Association between serum adipocyte fatty-acid binding protein concentrations, left ventricular function and myocardial perfusion abnormalities in patients with coronary artery ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Chi-Lun Huang, Yen-Wen Wu, Chih-Cheng Wu, Lin Lin, Yu-Chin Wu, Pei-Ying Hsu, Yuh-Shiun Jong, Wei-Shiung Yang

ABSTRACT

BACKGROUND: Adipokines, including adipocyte fatty acid-binding protein (A-FABP), have been demonstrated to be involved in the pathogenesis of atherosclerosis. In the present study, we investigated the association of circulating A-FABP level with severity of myocardial perfusion abnormalities analyzed by Tl-201 dipyridamole single-photon emission computed tomography. METHODS: A total of 170 patients with coronary artery disease (CAD) from cardiovascular clinics were enrolled in the study. Serum A-FABP levels, echocardiography, and stress myocardial perfusion imaging results were analyzed. RESULTS: Compared with the patients with mild CAD (summed stress score [SSS] ≤ 8), those with moderate to severe CAD (SSS > 8) had significantly higher A-FABP concentrations. However, the difference was attenuated in the subgroup of patients with heart failure. In the correlation analyses, A-FABP level was correlated with age, body mass index, waist circumference, levels of creatinine, fasting glucose, high-sensitivity C-reactive protein, N-terminal pro-brain natriuretic peptide, adiponectin, and several echocardiographic parameters, including left ventricular ejection fraction. Multivariate logistic regression analysis demonstrated that the A-FABP level was not only associated with higher SSS (odds ratio, 1.30; 95% confidence interval [CI], 1.01-1.69; P = 0.048), but also an independent risk factor for heart failure (odds ratio 2.71, 95% CI, 1.23-5.94; P = 0.013). CONCLUSIONS: Serum A-FABP levels not only were associated with myocardial perfusion abnormalities and left ventricular function, but also predicted the presence of heart failure in our patients with CAD. More... »

PAGES

105

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1475-2840-12-105

DOI

http://dx.doi.org/10.1186/1475-2840-12-105

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047655632

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23866022


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1475-2840-12-105'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1475-2840-12-105'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1475-2840-12-105'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1475-2840-12-105'


 

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306 Department of Nuclear Medicine and Cardiology Division of Cardiovascular Medical Center, Far Eastern Memorial Hospital, No.21, Sec.2, Nanya S. Rd, Banciao Dist., New Taipei City, Taiwan
307 Department of Nuclear Medicine, National Taiwan University Hospital, Taipei, Taiwan
308 National Yang-Ming University School of Medicine, Taipei, Taiwan
309 rdf:type schema:Organization
310 https://www.grid.ac/institutes/grid.412094.a schema:alternateName National Taiwan University Hospital
311 schema:name Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu branch, Hsinchu City, Taiwan
312 Department of Nuclear Medicine, National Taiwan University Hospital Hsin-Chu branch, Hsinchu City, Taiwan
313 Department of Nuclear Medicine, National Taiwan University Hospital Yun-Lin Branch, Douliou City, Taiwan
314 rdf:type schema:Organization
315 https://www.grid.ac/institutes/grid.416911.a schema:alternateName Tao Yuan General Hospital
316 schema:name Department of Internal Medicine, Taoyuan General Hospital, Taoyuan, Taiwan
317 rdf:type schema:Organization
 




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