Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-12

AUTHORS

Quinton L Fivelman, Geoffrey A Butcher, Ipemida S Adagu, David C Warhurst, Geoffrey Pasvol

ABSTRACT

We report the first in vitro and genetic confirmation of Malarone (GlaxoSmithKline; atovaquone and proguanil hydrochloride) resistance in Plasmodium falciparum acquired in Africa. On presenting with malaria two weeks after returning from a 4-week visit to Lagos, Nigeria without prophylaxis, a male patient was given a standard 3-day treatment course of Malarone. Twenty-eight days later the parasitaemia recrudesced. Parasites were cultured from the blood and the isolate (NGATV01) was shown to be resistant to atovaquone and the antifolate pyrimethamine. The cytochrome b gene of isolate NGATV01 showed a single mutation, Tyr268Asn which has not been seen previously. More... »

PAGES

1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1475-2875-1-1

DOI

http://dx.doi.org/10.1186/1475-2875-1-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022877339

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12057021


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