A systematic review and meta-analysis of evidence for correlation between molecular markers of parasite resistance and treatment outcome in falciparum ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-12

AUTHORS

Stéphane Picot, Piero Olliaro, Frédérique de Monbrison, Anne-Lise Bienvenu, Ric N Price, Pascal Ringwald

ABSTRACT

BACKGROUND: An assessment of the correlation between anti-malarial treatment outcome and molecular markers would improve the early detection and monitoring of drug resistance by Plasmodium falciparum. The purpose of this systematic review was to determine the risk of treatment failure associated with specific polymorphisms in the parasite genome or gene copy number. METHODS: Clinical studies of non-severe malaria reporting on target genetic markers (SNPs for pfmdr1, pfcrt, dhfr, dhps, gene copy number for pfmdr1) providing complete information on inclusion criteria, outcome, follow up and genotyping, were included. Three investigators independently extracted data from articles. Results were stratified by gene, codon, drug and duration of follow-up. For each study and aggregate data the random effect odds ratio (OR) with 95%CIs was estimated and presented as Forest plots. An OR with a lower 95th confidence interval > 1 was considered consistent with a failure being associated to a given gene mutation. RESULTS: 92 studies were eligible among the selection from computerized search, with information on pfcrt (25/159 studies), pfmdr1 (29/236 studies), dhfr (18/373 studies), dhps (20/195 studies). The risk of therapeutic failure after chloroquine was increased by the presence of pfcrt K76T (Day 28, OR = 7.2 [95%CI: 4.5-11.5]), pfmdr1 N86Y was associated with both chloroquine (Day 28, OR = 1.8 [95%CI: 1.3-2.4]) and amodiaquine failures (OR = 5.4 [95%CI: 2.6-11.3, p < 0.001]). For sulphadoxine-pyrimethamine the dhfr single (S108N) (Day 28, OR = 3.5 [95%CI: 1.9-6.3]) and triple mutants (S108N, N51I, C59R) (Day 28, OR = 3.1 [95%CI: 2.0-4.9]) and dhfr-dhps quintuple mutants (Day 28, OR = 5.2 [95%CI: 3.2-8.8]) also increased the risk of treatment failure. Increased pfmdr1 copy number was correlated with treatment failure following mefloquine (OR = 8.6 [95%CI: 3.3-22.9]). CONCLUSION: When applying the selection procedure for comparative analysis, few studies fulfilled all inclusion criteria compared to the large number of papers identified, but heterogeneity was limited. Genetic molecular markers were related to an increased risk of therapeutic failure. Guidelines are discussed and a checklist for further studies is proposed. More... »

PAGES

89

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1475-2875-8-89

DOI

http://dx.doi.org/10.1186/1475-2875-8-89

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041383647

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19413906


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antimalarials", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Resistance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Dosage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Protozoan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Markers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Malaria, Falciparum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plasmodium falciparum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Failure", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Malaria Research Unit, EA 4170, University Lyon 1, Faculty of Medicine, 8 Avenue Rockefeller, 69373, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Picot", 
        "givenName": "St\u00e9phane", 
        "id": "sg:person.01023257736.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023257736.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "UNICEF/UNDP/WB/WHO Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland", 
            "Centre for Vaccinology & Tropical Medicine, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Olliaro", 
        "givenName": "Piero", 
        "id": "sg:person.01074272363.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074272363.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Malaria Research Unit, EA 4170, University Lyon 1, Faculty of Medicine, 8 Avenue Rockefeller, 69373, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Monbrison", 
        "givenName": "Fr\u00e9d\u00e9rique", 
        "id": "sg:person.01307625361.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307625361.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Malaria Research Unit, EA 4170, University Lyon 1, Faculty of Medicine, 8 Avenue Rockefeller, 69373, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bienvenu", 
        "givenName": "Anne-Lise", 
        "id": "sg:person.01340264442.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340264442.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charles Darwin University", 
          "id": "https://www.grid.ac/institutes/grid.1043.6", 
          "name": [
            "International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Price", 
        "givenName": "Ric N", 
        "id": "sg:person.013405371002.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013405371002.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "World Health Organization", 
          "id": "https://www.grid.ac/institutes/grid.3575.4", 
          "name": [
            "Global Malaria Programme, World Health Organization, Geneva, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ringwald", 
        "givenName": "Pascal", 
        "id": "sg:person.0727072567.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727072567.02"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.meegid.2003.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000290100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.meegid.2003.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000290100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkg294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000656996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/379323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001012084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/514159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002916171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1567-1348(01)00021-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002996032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-006-6071-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006510881", 
          "https://doi.org/10.1007/s00018-006-6071-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1179/136485907x154584", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007514528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/375419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007570230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0169-4758(91)90197-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009500742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0169-4758(91)90197-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009500742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-3156.2003.01099.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009654711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(01)06040-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009851831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/319865", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010714038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0035-9203(02)90346-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010905407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1471-4922(02)00017-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012449022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1471-4922(02)00017-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012449022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1369-5274(00)00228-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012516200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3156.2008.02150.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012651338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/315731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013974274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-6-121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015364901", 
          "https://doi.org/10.1186/1475-2875-6-121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-4658.2007.05999.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015815512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1179/136485905x75395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017274034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1179/136485905x75395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017274034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1179/000349802125001249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017758958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm200101253440403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019084310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-6-122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019297061", 
          "https://doi.org/10.1186/1475-2875-6-122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-5-127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019657300", 
          "https://doi.org/10.1186/1475-2875-5-127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-008-0499-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019864889", 
          "https://doi.org/10.1007/s10096-008-0499-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-008-0499-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019864889", 
          "https://doi.org/10.1007/s10096-008-0499-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-008-0499-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019864889", 
          "https://doi.org/10.1007/s10096-008-0499-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01813", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023024453", 
          "https://doi.org/10.1038/nature01813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01813", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023024453", 
          "https://doi.org/10.1038/nature01813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3156.2005.01414.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023148313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3156.2005.01414.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023148313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actatropica.2005.06.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023192408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actatropica.2005.06.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023192408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3156.2007.01904.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023497284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3156.2007.01904.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023497284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0030335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024808046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0030335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024808046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actatropica.2007.07.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024876637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00436-005-1406-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025634127", 
          "https://doi.org/10.1007/s00436-005-1406-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jeb.00658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026013397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actatropica.2005.04.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028008717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0031182096008487", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028864272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0031182096008487", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028864272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actatropica.2005.07.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031788108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actatropica.2005.07.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031788108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(07)70214-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032717204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(98)24022-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034198331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3156.2007.01995.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035319904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3156.2007.01995.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035319904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/318836", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035563082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0163-7258(98)00012-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036686089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-6-41", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037361864", 
          "https://doi.org/10.1186/1475-2875-6-41"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actatropica.2007.04.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037509841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3156.2004.01249.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037756378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(04)16767-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039469915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1179/000349803235002489", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039957733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1179/136485905x46441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040459473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1179/136485905x46441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040459473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0035-9203(97)90227-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041319716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci21682", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041881557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/338566", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044250968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3156.2005.01471.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044901893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3156.2005.01471.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044901893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mib.2007.07.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045272453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0035-9203(01)90329-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045286839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0169-4758(97)01124-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045672749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0001578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047060173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0035-9203(03)00014-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047290128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-3156.2000.00543.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047374584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/cmr.00021-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047866196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0035-9203(01)90250-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049275393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00436-006-0291-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051395571", 
          "https://doi.org/10.1007/s00436-006-0291-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00436-006-0291-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051395571", 
          "https://doi.org/10.1007/s00436-006-0291-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/319856", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051874669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pt.2007.09.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052186131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1179/000349804x3162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052510396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.meegid.2005.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052872343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.meegid.2005.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052872343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.trstmh.2003.10.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054750900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.trstmh.2004.10.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054751027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.trstmh.2004.10.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054751027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.trstmh.2007.01.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054751409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.trstmh.2008.11.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054751854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00034980120092516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058260547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/517831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058791399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.1999.61.125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074501126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.1999.61.245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074512869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.43.9.2205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074515067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.43.12.2943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074557611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2002.67.225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075183304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2002.67.392", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075197373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2002.67.449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075203321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2002.67.578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075215253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2003.68.398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075319706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2003.68.413", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075319709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2003.69.184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075929416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2003.69.247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076601162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2003.69.601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076629626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2004.71.40", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076862918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2004.71.696", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076991820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2005.73.174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077080164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2006.75.155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077268423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2007.76.608", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077401659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2007.76.844", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077415168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2007.77.36", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077443187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2007.77.160", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077584384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.42.7.1811", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083290039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/9781555817558.ch23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1088809457"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-12", 
    "datePublishedReg": "2009-12-01", 
    "description": "BACKGROUND: An assessment of the correlation between anti-malarial treatment outcome and molecular markers would improve the early detection and monitoring of drug resistance by Plasmodium falciparum. The purpose of this systematic review was to determine the risk of treatment failure associated with specific polymorphisms in the parasite genome or gene copy number.\nMETHODS: Clinical studies of non-severe malaria reporting on target genetic markers (SNPs for pfmdr1, pfcrt, dhfr, dhps, gene copy number for pfmdr1) providing complete information on inclusion criteria, outcome, follow up and genotyping, were included. Three investigators independently extracted data from articles. Results were stratified by gene, codon, drug and duration of follow-up. For each study and aggregate data the random effect odds ratio (OR) with 95%CIs was estimated and presented as Forest plots. An OR with a lower 95th confidence interval > 1 was considered consistent with a failure being associated to a given gene mutation.\nRESULTS: 92 studies were eligible among the selection from computerized search, with information on pfcrt (25/159 studies), pfmdr1 (29/236 studies), dhfr (18/373 studies), dhps (20/195 studies). The risk of therapeutic failure after chloroquine was increased by the presence of pfcrt K76T (Day 28, OR = 7.2 [95%CI: 4.5-11.5]), pfmdr1 N86Y was associated with both chloroquine (Day 28, OR = 1.8 [95%CI: 1.3-2.4]) and amodiaquine failures (OR = 5.4 [95%CI: 2.6-11.3, p < 0.001]). For sulphadoxine-pyrimethamine the dhfr single (S108N) (Day 28, OR = 3.5 [95%CI: 1.9-6.3]) and triple mutants (S108N, N51I, C59R) (Day 28, OR = 3.1 [95%CI: 2.0-4.9]) and dhfr-dhps quintuple mutants (Day 28, OR = 5.2 [95%CI: 3.2-8.8]) also increased the risk of treatment failure. Increased pfmdr1 copy number was correlated with treatment failure following mefloquine (OR = 8.6 [95%CI: 3.3-22.9]).\nCONCLUSION: When applying the selection procedure for comparative analysis, few studies fulfilled all inclusion criteria compared to the large number of papers identified, but heterogeneity was limited. Genetic molecular markers were related to an increased risk of therapeutic failure. Guidelines are discussed and a checklist for further studies is proposed.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1475-2875-8-89", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1030597", 
        "issn": [
          "1475-2875"
        ], 
        "name": "Malaria Journal", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "A systematic review and meta-analysis of evidence for correlation between molecular markers of parasite resistance and treatment outcome in falciparum malaria", 
    "pagination": "89", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c523c120a30c42f023eeaa695f0b73670a8d610d1fff101b98d36e2dcdab4937"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19413906"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101139802"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1475-2875-8-89"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1041383647"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1475-2875-8-89", 
      "https://app.dimensions.ai/details/publication/pub.1041383647"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:53", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000551.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1475-2875-8-89"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1475-2875-8-89'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1475-2875-8-89'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1475-2875-8-89'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1475-2875-8-89'


 

This table displays all metadata directly associated to this object as RDF triples.

448 TRIPLES      21 PREDICATES      133 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1475-2875-8-89 schema:about N23d456f0c8b84acba313120c34d08f9c
2 N2707bc571b3e44aeb0a2c90011cd3e24
3 N355207f4e0dd4f97b0a0cd3b7b2d8cc9
4 N45dc02875dc648adaad45bd91e78e360
5 N9e53c2e26e374d73a6f2f2a9dc1c4927
6 Nad3503bd48234d81b4e639a6e57d6f8f
7 Nb168ccfee8e84a7990f7cab57c2db530
8 Nb910124df3aa4b4590f0e4faf1f25b76
9 Nc02848f378d547f9bc31c68753a90623
10 Nc6eb677736924b2b88c86963a57d17fd
11 Ned0e6ce587be46329320d99e6c22e970
12 anzsrc-for:06
13 anzsrc-for:0604
14 schema:author N9092b358b8d34de29b48d9e2c8c4beed
15 schema:citation sg:pub.10.1007/s00018-006-6071-1
16 sg:pub.10.1007/s00436-005-1406-7
17 sg:pub.10.1007/s00436-006-0291-z
18 sg:pub.10.1007/s10096-008-0499-1
19 sg:pub.10.1038/nature01813
20 sg:pub.10.1186/1475-2875-5-127
21 sg:pub.10.1186/1475-2875-6-121
22 sg:pub.10.1186/1475-2875-6-122
23 sg:pub.10.1186/1475-2875-6-41
24 https://doi.org/10.1016/0169-4758(91)90197-v
25 https://doi.org/10.1016/j.actatropica.2005.04.003
26 https://doi.org/10.1016/j.actatropica.2005.06.015
27 https://doi.org/10.1016/j.actatropica.2005.07.030
28 https://doi.org/10.1016/j.actatropica.2007.04.008
29 https://doi.org/10.1016/j.actatropica.2007.07.014
30 https://doi.org/10.1016/j.meegid.2003.08.002
31 https://doi.org/10.1016/j.meegid.2005.09.001
32 https://doi.org/10.1016/j.mib.2007.07.007
33 https://doi.org/10.1016/j.pt.2007.09.008
34 https://doi.org/10.1016/j.trstmh.2003.10.010
35 https://doi.org/10.1016/j.trstmh.2004.10.003
36 https://doi.org/10.1016/j.trstmh.2007.01.008
37 https://doi.org/10.1016/j.trstmh.2008.11.002
38 https://doi.org/10.1016/s0035-9203(01)90250-0
39 https://doi.org/10.1016/s0035-9203(01)90329-3
40 https://doi.org/10.1016/s0035-9203(02)90346-9
41 https://doi.org/10.1016/s0035-9203(03)00014-2
42 https://doi.org/10.1016/s0035-9203(97)90227-3
43 https://doi.org/10.1016/s0140-6736(01)06040-8
44 https://doi.org/10.1016/s0140-6736(04)16767-6
45 https://doi.org/10.1016/s0140-6736(98)24022-0
46 https://doi.org/10.1016/s0163-7258(98)00012-6
47 https://doi.org/10.1016/s0169-4758(97)01124-1
48 https://doi.org/10.1016/s1369-5274(00)00228-9
49 https://doi.org/10.1016/s1471-4922(02)00017-x
50 https://doi.org/10.1016/s1473-3099(07)70214-1
51 https://doi.org/10.1016/s1567-1348(01)00021-1
52 https://doi.org/10.1017/s0031182096008487
53 https://doi.org/10.1046/j.1365-3156.2000.00543.x
54 https://doi.org/10.1046/j.1365-3156.2003.01099.x
55 https://doi.org/10.1056/nejm200101253440403
56 https://doi.org/10.1080/00034980120092516
57 https://doi.org/10.1086/315731
58 https://doi.org/10.1086/318836
59 https://doi.org/10.1086/319856
60 https://doi.org/10.1086/319865
61 https://doi.org/10.1086/338566
62 https://doi.org/10.1086/375419
63 https://doi.org/10.1086/379323
64 https://doi.org/10.1086/514159
65 https://doi.org/10.1086/517831
66 https://doi.org/10.1093/jac/dkg294
67 https://doi.org/10.1111/j.1365-3156.2004.01249.x
68 https://doi.org/10.1111/j.1365-3156.2005.01414.x
69 https://doi.org/10.1111/j.1365-3156.2005.01471.x
70 https://doi.org/10.1111/j.1365-3156.2007.01904.x
71 https://doi.org/10.1111/j.1365-3156.2007.01995.x
72 https://doi.org/10.1111/j.1365-3156.2008.02150.x
73 https://doi.org/10.1111/j.1742-4658.2007.05999.x
74 https://doi.org/10.1128/9781555817558.ch23
75 https://doi.org/10.1128/aac.42.7.1811
76 https://doi.org/10.1128/aac.43.12.2943
77 https://doi.org/10.1128/aac.43.9.2205
78 https://doi.org/10.1128/cmr.00021-06
79 https://doi.org/10.1172/jci21682
80 https://doi.org/10.1179/000349802125001249
81 https://doi.org/10.1179/000349803235002489
82 https://doi.org/10.1179/000349804x3162
83 https://doi.org/10.1179/136485905x46441
84 https://doi.org/10.1179/136485905x75395
85 https://doi.org/10.1179/136485907x154584
86 https://doi.org/10.1242/jeb.00658
87 https://doi.org/10.1371/journal.pbio.0030335
88 https://doi.org/10.1371/journal.pone.0001578
89 https://doi.org/10.4269/ajtmh.1999.61.125
90 https://doi.org/10.4269/ajtmh.1999.61.245
91 https://doi.org/10.4269/ajtmh.2002.67.225
92 https://doi.org/10.4269/ajtmh.2002.67.392
93 https://doi.org/10.4269/ajtmh.2002.67.449
94 https://doi.org/10.4269/ajtmh.2002.67.578
95 https://doi.org/10.4269/ajtmh.2003.68.398
96 https://doi.org/10.4269/ajtmh.2003.68.413
97 https://doi.org/10.4269/ajtmh.2003.69.184
98 https://doi.org/10.4269/ajtmh.2003.69.247
99 https://doi.org/10.4269/ajtmh.2003.69.601
100 https://doi.org/10.4269/ajtmh.2004.71.40
101 https://doi.org/10.4269/ajtmh.2004.71.696
102 https://doi.org/10.4269/ajtmh.2005.73.174
103 https://doi.org/10.4269/ajtmh.2006.75.155
104 https://doi.org/10.4269/ajtmh.2007.76.608
105 https://doi.org/10.4269/ajtmh.2007.76.844
106 https://doi.org/10.4269/ajtmh.2007.77.160
107 https://doi.org/10.4269/ajtmh.2007.77.36
108 schema:datePublished 2009-12
109 schema:datePublishedReg 2009-12-01
110 schema:description BACKGROUND: An assessment of the correlation between anti-malarial treatment outcome and molecular markers would improve the early detection and monitoring of drug resistance by Plasmodium falciparum. The purpose of this systematic review was to determine the risk of treatment failure associated with specific polymorphisms in the parasite genome or gene copy number. METHODS: Clinical studies of non-severe malaria reporting on target genetic markers (SNPs for pfmdr1, pfcrt, dhfr, dhps, gene copy number for pfmdr1) providing complete information on inclusion criteria, outcome, follow up and genotyping, were included. Three investigators independently extracted data from articles. Results were stratified by gene, codon, drug and duration of follow-up. For each study and aggregate data the random effect odds ratio (OR) with 95%CIs was estimated and presented as Forest plots. An OR with a lower 95th confidence interval > 1 was considered consistent with a failure being associated to a given gene mutation. RESULTS: 92 studies were eligible among the selection from computerized search, with information on pfcrt (25/159 studies), pfmdr1 (29/236 studies), dhfr (18/373 studies), dhps (20/195 studies). The risk of therapeutic failure after chloroquine was increased by the presence of pfcrt K76T (Day 28, OR = 7.2 [95%CI: 4.5-11.5]), pfmdr1 N86Y was associated with both chloroquine (Day 28, OR = 1.8 [95%CI: 1.3-2.4]) and amodiaquine failures (OR = 5.4 [95%CI: 2.6-11.3, p < 0.001]). For sulphadoxine-pyrimethamine the dhfr single (S108N) (Day 28, OR = 3.5 [95%CI: 1.9-6.3]) and triple mutants (S108N, N51I, C59R) (Day 28, OR = 3.1 [95%CI: 2.0-4.9]) and dhfr-dhps quintuple mutants (Day 28, OR = 5.2 [95%CI: 3.2-8.8]) also increased the risk of treatment failure. Increased pfmdr1 copy number was correlated with treatment failure following mefloquine (OR = 8.6 [95%CI: 3.3-22.9]). CONCLUSION: When applying the selection procedure for comparative analysis, few studies fulfilled all inclusion criteria compared to the large number of papers identified, but heterogeneity was limited. Genetic molecular markers were related to an increased risk of therapeutic failure. Guidelines are discussed and a checklist for further studies is proposed.
111 schema:genre research_article
112 schema:inLanguage en
113 schema:isAccessibleForFree true
114 schema:isPartOf Na54c2690bd57492f8c41eb91d33df3ab
115 Nb1b0d8c9ef36488bab4dc81898a22878
116 sg:journal.1030597
117 schema:name A systematic review and meta-analysis of evidence for correlation between molecular markers of parasite resistance and treatment outcome in falciparum malaria
118 schema:pagination 89
119 schema:productId N6fa726403c7442e094acb2894e48a6fd
120 Nb5aa64e2f16a40abae5f36bcae75aa82
121 Ncbaa38869fcc4c258e45d935056c22a8
122 Ne6b739d0461b4fb8ae16c0a5431c2699
123 Nfa0c4758f4c5410aaba0872e5e885a63
124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041383647
125 https://doi.org/10.1186/1475-2875-8-89
126 schema:sdDatePublished 2019-04-10T20:53
127 schema:sdLicense https://scigraph.springernature.com/explorer/license/
128 schema:sdPublisher Ncf6c4abd27284ed0b16127568f640fa5
129 schema:url http://link.springer.com/10.1186%2F1475-2875-8-89
130 sgo:license sg:explorer/license/
131 sgo:sdDataset articles
132 rdf:type schema:ScholarlyArticle
133 N081a6d1145eb4bd8a908fecf05a64c06 rdf:first sg:person.013405371002.20
134 rdf:rest N32dadeaa5804458eb735a2a5f2424346
135 N12e2a8187d8a4f54b809e967e57cf577 schema:name Malaria Research Unit, EA 4170, University Lyon 1, Faculty of Medicine, 8 Avenue Rockefeller, 69373, Lyon, France
136 rdf:type schema:Organization
137 N23d456f0c8b84acba313120c34d08f9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Antimalarials
139 rdf:type schema:DefinedTerm
140 N2707bc571b3e44aeb0a2c90011cd3e24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Malaria, Falciparum
142 rdf:type schema:DefinedTerm
143 N32dadeaa5804458eb735a2a5f2424346 rdf:first sg:person.0727072567.02
144 rdf:rest rdf:nil
145 N355207f4e0dd4f97b0a0cd3b7b2d8cc9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Treatment Failure
147 rdf:type schema:DefinedTerm
148 N36ac7e396f83405585b57ee640b5af46 rdf:first sg:person.01340264442.10
149 rdf:rest N081a6d1145eb4bd8a908fecf05a64c06
150 N45dc02875dc648adaad45bd91e78e360 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Genes, Protozoan
152 rdf:type schema:DefinedTerm
153 N4875bd6c234a4dfc985295b809c13056 rdf:first sg:person.01307625361.27
154 rdf:rest N36ac7e396f83405585b57ee640b5af46
155 N5c81f0eb12834ff1a64700c97543d9bd schema:name Malaria Research Unit, EA 4170, University Lyon 1, Faculty of Medicine, 8 Avenue Rockefeller, 69373, Lyon, France
156 rdf:type schema:Organization
157 N6fa726403c7442e094acb2894e48a6fd schema:name doi
158 schema:value 10.1186/1475-2875-8-89
159 rdf:type schema:PropertyValue
160 N9092b358b8d34de29b48d9e2c8c4beed rdf:first sg:person.01023257736.40
161 rdf:rest Nbf38a7ce985b4a719a2d496623c1ec1d
162 N984c6307a8c6483393f89e23e7d6a312 schema:name Malaria Research Unit, EA 4170, University Lyon 1, Faculty of Medicine, 8 Avenue Rockefeller, 69373, Lyon, France
163 rdf:type schema:Organization
164 N9e53c2e26e374d73a6f2f2a9dc1c4927 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Humans
166 rdf:type schema:DefinedTerm
167 Na54c2690bd57492f8c41eb91d33df3ab schema:issueNumber 1
168 rdf:type schema:PublicationIssue
169 Nad3503bd48234d81b4e639a6e57d6f8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Animals
171 rdf:type schema:DefinedTerm
172 Nb168ccfee8e84a7990f7cab57c2db530 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Plasmodium falciparum
174 rdf:type schema:DefinedTerm
175 Nb1b0d8c9ef36488bab4dc81898a22878 schema:volumeNumber 8
176 rdf:type schema:PublicationVolume
177 Nb5aa64e2f16a40abae5f36bcae75aa82 schema:name pubmed_id
178 schema:value 19413906
179 rdf:type schema:PropertyValue
180 Nb910124df3aa4b4590f0e4faf1f25b76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Genetic Markers
182 rdf:type schema:DefinedTerm
183 Nbf38a7ce985b4a719a2d496623c1ec1d rdf:first sg:person.01074272363.42
184 rdf:rest N4875bd6c234a4dfc985295b809c13056
185 Nc02848f378d547f9bc31c68753a90623 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Drug Resistance
187 rdf:type schema:DefinedTerm
188 Nc6eb677736924b2b88c86963a57d17fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Gene Dosage
190 rdf:type schema:DefinedTerm
191 Ncbaa38869fcc4c258e45d935056c22a8 schema:name nlm_unique_id
192 schema:value 101139802
193 rdf:type schema:PropertyValue
194 Ncf6c4abd27284ed0b16127568f640fa5 schema:name Springer Nature - SN SciGraph project
195 rdf:type schema:Organization
196 Ne6b739d0461b4fb8ae16c0a5431c2699 schema:name dimensions_id
197 schema:value pub.1041383647
198 rdf:type schema:PropertyValue
199 Ned0e6ce587be46329320d99e6c22e970 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Polymorphism, Genetic
201 rdf:type schema:DefinedTerm
202 Nfa0c4758f4c5410aaba0872e5e885a63 schema:name readcube_id
203 schema:value c523c120a30c42f023eeaa695f0b73670a8d610d1fff101b98d36e2dcdab4937
204 rdf:type schema:PropertyValue
205 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
206 schema:name Biological Sciences
207 rdf:type schema:DefinedTerm
208 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
209 schema:name Genetics
210 rdf:type schema:DefinedTerm
211 sg:journal.1030597 schema:issn 1475-2875
212 schema:name Malaria Journal
213 rdf:type schema:Periodical
214 sg:person.01023257736.40 schema:affiliation N5c81f0eb12834ff1a64700c97543d9bd
215 schema:familyName Picot
216 schema:givenName Stéphane
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023257736.40
218 rdf:type schema:Person
219 sg:person.01074272363.42 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
220 schema:familyName Olliaro
221 schema:givenName Piero
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074272363.42
223 rdf:type schema:Person
224 sg:person.01307625361.27 schema:affiliation N984c6307a8c6483393f89e23e7d6a312
225 schema:familyName de Monbrison
226 schema:givenName Frédérique
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307625361.27
228 rdf:type schema:Person
229 sg:person.01340264442.10 schema:affiliation N12e2a8187d8a4f54b809e967e57cf577
230 schema:familyName Bienvenu
231 schema:givenName Anne-Lise
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340264442.10
233 rdf:type schema:Person
234 sg:person.013405371002.20 schema:affiliation https://www.grid.ac/institutes/grid.1043.6
235 schema:familyName Price
236 schema:givenName Ric N
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013405371002.20
238 rdf:type schema:Person
239 sg:person.0727072567.02 schema:affiliation https://www.grid.ac/institutes/grid.3575.4
240 schema:familyName Ringwald
241 schema:givenName Pascal
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727072567.02
243 rdf:type schema:Person
244 sg:pub.10.1007/s00018-006-6071-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006510881
245 https://doi.org/10.1007/s00018-006-6071-1
246 rdf:type schema:CreativeWork
247 sg:pub.10.1007/s00436-005-1406-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025634127
248 https://doi.org/10.1007/s00436-005-1406-7
249 rdf:type schema:CreativeWork
250 sg:pub.10.1007/s00436-006-0291-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1051395571
251 https://doi.org/10.1007/s00436-006-0291-z
252 rdf:type schema:CreativeWork
253 sg:pub.10.1007/s10096-008-0499-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019864889
254 https://doi.org/10.1007/s10096-008-0499-1
255 rdf:type schema:CreativeWork
256 sg:pub.10.1038/nature01813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023024453
257 https://doi.org/10.1038/nature01813
258 rdf:type schema:CreativeWork
259 sg:pub.10.1186/1475-2875-5-127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019657300
260 https://doi.org/10.1186/1475-2875-5-127
261 rdf:type schema:CreativeWork
262 sg:pub.10.1186/1475-2875-6-121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015364901
263 https://doi.org/10.1186/1475-2875-6-121
264 rdf:type schema:CreativeWork
265 sg:pub.10.1186/1475-2875-6-122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019297061
266 https://doi.org/10.1186/1475-2875-6-122
267 rdf:type schema:CreativeWork
268 sg:pub.10.1186/1475-2875-6-41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037361864
269 https://doi.org/10.1186/1475-2875-6-41
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/0169-4758(91)90197-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1009500742
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.actatropica.2005.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028008717
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.actatropica.2005.06.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023192408
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.actatropica.2005.07.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031788108
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.actatropica.2007.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037509841
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.actatropica.2007.07.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024876637
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.meegid.2003.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000290100
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.meegid.2005.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052872343
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.mib.2007.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045272453
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.pt.2007.09.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052186131
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.trstmh.2003.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054750900
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.trstmh.2004.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054751027
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/j.trstmh.2007.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054751409
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/j.trstmh.2008.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054751854
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/s0035-9203(01)90250-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049275393
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/s0035-9203(01)90329-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045286839
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/s0035-9203(02)90346-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010905407
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/s0035-9203(03)00014-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047290128
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/s0035-9203(97)90227-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041319716
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/s0140-6736(01)06040-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009851831
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/s0140-6736(04)16767-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039469915
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/s0140-6736(98)24022-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034198331
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/s0163-7258(98)00012-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036686089
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/s0169-4758(97)01124-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045672749
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/s1369-5274(00)00228-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012516200
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/s1471-4922(02)00017-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012449022
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/s1473-3099(07)70214-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032717204
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/s1567-1348(01)00021-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002996032
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1017/s0031182096008487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028864272
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1046/j.1365-3156.2000.00543.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047374584
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1046/j.1365-3156.2003.01099.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009654711
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1056/nejm200101253440403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019084310
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1080/00034980120092516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058260547
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1086/315731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013974274
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1086/318836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035563082
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1086/319856 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051874669
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1086/319865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010714038
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1086/338566 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044250968
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1086/375419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007570230
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1086/379323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001012084
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1086/514159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002916171
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1086/517831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058791399
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1093/jac/dkg294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000656996
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1111/j.1365-3156.2004.01249.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037756378
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1111/j.1365-3156.2005.01414.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023148313
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1111/j.1365-3156.2005.01471.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044901893
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1111/j.1365-3156.2007.01904.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023497284
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1111/j.1365-3156.2007.01995.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035319904
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1111/j.1365-3156.2008.02150.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012651338
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1111/j.1742-4658.2007.05999.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015815512
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1128/9781555817558.ch23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1088809457
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1128/aac.42.7.1811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083290039
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1128/aac.43.12.2943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074557611
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1128/aac.43.9.2205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074515067
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1128/cmr.00021-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047866196
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1172/jci21682 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041881557
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1179/000349802125001249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017758958
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1179/000349803235002489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039957733
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1179/000349804x3162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052510396
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1179/136485905x46441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040459473
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1179/136485905x75395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017274034
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1179/136485907x154584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007514528
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1242/jeb.00658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026013397
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1371/journal.pbio.0030335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024808046
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1371/journal.pone.0001578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047060173
400 rdf:type schema:CreativeWork
401 https://doi.org/10.4269/ajtmh.1999.61.125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074501126
402 rdf:type schema:CreativeWork
403 https://doi.org/10.4269/ajtmh.1999.61.245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074512869
404 rdf:type schema:CreativeWork
405 https://doi.org/10.4269/ajtmh.2002.67.225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075183304
406 rdf:type schema:CreativeWork
407 https://doi.org/10.4269/ajtmh.2002.67.392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075197373
408 rdf:type schema:CreativeWork
409 https://doi.org/10.4269/ajtmh.2002.67.449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075203321
410 rdf:type schema:CreativeWork
411 https://doi.org/10.4269/ajtmh.2002.67.578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075215253
412 rdf:type schema:CreativeWork
413 https://doi.org/10.4269/ajtmh.2003.68.398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075319706
414 rdf:type schema:CreativeWork
415 https://doi.org/10.4269/ajtmh.2003.68.413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075319709
416 rdf:type schema:CreativeWork
417 https://doi.org/10.4269/ajtmh.2003.69.184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075929416
418 rdf:type schema:CreativeWork
419 https://doi.org/10.4269/ajtmh.2003.69.247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076601162
420 rdf:type schema:CreativeWork
421 https://doi.org/10.4269/ajtmh.2003.69.601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076629626
422 rdf:type schema:CreativeWork
423 https://doi.org/10.4269/ajtmh.2004.71.40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076862918
424 rdf:type schema:CreativeWork
425 https://doi.org/10.4269/ajtmh.2004.71.696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076991820
426 rdf:type schema:CreativeWork
427 https://doi.org/10.4269/ajtmh.2005.73.174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077080164
428 rdf:type schema:CreativeWork
429 https://doi.org/10.4269/ajtmh.2006.75.155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077268423
430 rdf:type schema:CreativeWork
431 https://doi.org/10.4269/ajtmh.2007.76.608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077401659
432 rdf:type schema:CreativeWork
433 https://doi.org/10.4269/ajtmh.2007.76.844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077415168
434 rdf:type schema:CreativeWork
435 https://doi.org/10.4269/ajtmh.2007.77.160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077584384
436 rdf:type schema:CreativeWork
437 https://doi.org/10.4269/ajtmh.2007.77.36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077443187
438 rdf:type schema:CreativeWork
439 https://www.grid.ac/institutes/grid.1043.6 schema:alternateName Charles Darwin University
440 schema:name International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
441 rdf:type schema:Organization
442 https://www.grid.ac/institutes/grid.3575.4 schema:alternateName World Health Organization
443 schema:name Global Malaria Programme, World Health Organization, Geneva, Switzerland
444 rdf:type schema:Organization
445 https://www.grid.ac/institutes/grid.4991.5 schema:alternateName University of Oxford
446 schema:name Centre for Vaccinology & Tropical Medicine, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, UK
447 UNICEF/UNDP/WB/WHO Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland
448 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...