Short-chain fatty acid level and field cancerization show opposing associations with enteroendocrine cell number and neuropilin expression in patients with ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-03-14

AUTHORS

Danny CW Yu, Jonathan P Bury, James Tiernan, Jennifer S Waby, Carolyn A Staton, Bernard M Corfe

ABSTRACT

BACKGROUND: Previous reports have suggested that the VEGF receptor neuropilin-1 (NRP-1) is expressed in a singly dispersed subpopulation of cells in the normal colonic epithelium, but that expression becomes dysregulated during colorectal carcinogenesis, with higher levels in tumour suggestive of a poor prognosis. We noted that the spatial distribution and morphology if NRP-1 expressing cells resembles that of enteroendocrine cells (EEC) which are altered in response to disease state including cancer and irritable bowel syndrome (IBS). We have shown that NRP-1 is down-regulated by butyrate in colon cancer cell lines in vitro and we hypothesized that butyrate produced in the lumen would have an analogous effect on the colon mucosa in vivo. Therefore we sought to investigate whether NRP-1 is expressed in EEC and how NRP-1 and EEC respond to butyrate and other short-chain fatty acids (SCFA - principally acetate and propionate). Additionally we sought to assess whether there is a field effect around adenomas. METHODOLOGY: Biopsies were collected at the mid-sigmoid, at the adenoma and at the contralateral wall (field) of 28 subjects during endoscopy. Samples were fixed for IHC and stained for either NRP-1 or for chromogranin A (CgA), a marker of EEC. Stool sampling was undertaken to assess individuals' butyrate, acetate and propionate levels. RESULT: NRP-1 expression was inversely related to SCFA concentration at the colon landmark (mid-sigmoid), but expression was lower and not related to SCFA concentration at the field. Likewise CgA+ cell number was also inversely related to SCFA at the landmark, but was lower and unresponsive at the field. Crypt cellularity was unaltered by field effect. A colocalisation analysis showed only a small subset of NRP-1 localised with CgA. Adenomas showed extensive, weaker staining for NRP-1 which contrastingly correlated positively with butyrate level. Field effects cause this relationship to be lost. Adenoma tissue shows dissociation of the co-regulation of NRP-1 and EEC. CONCLUSION: NRP-1 is inversely associated with levels of butyrate and other SCFA in vivo and is expressed in a subset of CgA expressing cells. EEC number is related to butyrate level in the same way. More... »

PAGES

27-27

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1476-4598-10-27

DOI

http://dx.doi.org/10.1186/1476-4598-10-27

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030331588

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21401950


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Butyrates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Count", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromogranin A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colonic Polyps", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Demography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enteroendocrine Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epithelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epithelium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fatty Acids, Volatile", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuropilins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Transport", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Oncology, University of Sheffield, The Medical School, Beech Hill Road, Sheffield, S10 2JF, UK", 
          "id": "http://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Department of Oncology, University of Sheffield, The Medical School, Beech Hill Road, Sheffield, S10 2JF, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "Danny CW", 
        "id": "sg:person.0656542305.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656542305.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, University of Sheffield, The Medical School, Beech Hill Road, Sheffield, S10 2JF, UK", 
          "id": "http://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Department of Oncology, University of Sheffield, The Medical School, Beech Hill Road, Sheffield, S10 2JF, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bury", 
        "givenName": "Jonathan P", 
        "id": "sg:person.01202531224.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202531224.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, University of Sheffield, The Medical School, Beech Hill Road, Sheffield, S10 2JF, UK", 
          "id": "http://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Department of Oncology, University of Sheffield, The Medical School, Beech Hill Road, Sheffield, S10 2JF, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tiernan", 
        "givenName": "James", 
        "id": "sg:person.01123227455.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123227455.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, University of Sheffield, The Medical School, Beech Hill Road, Sheffield, S10 2JF, UK", 
          "id": "http://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Department of Oncology, University of Sheffield, The Medical School, Beech Hill Road, Sheffield, S10 2JF, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Waby", 
        "givenName": "Jennifer S", 
        "id": "sg:person.01304160177.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304160177.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, University of Sheffield, The Medical School, Beech Hill Road, Sheffield, S10 2JF, UK", 
          "id": "http://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Department of Oncology, University of Sheffield, The Medical School, Beech Hill Road, Sheffield, S10 2JF, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Staton", 
        "givenName": "Carolyn A", 
        "id": "sg:person.01154256377.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154256377.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, University of Sheffield, The Medical School, Beech Hill Road, Sheffield, S10 2JF, UK", 
          "id": "http://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Department of Oncology, University of Sheffield, The Medical School, Beech Hill Road, Sheffield, S10 2JF, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Corfe", 
        "givenName": "Bernard M", 
        "id": "sg:person.01322020151.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322020151.91"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s002100100461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033346280", 
          "https://doi.org/10.1007/s002100100461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-4598-9-276", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050286155", 
          "https://doi.org/10.1186/1476-4598-9-276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-9-332", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002405293", 
          "https://doi.org/10.1186/1471-2407-9-332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052217365", 
          "https://doi.org/10.1038/sj.onc.1209702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10735-007-9145-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009825544", 
          "https://doi.org/10.1007/s10735-007-9145-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1006831330340", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009051181", 
          "https://doi.org/10.1023/a:1006831330340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2392", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053042364", 
          "https://doi.org/10.1038/nrc2392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02213129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017417316", 
          "https://doi.org/10.1007/bf02213129"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-03-14", 
    "datePublishedReg": "2011-03-14", 
    "description": "BACKGROUND: Previous reports have suggested that the VEGF receptor neuropilin-1 (NRP-1) is expressed in a singly dispersed subpopulation of cells in the normal colonic epithelium, but that expression becomes dysregulated during colorectal carcinogenesis, with higher levels in tumour suggestive of a poor prognosis. We noted that the spatial distribution and morphology if NRP-1 expressing cells resembles that of enteroendocrine cells (EEC) which are altered in response to disease state including cancer and irritable bowel syndrome (IBS). We have shown that NRP-1 is down-regulated by butyrate in colon cancer cell lines in vitro and we hypothesized that butyrate produced in the lumen would have an analogous effect on the colon mucosa in vivo. Therefore we sought to investigate whether NRP-1 is expressed in EEC and how NRP-1 and EEC respond to butyrate and other short-chain fatty acids (SCFA - principally acetate and propionate). Additionally we sought to assess whether there is a field effect around adenomas.\nMETHODOLOGY: Biopsies were collected at the mid-sigmoid, at the adenoma and at the contralateral wall (field) of 28 subjects during endoscopy. Samples were fixed for IHC and stained for either NRP-1 or for chromogranin A (CgA), a marker of EEC. Stool sampling was undertaken to assess individuals' butyrate, acetate and propionate levels.\nRESULT: NRP-1 expression was inversely related to SCFA concentration at the colon landmark (mid-sigmoid), but expression was lower and not related to SCFA concentration at the field. Likewise CgA+ cell number was also inversely related to SCFA at the landmark, but was lower and unresponsive at the field. Crypt cellularity was unaltered by field effect. A colocalisation analysis showed only a small subset of NRP-1 localised with CgA. Adenomas showed extensive, weaker staining for NRP-1 which contrastingly correlated positively with butyrate level. Field effects cause this relationship to be lost. Adenoma tissue shows dissociation of the co-regulation of NRP-1 and EEC.\nCONCLUSION: NRP-1 is inversely associated with levels of butyrate and other SCFA in vivo and is expressed in a subset of CgA expressing cells. EEC number is related to butyrate level in the same way.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/1476-4598-10-27", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1031030", 
        "issn": [
          "1476-4598"
        ], 
        "name": "Molecular Cancer", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "keywords": [
      "irritable bowel syndrome", 
      "enteroendocrine cells", 
      "neuropilin-1", 
      "VEGF receptor neuropilin-1", 
      "SCFA concentrations", 
      "short-chain fatty acid levels", 
      "enteroendocrine cell number", 
      "NRP-1 expression", 
      "receptor neuropilin-1", 
      "levels of butyrate", 
      "cell number", 
      "fatty acid levels", 
      "normal colonic epithelium", 
      "short-chain fatty acids", 
      "colon cancer cell lines", 
      "cancer cell lines", 
      "bowel syndrome", 
      "poor prognosis", 
      "crypt cellularity", 
      "field cancerization", 
      "colorectal adenomas", 
      "neuropilin expression", 
      "stool sampling", 
      "colorectal carcinogenesis", 
      "adenoma tissue", 
      "colonic epithelium", 
      "colon mucosa", 
      "weak staining", 
      "butyrate levels", 
      "contralateral wall", 
      "adenomas", 
      "EEC number", 
      "disease states", 
      "acid levels", 
      "propionate levels", 
      "cell lines", 
      "previous reports", 
      "fatty acids", 
      "SCFA", 
      "cells", 
      "vivo", 
      "expression", 
      "butyrate", 
      "high levels", 
      "levels", 
      "patients", 
      "prognosis", 
      "biopsy", 
      "mucosa", 
      "syndrome", 
      "endoscopy", 
      "chromogranin", 
      "cancerization", 
      "tumors", 
      "CgA.", 
      "cancer", 
      "small subset", 
      "cellularity", 
      "IHC", 
      "epithelium", 
      "subset", 
      "carcinogenesis", 
      "staining", 
      "effect", 
      "subpopulations", 
      "vitro", 
      "lumen", 
      "tissue", 
      "markers", 
      "association", 
      "subjects", 
      "report", 
      "CgA", 
      "landmarks", 
      "concentration", 
      "response", 
      "number", 
      "analogous effect", 
      "colocalisation analysis", 
      "acid", 
      "respond", 
      "same way", 
      "samples", 
      "wall", 
      "lines", 
      "relationship", 
      "sampling", 
      "analysis", 
      "dissociation", 
      "morphology", 
      "state", 
      "distribution", 
      "way", 
      "field", 
      "spatial distribution", 
      "field effects", 
      "dispersed subpopulation", 
      "EEC respond", 
      "marker of EEC", 
      "individuals' butyrate", 
      "colon landmark", 
      "subset of CgA"
    ], 
    "name": "Short-chain fatty acid level and field cancerization show opposing associations with enteroendocrine cell number and neuropilin expression in patients with colorectal adenoma", 
    "pagination": "27-27", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030331588"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1476-4598-10-27"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21401950"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1476-4598-10-27", 
      "https://app.dimensions.ai/details/publication/pub.1030331588"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_544.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/1476-4598-10-27"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1476-4598-10-27'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1476-4598-10-27'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1476-4598-10-27'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1476-4598-10-27'


 

This table displays all metadata directly associated to this object as RDF triples.

290 TRIPLES      22 PREDICATES      151 URIs      135 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1476-4598-10-27 schema:about N0457e489560646a287c2195d8a5d21ec
2 N06ce0ea166a942fba3966b11e9aeddff
3 N094a0beee3e24a38ba70359c402ccbec
4 N13383f28e340473bb4603305fb09262e
5 N53b65fffc82f4f8997fe08d6f30fe9f3
6 N68834fab58a1488c9be6cc87960e67cb
7 N7dc22691cb384cf8859023330b6855d8
8 Na7e0c1e1b4c841e79d2fed6ab11a1945
9 Nb4384ec73c7849a6b8815c75c9d2c6fe
10 Nba50140e1bfc4f3c958d234a5641d22e
11 Nc0ccb2fe05e545e5b18ef3f1f73a4f4d
12 Nd19c00e5fd8f4b47a85af96a9ac7dd1c
13 Ndbb4c2bcdf0b4a9cb7ca1e9df908c414
14 Ne39f8420641043ffb6cf0e89f6eb6aea
15 Nf93a32283c884909a2e823ce0da6da13
16 anzsrc-for:11
17 anzsrc-for:1112
18 schema:author Nb498aabd0f754f18a4df8feaeb5cbcce
19 schema:citation sg:pub.10.1007/bf02213129
20 sg:pub.10.1007/s002100100461
21 sg:pub.10.1007/s10735-007-9145-y
22 sg:pub.10.1023/a:1006831330340
23 sg:pub.10.1038/nrc2392
24 sg:pub.10.1038/sj.onc.1209702
25 sg:pub.10.1186/1471-2407-9-332
26 sg:pub.10.1186/1476-4598-9-276
27 schema:datePublished 2011-03-14
28 schema:datePublishedReg 2011-03-14
29 schema:description BACKGROUND: Previous reports have suggested that the VEGF receptor neuropilin-1 (NRP-1) is expressed in a singly dispersed subpopulation of cells in the normal colonic epithelium, but that expression becomes dysregulated during colorectal carcinogenesis, with higher levels in tumour suggestive of a poor prognosis. We noted that the spatial distribution and morphology if NRP-1 expressing cells resembles that of enteroendocrine cells (EEC) which are altered in response to disease state including cancer and irritable bowel syndrome (IBS). We have shown that NRP-1 is down-regulated by butyrate in colon cancer cell lines in vitro and we hypothesized that butyrate produced in the lumen would have an analogous effect on the colon mucosa in vivo. Therefore we sought to investigate whether NRP-1 is expressed in EEC and how NRP-1 and EEC respond to butyrate and other short-chain fatty acids (SCFA - principally acetate and propionate). Additionally we sought to assess whether there is a field effect around adenomas. METHODOLOGY: Biopsies were collected at the mid-sigmoid, at the adenoma and at the contralateral wall (field) of 28 subjects during endoscopy. Samples were fixed for IHC and stained for either NRP-1 or for chromogranin A (CgA), a marker of EEC. Stool sampling was undertaken to assess individuals' butyrate, acetate and propionate levels. RESULT: NRP-1 expression was inversely related to SCFA concentration at the colon landmark (mid-sigmoid), but expression was lower and not related to SCFA concentration at the field. Likewise CgA+ cell number was also inversely related to SCFA at the landmark, but was lower and unresponsive at the field. Crypt cellularity was unaltered by field effect. A colocalisation analysis showed only a small subset of NRP-1 localised with CgA. Adenomas showed extensive, weaker staining for NRP-1 which contrastingly correlated positively with butyrate level. Field effects cause this relationship to be lost. Adenoma tissue shows dissociation of the co-regulation of NRP-1 and EEC. CONCLUSION: NRP-1 is inversely associated with levels of butyrate and other SCFA in vivo and is expressed in a subset of CgA expressing cells. EEC number is related to butyrate level in the same way.
30 schema:genre article
31 schema:inLanguage en
32 schema:isAccessibleForFree true
33 schema:isPartOf N149e712fbbd84f218b53fcc0c0a28946
34 Na2c2c8f5bc654a4d9befb56c24bf1e0b
35 sg:journal.1031030
36 schema:keywords CgA
37 CgA.
38 EEC number
39 EEC respond
40 IHC
41 NRP-1 expression
42 SCFA
43 SCFA concentrations
44 VEGF receptor neuropilin-1
45 acid
46 acid levels
47 adenoma tissue
48 adenomas
49 analogous effect
50 analysis
51 association
52 biopsy
53 bowel syndrome
54 butyrate
55 butyrate levels
56 cancer
57 cancer cell lines
58 cancerization
59 carcinogenesis
60 cell lines
61 cell number
62 cells
63 cellularity
64 chromogranin
65 colocalisation analysis
66 colon cancer cell lines
67 colon landmark
68 colon mucosa
69 colonic epithelium
70 colorectal adenomas
71 colorectal carcinogenesis
72 concentration
73 contralateral wall
74 crypt cellularity
75 disease states
76 dispersed subpopulation
77 dissociation
78 distribution
79 effect
80 endoscopy
81 enteroendocrine cell number
82 enteroendocrine cells
83 epithelium
84 expression
85 fatty acid levels
86 fatty acids
87 field
88 field cancerization
89 field effects
90 high levels
91 individuals' butyrate
92 irritable bowel syndrome
93 landmarks
94 levels
95 levels of butyrate
96 lines
97 lumen
98 marker of EEC
99 markers
100 morphology
101 mucosa
102 neuropilin expression
103 neuropilin-1
104 normal colonic epithelium
105 number
106 patients
107 poor prognosis
108 previous reports
109 prognosis
110 propionate levels
111 receptor neuropilin-1
112 relationship
113 report
114 respond
115 response
116 same way
117 samples
118 sampling
119 short-chain fatty acid levels
120 short-chain fatty acids
121 small subset
122 spatial distribution
123 staining
124 state
125 stool sampling
126 subjects
127 subpopulations
128 subset
129 subset of CgA
130 syndrome
131 tissue
132 tumors
133 vitro
134 vivo
135 wall
136 way
137 weak staining
138 schema:name Short-chain fatty acid level and field cancerization show opposing associations with enteroendocrine cell number and neuropilin expression in patients with colorectal adenoma
139 schema:pagination 27-27
140 schema:productId N57f3c2f3e531483fb8a1980372d1c652
141 N8c3475a8f289490c86cb3f3bb59b8cdd
142 Nd710b17263a7450c883f5ce0b244a610
143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030331588
144 https://doi.org/10.1186/1476-4598-10-27
145 schema:sdDatePublished 2021-12-01T19:25
146 schema:sdLicense https://scigraph.springernature.com/explorer/license/
147 schema:sdPublisher Nb36a1726dc0e497fbbca9e687615e8f2
148 schema:url https://doi.org/10.1186/1476-4598-10-27
149 sgo:license sg:explorer/license/
150 sgo:sdDataset articles
151 rdf:type schema:ScholarlyArticle
152 N043718a499614396895fb2d535d55c3c rdf:first sg:person.01154256377.90
153 rdf:rest N694988a6d1c94ff086894eba9aa0fb40
154 N0457e489560646a287c2195d8a5d21ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Colorectal Neoplasms
156 rdf:type schema:DefinedTerm
157 N06ce0ea166a942fba3966b11e9aeddff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Fatty Acids, Volatile
159 rdf:type schema:DefinedTerm
160 N094a0beee3e24a38ba70359c402ccbec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Colonic Polyps
162 rdf:type schema:DefinedTerm
163 N13383f28e340473bb4603305fb09262e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Epithelium
165 rdf:type schema:DefinedTerm
166 N149e712fbbd84f218b53fcc0c0a28946 schema:issueNumber 1
167 rdf:type schema:PublicationIssue
168 N2a2c2ebb17cb497b9f871a8e18af5c5a rdf:first sg:person.01202531224.23
169 rdf:rest Na34f188d4cfd4a02b4293fb7ea6ba13e
170 N53b65fffc82f4f8997fe08d6f30fe9f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Humans
172 rdf:type schema:DefinedTerm
173 N57f3c2f3e531483fb8a1980372d1c652 schema:name doi
174 schema:value 10.1186/1476-4598-10-27
175 rdf:type schema:PropertyValue
176 N68834fab58a1488c9be6cc87960e67cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Protein Transport
178 rdf:type schema:DefinedTerm
179 N694988a6d1c94ff086894eba9aa0fb40 rdf:first sg:person.01322020151.91
180 rdf:rest rdf:nil
181 N7dc22691cb384cf8859023330b6855d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Aged
183 rdf:type schema:DefinedTerm
184 N8c3475a8f289490c86cb3f3bb59b8cdd schema:name pubmed_id
185 schema:value 21401950
186 rdf:type schema:PropertyValue
187 Na2c2c8f5bc654a4d9befb56c24bf1e0b schema:volumeNumber 10
188 rdf:type schema:PublicationVolume
189 Na34f188d4cfd4a02b4293fb7ea6ba13e rdf:first sg:person.01123227455.48
190 rdf:rest Nc090b2cad7fe4a559b23497f44aaa09e
191 Na7e0c1e1b4c841e79d2fed6ab11a1945 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Adenoma
193 rdf:type schema:DefinedTerm
194 Nb36a1726dc0e497fbbca9e687615e8f2 schema:name Springer Nature - SN SciGraph project
195 rdf:type schema:Organization
196 Nb4384ec73c7849a6b8815c75c9d2c6fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Epithelial Cells
198 rdf:type schema:DefinedTerm
199 Nb498aabd0f754f18a4df8feaeb5cbcce rdf:first sg:person.0656542305.42
200 rdf:rest N2a2c2ebb17cb497b9f871a8e18af5c5a
201 Nba50140e1bfc4f3c958d234a5641d22e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Chromogranin A
203 rdf:type schema:DefinedTerm
204 Nc090b2cad7fe4a559b23497f44aaa09e rdf:first sg:person.01304160177.12
205 rdf:rest N043718a499614396895fb2d535d55c3c
206 Nc0ccb2fe05e545e5b18ef3f1f73a4f4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Demography
208 rdf:type schema:DefinedTerm
209 Nd19c00e5fd8f4b47a85af96a9ac7dd1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Cell Count
211 rdf:type schema:DefinedTerm
212 Nd710b17263a7450c883f5ce0b244a610 schema:name dimensions_id
213 schema:value pub.1030331588
214 rdf:type schema:PropertyValue
215 Ndbb4c2bcdf0b4a9cb7ca1e9df908c414 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Enteroendocrine Cells
217 rdf:type schema:DefinedTerm
218 Ne39f8420641043ffb6cf0e89f6eb6aea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Neuropilins
220 rdf:type schema:DefinedTerm
221 Nf93a32283c884909a2e823ce0da6da13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Butyrates
223 rdf:type schema:DefinedTerm
224 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
225 schema:name Medical and Health Sciences
226 rdf:type schema:DefinedTerm
227 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
228 schema:name Oncology and Carcinogenesis
229 rdf:type schema:DefinedTerm
230 sg:journal.1031030 schema:issn 1476-4598
231 schema:name Molecular Cancer
232 schema:publisher Springer Nature
233 rdf:type schema:Periodical
234 sg:person.01123227455.48 schema:affiliation grid-institutes:grid.11835.3e
235 schema:familyName Tiernan
236 schema:givenName James
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123227455.48
238 rdf:type schema:Person
239 sg:person.01154256377.90 schema:affiliation grid-institutes:grid.11835.3e
240 schema:familyName Staton
241 schema:givenName Carolyn A
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154256377.90
243 rdf:type schema:Person
244 sg:person.01202531224.23 schema:affiliation grid-institutes:grid.11835.3e
245 schema:familyName Bury
246 schema:givenName Jonathan P
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202531224.23
248 rdf:type schema:Person
249 sg:person.01304160177.12 schema:affiliation grid-institutes:grid.11835.3e
250 schema:familyName Waby
251 schema:givenName Jennifer S
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304160177.12
253 rdf:type schema:Person
254 sg:person.01322020151.91 schema:affiliation grid-institutes:grid.11835.3e
255 schema:familyName Corfe
256 schema:givenName Bernard M
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322020151.91
258 rdf:type schema:Person
259 sg:person.0656542305.42 schema:affiliation grid-institutes:grid.11835.3e
260 schema:familyName Yu
261 schema:givenName Danny CW
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656542305.42
263 rdf:type schema:Person
264 sg:pub.10.1007/bf02213129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017417316
265 https://doi.org/10.1007/bf02213129
266 rdf:type schema:CreativeWork
267 sg:pub.10.1007/s002100100461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033346280
268 https://doi.org/10.1007/s002100100461
269 rdf:type schema:CreativeWork
270 sg:pub.10.1007/s10735-007-9145-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1009825544
271 https://doi.org/10.1007/s10735-007-9145-y
272 rdf:type schema:CreativeWork
273 sg:pub.10.1023/a:1006831330340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009051181
274 https://doi.org/10.1023/a:1006831330340
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/nrc2392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053042364
277 https://doi.org/10.1038/nrc2392
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/sj.onc.1209702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052217365
280 https://doi.org/10.1038/sj.onc.1209702
281 rdf:type schema:CreativeWork
282 sg:pub.10.1186/1471-2407-9-332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002405293
283 https://doi.org/10.1186/1471-2407-9-332
284 rdf:type schema:CreativeWork
285 sg:pub.10.1186/1476-4598-9-276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050286155
286 https://doi.org/10.1186/1476-4598-9-276
287 rdf:type schema:CreativeWork
288 grid-institutes:grid.11835.3e schema:alternateName Department of Oncology, University of Sheffield, The Medical School, Beech Hill Road, Sheffield, S10 2JF, UK
289 schema:name Department of Oncology, University of Sheffield, The Medical School, Beech Hill Road, Sheffield, S10 2JF, UK
290 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...