Chloroquine and sulphadoxine-pyrimethamine sensitivity of Plasmodium falciparum parasites in a Brazilian endemic area View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-12

AUTHORS

Bianca Ervatti Gama, Natália K Almeida de Oliveira, Mariano G Zalis, José Maria de Souza, Fátima Santos, Cláudio Tadeu Daniel-Ribeiro, Maria de Fátima Ferreira-da-Cruz

ABSTRACT

BACKGROUND: The goal of the present study was the characterization of Plasmodium falciparum genes associated to malaria drug resistance (pfcrt, pfdhfr and pfdhps), in samples from two Brazilian localities. METHODS: Parasites from 65 P. falciparum samples were genotyped using nested-PCR and direct DNA sequencing. RESULTS: Six resistant sulphadoxine-pyrimethamine (SP) pfdhfr genotypes and one haplotype associated to SP sensitivity were detected. For pfcrt gene, SVMNT chloroquine (CQ)-resistant genotype was detected as well as the CVMNK CQ-sensitive haplotype in the same sample from Paragominas, that showed a SP-sensitive genotype. CONCLUSION: This study is the first to document the sensitivity of P. falciparum parasites to CQ and SP in Brazilian field samples. The importance of these findings is discussed. More... »

PAGES

156

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1475-2875-8-156

DOI

http://dx.doi.org/10.1186/1475-2875-8-156

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009656651

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19602248


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