.3.747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059705399
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1093/jnci/93.17.1325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001098923
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1093/jnci/djj297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006348604
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1111/j.1349-7006.2003.tb01424.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011682309
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1128/jvi.78.11.5934-5945.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040726652
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1146/annurev.cellbio.23.090506.123357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050750066
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1158/0008-5472.can-05-0455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037267241
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1158/1055-9965.epi-05-0864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038514200
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1158/1055-9965.epi-06-0670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033785449
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1242/dev.01148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005221853
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1242/jcs.01080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021379825
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1242/jcs.01490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041737037
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1593/neo.07986 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002772293
321 rdf:type schema:CreativeWork
322 https://www.grid.ac/institutes/grid.12136.37 schema:alternateName Tel Aviv University
323 schema:name Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
324 rdf:type schema:Organization
325 https://www.grid.ac/institutes/grid.14003.36 schema:alternateName University of Wisconsin–Madison
326 schema:name McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI, USA
327 rdf:type schema:Organization
328 https://www.grid.ac/institutes/grid.17703.32 schema:alternateName International Agency For Research On Cancer
329 schema:name International Agency for Research on Cancer, World Health Organization, Lyon, France
330 rdf:type schema:Organization
331 https://www.grid.ac/institutes/grid.452835.d schema:alternateName Thunder Bay Regional Research Institute
332 schema:name Thunder Bay Regional Research Institute, Probe Development & Biomarker Exploration, Thunder Bay, Ontario, Canada
333 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...