A randomized trial of artemether-lumefantrine and dihydroartemisinin-piperaquine in the treatment of uncomplicated malaria among children in western Kenya View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Aarti Agarwal, Meredith McMorrow, Peter Onyango, Kephas Otieno, Christopher Odero, John Williamson, Simon Kariuki, Stephen Patrick Kachur, Laurence Slutsker, Meghna Desai

ABSTRACT

BACKGROUND: Artemether-lumefantrine (AL) was adopted as first-line treatment for uncomplicated malaria in Kenya in 2006. Monitoring drug efficacy at regular intervals is essential to prevent unnecessary morbidity and mortality. The efficacy of AL and dihydroartemisinin-piperaquine (DP) were evaluated for the treatment of uncomplicated malaria in children aged six to 59 months in western Kenya. METHODS: From October 2010 to August 2011, children with fever or history of fever with uncomplicated Plasmodium falciparum mono-infection were enrolled in an in vivo efficacy trial in accordance with World Health Organization (WHO) guidelines. The children were randomized to treatment with a three-day course of AL or DP and efficacy outcomes were measured at 28 and 42 days after treatment initiation. RESULTS: A total of 137 children were enrolled in each treatment arm. There were no early treatment failures and all children except one had cleared parasites by day 3. Polymerase chain reaction (PCR)-uncorrected adequate clinical and parasitological response rate (ACPR) was 61% in the AL arm and 83% in the DP arm at day 28 (p = 0.001). PCR-corrected ACPR at day 28 was 97% in the AL group and 99% in the DP group, and it was 96% in both arms at day 42. CONCLUSIONS: AL and DP remain efficacious for the treatment of uncomplicated malaria among children in western Kenya. The longer half-life of piperaquine relative to lumefantrine may provide a prophylactic effect, accounting for the lower rate of re-infection in the first 28 days after treatment in the DP arm. More... »

PAGES

254

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1475-2875-12-254

DOI

http://dx.doi.org/10.1186/1475-2875-12-254

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021552487

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23870627


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antimalarials", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Artemisinins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child, Preschool", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Combinations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ethanolamines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kenya", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Malaria, Falciparum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quinolines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "United States Public Health Service", 
          "id": "https://www.grid.ac/institutes/grid.417684.8", 
          "name": [
            "Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, USA", 
            "US Public Health Service, Rockville, Maryland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Agarwal", 
        "givenName": "Aarti", 
        "id": "sg:person.01364714333.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364714333.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "United States Public Health Service", 
          "id": "https://www.grid.ac/institutes/grid.417684.8", 
          "name": [
            "US Public Health Service, Rockville, Maryland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McMorrow", 
        "givenName": "Meredith", 
        "id": "sg:person.0751351640.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751351640.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Kenya Medical Research Institute/Centers for Disease Control, Prevention Research and Public Health Collaboration, Kisumu, Kenya"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Onyango", 
        "givenName": "Peter", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Kenya Medical Research Institute/Centers for Disease Control, Prevention Research and Public Health Collaboration, Kisumu, Kenya"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Otieno", 
        "givenName": "Kephas", 
        "id": "sg:person.0630501453.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630501453.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Kenya Medical Research Institute/Centers for Disease Control, Prevention Research and Public Health Collaboration, Kisumu, Kenya"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Odero", 
        "givenName": "Christopher", 
        "id": "sg:person.0750050716.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750050716.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Kenya Medical Research Institute/Centers for Disease Control, Prevention Research and Public Health Collaboration, Kisumu, Kenya"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Williamson", 
        "givenName": "John", 
        "id": "sg:person.01002214247.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002214247.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Kenya Medical Research Institute/Centers for Disease Control, Prevention Research and Public Health Collaboration, Kisumu, Kenya"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kariuki", 
        "givenName": "Simon", 
        "id": "sg:person.011735225674.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011735225674.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "United States Public Health Service", 
          "id": "https://www.grid.ac/institutes/grid.417684.8", 
          "name": [
            "US Public Health Service, Rockville, Maryland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kachur", 
        "givenName": "Stephen Patrick", 
        "id": "sg:person.01021431257.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021431257.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centers for Disease Control and Prevention", 
          "id": "https://www.grid.ac/institutes/grid.416738.f", 
          "name": [
            "Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Slutsker", 
        "givenName": "Laurence", 
        "id": "sg:person.01276166263.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276166263.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centers for Disease Control and Prevention", 
          "id": "https://www.grid.ac/institutes/grid.416738.f", 
          "name": [
            "Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, USA", 
            "Kenya Medical Research Institute/Centers for Disease Control, Prevention Research and Public Health Collaboration, Kisumu, Kenya"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Desai", 
        "givenName": "Meghna", 
        "id": "sg:person.01367200432.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367200432.80"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1046/j.1365-3156.2000.00643.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002238027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-6-72", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003500735", 
          "https://doi.org/10.1186/1475-2875-6-72"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-10-198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006982726", 
          "https://doi.org/10.1186/1475-2875-10-198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0808859", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011738279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-10-209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013618746", 
          "https://doi.org/10.1186/1475-2875-10-209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.297.20.2210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013820981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003495-200262090-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023304915", 
          "https://doi.org/10.2165/00003495-200262090-00003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003495-200262090-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023304915", 
          "https://doi.org/10.2165/00003495-200262090-00003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-7-262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032240911", 
          "https://doi.org/10.1186/1475-2875-7-262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.1001119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032565194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-10-50", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035993080", 
          "https://doi.org/10.1186/1475-2875-10-50"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/647946", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038211056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2010.10-0158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038948201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/jit077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040456777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmc0805011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041561416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci21682", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041881557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-9-144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042007838", 
          "https://doi.org/10.1186/1475-2875-9-144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0026005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042123343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-7-237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050408078", 
          "https://doi.org/10.1186/1475-2875-7-237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0169-4758(87)90147-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052645319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0169-4758(87)90147-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052645319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0007871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053287199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2010.09-0403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053396208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jmedent/27.4.570", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059808953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2471/blt.08.055632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070837241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.1999.61.109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074501123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2007.77.153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077584383"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-12", 
    "datePublishedReg": "2013-12-01", 
    "description": "BACKGROUND: Artemether-lumefantrine (AL) was adopted as first-line treatment for uncomplicated malaria in Kenya in 2006. Monitoring drug efficacy at regular intervals is essential to prevent unnecessary morbidity and mortality. The efficacy of AL and dihydroartemisinin-piperaquine (DP) were evaluated for the treatment of uncomplicated malaria in children aged six to 59 months in western Kenya.\nMETHODS: From October 2010 to August 2011, children with fever or history of fever with uncomplicated Plasmodium falciparum mono-infection were enrolled in an in vivo efficacy trial in accordance with World Health Organization (WHO) guidelines. The children were randomized to treatment with a three-day course of AL or DP and efficacy outcomes were measured at 28 and 42 days after treatment initiation.\nRESULTS: A total of 137 children were enrolled in each treatment arm. There were no early treatment failures and all children except one had cleared parasites by day 3. Polymerase chain reaction (PCR)-uncorrected adequate clinical and parasitological response rate (ACPR) was 61% in the AL arm and 83% in the DP arm at day 28 (p\u2009=\u20090.001). PCR-corrected ACPR at day 28 was 97% in the AL group and 99% in the DP group, and it was 96% in both arms at day 42.\nCONCLUSIONS: AL and DP remain efficacious for the treatment of uncomplicated malaria among children in western Kenya. The longer half-life of piperaquine relative to lumefantrine may provide a prophylactic effect, accounting for the lower rate of re-infection in the first 28 days after treatment in the DP arm.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1475-2875-12-254", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1030597", 
        "issn": [
          "1475-2875"
        ], 
        "name": "Malaria Journal", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "A randomized trial of artemether-lumefantrine and dihydroartemisinin-piperaquine in the treatment of uncomplicated malaria among children in western Kenya", 
    "pagination": "254", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "66afe24c1bb905ac2ae518adfff6a66a1a9001eb30206b343d0ee20696943ee9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23870627"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101139802"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1475-2875-12-254"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021552487"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1475-2875-12-254", 
      "https://app.dimensions.ai/details/publication/pub.1021552487"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000512.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1475-2875-12-254"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1475-2875-12-254'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1475-2875-12-254'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1475-2875-12-254'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1475-2875-12-254'


 

This table displays all metadata directly associated to this object as RDF triples.

284 TRIPLES      21 PREDICATES      68 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1475-2875-12-254 schema:about N13b999ff7aeb46349967999b7a6e84ee
2 N16eaca3c9b064e62ae9300b9592e383a
3 N34fd669a147842eca333b6756aa4eb5f
4 N36cabf2d62a14d1fb14d418050f4d0f9
5 N4a0a6d8b60364d218b62f1ffe4cfa673
6 N5a30603a9608474da47b6a8f064152a2
7 N631dbbf6fa8242c6a6778cc9a8edbd40
8 N6925a57975c142ddbe5a893247321fb6
9 Na4a4d856a09041dd9a64ee2553c43acf
10 Nb681efeab720411da6f39d271c6e8f91
11 Nba6a4b52cee940008e201cd43f902ad6
12 Nbbadde7e50c64c679cc845951da8e23a
13 Nd64acfd3ca494d498871b40d85fd2b69
14 Ndff2893878ba4ed4a4ed993ac4c9d274
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author N468b9ea1f62844dd84974aa3f3dcc9f7
18 schema:citation sg:pub.10.1186/1475-2875-10-198
19 sg:pub.10.1186/1475-2875-10-209
20 sg:pub.10.1186/1475-2875-10-50
21 sg:pub.10.1186/1475-2875-6-72
22 sg:pub.10.1186/1475-2875-7-237
23 sg:pub.10.1186/1475-2875-7-262
24 sg:pub.10.1186/1475-2875-9-144
25 sg:pub.10.2165/00003495-200262090-00003
26 https://doi.org/10.1001/jama.297.20.2210
27 https://doi.org/10.1016/0169-4758(87)90147-5
28 https://doi.org/10.1046/j.1365-3156.2000.00643.x
29 https://doi.org/10.1056/nejmc0805011
30 https://doi.org/10.1056/nejmoa0808859
31 https://doi.org/10.1086/647946
32 https://doi.org/10.1093/infdis/jit077
33 https://doi.org/10.1093/jmedent/27.4.570
34 https://doi.org/10.1172/jci21682
35 https://doi.org/10.1371/journal.pmed.1001119
36 https://doi.org/10.1371/journal.pone.0007871
37 https://doi.org/10.1371/journal.pone.0026005
38 https://doi.org/10.2471/blt.08.055632
39 https://doi.org/10.4269/ajtmh.1999.61.109
40 https://doi.org/10.4269/ajtmh.2007.77.153
41 https://doi.org/10.4269/ajtmh.2010.09-0403
42 https://doi.org/10.4269/ajtmh.2010.10-0158
43 schema:datePublished 2013-12
44 schema:datePublishedReg 2013-12-01
45 schema:description BACKGROUND: Artemether-lumefantrine (AL) was adopted as first-line treatment for uncomplicated malaria in Kenya in 2006. Monitoring drug efficacy at regular intervals is essential to prevent unnecessary morbidity and mortality. The efficacy of AL and dihydroartemisinin-piperaquine (DP) were evaluated for the treatment of uncomplicated malaria in children aged six to 59 months in western Kenya. METHODS: From October 2010 to August 2011, children with fever or history of fever with uncomplicated Plasmodium falciparum mono-infection were enrolled in an in vivo efficacy trial in accordance with World Health Organization (WHO) guidelines. The children were randomized to treatment with a three-day course of AL or DP and efficacy outcomes were measured at 28 and 42 days after treatment initiation. RESULTS: A total of 137 children were enrolled in each treatment arm. There were no early treatment failures and all children except one had cleared parasites by day 3. Polymerase chain reaction (PCR)-uncorrected adequate clinical and parasitological response rate (ACPR) was 61% in the AL arm and 83% in the DP arm at day 28 (p = 0.001). PCR-corrected ACPR at day 28 was 97% in the AL group and 99% in the DP group, and it was 96% in both arms at day 42. CONCLUSIONS: AL and DP remain efficacious for the treatment of uncomplicated malaria among children in western Kenya. The longer half-life of piperaquine relative to lumefantrine may provide a prophylactic effect, accounting for the lower rate of re-infection in the first 28 days after treatment in the DP arm.
46 schema:genre research_article
47 schema:inLanguage en
48 schema:isAccessibleForFree true
49 schema:isPartOf N4ffb8f74f0d54a6cbbbc36909ceb5f8a
50 Nfa087c64ac4d45aba41c48f8b52417b8
51 sg:journal.1030597
52 schema:name A randomized trial of artemether-lumefantrine and dihydroartemisinin-piperaquine in the treatment of uncomplicated malaria among children in western Kenya
53 schema:pagination 254
54 schema:productId N17c81630adea4e9a8c918cf2041b8fb6
55 N56ab4f6e93e34aa5a7a919fbef91a472
56 N5b24a4cce8f149da9a6590de65d6f521
57 N7c27fa1df8b242ff972f5a21c66cb855
58 Nc0dc73c570d449c29ba7dffa5abc34c9
59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021552487
60 https://doi.org/10.1186/1475-2875-12-254
61 schema:sdDatePublished 2019-04-11T01:07
62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
63 schema:sdPublisher N7ed9656b2ba54a7abc4a9607a81577b1
64 schema:url http://link.springer.com/10.1186%2F1475-2875-12-254
65 sgo:license sg:explorer/license/
66 sgo:sdDataset articles
67 rdf:type schema:ScholarlyArticle
68 N0918b9c12beb48a6a6762ec6cb7d295c schema:name Kenya Medical Research Institute/Centers for Disease Control, Prevention Research and Public Health Collaboration, Kisumu, Kenya
69 rdf:type schema:Organization
70 N0e7d4e07926f4aed9a65e33c981cfa0d rdf:first sg:person.01276166263.31
71 rdf:rest N8270bdcb34f44361a757260dbc0d989b
72 N13b999ff7aeb46349967999b7a6e84ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Child, Preschool
74 rdf:type schema:DefinedTerm
75 N16eaca3c9b064e62ae9300b9592e383a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Female
77 rdf:type schema:DefinedTerm
78 N17c81630adea4e9a8c918cf2041b8fb6 schema:name dimensions_id
79 schema:value pub.1021552487
80 rdf:type schema:PropertyValue
81 N316493f68cb949b491f2e3705ef95b8f schema:name Kenya Medical Research Institute/Centers for Disease Control, Prevention Research and Public Health Collaboration, Kisumu, Kenya
82 rdf:type schema:Organization
83 N34282635b1904c9581c44af512154bc1 schema:affiliation N0918b9c12beb48a6a6762ec6cb7d295c
84 schema:familyName Onyango
85 schema:givenName Peter
86 rdf:type schema:Person
87 N34fd669a147842eca333b6756aa4eb5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Malaria, Falciparum
89 rdf:type schema:DefinedTerm
90 N36cabf2d62a14d1fb14d418050f4d0f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Ethanolamines
92 rdf:type schema:DefinedTerm
93 N468b9ea1f62844dd84974aa3f3dcc9f7 rdf:first sg:person.01364714333.38
94 rdf:rest Nab6c6321dead4eab9f64b406dde39b97
95 N4a0a6d8b60364d218b62f1ffe4cfa673 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Fluorenes
97 rdf:type schema:DefinedTerm
98 N4ffb8f74f0d54a6cbbbc36909ceb5f8a schema:issueNumber 1
99 rdf:type schema:PublicationIssue
100 N56ab4f6e93e34aa5a7a919fbef91a472 schema:name pubmed_id
101 schema:value 23870627
102 rdf:type schema:PropertyValue
103 N5a30603a9608474da47b6a8f064152a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Infant
105 rdf:type schema:DefinedTerm
106 N5b24a4cce8f149da9a6590de65d6f521 schema:name readcube_id
107 schema:value 66afe24c1bb905ac2ae518adfff6a66a1a9001eb30206b343d0ee20696943ee9
108 rdf:type schema:PropertyValue
109 N5b266a2a1697464e82401e3dd2da697a rdf:first sg:person.01021431257.27
110 rdf:rest N0e7d4e07926f4aed9a65e33c981cfa0d
111 N61a96124f0ec462d9266b5172fc55710 rdf:first sg:person.0750050716.08
112 rdf:rest Neab47b7785254fe7a7c8c482afd1bae9
113 N631dbbf6fa8242c6a6778cc9a8edbd40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Artemisinins
115 rdf:type schema:DefinedTerm
116 N6814b3cfe3394b42a203a80b79f6d0dc schema:name Kenya Medical Research Institute/Centers for Disease Control, Prevention Research and Public Health Collaboration, Kisumu, Kenya
117 rdf:type schema:Organization
118 N6925a57975c142ddbe5a893247321fb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Treatment Outcome
120 rdf:type schema:DefinedTerm
121 N7c27fa1df8b242ff972f5a21c66cb855 schema:name doi
122 schema:value 10.1186/1475-2875-12-254
123 rdf:type schema:PropertyValue
124 N7ed9656b2ba54a7abc4a9607a81577b1 schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 N8270bdcb34f44361a757260dbc0d989b rdf:first sg:person.01367200432.80
127 rdf:rest rdf:nil
128 Na4a4d856a09041dd9a64ee2553c43acf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Male
130 rdf:type schema:DefinedTerm
131 Nab6c6321dead4eab9f64b406dde39b97 rdf:first sg:person.0751351640.51
132 rdf:rest Nd94e77434c8847de842d100cfe713816
133 Nabdb8c7e3bd74d159e68790159761081 rdf:first sg:person.011735225674.11
134 rdf:rest N5b266a2a1697464e82401e3dd2da697a
135 Nb681efeab720411da6f39d271c6e8f91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Antimalarials
137 rdf:type schema:DefinedTerm
138 Nba6a4b52cee940008e201cd43f902ad6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Drug Combinations
140 rdf:type schema:DefinedTerm
141 Nbbadde7e50c64c679cc845951da8e23a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Quinolines
143 rdf:type schema:DefinedTerm
144 Nc0dc73c570d449c29ba7dffa5abc34c9 schema:name nlm_unique_id
145 schema:value 101139802
146 rdf:type schema:PropertyValue
147 Nc6fba083627340f7a4571fb3aa61c289 rdf:first sg:person.0630501453.18
148 rdf:rest N61a96124f0ec462d9266b5172fc55710
149 Nc863e59b487d4f528375953f3a89004d schema:name Kenya Medical Research Institute/Centers for Disease Control, Prevention Research and Public Health Collaboration, Kisumu, Kenya
150 rdf:type schema:Organization
151 Nd64acfd3ca494d498871b40d85fd2b69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Kenya
153 rdf:type schema:DefinedTerm
154 Nd94e77434c8847de842d100cfe713816 rdf:first N34282635b1904c9581c44af512154bc1
155 rdf:rest Nc6fba083627340f7a4571fb3aa61c289
156 Ndff2893878ba4ed4a4ed993ac4c9d274 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Humans
158 rdf:type schema:DefinedTerm
159 Neab47b7785254fe7a7c8c482afd1bae9 rdf:first sg:person.01002214247.40
160 rdf:rest Nabdb8c7e3bd74d159e68790159761081
161 Nee4b5bc4c92445c087eff327562fd0ce schema:name Kenya Medical Research Institute/Centers for Disease Control, Prevention Research and Public Health Collaboration, Kisumu, Kenya
162 rdf:type schema:Organization
163 Nfa087c64ac4d45aba41c48f8b52417b8 schema:volumeNumber 12
164 rdf:type schema:PublicationVolume
165 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
166 schema:name Medical and Health Sciences
167 rdf:type schema:DefinedTerm
168 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
169 schema:name Clinical Sciences
170 rdf:type schema:DefinedTerm
171 sg:journal.1030597 schema:issn 1475-2875
172 schema:name Malaria Journal
173 rdf:type schema:Periodical
174 sg:person.01002214247.40 schema:affiliation N6814b3cfe3394b42a203a80b79f6d0dc
175 schema:familyName Williamson
176 schema:givenName John
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002214247.40
178 rdf:type schema:Person
179 sg:person.01021431257.27 schema:affiliation https://www.grid.ac/institutes/grid.417684.8
180 schema:familyName Kachur
181 schema:givenName Stephen Patrick
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021431257.27
183 rdf:type schema:Person
184 sg:person.011735225674.11 schema:affiliation Nc863e59b487d4f528375953f3a89004d
185 schema:familyName Kariuki
186 schema:givenName Simon
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011735225674.11
188 rdf:type schema:Person
189 sg:person.01276166263.31 schema:affiliation https://www.grid.ac/institutes/grid.416738.f
190 schema:familyName Slutsker
191 schema:givenName Laurence
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276166263.31
193 rdf:type schema:Person
194 sg:person.01364714333.38 schema:affiliation https://www.grid.ac/institutes/grid.417684.8
195 schema:familyName Agarwal
196 schema:givenName Aarti
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364714333.38
198 rdf:type schema:Person
199 sg:person.01367200432.80 schema:affiliation https://www.grid.ac/institutes/grid.416738.f
200 schema:familyName Desai
201 schema:givenName Meghna
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367200432.80
203 rdf:type schema:Person
204 sg:person.0630501453.18 schema:affiliation Nee4b5bc4c92445c087eff327562fd0ce
205 schema:familyName Otieno
206 schema:givenName Kephas
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630501453.18
208 rdf:type schema:Person
209 sg:person.0750050716.08 schema:affiliation N316493f68cb949b491f2e3705ef95b8f
210 schema:familyName Odero
211 schema:givenName Christopher
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750050716.08
213 rdf:type schema:Person
214 sg:person.0751351640.51 schema:affiliation https://www.grid.ac/institutes/grid.417684.8
215 schema:familyName McMorrow
216 schema:givenName Meredith
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751351640.51
218 rdf:type schema:Person
219 sg:pub.10.1186/1475-2875-10-198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006982726
220 https://doi.org/10.1186/1475-2875-10-198
221 rdf:type schema:CreativeWork
222 sg:pub.10.1186/1475-2875-10-209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013618746
223 https://doi.org/10.1186/1475-2875-10-209
224 rdf:type schema:CreativeWork
225 sg:pub.10.1186/1475-2875-10-50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035993080
226 https://doi.org/10.1186/1475-2875-10-50
227 rdf:type schema:CreativeWork
228 sg:pub.10.1186/1475-2875-6-72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003500735
229 https://doi.org/10.1186/1475-2875-6-72
230 rdf:type schema:CreativeWork
231 sg:pub.10.1186/1475-2875-7-237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050408078
232 https://doi.org/10.1186/1475-2875-7-237
233 rdf:type schema:CreativeWork
234 sg:pub.10.1186/1475-2875-7-262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032240911
235 https://doi.org/10.1186/1475-2875-7-262
236 rdf:type schema:CreativeWork
237 sg:pub.10.1186/1475-2875-9-144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042007838
238 https://doi.org/10.1186/1475-2875-9-144
239 rdf:type schema:CreativeWork
240 sg:pub.10.2165/00003495-200262090-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023304915
241 https://doi.org/10.2165/00003495-200262090-00003
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1001/jama.297.20.2210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013820981
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/0169-4758(87)90147-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052645319
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1046/j.1365-3156.2000.00643.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002238027
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1056/nejmc0805011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041561416
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1056/nejmoa0808859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011738279
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1086/647946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038211056
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1093/infdis/jit077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040456777
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1093/jmedent/27.4.570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059808953
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1172/jci21682 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041881557
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1371/journal.pmed.1001119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032565194
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1371/journal.pone.0007871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053287199
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1371/journal.pone.0026005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042123343
266 rdf:type schema:CreativeWork
267 https://doi.org/10.2471/blt.08.055632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070837241
268 rdf:type schema:CreativeWork
269 https://doi.org/10.4269/ajtmh.1999.61.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074501123
270 rdf:type schema:CreativeWork
271 https://doi.org/10.4269/ajtmh.2007.77.153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077584383
272 rdf:type schema:CreativeWork
273 https://doi.org/10.4269/ajtmh.2010.09-0403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053396208
274 rdf:type schema:CreativeWork
275 https://doi.org/10.4269/ajtmh.2010.10-0158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038948201
276 rdf:type schema:CreativeWork
277 https://www.grid.ac/institutes/grid.416738.f schema:alternateName Centers for Disease Control and Prevention
278 schema:name Kenya Medical Research Institute/Centers for Disease Control, Prevention Research and Public Health Collaboration, Kisumu, Kenya
279 Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, USA
280 rdf:type schema:Organization
281 https://www.grid.ac/institutes/grid.417684.8 schema:alternateName United States Public Health Service
282 schema:name Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, USA
283 US Public Health Service, Rockville, Maryland
284 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...