Relationship between Advanced Glycation End Products and Plaque Progression in Patients with Acute Coronary Syndrome: The JAPAN-ACS Sub-study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-01-07

AUTHORS

Yoshifumi Fukushima, Hiroyuki Daida, Takeshi Morimoto, Takatoshi Kasai, Katsumi Miyauchi, Sho-ichi Yamagishi, Masayoshi Takeuchi, Takafumi Hiro, Takeshi Kimura, Yoshihisa Nakagawa, Masakazu Yamagishi, Yukio Ozaki, Masunori Matsuzaki, JAPAN-ACS Investigators

ABSTRACT

BackgroundThe Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome (JAPAN-ACS) trial demonstrated that early aggressive statin therapy in patients with ACS significantly reduces plaque volume (PV). Advanced glycation end products (AGEs) and the receptors of AGEs (RAGE) may lead to angiopathy in diabetes mellitus (DM) and may affect on the development of coronary PV. The present sub-study of JAPAN-ACS investigates the association between AGEs and RAGE, and PV.MethodsIntravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) was undertaken, followed by the initiation of statin treatment (either 4 mg/day of pitavastatin or 20 mg/day of atorvastatin), in patients with ACS. In the 208 JAPAN-ACS subjects, PV using IVUS in non-culprit segment > 5 mm proximal or distal to the culprit lesion and, serum levels of AGEs and soluble RAGE (sRAGE) were measured at baseline and 8–12 months after PCI.ResultsAt baseline, no differences in the levels of either AGEs or sRAGE were found between patients with DM and those without DM. The levels of AGEs decreased significantly with statin therapy from 8.6 ± 2.2 to 8.0 ± 2.1 U/ml (p < 0.001), whereas the levels of sRAGE did not change. There were no significant correlations between changes in PV and the changes in levels of AGEs as well as sRAGE. However, high baseline AGEs levels were significantly associated with plaque progression (odds ratio, 1.21; 95% confidence interval, 1.01 - 1.48; p = 0.044) even after adjusting for DM in multivariate logistic regression models.ConclusionsHigh baseline AGEs levels were associated with plaque progression in the JAPAN-ACS trial. This relationship was independent of DM. These findings suggest AGEs may be related to long-term glucose control and other oxidative stresses in ACS.Trial registrationNCT00242944 More... »

PAGES

5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1475-2840-12-5

DOI

http://dx.doi.org/10.1186/1475-2840-12-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038251780

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23289728


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25 schema:description BackgroundThe Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome (JAPAN-ACS) trial demonstrated that early aggressive statin therapy in patients with ACS significantly reduces plaque volume (PV). Advanced glycation end products (AGEs) and the receptors of AGEs (RAGE) may lead to angiopathy in diabetes mellitus (DM) and may affect on the development of coronary PV. The present sub-study of JAPAN-ACS investigates the association between AGEs and RAGE, and PV.MethodsIntravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) was undertaken, followed by the initiation of statin treatment (either 4 mg/day of pitavastatin or 20 mg/day of atorvastatin), in patients with ACS. In the 208 JAPAN-ACS subjects, PV using IVUS in non-culprit segment > 5 mm proximal or distal to the culprit lesion and, serum levels of AGEs and soluble RAGE (sRAGE) were measured at baseline and 8–12 months after PCI.ResultsAt baseline, no differences in the levels of either AGEs or sRAGE were found between patients with DM and those without DM. The levels of AGEs decreased significantly with statin therapy from 8.6 ± 2.2 to 8.0 ± 2.1 U/ml (p < 0.001), whereas the levels of sRAGE did not change. There were no significant correlations between changes in PV and the changes in levels of AGEs as well as sRAGE. However, high baseline AGEs levels were significantly associated with plaque progression (odds ratio, 1.21; 95% confidence interval, 1.01 - 1.48; p = 0.044) even after adjusting for DM in multivariate logistic regression models.ConclusionsHigh baseline AGEs levels were associated with plaque progression in the JAPAN-ACS trial. This relationship was independent of DM. These findings suggest AGEs may be related to long-term glucose control and other oxidative stresses in ACS.Trial registrationNCT00242944
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31 schema:keywords ACS
32 IVUS
33 Japan Assessment
34 ResultsAt baseline
35 acute coronary syndrome
36 acute coronary syndrome trials
37 advanced glycation end products
38 age levels
39 aggressive statin therapy
40 angiopathy
41 assessment
42 association
43 atorvastatin
44 baseline
45 changes
46 control
47 coronary intervention
48 coronary plaque volume
49 coronary syndrome
50 correlation
51 culprit lesion
52 development
53 diabetes mellitus
54 differences
55 end products
56 findings
57 glucose control
58 glycation end products
59 initiation
60 intervention
61 lesions
62 levels
63 levels of AGEs
64 levels of sRAGE
65 logistic regression models
66 long-term glucose control
67 mellitus
68 model
69 months
70 multivariate logistic regression model
71 non-culprit segments
72 oxidative stress
73 patients
74 percutaneous coronary intervention
75 pitavastatin
76 plaque progression
77 plaque volume
78 products
79 progression
80 receptor of AGE
81 receptor of AGEs
82 receptors
83 regression models
84 relationship
85 segments
86 serum levels
87 significant correlation
88 soluble RAGE
89 statin therapy
90 statin treatment
91 stress
92 study
93 sub
94 subjects
95 syndrome
96 therapy
97 treatment
98 trials
99 ultrasound
100 volume
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