Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-05-21

AUTHORS

Chiara Tommasi, Rita Bellagamba, Massimo Tempestilli, Antonio D'Avolio, Anna L Gallo, Jelena Ivanovic, Emanuele Nicastri, Leopoldo P Pucillo, Pasquale Narciso

ABSTRACT

The case of a 32-year-old Caucasian female with multi-drug resistant HIV-1 subtype B infection treated with a salvage regimen including maraviroc, raltegravir, etravirine and unboosted saquinavir who started atovaquone/proguanil prophylaxis, is reported. The potential interactions between atovaquone/proguanil and these anti-retroviral drugs are investigated. Pharmacokinetic analyses documented a marked increase in etravirine and saquinavir plasma concentrations (+55% and +274%, respectively), but not in raltegravir and maraviroc plasma concentrations. The evidence that atovaquone/proguanil significantly interacts with etravirine and saquinavir, but not with raltegravir and maraviroc, suggests that the mechanism of interaction is related to cytochrome P450. More... »

PAGES

141-141

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1475-2875-10-141

DOI

http://dx.doi.org/10.1186/1475-2875-10-141

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025707002

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21600016


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