Absence of erythrocyte sequestration in a case of babesiosis in a splenectomized human patient View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-08-04

AUTHORS

Ian A Clark, Alison C Budd, Gunther Hsue, Bret R Haymore, Alina J Joyce, Richard Thorner, Peter J Krause

ABSTRACT

BackgroundThe importance of vascular occlusion in the pathogenesis of human haemoprotozoal disease is unresolved.MethodsGiemsa-stained tissue sections from a human case of Babesia microti infection in a splenectomized patient with chronic lymphocytic leukaemia and colon cancer were examined to ascertain the distribution of parasitized erythrocytes within the vascular lumen.ResultsNo evidence of sequestration was observed.ConclusionThis first report on the vascular location of B. microti in human tissue suggests that severe multi-organ failure due to babesiosis is independent of sequestration of parasitized erythrocytes. A similar pathogenesis may also cause multi-organ failure in other intraerythrocytic protozoal infections, including falciparum malaria. More... »

PAGES

69

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1475-2875-5-69

DOI

http://dx.doi.org/10.1186/1475-2875-5-69

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031580138

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16887045


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