Atorvastatin treatment is effective when used in combination with mefloquine in an experimental cerebral malaria murine model View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

Jean-Baptiste Souraud, Sébastien Briolant, Jérome Dormoi, Joel Mosnier, Hélène Savini, Eric Baret, Rémy Amalvict, Raoulin Soulard, Christophe Rogier, Bruno Pradines

ABSTRACT

BACKGROUND: One of the major complications of Plasmodium falciparum infection is cerebral malaria (CM), which causes one million deaths worldwide each year, results in long-term neurological sequelae and the treatment for which is only partially effective. Statins are recognized to have an immunomodulatory action, attenuate sepsis and have a neuroprotective effect. Atorvastatin (AVA) has shown in vitro anti-malarial activity and has improved the activity of mefloquine (MQ) and quinine. METHODS: The efficiency of 40 mg/kg intraperitoneal AVA, alone or in association with MQ, was assessed in an experimental Plasmodium berghei ANKA rodent parasite model of CM and performed according to different therapeutic schemes. The effects on experimental CM were assessed through the evaluation of brain histopathological changes and neuronal apoptosis by TUNEL staining. RESULTS: AVA alone in the therapeutic scheme show no effect on survival, but the prophylactic scheme employing AVA associated with MQ, rather than MQ alone, led to a significant delay in mouse death and had an effect on the onset of CM symptoms and on the level of parasitaemia. Histopathological findings show a correlation between brain lesions and CM onset. A neuronal anti-apoptotic effect of AVA in the AVA + MQ combination was not shown. CONCLUSIONS: The combination of AVA and MQ therapy led to a significant delay in mouse mortality. There were differences in the incidence, time to cerebral malaria and the level of parasitaemia when the drug combination was administered to mice. When used in combination with MQ, AVA had a relevant effect on the in vivo growth inhibition and clinical outcome of P. berghei ANKA-infected mice. More... »

PAGES

13

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1475-2875-11-13

DOI

http://dx.doi.org/10.1186/1475-2875-11-13

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035353002

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22233563


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antimalarials", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Atorvastatin Calcium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Therapy, Combination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heptanoic Acids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histocytochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Malaria, Cerebral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mefloquine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plasmodium berghei", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pyrroles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Minist\u00e8re de la D\u00e9fense", 
          "id": "https://www.grid.ac/institutes/grid.418221.c", 
          "name": [
            "Unit\u00e9 de parasitologie, Unit\u00e9 de recherche sur les maladies infectieuses et transmissibles \u00e9mergentes - UMR 6236, Institut de recherche biom\u00e9dicale des arm\u00e9es - antenne de Marseille, All\u00e9e du M\u00e9decin-colonel Jamot, Parc le Pharo, BP 60109, 13262, Marseille Cedex 7, France", 
            "Service d'Anatomie et Cytologie Pathologiques, H\u00f4pital d'Instruction des Arm\u00e9es Saint-Anne, Toulon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Souraud", 
        "givenName": "Jean-Baptiste", 
        "id": "sg:person.01276637222.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276637222.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Minist\u00e8re de la D\u00e9fense", 
          "id": "https://www.grid.ac/institutes/grid.418221.c", 
          "name": [
            "Unit\u00e9 de parasitologie, Unit\u00e9 de recherche sur les maladies infectieuses et transmissibles \u00e9mergentes - UMR 6236, Institut de recherche biom\u00e9dicale des arm\u00e9es - antenne de Marseille, All\u00e9e du M\u00e9decin-colonel Jamot, Parc le Pharo, BP 60109, 13262, Marseille Cedex 7, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Briolant", 
        "givenName": "S\u00e9bastien", 
        "id": "sg:person.01025041206.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025041206.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Minist\u00e8re de la D\u00e9fense", 
          "id": "https://www.grid.ac/institutes/grid.418221.c", 
          "name": [
            "Unit\u00e9 de parasitologie, Unit\u00e9 de recherche sur les maladies infectieuses et transmissibles \u00e9mergentes - UMR 6236, Institut de recherche biom\u00e9dicale des arm\u00e9es - antenne de Marseille, All\u00e9e du M\u00e9decin-colonel Jamot, Parc le Pharo, BP 60109, 13262, Marseille Cedex 7, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dormoi", 
        "givenName": "J\u00e9rome", 
        "id": "sg:person.01221752377.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221752377.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Minist\u00e8re de la D\u00e9fense", 
          "id": "https://www.grid.ac/institutes/grid.418221.c", 
          "name": [
            "Service de Biochimie, H\u00f4pital d'Instruction des Arm\u00e9es Laveran, Marseille, France", 
            "Unit\u00e9 de Chirurgie et Physiologie Exp\u00e9rimentale, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mosnier", 
        "givenName": "Joel", 
        "id": "sg:person.0665714151.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665714151.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Laveran", 
          "id": "https://www.grid.ac/institutes/grid.414005.4", 
          "name": [
            "Unit\u00e9 de parasitologie, Unit\u00e9 de recherche sur les maladies infectieuses et transmissibles \u00e9mergentes - UMR 6236, Institut de recherche biom\u00e9dicale des arm\u00e9es - antenne de Marseille, All\u00e9e du M\u00e9decin-colonel Jamot, Parc le Pharo, BP 60109, 13262, Marseille Cedex 7, France", 
            "Service de Maladies Infectieuses, H\u00f4pital d'Instruction des Arm\u00e9es Laveran, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Savini", 
        "givenName": "H\u00e9l\u00e8ne", 
        "id": "sg:person.01273260707.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273260707.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Minist\u00e8re de la D\u00e9fense", 
          "id": "https://www.grid.ac/institutes/grid.418221.c", 
          "name": [
            "Unit\u00e9 de parasitologie, Unit\u00e9 de recherche sur les maladies infectieuses et transmissibles \u00e9mergentes - UMR 6236, Institut de recherche biom\u00e9dicale des arm\u00e9es - antenne de Marseille, All\u00e9e du M\u00e9decin-colonel Jamot, Parc le Pharo, BP 60109, 13262, Marseille Cedex 7, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baret", 
        "givenName": "Eric", 
        "id": "sg:person.01310332405.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310332405.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Minist\u00e8re de la D\u00e9fense", 
          "id": "https://www.grid.ac/institutes/grid.418221.c", 
          "name": [
            "Unit\u00e9 de parasitologie, Unit\u00e9 de recherche sur les maladies infectieuses et transmissibles \u00e9mergentes - UMR 6236, Institut de recherche biom\u00e9dicale des arm\u00e9es - antenne de Marseille, All\u00e9e du M\u00e9decin-colonel Jamot, Parc le Pharo, BP 60109, 13262, Marseille Cedex 7, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Amalvict", 
        "givenName": "R\u00e9my", 
        "id": "sg:person.01243625231.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243625231.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Service d'Anatomie et Cytologie Pathologiques, H\u00f4pital d'Instruction des Arm\u00e9es Saint-Anne, Toulon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Soulard", 
        "givenName": "Raoulin", 
        "id": "sg:person.01311740431.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311740431.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Minist\u00e8re de la D\u00e9fense", 
          "id": "https://www.grid.ac/institutes/grid.418221.c", 
          "name": [
            "Unit\u00e9 de parasitologie, Unit\u00e9 de recherche sur les maladies infectieuses et transmissibles \u00e9mergentes - UMR 6236, Institut de recherche biom\u00e9dicale des arm\u00e9es - antenne de Marseille, All\u00e9e du M\u00e9decin-colonel Jamot, Parc le Pharo, BP 60109, 13262, Marseille Cedex 7, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rogier", 
        "givenName": "Christophe", 
        "id": "sg:person.01347412714.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347412714.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Minist\u00e8re de la D\u00e9fense", 
          "id": "https://www.grid.ac/institutes/grid.418221.c", 
          "name": [
            "Unit\u00e9 de parasitologie, Unit\u00e9 de recherche sur les maladies infectieuses et transmissibles \u00e9mergentes - UMR 6236, Institut de recherche biom\u00e9dicale des arm\u00e9es - antenne de Marseille, All\u00e9e du M\u00e9decin-colonel Jamot, Parc le Pharo, BP 60109, 13262, Marseille Cedex 7, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pradines", 
        "givenName": "Bruno", 
        "id": "sg:person.0734433067.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734433067.10"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00216-006-0655-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001392109", 
          "https://doi.org/10.1007/s00216-006-0655-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00216-006-0655-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001392109", 
          "https://doi.org/10.1007/s00216-006-0655-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-2999(00)00870-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001697738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.01006-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002595713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.00513-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005586547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpara.2006.02.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006469659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1471-4906(03)00229-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007196836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1471-4906(03)00229-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007196836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000037098.20829.31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009160006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-9-139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010629169", 
          "https://doi.org/10.1186/1475-2875-9-139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/10.shk.0000115756.74059.ce", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010945729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/10.shk.0000115756.74059.ce", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010945729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0808859", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011738279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.104.502195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015236136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2164-8-452", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015324104", 
          "https://doi.org/10.1186/1471-2164-8-452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.200838863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016984329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.200838863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016984329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-10-52", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016991374", 
          "https://doi.org/10.1186/1475-2875-10-52"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.01428-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018032278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.01462-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018180266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atherosclerosis.2008.08.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018543623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrneurol.2009.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024717630", 
          "https://doi.org/10.1038/nrneurol.2009.23"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrneurol.2009.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024717630", 
          "https://doi.org/10.1038/nrneurol.2009.23"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3600363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025350761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3600363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025350761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2009.09-0204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027388052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.01330-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031956818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pt.2006.09.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034754652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02256431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034797612", 
          "https://doi.org/10.1007/bf02256431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02256431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034797612", 
          "https://doi.org/10.1007/bf02256431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/cmr.14.4.810-820.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035581398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/cmr.17.3.509-539.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036147695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.expneurol.2006.02.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036559207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-0691.2009.02750.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039203175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000059384.34874.f0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042763345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000059384.34874.f0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042763345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000180268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043151215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/82219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044195060", 
          "https://doi.org/10.1038/82219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkq173", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049350858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkq173", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049350858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000165920.67784.58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050522422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000165920.67784.58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050522422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(07)70111-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051917368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2990.2006.00706.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051928908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2990.2006.00706.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051928908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/expr.2000.4508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052738229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0008-6363(03)00515-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054578652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/0264-6021:3600363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056715869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1542/peds.2007-3709", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067826795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074685346", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.170.4.2221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075233132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2004.71.2_suppl.0700001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076883960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077318342", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.178.9.5779", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077405675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083351406", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-12", 
    "datePublishedReg": "2012-12-01", 
    "description": "BACKGROUND: One of the major complications of Plasmodium falciparum infection is cerebral malaria (CM), which causes one million deaths worldwide each year, results in long-term neurological sequelae and the treatment for which is only partially effective. Statins are recognized to have an immunomodulatory action, attenuate sepsis and have a neuroprotective effect. Atorvastatin (AVA) has shown in vitro anti-malarial activity and has improved the activity of mefloquine (MQ) and quinine.\nMETHODS: The efficiency of 40 mg/kg intraperitoneal AVA, alone or in association with MQ, was assessed in an experimental Plasmodium berghei ANKA rodent parasite model of CM and performed according to different therapeutic schemes. The effects on experimental CM were assessed through the evaluation of brain histopathological changes and neuronal apoptosis by TUNEL staining.\nRESULTS: AVA alone in the therapeutic scheme show no effect on survival, but the prophylactic scheme employing AVA associated with MQ, rather than MQ alone, led to a significant delay in mouse death and had an effect on the onset of CM symptoms and on the level of parasitaemia. Histopathological findings show a correlation between brain lesions and CM onset. A neuronal anti-apoptotic effect of AVA in the AVA + MQ combination was not shown.\nCONCLUSIONS: The combination of AVA and MQ therapy led to a significant delay in mouse mortality. There were differences in the incidence, time to cerebral malaria and the level of parasitaemia when the drug combination was administered to mice. When used in combination with MQ, AVA had a relevant effect on the in vivo growth inhibition and clinical outcome of P. berghei ANKA-infected mice.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1475-2875-11-13", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1030597", 
        "issn": [
          "1475-2875"
        ], 
        "name": "Malaria Journal", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "name": "Atorvastatin treatment is effective when used in combination with mefloquine in an experimental cerebral malaria murine model", 
    "pagination": "13", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a86846597fa1fb43a621269cd2db76da9187d12aa9a8ee6248b85f879acc8a5c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22233563"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101139802"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1475-2875-11-13"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1035353002"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1475-2875-11-13", 
      "https://app.dimensions.ai/details/publication/pub.1035353002"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000514.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1475-2875-11-13"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1475-2875-11-13'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1475-2875-11-13'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1475-2875-11-13'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1475-2875-11-13'


 

This table displays all metadata directly associated to this object as RDF triples.

352 TRIPLES      21 PREDICATES      92 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1475-2875-11-13 schema:about N1171a1278e4140d9be31a79c8d0320e4
2 N200d0c25d03d4bf2b74b8abd0c7c171c
3 N2d6c5898e865461da2f5002da42b8a52
4 N4b2ddb37748b49078721f5fa6c230306
5 N4f7c629eb2d9472d8090dfe87b3cd7a9
6 N53556fec9c304f8c9d7ebeaea41c2e1b
7 N53cd949fe1bf4e529251a76ef1c345bc
8 N54cd2e60769349e7a05b891654aeb275
9 N7def1c4a50ac43218c757e3b43e13a97
10 N8264cb454b294327bc8b71e68e2e027f
11 N845c83df16984cb5929c795408bee542
12 Na1905bfc00054f20b82aceeee26a340f
13 Na81669399d044b60bf4c0f5457dfbc67
14 Naa472d034b4345c095ff5c4de68495f8
15 Nb4ff3c90af37449c917acba47d8e8f9f
16 Nba148dadeec241dcb67a6d758a0a68f1
17 Nbea4a8d7784444a0932897fa6f3bdc0e
18 Ne074f2c5327f4c3798106f9fd7c10106
19 Nf28be7f6292b474687ee1f146bda2ac8
20 anzsrc-for:11
21 anzsrc-for:1109
22 schema:author N1275b47713914ca5b154b1b305b4a375
23 schema:citation sg:pub.10.1007/bf02256431
24 sg:pub.10.1007/s00216-006-0655-3
25 sg:pub.10.1038/82219
26 sg:pub.10.1038/nrneurol.2009.23
27 sg:pub.10.1186/1471-2164-8-452
28 sg:pub.10.1186/1475-2875-10-52
29 sg:pub.10.1186/1475-2875-9-139
30 https://app.dimensions.ai/details/publication/pub.1074685346
31 https://app.dimensions.ai/details/publication/pub.1077318342
32 https://app.dimensions.ai/details/publication/pub.1083351406
33 https://doi.org/10.1002/eji.200838863
34 https://doi.org/10.1006/expr.2000.4508
35 https://doi.org/10.1016/j.atherosclerosis.2008.08.022
36 https://doi.org/10.1016/j.expneurol.2006.02.011
37 https://doi.org/10.1016/j.ijpara.2006.02.007
38 https://doi.org/10.1016/j.pt.2006.09.002
39 https://doi.org/10.1016/s0008-6363(03)00515-7
40 https://doi.org/10.1016/s0014-2999(00)00870-0
41 https://doi.org/10.1016/s1471-4906(03)00229-1
42 https://doi.org/10.1016/s1473-3099(07)70111-1
43 https://doi.org/10.1042/0264-6021:3600363
44 https://doi.org/10.1042/bj3600363
45 https://doi.org/10.1056/nejmoa0808859
46 https://doi.org/10.1093/jac/dkq173
47 https://doi.org/10.1097/10.shk.0000115756.74059.ce
48 https://doi.org/10.1111/j.1365-2990.2006.00706.x
49 https://doi.org/10.1111/j.1469-0691.2009.02750.x
50 https://doi.org/10.1128/aac.00513-08
51 https://doi.org/10.1128/aac.01006-09
52 https://doi.org/10.1128/aac.01330-06
53 https://doi.org/10.1128/aac.01428-07
54 https://doi.org/10.1128/aac.01462-08
55 https://doi.org/10.1128/cmr.14.4.810-820.2001
56 https://doi.org/10.1128/cmr.17.3.509-539.2004
57 https://doi.org/10.1159/000180268
58 https://doi.org/10.1161/01.atv.0000037098.20829.31
59 https://doi.org/10.1161/01.atv.0000059384.34874.f0
60 https://doi.org/10.1161/01.str.0000165920.67784.58
61 https://doi.org/10.1161/circulationaha.104.502195
62 https://doi.org/10.1542/peds.2007-3709
63 https://doi.org/10.4049/jimmunol.170.4.2221
64 https://doi.org/10.4049/jimmunol.178.9.5779
65 https://doi.org/10.4269/ajtmh.2004.71.2_suppl.0700001
66 https://doi.org/10.4269/ajtmh.2009.09-0204
67 schema:datePublished 2012-12
68 schema:datePublishedReg 2012-12-01
69 schema:description BACKGROUND: One of the major complications of Plasmodium falciparum infection is cerebral malaria (CM), which causes one million deaths worldwide each year, results in long-term neurological sequelae and the treatment for which is only partially effective. Statins are recognized to have an immunomodulatory action, attenuate sepsis and have a neuroprotective effect. Atorvastatin (AVA) has shown in vitro anti-malarial activity and has improved the activity of mefloquine (MQ) and quinine. METHODS: The efficiency of 40 mg/kg intraperitoneal AVA, alone or in association with MQ, was assessed in an experimental Plasmodium berghei ANKA rodent parasite model of CM and performed according to different therapeutic schemes. The effects on experimental CM were assessed through the evaluation of brain histopathological changes and neuronal apoptosis by TUNEL staining. RESULTS: AVA alone in the therapeutic scheme show no effect on survival, but the prophylactic scheme employing AVA associated with MQ, rather than MQ alone, led to a significant delay in mouse death and had an effect on the onset of CM symptoms and on the level of parasitaemia. Histopathological findings show a correlation between brain lesions and CM onset. A neuronal anti-apoptotic effect of AVA in the AVA + MQ combination was not shown. CONCLUSIONS: The combination of AVA and MQ therapy led to a significant delay in mouse mortality. There were differences in the incidence, time to cerebral malaria and the level of parasitaemia when the drug combination was administered to mice. When used in combination with MQ, AVA had a relevant effect on the in vivo growth inhibition and clinical outcome of P. berghei ANKA-infected mice.
70 schema:genre research_article
71 schema:inLanguage en
72 schema:isAccessibleForFree true
73 schema:isPartOf N2141a37334404c6fae17e2ebf6b2c522
74 Ncc2b8559957b4478a57ad69320db37fe
75 sg:journal.1030597
76 schema:name Atorvastatin treatment is effective when used in combination with mefloquine in an experimental cerebral malaria murine model
77 schema:pagination 13
78 schema:productId N46aadc7aa21e4cc1b65463c1fe2ef95f
79 N90ad43ced108491a8321b420ba4a4b54
80 Nc0d1468c63e74efc8db62f108fc4e1fc
81 Nd997e41790e941b1a72efc4c67a7a8a4
82 Nf0dc8d791a6c461a8e5b532e9e89208e
83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035353002
84 https://doi.org/10.1186/1475-2875-11-13
85 schema:sdDatePublished 2019-04-11T00:16
86 schema:sdLicense https://scigraph.springernature.com/explorer/license/
87 schema:sdPublisher N5720cb90070846ac811293d24a5767cb
88 schema:url http://link.springer.com/10.1186%2F1475-2875-11-13
89 sgo:license sg:explorer/license/
90 sgo:sdDataset articles
91 rdf:type schema:ScholarlyArticle
92 N1171a1278e4140d9be31a79c8d0320e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Disease Models, Animal
94 rdf:type schema:DefinedTerm
95 N1275b47713914ca5b154b1b305b4a375 rdf:first sg:person.01276637222.30
96 rdf:rest N5638e07cfb1f4ec3a84e3b162f1cfde5
97 N195f9e5e4b3648828c61ebc251d01805 rdf:first sg:person.0665714151.38
98 rdf:rest N21209544e34b418fb7d0ed258e880c6d
99 N200d0c25d03d4bf2b74b8abd0c7c171c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Plasmodium berghei
101 rdf:type schema:DefinedTerm
102 N21209544e34b418fb7d0ed258e880c6d rdf:first sg:person.01273260707.47
103 rdf:rest N36b9c85784e54a3cbf3642df86475d4f
104 N2141a37334404c6fae17e2ebf6b2c522 schema:volumeNumber 11
105 rdf:type schema:PublicationVolume
106 N29b1729d21154e7ba3be92e466eea91a rdf:first sg:person.01243625231.58
107 rdf:rest N7f59237238f74891ab87011ff7c66b6d
108 N2d6c5898e865461da2f5002da42b8a52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Malaria, Cerebral
110 rdf:type schema:DefinedTerm
111 N36b9c85784e54a3cbf3642df86475d4f rdf:first sg:person.01310332405.73
112 rdf:rest N29b1729d21154e7ba3be92e466eea91a
113 N46aadc7aa21e4cc1b65463c1fe2ef95f schema:name pubmed_id
114 schema:value 22233563
115 rdf:type schema:PropertyValue
116 N4b2ddb37748b49078721f5fa6c230306 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Female
118 rdf:type schema:DefinedTerm
119 N4f7c629eb2d9472d8090dfe87b3cd7a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Survival Analysis
121 rdf:type schema:DefinedTerm
122 N53556fec9c304f8c9d7ebeaea41c2e1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Antimalarials
124 rdf:type schema:DefinedTerm
125 N53cd949fe1bf4e529251a76ef1c345bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Brain
127 rdf:type schema:DefinedTerm
128 N54cd2e60769349e7a05b891654aeb275 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Immunohistochemistry
130 rdf:type schema:DefinedTerm
131 N5638e07cfb1f4ec3a84e3b162f1cfde5 rdf:first sg:person.01025041206.79
132 rdf:rest Naf1c8107f53c4f6586632e07401b5e26
133 N5720cb90070846ac811293d24a5767cb schema:name Springer Nature - SN SciGraph project
134 rdf:type schema:Organization
135 N69e08f1c3b8a4333908d34057e813bcf rdf:first sg:person.01347412714.28
136 rdf:rest Nb4d69c9027064d868337c5b29bb0984c
137 N7def1c4a50ac43218c757e3b43e13a97 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Mice
139 rdf:type schema:DefinedTerm
140 N7f59237238f74891ab87011ff7c66b6d rdf:first sg:person.01311740431.06
141 rdf:rest N69e08f1c3b8a4333908d34057e813bcf
142 N8264cb454b294327bc8b71e68e2e027f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Drug Therapy, Combination
144 rdf:type schema:DefinedTerm
145 N845c83df16984cb5929c795408bee542 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Heptanoic Acids
147 rdf:type schema:DefinedTerm
148 N90ad43ced108491a8321b420ba4a4b54 schema:name readcube_id
149 schema:value a86846597fa1fb43a621269cd2db76da9187d12aa9a8ee6248b85f879acc8a5c
150 rdf:type schema:PropertyValue
151 Na1905bfc00054f20b82aceeee26a340f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Atorvastatin Calcium
153 rdf:type schema:DefinedTerm
154 Na81669399d044b60bf4c0f5457dfbc67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Neurons
156 rdf:type schema:DefinedTerm
157 Naa21df3b8f0948a2abf00c48b2ee2042 schema:name Service d'Anatomie et Cytologie Pathologiques, Hôpital d'Instruction des Armées Saint-Anne, Toulon, France
158 rdf:type schema:Organization
159 Naa472d034b4345c095ff5c4de68495f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Apoptosis
161 rdf:type schema:DefinedTerm
162 Naf1c8107f53c4f6586632e07401b5e26 rdf:first sg:person.01221752377.02
163 rdf:rest N195f9e5e4b3648828c61ebc251d01805
164 Nb4d69c9027064d868337c5b29bb0984c rdf:first sg:person.0734433067.10
165 rdf:rest rdf:nil
166 Nb4ff3c90af37449c917acba47d8e8f9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Treatment Outcome
168 rdf:type schema:DefinedTerm
169 Nba148dadeec241dcb67a6d758a0a68f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Mefloquine
171 rdf:type schema:DefinedTerm
172 Nbea4a8d7784444a0932897fa6f3bdc0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Animals
174 rdf:type schema:DefinedTerm
175 Nc0d1468c63e74efc8db62f108fc4e1fc schema:name doi
176 schema:value 10.1186/1475-2875-11-13
177 rdf:type schema:PropertyValue
178 Ncc2b8559957b4478a57ad69320db37fe schema:issueNumber 1
179 rdf:type schema:PublicationIssue
180 Nd997e41790e941b1a72efc4c67a7a8a4 schema:name dimensions_id
181 schema:value pub.1035353002
182 rdf:type schema:PropertyValue
183 Ne074f2c5327f4c3798106f9fd7c10106 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Pyrroles
185 rdf:type schema:DefinedTerm
186 Nf0dc8d791a6c461a8e5b532e9e89208e schema:name nlm_unique_id
187 schema:value 101139802
188 rdf:type schema:PropertyValue
189 Nf28be7f6292b474687ee1f146bda2ac8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Histocytochemistry
191 rdf:type schema:DefinedTerm
192 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
193 schema:name Medical and Health Sciences
194 rdf:type schema:DefinedTerm
195 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
196 schema:name Neurosciences
197 rdf:type schema:DefinedTerm
198 sg:journal.1030597 schema:issn 1475-2875
199 schema:name Malaria Journal
200 rdf:type schema:Periodical
201 sg:person.01025041206.79 schema:affiliation https://www.grid.ac/institutes/grid.418221.c
202 schema:familyName Briolant
203 schema:givenName Sébastien
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025041206.79
205 rdf:type schema:Person
206 sg:person.01221752377.02 schema:affiliation https://www.grid.ac/institutes/grid.418221.c
207 schema:familyName Dormoi
208 schema:givenName Jérome
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221752377.02
210 rdf:type schema:Person
211 sg:person.01243625231.58 schema:affiliation https://www.grid.ac/institutes/grid.418221.c
212 schema:familyName Amalvict
213 schema:givenName Rémy
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243625231.58
215 rdf:type schema:Person
216 sg:person.01273260707.47 schema:affiliation https://www.grid.ac/institutes/grid.414005.4
217 schema:familyName Savini
218 schema:givenName Hélène
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273260707.47
220 rdf:type schema:Person
221 sg:person.01276637222.30 schema:affiliation https://www.grid.ac/institutes/grid.418221.c
222 schema:familyName Souraud
223 schema:givenName Jean-Baptiste
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276637222.30
225 rdf:type schema:Person
226 sg:person.01310332405.73 schema:affiliation https://www.grid.ac/institutes/grid.418221.c
227 schema:familyName Baret
228 schema:givenName Eric
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310332405.73
230 rdf:type schema:Person
231 sg:person.01311740431.06 schema:affiliation Naa21df3b8f0948a2abf00c48b2ee2042
232 schema:familyName Soulard
233 schema:givenName Raoulin
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311740431.06
235 rdf:type schema:Person
236 sg:person.01347412714.28 schema:affiliation https://www.grid.ac/institutes/grid.418221.c
237 schema:familyName Rogier
238 schema:givenName Christophe
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347412714.28
240 rdf:type schema:Person
241 sg:person.0665714151.38 schema:affiliation https://www.grid.ac/institutes/grid.418221.c
242 schema:familyName Mosnier
243 schema:givenName Joel
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665714151.38
245 rdf:type schema:Person
246 sg:person.0734433067.10 schema:affiliation https://www.grid.ac/institutes/grid.418221.c
247 schema:familyName Pradines
248 schema:givenName Bruno
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734433067.10
250 rdf:type schema:Person
251 sg:pub.10.1007/bf02256431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034797612
252 https://doi.org/10.1007/bf02256431
253 rdf:type schema:CreativeWork
254 sg:pub.10.1007/s00216-006-0655-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001392109
255 https://doi.org/10.1007/s00216-006-0655-3
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/82219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044195060
258 https://doi.org/10.1038/82219
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/nrneurol.2009.23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024717630
261 https://doi.org/10.1038/nrneurol.2009.23
262 rdf:type schema:CreativeWork
263 sg:pub.10.1186/1471-2164-8-452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015324104
264 https://doi.org/10.1186/1471-2164-8-452
265 rdf:type schema:CreativeWork
266 sg:pub.10.1186/1475-2875-10-52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016991374
267 https://doi.org/10.1186/1475-2875-10-52
268 rdf:type schema:CreativeWork
269 sg:pub.10.1186/1475-2875-9-139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010629169
270 https://doi.org/10.1186/1475-2875-9-139
271 rdf:type schema:CreativeWork
272 https://app.dimensions.ai/details/publication/pub.1074685346 schema:CreativeWork
273 https://app.dimensions.ai/details/publication/pub.1077318342 schema:CreativeWork
274 https://app.dimensions.ai/details/publication/pub.1083351406 schema:CreativeWork
275 https://doi.org/10.1002/eji.200838863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016984329
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1006/expr.2000.4508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052738229
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.atherosclerosis.2008.08.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018543623
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.expneurol.2006.02.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036559207
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.ijpara.2006.02.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006469659
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.pt.2006.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034754652
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/s0008-6363(03)00515-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054578652
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/s0014-2999(00)00870-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001697738
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/s1471-4906(03)00229-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007196836
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/s1473-3099(07)70111-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051917368
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1042/0264-6021:3600363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056715869
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1042/bj3600363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025350761
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1056/nejmoa0808859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011738279
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1093/jac/dkq173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049350858
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1097/10.shk.0000115756.74059.ce schema:sameAs https://app.dimensions.ai/details/publication/pub.1010945729
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1111/j.1365-2990.2006.00706.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051928908
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1111/j.1469-0691.2009.02750.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039203175
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1128/aac.00513-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005586547
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1128/aac.01006-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002595713
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1128/aac.01330-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031956818
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1128/aac.01428-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018032278
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1128/aac.01462-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018180266
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1128/cmr.14.4.810-820.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035581398
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1128/cmr.17.3.509-539.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036147695
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1159/000180268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043151215
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1161/01.atv.0000037098.20829.31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009160006
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1161/01.atv.0000059384.34874.f0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042763345
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1161/01.str.0000165920.67784.58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050522422
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1161/circulationaha.104.502195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015236136
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1542/peds.2007-3709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067826795
334 rdf:type schema:CreativeWork
335 https://doi.org/10.4049/jimmunol.170.4.2221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075233132
336 rdf:type schema:CreativeWork
337 https://doi.org/10.4049/jimmunol.178.9.5779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077405675
338 rdf:type schema:CreativeWork
339 https://doi.org/10.4269/ajtmh.2004.71.2_suppl.0700001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076883960
340 rdf:type schema:CreativeWork
341 https://doi.org/10.4269/ajtmh.2009.09-0204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027388052
342 rdf:type schema:CreativeWork
343 https://www.grid.ac/institutes/grid.414005.4 schema:alternateName Hôpital Laveran
344 schema:name Service de Maladies Infectieuses, Hôpital d'Instruction des Armées Laveran, Marseille, France
345 Unité de parasitologie, Unité de recherche sur les maladies infectieuses et transmissibles émergentes - UMR 6236, Institut de recherche biomédicale des armées - antenne de Marseille, Allée du Médecin-colonel Jamot, Parc le Pharo, BP 60109, 13262, Marseille Cedex 7, France
346 rdf:type schema:Organization
347 https://www.grid.ac/institutes/grid.418221.c schema:alternateName Ministère de la Défense
348 schema:name Service d'Anatomie et Cytologie Pathologiques, Hôpital d'Instruction des Armées Saint-Anne, Toulon, France
349 Service de Biochimie, Hôpital d'Instruction des Armées Laveran, Marseille, France
350 Unité de Chirurgie et Physiologie Expérimentale, Institut de Recherche Biomédicale des Armées, Marseille, France
351 Unité de parasitologie, Unité de recherche sur les maladies infectieuses et transmissibles émergentes - UMR 6236, Institut de recherche biomédicale des armées - antenne de Marseille, Allée du Médecin-colonel Jamot, Parc le Pharo, BP 60109, 13262, Marseille Cedex 7, France
352 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...