Blackwater fever in an uncomplicated Plasmodium falciparum patient treated with dihydroartemisinin-piperaquine View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-03-14

AUTHORS

Chanthap Lon, Michele Spring, Somethy Sok, Soklyda Chann, Rathvichet Bun, Mali Ittiverakul, Nillawan Buathong, Khengheng Thay, Nareth Kong, Yom You, Worachet Kuntawunginn, Charlotte A Lanteri, David L Saunders

ABSTRACT

The mechanism of massive intravascular haemolysis occurring during the treatment of malaria infection resulting in haemoglobinuria, commonly known as blackwater fever (BWF), remains unknown. BWF is most often seen in those with severe malaria treated with amino-alcohol drugs, including quinine, mefloquine and halofantrine. The potential for drugs containing artemisinins, chloroquine or piperaquine to cause oxidant haemolysis is believed to be much lower, particularly during treatment of uncomplicated malaria. Here is an unusual case of BWF, which developed on day 2 of treatment for uncomplicated Plasmodium falciparum infection with dihydroartemisinin-piperaquine (DHA-PIP) with documented evidence of concomitant seropositivity for Chikungunya infection. More... »

PAGES

96-96

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1475-2875-13-96

DOI

http://dx.doi.org/10.1186/1475-2875-13-96

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035981087

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24629047


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