Olmesartan/amlodipine/hydrochlorothiazide in participants with hypertension and diabetes, chronic kidney disease, or chronic cardiovascular disease: a subanalysis of the multicenter, randomized, ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

Dean J Kereiakes, Steven G Chrysant, Joseph L Izzo, Thomas Littlejohn, Michael Melino, James Lee, Victor Fernandez, Reinilde Heyrman

ABSTRACT

BACKGROUND: Patients with hypertension and cardiovascular disease (CVD), diabetes, or chronic kidney disease (CKD) usually require two or more antihypertensive agents to achieve blood pressure (BP) goals. METHODS: The efficacy/safety of olmesartan (OM) 40 mg, amlodipine besylate (AML) 10 mg, and hydrochlorothiazide (HCTZ) 25 mg versus the component dual-combinations (OM 40/AML 10 mg, OM 40/HCTZ 25 mg, and AML 10/HCTZ 25 mg) was evaluated in participants with diabetes, CKD, or chronic CVD in the Triple Therapy with Olmesartan Medoxomil, Amlodipine, and Hydrochlorothiazide in Hypertensive Patients Study (TRINITY). The primary efficacy end point was least squares (LS) mean reduction from baseline in seated diastolic BP (SeDBP) at week 12. Secondary end points included LS mean reduction in SeSBP and proportion of participants achieving BP goal (<130/80 mm Hg) at week 12 (double-blind randomized period), and LS mean reduction in SeBP and BP goal achievement at week 52/early termination (open-label period). RESULTS: At week 12, OM 40/AML 10/HCTZ 25 mg resulted in significantly greater SeBP reductions in participants with diabetes (-37.9/22.0 mm Hg vs -28.0/17.6 mm Hg for OM 40/AML 10 mg, -26.4/14.7 mm Hg for OM 40/HCTZ 25 mg, and -27.6/14.8 mm Hg for AML 10/HCTZ 25 mg), CKD (-44.3/25.5 mm Hg vs -39.5/23.8 mm Hg for OM 40/AML 10 mg, -25.3/17.0 mm Hg for OM 40/HCTZ 25 mg, and -33.4/20.6 mm Hg for AML 10/HCTZ 25 mg), and chronic CVD (-37.8/20.6 mm Hg vs -31.7/18.2 mm Hg for OM 40/AML 10 mg, -30.9/17.1 mm Hg for OM 40/HCTZ 25 mg, and -27.5/16.1 mm Hg for AML 10/HCTZ 25 mg) (P<0.05 for all subgroups vs dual-component treatments). BP goal achievement was greater for participants receiving triple-combination treatment compared with the dual-combination treatments, and was achieved in 41.1%, 55.0%, and 38.9% of participants with diabetes, CKD, and chronic CVD on OM 40/AML 10/HCTZ 25 mg, respectively. At week 52, there was sustained BP lowering with the OM/AML/HCTZ regimen. Overall, the triple combination was well tolerated. CONCLUSIONS: In patients with diabetes, CKD, or chronic CVD, short-term (12 weeks) and long-term treatment with OM 40/AML 10/HCTZ 25 mg was well tolerated, lowered BP more effectively, and enabled more participants to reach BP goal than the corresponding 2-component regimens. TRIAL IDENTIFICATION NUMBER: NCT00649389. More... »

PAGES

134

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1475-2840-11-134

DOI

http://dx.doi.org/10.1186/1475-2840-11-134

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035231216

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23110471


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amlodipine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antihypertensive Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cardiovascular Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Complications", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Double-Blind Method", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Therapy, Combination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydrochlorothiazide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypertension", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Imidazoles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Olmesartan Medoxomil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Renal Insufficiency, Chronic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tetrazoles", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Christ Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414288.3", 
          "name": [
            "The Christ Hospital Heart and Vascular Center and The Carl and Edyth Lindner Center for Research and Education at the Christ Hospital, Cincinnati, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kereiakes", 
        "givenName": "Dean J", 
        "id": "sg:person.01114512311.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114512311.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oklahoma", 
          "id": "https://www.grid.ac/institutes/grid.266900.b", 
          "name": [
            "Oklahoma Cardiovascular and Hypertension Center and University of Oklahoma College of Medicine, Oklahoma City, OK, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chrysant", 
        "givenName": "Steven G", 
        "id": "sg:person.01072477732.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072477732.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University at Buffalo, State University of New York", 
          "id": "https://www.grid.ac/institutes/grid.273335.3", 
          "name": [
            "State University of New York at Buffalo, Buffalo, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Izzo", 
        "givenName": "Joseph L", 
        "id": "sg:person.01174457147.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174457147.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "PMG Research", 
          "id": "https://www.grid.ac/institutes/grid.477478.f", 
          "name": [
            "Piedmont Medical Research Associates, Winston-Salem, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Littlejohn", 
        "givenName": "Thomas", 
        "id": "sg:person.01200107312.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200107312.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Daiichi Sankyo (United States)", 
          "id": "https://www.grid.ac/institutes/grid.428496.5", 
          "name": [
            "Daiichi Sankyo, Inc, Parsippany, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Melino", 
        "givenName": "Michael", 
        "id": "sg:person.01360534725.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360534725.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Daiichi Sankyo (United States)", 
          "id": "https://www.grid.ac/institutes/grid.428496.5", 
          "name": [
            "Daiichi Sankyo, Inc, Parsippany, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "James", 
        "id": "sg:person.01371270132.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371270132.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Daiichi Sankyo (United States)", 
          "id": "https://www.grid.ac/institutes/grid.428496.5", 
          "name": [
            "Daiichi Sankyo, Inc, Parsippany, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fernandez", 
        "givenName": "Victor", 
        "id": "sg:person.0600054072.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600054072.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Daiichi Sankyo (United States)", 
          "id": "https://www.grid.ac/institutes/grid.428496.5", 
          "name": [
            "Former employee, Daiichi Sankyo, Inc, Parsippany, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heyrman", 
        "givenName": "Reinilde", 
        "id": "sg:person.01024107161.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024107161.48"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.2165/00044011-200828110-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000392598", 
          "https://doi.org/10.2165/00044011-200828110-00005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1751-7176.2010.00360.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002811692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1751-7176.2010.00360.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002811692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hjh.0b013e328333146d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003248529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hjh.0b013e328333146d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003248529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hjh.0b013e328333146d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003248529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-6175.2002.02045.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005372080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-6175.2002.02045.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005372080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.amjmed.2008.09.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006858879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa011303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007722379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa011161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007846236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(07)61303-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009351318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2010.884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009843347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jash.2010.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010605678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hjh.0b013e3281fc975a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012616091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hjh.0b013e3281fc975a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012616091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1751-7176.2011.00588.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013565665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.289.19.2560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013958161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.b1665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014500475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.111.175463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015827977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.111.175463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015827977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000321688", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016460903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1185/030079906x162854", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018746091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinte.1993.00410050036006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020205977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinte.167.22.2431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027741376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00063110-200109000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028371858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00063110-200109000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028371858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1185/03007990802319364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030204820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clinthera.2008.08.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031346559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ahj.2008.02.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033619363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.ajkd.2006.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034813008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jash.2010.03.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036711054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.amjmed.2006.08.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037450962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03261832", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038936996", 
          "https://doi.org/10.1007/bf03261832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1751-7176.2008.08172.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040707263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.109.139816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041011472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.109.139816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041011472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1751-7176.2011.00437.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042048165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clinthera.2010.07.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042917673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clinthera.2007.05.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044633062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.107.183885", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046513676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2840-11-32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046537146", 
          "https://doi.org/10.1186/1475-2840-11-32"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0806182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048242630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2011.05.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048435881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199311113292004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049636791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1001286", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050561479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/cir.0b013e31820a55f5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053219513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/14656560902980210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053546120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinte.153.5.598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054114154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1753944709334947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064075852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1753944709334947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064075852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1753944709356012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064075885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1753944709356012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064075885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2165/11634160-000000000-00000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069132394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077979904", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078201837", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-12", 
    "datePublishedReg": "2012-12-01", 
    "description": "BACKGROUND: Patients with hypertension and cardiovascular disease (CVD), diabetes, or chronic kidney disease (CKD) usually require two or more antihypertensive agents to achieve blood pressure (BP) goals.\nMETHODS: The efficacy/safety of olmesartan (OM) 40 mg, amlodipine besylate (AML) 10 mg, and hydrochlorothiazide (HCTZ) 25 mg versus the component dual-combinations (OM 40/AML 10 mg, OM 40/HCTZ 25 mg, and AML 10/HCTZ 25 mg) was evaluated in participants with diabetes, CKD, or chronic CVD in the Triple Therapy with Olmesartan Medoxomil, Amlodipine, and Hydrochlorothiazide in Hypertensive Patients Study (TRINITY). The primary efficacy end point was least squares (LS) mean reduction from baseline in seated diastolic BP (SeDBP) at week 12. Secondary end points included LS mean reduction in SeSBP and proportion of participants achieving BP goal (<130/80 mm Hg) at week 12 (double-blind randomized period), and LS mean reduction in SeBP and BP goal achievement at week 52/early termination (open-label period).\nRESULTS: At week 12, OM 40/AML 10/HCTZ 25 mg resulted in significantly greater SeBP reductions in participants with diabetes (-37.9/22.0 mm Hg vs -28.0/17.6 mm Hg for OM 40/AML 10 mg, -26.4/14.7 mm Hg for OM 40/HCTZ 25 mg, and -27.6/14.8 mm Hg for AML 10/HCTZ 25 mg), CKD (-44.3/25.5 mm Hg vs -39.5/23.8 mm Hg for OM 40/AML 10 mg, -25.3/17.0 mm Hg for OM 40/HCTZ 25 mg, and -33.4/20.6 mm Hg for AML 10/HCTZ 25 mg), and chronic CVD (-37.8/20.6 mm Hg vs -31.7/18.2 mm Hg for OM 40/AML 10 mg, -30.9/17.1 mm Hg for OM 40/HCTZ 25 mg, and -27.5/16.1 mm Hg for AML 10/HCTZ 25 mg) (P<0.05 for all subgroups vs dual-component treatments). BP goal achievement was greater for participants receiving triple-combination treatment compared with the dual-combination treatments, and was achieved in 41.1%, 55.0%, and 38.9% of participants with diabetes, CKD, and chronic CVD on OM 40/AML 10/HCTZ 25 mg, respectively. At week 52, there was sustained BP lowering with the OM/AML/HCTZ regimen. Overall, the triple combination was well tolerated.\nCONCLUSIONS: In patients with diabetes, CKD, or chronic CVD, short-term (12 weeks) and long-term treatment with OM 40/AML 10/HCTZ 25 mg was well tolerated, lowered BP more effectively, and enabled more participants to reach BP goal than the corresponding 2-component regimens. TRIAL IDENTIFICATION NUMBER: NCT00649389.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1475-2840-11-134", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1031021", 
        "issn": [
          "1475-2840"
        ], 
        "name": "Cardiovascular Diabetology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "name": "Olmesartan/amlodipine/hydrochlorothiazide in participants with hypertension and diabetes, chronic kidney disease, or chronic cardiovascular disease: a subanalysis of the multicenter, randomized, double-blind, parallel-group TRINITY study", 
    "pagination": "134", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a7d3564c01000f3ac7f5693533324c976e0593b91f74f1d225ca0bf0af0ab0f8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23110471"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101147637"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1475-2840-11-134"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1035231216"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1475-2840-11-134", 
      "https://app.dimensions.ai/details/publication/pub.1035231216"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000514.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1475-2840-11-134"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1475-2840-11-134'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1475-2840-11-134'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1475-2840-11-134'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1475-2840-11-134'


 

This table displays all metadata directly associated to this object as RDF triples.

337 TRIPLES      21 PREDICATES      92 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1475-2840-11-134 schema:about N07c09f9244944af3993cdddb9780be68
2 N19a266e1764e4580be4773e67c44abfb
3 N1c132a29ef4c44beb62be95b602242fe
4 N1d9365d534934ffcb19222f23916d1a4
5 N255e2186783e41d3ac3bf6f8b9a882c8
6 N58f2f79208324cb6982f2f74dcd80726
7 N63e1175b3f4f482c92a368a599de56b7
8 N7098026c7f844c2eaed805b445d5a859
9 N7abe668beaf4488b9907041b19414949
10 Nab50538b4eb246bda43c25527840627e
11 Nb358f3ec4c2c4ff188bbcbc298ee93ec
12 Nb994df604b2542e8898824498a2eaba9
13 Nbe74cab1e0bb47239c51ece622696a29
14 Ne02c539c54714a0d92947c976cd5e7da
15 Neefbe88847c9446da90cc7dd3bdd6dcc
16 Nef1e6e164a444e1ca54f6f8d77edf710
17 Nfbf2ad3ac839459d9eb8bcb09b59a474
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author Ndc704f51afa84fa197897d113d920061
21 schema:citation sg:pub.10.1007/bf03261832
22 sg:pub.10.1186/1475-2840-11-32
23 sg:pub.10.2165/00044011-200828110-00005
24 https://app.dimensions.ai/details/publication/pub.1077979904
25 https://app.dimensions.ai/details/publication/pub.1078201837
26 https://doi.org/10.1001/archinte.153.5.598
27 https://doi.org/10.1001/archinte.167.22.2431
28 https://doi.org/10.1001/archinte.1993.00410050036006
29 https://doi.org/10.1001/jama.2010.884
30 https://doi.org/10.1001/jama.289.19.2560
31 https://doi.org/10.1016/j.ahj.2008.02.023
32 https://doi.org/10.1016/j.amjmed.2006.08.033
33 https://doi.org/10.1016/j.amjmed.2008.09.038
34 https://doi.org/10.1016/j.clinthera.2007.05.010
35 https://doi.org/10.1016/j.clinthera.2008.08.010
36 https://doi.org/10.1016/j.clinthera.2010.07.008
37 https://doi.org/10.1016/j.jacc.2011.05.002
38 https://doi.org/10.1016/j.jash.2010.02.005
39 https://doi.org/10.1016/j.jash.2010.03.005
40 https://doi.org/10.1016/s0140-6736(07)61303-8
41 https://doi.org/10.1053/j.ajkd.2006.12.005
42 https://doi.org/10.1056/nejm199311113292004
43 https://doi.org/10.1056/nejmoa011161
44 https://doi.org/10.1056/nejmoa011303
45 https://doi.org/10.1056/nejmoa0806182
46 https://doi.org/10.1056/nejmoa1001286
47 https://doi.org/10.1097/00063110-200109000-00010
48 https://doi.org/10.1097/hjh.0b013e3281fc975a
49 https://doi.org/10.1097/hjh.0b013e328333146d
50 https://doi.org/10.1111/j.1524-6175.2002.02045.x
51 https://doi.org/10.1111/j.1751-7176.2008.08172.x
52 https://doi.org/10.1111/j.1751-7176.2010.00360.x
53 https://doi.org/10.1111/j.1751-7176.2011.00437.x
54 https://doi.org/10.1111/j.1751-7176.2011.00588.x
55 https://doi.org/10.1136/bmj.b1665
56 https://doi.org/10.1159/000321688
57 https://doi.org/10.1161/cir.0b013e31820a55f5
58 https://doi.org/10.1161/circulationaha.107.183885
59 https://doi.org/10.1161/hypertensionaha.109.139816
60 https://doi.org/10.1161/hypertensionaha.111.175463
61 https://doi.org/10.1177/1753944709334947
62 https://doi.org/10.1177/1753944709356012
63 https://doi.org/10.1185/030079906x162854
64 https://doi.org/10.1185/03007990802319364
65 https://doi.org/10.1517/14656560902980210
66 https://doi.org/10.2165/11634160-000000000-00000
67 schema:datePublished 2012-12
68 schema:datePublishedReg 2012-12-01
69 schema:description BACKGROUND: Patients with hypertension and cardiovascular disease (CVD), diabetes, or chronic kidney disease (CKD) usually require two or more antihypertensive agents to achieve blood pressure (BP) goals. METHODS: The efficacy/safety of olmesartan (OM) 40 mg, amlodipine besylate (AML) 10 mg, and hydrochlorothiazide (HCTZ) 25 mg versus the component dual-combinations (OM 40/AML 10 mg, OM 40/HCTZ 25 mg, and AML 10/HCTZ 25 mg) was evaluated in participants with diabetes, CKD, or chronic CVD in the Triple Therapy with Olmesartan Medoxomil, Amlodipine, and Hydrochlorothiazide in Hypertensive Patients Study (TRINITY). The primary efficacy end point was least squares (LS) mean reduction from baseline in seated diastolic BP (SeDBP) at week 12. Secondary end points included LS mean reduction in SeSBP and proportion of participants achieving BP goal (<130/80 mm Hg) at week 12 (double-blind randomized period), and LS mean reduction in SeBP and BP goal achievement at week 52/early termination (open-label period). RESULTS: At week 12, OM 40/AML 10/HCTZ 25 mg resulted in significantly greater SeBP reductions in participants with diabetes (-37.9/22.0 mm Hg vs -28.0/17.6 mm Hg for OM 40/AML 10 mg, -26.4/14.7 mm Hg for OM 40/HCTZ 25 mg, and -27.6/14.8 mm Hg for AML 10/HCTZ 25 mg), CKD (-44.3/25.5 mm Hg vs -39.5/23.8 mm Hg for OM 40/AML 10 mg, -25.3/17.0 mm Hg for OM 40/HCTZ 25 mg, and -33.4/20.6 mm Hg for AML 10/HCTZ 25 mg), and chronic CVD (-37.8/20.6 mm Hg vs -31.7/18.2 mm Hg for OM 40/AML 10 mg, -30.9/17.1 mm Hg for OM 40/HCTZ 25 mg, and -27.5/16.1 mm Hg for AML 10/HCTZ 25 mg) (P<0.05 for all subgroups vs dual-component treatments). BP goal achievement was greater for participants receiving triple-combination treatment compared with the dual-combination treatments, and was achieved in 41.1%, 55.0%, and 38.9% of participants with diabetes, CKD, and chronic CVD on OM 40/AML 10/HCTZ 25 mg, respectively. At week 52, there was sustained BP lowering with the OM/AML/HCTZ regimen. Overall, the triple combination was well tolerated. CONCLUSIONS: In patients with diabetes, CKD, or chronic CVD, short-term (12 weeks) and long-term treatment with OM 40/AML 10/HCTZ 25 mg was well tolerated, lowered BP more effectively, and enabled more participants to reach BP goal than the corresponding 2-component regimens. TRIAL IDENTIFICATION NUMBER: NCT00649389.
70 schema:genre research_article
71 schema:inLanguage en
72 schema:isAccessibleForFree true
73 schema:isPartOf Nbab7df879cfb4f01ad2660f3cb664889
74 Nf6ea431ab87d4918bad6eb3397ee71db
75 sg:journal.1031021
76 schema:name Olmesartan/amlodipine/hydrochlorothiazide in participants with hypertension and diabetes, chronic kidney disease, or chronic cardiovascular disease: a subanalysis of the multicenter, randomized, double-blind, parallel-group TRINITY study
77 schema:pagination 134
78 schema:productId N317359f307b04290ad9ab7cb94c2223a
79 Nb71bdda389aa411db30d60d40fb8beab
80 Ncc3df504cc2f4577bfee1e714074941c
81 Nd83c206ae85040d79465dd52f697f916
82 Nde5db9f422144dda91cedb0d81fed3b9
83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035231216
84 https://doi.org/10.1186/1475-2840-11-134
85 schema:sdDatePublished 2019-04-10T18:21
86 schema:sdLicense https://scigraph.springernature.com/explorer/license/
87 schema:sdPublisher N2cc84a3bce83411dbc157645333cc8ad
88 schema:url http://link.springer.com/10.1186%2F1475-2840-11-134
89 sgo:license sg:explorer/license/
90 sgo:sdDataset articles
91 rdf:type schema:ScholarlyArticle
92 N07c09f9244944af3993cdddb9780be68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Renal Insufficiency, Chronic
94 rdf:type schema:DefinedTerm
95 N1232131f50fb44d4aea37de85868e2e2 rdf:first sg:person.0600054072.87
96 rdf:rest N79fc77593b3744d4888f7cb95277e2d0
97 N19a266e1764e4580be4773e67c44abfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Double-Blind Method
99 rdf:type schema:DefinedTerm
100 N1c132a29ef4c44beb62be95b602242fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Imidazoles
102 rdf:type schema:DefinedTerm
103 N1d9365d534934ffcb19222f23916d1a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Female
105 rdf:type schema:DefinedTerm
106 N255e2186783e41d3ac3bf6f8b9a882c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Antihypertensive Agents
108 rdf:type schema:DefinedTerm
109 N2cc84a3bce83411dbc157645333cc8ad schema:name Springer Nature - SN SciGraph project
110 rdf:type schema:Organization
111 N317359f307b04290ad9ab7cb94c2223a schema:name dimensions_id
112 schema:value pub.1035231216
113 rdf:type schema:PropertyValue
114 N58f2f79208324cb6982f2f74dcd80726 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Middle Aged
116 rdf:type schema:DefinedTerm
117 N63e1175b3f4f482c92a368a599de56b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Humans
119 rdf:type schema:DefinedTerm
120 N6d5adcef0ed7474ea3b8719cd9e58c0c rdf:first sg:person.01174457147.49
121 rdf:rest Nc20b4445d8d0420a88d19d8bd406117f
122 N7098026c7f844c2eaed805b445d5a859 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Hypertension
124 rdf:type schema:DefinedTerm
125 N70a1b5455a154a3089cc428911ec6917 rdf:first sg:person.01371270132.51
126 rdf:rest N1232131f50fb44d4aea37de85868e2e2
127 N79fc77593b3744d4888f7cb95277e2d0 rdf:first sg:person.01024107161.48
128 rdf:rest rdf:nil
129 N7abe668beaf4488b9907041b19414949 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Male
131 rdf:type schema:DefinedTerm
132 Nab50538b4eb246bda43c25527840627e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Tetrazoles
134 rdf:type schema:DefinedTerm
135 Nb358f3ec4c2c4ff188bbcbc298ee93ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Cardiovascular Diseases
137 rdf:type schema:DefinedTerm
138 Nb71bdda389aa411db30d60d40fb8beab schema:name doi
139 schema:value 10.1186/1475-2840-11-134
140 rdf:type schema:PropertyValue
141 Nb994df604b2542e8898824498a2eaba9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Aged
143 rdf:type schema:DefinedTerm
144 Nbab7df879cfb4f01ad2660f3cb664889 schema:volumeNumber 11
145 rdf:type schema:PublicationVolume
146 Nbe74cab1e0bb47239c51ece622696a29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Diabetes Complications
148 rdf:type schema:DefinedTerm
149 Nc20b4445d8d0420a88d19d8bd406117f rdf:first sg:person.01200107312.93
150 rdf:rest Nd1153af0b4174ed0a180faaa9a347fd3
151 Ncc3df504cc2f4577bfee1e714074941c schema:name pubmed_id
152 schema:value 23110471
153 rdf:type schema:PropertyValue
154 Nd1153af0b4174ed0a180faaa9a347fd3 rdf:first sg:person.01360534725.10
155 rdf:rest N70a1b5455a154a3089cc428911ec6917
156 Nd83c206ae85040d79465dd52f697f916 schema:name readcube_id
157 schema:value a7d3564c01000f3ac7f5693533324c976e0593b91f74f1d225ca0bf0af0ab0f8
158 rdf:type schema:PropertyValue
159 Ndc704f51afa84fa197897d113d920061 rdf:first sg:person.01114512311.14
160 rdf:rest Nf6fae585ae914801b7acd727e938d24c
161 Nde5db9f422144dda91cedb0d81fed3b9 schema:name nlm_unique_id
162 schema:value 101147637
163 rdf:type schema:PropertyValue
164 Ne02c539c54714a0d92947c976cd5e7da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Olmesartan Medoxomil
166 rdf:type schema:DefinedTerm
167 Neefbe88847c9446da90cc7dd3bdd6dcc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Amlodipine
169 rdf:type schema:DefinedTerm
170 Nef1e6e164a444e1ca54f6f8d77edf710 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Drug Therapy, Combination
172 rdf:type schema:DefinedTerm
173 Nf6ea431ab87d4918bad6eb3397ee71db schema:issueNumber 1
174 rdf:type schema:PublicationIssue
175 Nf6fae585ae914801b7acd727e938d24c rdf:first sg:person.01072477732.04
176 rdf:rest N6d5adcef0ed7474ea3b8719cd9e58c0c
177 Nfbf2ad3ac839459d9eb8bcb09b59a474 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Hydrochlorothiazide
179 rdf:type schema:DefinedTerm
180 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
181 schema:name Medical and Health Sciences
182 rdf:type schema:DefinedTerm
183 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
184 schema:name Clinical Sciences
185 rdf:type schema:DefinedTerm
186 sg:journal.1031021 schema:issn 1475-2840
187 schema:name Cardiovascular Diabetology
188 rdf:type schema:Periodical
189 sg:person.01024107161.48 schema:affiliation https://www.grid.ac/institutes/grid.428496.5
190 schema:familyName Heyrman
191 schema:givenName Reinilde
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024107161.48
193 rdf:type schema:Person
194 sg:person.01072477732.04 schema:affiliation https://www.grid.ac/institutes/grid.266900.b
195 schema:familyName Chrysant
196 schema:givenName Steven G
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072477732.04
198 rdf:type schema:Person
199 sg:person.01114512311.14 schema:affiliation https://www.grid.ac/institutes/grid.414288.3
200 schema:familyName Kereiakes
201 schema:givenName Dean J
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114512311.14
203 rdf:type schema:Person
204 sg:person.01174457147.49 schema:affiliation https://www.grid.ac/institutes/grid.273335.3
205 schema:familyName Izzo
206 schema:givenName Joseph L
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174457147.49
208 rdf:type schema:Person
209 sg:person.01200107312.93 schema:affiliation https://www.grid.ac/institutes/grid.477478.f
210 schema:familyName Littlejohn
211 schema:givenName Thomas
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200107312.93
213 rdf:type schema:Person
214 sg:person.01360534725.10 schema:affiliation https://www.grid.ac/institutes/grid.428496.5
215 schema:familyName Melino
216 schema:givenName Michael
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360534725.10
218 rdf:type schema:Person
219 sg:person.01371270132.51 schema:affiliation https://www.grid.ac/institutes/grid.428496.5
220 schema:familyName Lee
221 schema:givenName James
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371270132.51
223 rdf:type schema:Person
224 sg:person.0600054072.87 schema:affiliation https://www.grid.ac/institutes/grid.428496.5
225 schema:familyName Fernandez
226 schema:givenName Victor
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600054072.87
228 rdf:type schema:Person
229 sg:pub.10.1007/bf03261832 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038936996
230 https://doi.org/10.1007/bf03261832
231 rdf:type schema:CreativeWork
232 sg:pub.10.1186/1475-2840-11-32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046537146
233 https://doi.org/10.1186/1475-2840-11-32
234 rdf:type schema:CreativeWork
235 sg:pub.10.2165/00044011-200828110-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000392598
236 https://doi.org/10.2165/00044011-200828110-00005
237 rdf:type schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1077979904 schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1078201837 schema:CreativeWork
240 https://doi.org/10.1001/archinte.153.5.598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054114154
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1001/archinte.167.22.2431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027741376
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1001/archinte.1993.00410050036006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020205977
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1001/jama.2010.884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009843347
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1001/jama.289.19.2560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013958161
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.ahj.2008.02.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033619363
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.amjmed.2006.08.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037450962
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.amjmed.2008.09.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006858879
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.clinthera.2007.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044633062
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.clinthera.2008.08.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031346559
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.clinthera.2010.07.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042917673
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.jacc.2011.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048435881
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.jash.2010.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010605678
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.jash.2010.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036711054
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/s0140-6736(07)61303-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009351318
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1053/j.ajkd.2006.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034813008
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1056/nejm199311113292004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049636791
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1056/nejmoa011161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007846236
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1056/nejmoa011303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007722379
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1056/nejmoa0806182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048242630
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1056/nejmoa1001286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050561479
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1097/00063110-200109000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028371858
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1097/hjh.0b013e3281fc975a schema:sameAs https://app.dimensions.ai/details/publication/pub.1012616091
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1097/hjh.0b013e328333146d schema:sameAs https://app.dimensions.ai/details/publication/pub.1003248529
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1111/j.1524-6175.2002.02045.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005372080
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1111/j.1751-7176.2008.08172.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040707263
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1111/j.1751-7176.2010.00360.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002811692
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1111/j.1751-7176.2011.00437.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042048165
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1111/j.1751-7176.2011.00588.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013565665
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1136/bmj.b1665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014500475
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1159/000321688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016460903
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1161/cir.0b013e31820a55f5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053219513
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1161/circulationaha.107.183885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046513676
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1161/hypertensionaha.109.139816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041011472
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1161/hypertensionaha.111.175463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015827977
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1177/1753944709334947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064075852
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1177/1753944709356012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064075885
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1185/030079906x162854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018746091
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1185/03007990802319364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030204820
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1517/14656560902980210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053546120
319 rdf:type schema:CreativeWork
320 https://doi.org/10.2165/11634160-000000000-00000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069132394
321 rdf:type schema:CreativeWork
322 https://www.grid.ac/institutes/grid.266900.b schema:alternateName University of Oklahoma
323 schema:name Oklahoma Cardiovascular and Hypertension Center and University of Oklahoma College of Medicine, Oklahoma City, OK, USA
324 rdf:type schema:Organization
325 https://www.grid.ac/institutes/grid.273335.3 schema:alternateName University at Buffalo, State University of New York
326 schema:name State University of New York at Buffalo, Buffalo, NY, USA
327 rdf:type schema:Organization
328 https://www.grid.ac/institutes/grid.414288.3 schema:alternateName Christ Hospital
329 schema:name The Christ Hospital Heart and Vascular Center and The Carl and Edyth Lindner Center for Research and Education at the Christ Hospital, Cincinnati, OH, USA
330 rdf:type schema:Organization
331 https://www.grid.ac/institutes/grid.428496.5 schema:alternateName Daiichi Sankyo (United States)
332 schema:name Daiichi Sankyo, Inc, Parsippany, NJ, USA
333 Former employee, Daiichi Sankyo, Inc, Parsippany, NJ, USA
334 rdf:type schema:Organization
335 https://www.grid.ac/institutes/grid.477478.f schema:alternateName PMG Research
336 schema:name Piedmont Medical Research Associates, Winston-Salem, NC, USA
337 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...