High HbA1c levels correlate with reduced plaque regression during statin treatment in patients with stable coronary artery disease: Results of ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-07-25

AUTHORS

Hiroyuki Daida, Tadateru Takayama, Takafumi Hiro, Masakazu Yamagishi, Atsushi Hirayama, Satoshi Saito, Tetsu Yamaguchi, Masunori Matsuzaki, for the COSMOS Investigators

ABSTRACT

BackgroundThe incidence of cardiac events is higher in patients with diabetes than in people without diabetes. The Coronary Atherosclerosis Study Measuring Effects of Rosuvastatin Using Intravascular Ultrasound in Japanese Subjects (COSMOS) demonstrated significant plaque regression in Japanese patients with chronic coronary disease after 76 weeks of rosuvastatin (2.5 mg once daily, up-titrated to a maximum of 20 mg/day to achieve LDL cholesterol <80 mg/dl).MethodsIn this subanalysis of COSMOS, we examined the association between HbA1c and plaque regression in 40 patients with HbA1c ≥6.5% (high group) and 86 patients with HbA1c <6.5% (low group).ResultsIn multivariate analyses, HbA1c and plaque volume at baseline were major determinants of plaque regression. LDL cholesterol decreased by 37% and 39% in the high and low groups, respectively, while HDL cholesterol increased by 16% and 22%, respectively. The reduction in plaque volume was significantly (p = 0.04) greater in the low group (from 71.0 ± 39.9 to 64.7 ± 34.7 mm3) than in the high group (from 74.3 ± 34.2 to 71.4 ± 32.3 mm3). Vessel volume increased in the high group but not in the low group (change from baseline: +4.2% vs −0.8%, p = 0.02). Change in plaque volume was significantly correlated with baseline HbA1c.ConclusionsDespite similar improvements in lipid levels, plaque regression was less pronounced in patients with high HbA1c levels compared with those with low levels. Tight glucose control during statin therapy may enhance plaque regression in patients with stable coronary disease.Trial registrationClinicalTrials.gov, Identifier NCT00329160 More... »

PAGES

87

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1475-2840-11-87

DOI

http://dx.doi.org/10.1186/1475-2840-11-87

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022511018

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22831708


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