Evidence of increasing Leu-Phe knockdown resistance mutation in Anopheles gambiae from Niger following a nationwide long-lasting insecticide-treated nets implementation View Full Text


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Article Info

DATE

2008-12

AUTHORS

Cyrille Czeher, Rabiou Labbo, Ibrahim Arzika, Jean-Bernard Duchemin

ABSTRACT

BACKGROUND: At the end of 2005, a nationwide long-lasting insecticide-treated net (LLIN) distribution targeting the most vulnerable populations was implemented throughout Niger. A large number of studies in Africa have reported the existence of anopheline populations resistant to various insecticides, partly due to knockdown resistance (kdr) mutations, but few operational wide-scale control programmes were coupled with the monitoring of such mutations. The distribution of the kdr-west (kdr-w) Leu-Phe mutation was studied in Anopheles gambiae s.l. populations from Niger and temporal variations were monitored following the nationwide LLIN implementation. METHODS: Mosquitoes were collected from 14 localities during the wet seasons of 2005, 2006 and 2007 with additional sampling in the capital city, Niamey. After morphological identification of Anopheles gambiae s.l. specimens, DNA extracts were used for the determination of species and molecular forms of the Anopheles gambiae complex and for the detection of the kdr-w mutation. RESULTS: Around 1,500 specimens collected in the three consecutive years were analysed. All Anopheles arabiensis specimens analysed were homozygous susceptible, whereas the few Anopheles gambiae S forms exhibited a high overall kdr-w frequency. The M form samples exhibited a low overall kdr-w frequency before the LLIN distribution, that increased significantly in the two wet season collections following the LLIN distribution. Higher kdr frequencies were repeatedly noticed within host-seeking females compared to resting ones in indoor collections. In addition, preliminary results in M form urban populations from Niamey showed far higher kdr frequencies than in all of the rural sites studied. DISCUSSION: This study describes the first case of kdr mutation in Anopheles gambiae populations from Niger. It is suspected that the LLIN have caused the important temporal increase of kdr-w mutation observed during this study. While the kdr mutation is still found at a low level, this rapid increase could potentially lead to high kdr frequencies within a few years. CONCLUSION: These results are of prime importance in the effort to document multiple effects of operational control programmes on mosquito vectors, and to conceive sustainable control strategies for future malaria control programmes. More... »

PAGES

189

References to SciGraph publications

  • 2006-12. Detection of the East and West African kdr mutation in Anopheles gambiae and Anopheles arabiensis from Uganda using a new assay based on FRET/Melt Curve analysis in MALARIA JOURNAL
  • 2006-12. Screening of pesticide residues in soil and water samples from agricultural settings in MALARIA JOURNAL
  • 2005-12. Experimental hut evaluation of bednets treated with an organophosphate (chlorpyrifos-methyl) or a pyrethroid (lambdacyhalothrin) alone and in combination against insecticide-resistant Anopheles gambiae and Culex quinquefasciatus mosquitoes in MALARIA JOURNAL
  • 2004-12. Dosage-dependent effects of permethrin-treated nets on the behaviour of Anopheles gambiae and the selection of pyrethroid resistance in MALARIA JOURNAL
  • 2008-12. An experimental hut evaluation of Olyset® nets against anopheline mosquitoes after seven years use in Tanzanian villages in MALARIA JOURNAL
  • 2007-12. Malaria vector control by indoor residual insecticide spraying on the tropical island of Bioko, Equatorial Guinea in MALARIA JOURNAL
  • 2003-12. Variation of malaria transmission and morbidity with altitude in Tanzania and with introduction of alphacypermethrin treated nets in MALARIA JOURNAL
  • 2006-12. Occurrence of the leucine-to-phenylalanine knockdown resistance (kdr) mutation in Anopheles arabiensis populations in Tanzania, detected by a simplified high-throughput SSOP-ELISA method in MALARIA JOURNAL
  • 2008-12. Distribution of knock-down resistance mutations in Anopheles gambiae molecular forms in west and west-central Africa in MALARIA JOURNAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1475-2875-7-189

    DOI

    http://dx.doi.org/10.1186/1475-2875-7-189

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032720262

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18817574


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