MicroRNA-148b is frequently down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting cell proliferation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

Yong-Xi Song, Zhen-Yu Yue, Zhen-Ning Wang, Ying-Ying Xu, Yang Luo, Hui-Mian Xu, Xue Zhang, Li Jiang, Cheng-Zhong Xing, Yong Zhang

ABSTRACT

BACKGROUND: MicroRNAs (miRNAs) are involved in cancer development and progression, acting as tumor suppressors or oncogenes. Our previous studies have revealed that miR-148a and miR-152 are significantly down-regulated in gastrointestinal cancers. Interestingly, miR-148b has the same "seed sequences" as miR-148a and miR-152. Although aberrant expression of miR-148b has been observed in several types of cancer, its pathophysiologic role and relevance to tumorigenesis are still largely unknown. The purpose of this study was to elucidate the molecular mechanisms by which miR-148b acts as a tumor suppressor in gastric cancer. RESULTS: We showed significant down-regulation of miR-148b in 106 gastric cancer tissues and four gastric cancer cell lines, compared with their non-tumor counterparts by real-time RT-PCR. In situ hybridization of ten cases confirmed an overt decrease in the level of miR-148b in gastric cancer tissues. Moreover, the expression of miR-148b was demonstrated to be associated with tumor size (P = 0.027) by a Mann-Whitney U test. We also found that miR-148b could inhibit cell proliferation in vitro by MTT assay, growth curves and an anchorage-independent growth assay in MGC-803, SGC-7901, BGC-823 and AGS cells. An experiment in nude mice revealed that miR-148b could suppress tumorigenicity in vivo. Using a luciferase activity assay and western blot, CCKBR was identified as a target of miR-148b in cells. Moreover, an obvious inverse correlation was observed between the expression of CCKBR protein and miR-148b in 49 pairs of tissues (P = 0.002, Spearman's correlation). CONCLUSIONS: These findings provide important evidence that miR-148b targets CCKBR and is significant in suppressing gastric cancer cell growth. Maybe miR-148b would become a potential biomarker and therapeutic target against gastric cancer. More... »

PAGES

1

References to SciGraph publications

  • 2001-05. Proliferation, cell cycle and apoptosis in cancer in NATURE
  • 2003-10. Identifying biological themes within lists of genes with EASE in GENOME BIOLOGY
  • 2010-10. Blocking gastrin and CCK-B autocrine loop affects cell proliferation and apoptosis in vitro in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2006-03. MicroRNAs in cell proliferation, cell death, and tumorigenesis in BRITISH JOURNAL OF CANCER
  • 2009-12. The expression profile of microRNAs in a model of 7,12-dimethyl-benz[a]anthrance-induced oral carcinogenesis in Syrian hamster in JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
  • 2005-02. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs in NATURE
  • 2010-07. Altered Expression of MiR-148a and MiR-152 in Gastrointestinal Cancers and Its Clinical Significance in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2004-07. MicroRNAs: small RNAs with a big role in gene regulation in NATURE REVIEWS GENETICS
  • 2010-12. MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2 in MOLECULAR CANCER
  • 2005-06. MicroRNA expression profiles classify human cancers in NATURE
  • 2008-11. The miR-15a–miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities in NATURE MEDICINE
  • 2010-12. Regulation of the transcription factor NF-κB1 by microRNA-9 in human gastric adenocarcinoma in MOLECULAR CANCER
  • 2007-05. MicroRNA-133 controls cardiac hypertrophy in NATURE MEDICINE
  • 2005-05. Combinatorial microRNA target predictions in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1476-4598-10-1

    DOI

    http://dx.doi.org/10.1186/1476-4598-10-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1015825134

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21205300


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