Genomic testing to determine drug response: measuring preferences of the public and patients using Discrete Choice Experiment (DCE) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Mehdi Najafzadeh, Karissa M Johnston, Stuart J Peacock, Joseph M Connors, Marco A Marra, Larry D Lynd, Carlo A Marra

ABSTRACT

BACKGROUND: The extent to which a genomic test will be used in practice is affected by factors such as ability of the test to correctly predict response to treatment (i.e. sensitivity and specificity of the test), invasiveness of the testing procedure, test cost, and the probability and severity of side effects associated with treatment. METHODS: Using discrete choice experimentation (DCE), we elicited preferences of the public (Sample 1, N = 533 and Sample 2, N = 525) and cancer patients (Sample 3, N = 38) for different attributes of a hypothetical genomic test for guiding cancer treatment. Samples 1 and 3 considered the test/treatment in the context of an aggressive curable cancer (scenario A) while the scenario for sample 2 was based on a non-aggressive incurable cancer (scenario B). RESULTS: In aggressive curable cancer (scenario A), everything else being equal, the odds ratio (OR) of choosing a test with 95% sensitivity was 1.41 (versus a test with 50% sensitivity) and willingness to pay (WTP) was $1331, on average, for this amount of improvement in test sensitivity. In this scenario, the OR of choosing a test with 95% specificity was 1.24 times that of a test with 50% specificity (WTP = $827). In non-aggressive incurable cancer (scenario B), the OR of choosing a test with 95% sensitivity was 1.65 (WTP = $1344), and the OR of choosing a test with 95% specificity was 1.50 (WTP = $1080). Reducing severity of treatment side effects from severe to mild was associated with large ORs in both scenarios (OR = 2.10 and 2.24 in scenario A and B, respectively). In contrast, patients had a very large preference for 95% sensitivity of the test (OR = 5.23). CONCLUSION: The type and prognosis of cancer affected preferences for genomically-guided treatment. In aggressive curable cancer, individuals emphasized more on the sensitivity rather than the specificity of the test. In contrast, for a non-aggressive incurable cancer, individuals put similar emphasis on sensitivity and specificity of the test. While the public expressed strong preference toward lowering severity of side effects, improving sensitivity of the test had by far the largest influence on patients' decision to use genomic testing. More... »

PAGES

454

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1472-6963-13-454

DOI

http://dx.doi.org/10.1186/1472-6963-13-454

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025451400

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24176050


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Choice Behavior", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Consumer Behavior", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Testing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Patient Preference", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pharmacogenetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sensitivity and Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Surveys and Questionnaires", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Medicine, Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Najafzadeh", 
        "givenName": "Mehdi", 
        "id": "sg:person.01006746763.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006746763.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "British Columbia Cancer Agency, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Johnston", 
        "givenName": "Karissa M", 
        "id": "sg:person.01065267143.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065267143.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "British Columbia Cancer Agency, Vancouver, BC, Canada", 
            "Faculty of Medicine, University of British Columbia, Vancouver, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peacock", 
        "givenName": "Stuart J", 
        "id": "sg:person.01076161056.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076161056.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "British Columbia Cancer Agency, Vancouver, BC, Canada", 
            "Faculty of Medicine, University of British Columbia, Vancouver, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Connors", 
        "givenName": "Joseph M", 
        "id": "sg:person.0677574517.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677574517.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Canada's Michael Smith Genome Sciences Centre", 
          "id": "https://www.grid.ac/institutes/grid.434706.2", 
          "name": [
            "Genome Sciences Centre, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marra", 
        "givenName": "Marco A", 
        "id": "sg:person.01150455763.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150455763.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Paul's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416553.0", 
          "name": [
            "Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada", 
            "Centre for Health Evaluation and Outcome Sciences (CHEOS), St. Paul\u2019s Hospital, 1081 Burrard Street, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lynd", 
        "givenName": "Larry D", 
        "id": "sg:person.0732333256.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732333256.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Paul's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416553.0", 
          "name": [
            "Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada", 
            "Centre for Health Evaluation and Outcome Sciences (CHEOS), St. Paul\u2019s Hospital, 1081 Burrard Street, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marra", 
        "givenName": "Carlo A", 
        "id": "sg:person.01021612012.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021612012.88"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1159/000226595", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003087032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hec.845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003146658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10689-008-9217-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004538244", 
          "https://doi.org/10.1007/s10689-008-9217-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/gim.0b013e3181837217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005331293", 
          "https://doi.org/10.1097/gim.0b013e3181837217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/gim.0b013e3181837217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005331293", 
          "https://doi.org/10.1097/gim.0b013e3181837217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-1203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007664124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00019053-200826080-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008806799", 
          "https://doi.org/10.2165/00019053-200826080-00004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.304.14.1628", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012409313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000189629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012485133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0004.2012.01908.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014741774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(11)70141-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015138258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(02)80607-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015491951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(02)80607-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015491951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhealeco.2008.11.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020651763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/14622416.7.1.49", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022245456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hec.984", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024016537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hec.1563", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024360320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hec.1563", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024360320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0191-2615(02)00046-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025239775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0191-2615(02)00046-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025239775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10640-005-4817-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027707441", 
          "https://doi.org/10.1007/s10640-005-4817-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10640-005-4817-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027707441", 
          "https://doi.org/10.1007/s10640-005-4817-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-4733.2007.00196.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030199644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/11530660-000000000-00000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033746385", 
          "https://doi.org/10.2165/11530660-000000000-00000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/11530660-000000000-00000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033746385", 
          "https://doi.org/10.2165/11530660-000000000-00000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhealeco.2005.09.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036680627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhealeco.2005.09.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036680627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0272989x09347014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036728087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0272989x09347014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036728087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jval.2012.08.2223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037115565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt0508-509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037865970", 
          "https://doi.org/10.1038/nbt0508-509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajmg.a.35811", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039018594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0272989x0102100505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039623479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0272989x0102100505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039623479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jval.2010.10.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042098931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0266462307080129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043410941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.8-suppl_2-25", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044892184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/296093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058605919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/586913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058800148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097gim.0b013e3181837217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077804733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/cbo9780511753831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1098665042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/cbo9780511753930", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1098721478"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-12", 
    "datePublishedReg": "2013-12-01", 
    "description": "BACKGROUND: The extent to which a genomic test will be used in practice is affected by factors such as ability of the test to correctly predict response to treatment (i.e. sensitivity and specificity of the test), invasiveness of the testing procedure, test cost, and the probability and severity of side effects associated with treatment.\nMETHODS: Using discrete choice experimentation (DCE), we elicited preferences of the public (Sample 1, N\u2009=\u2009533 and Sample 2, N\u2009=\u2009525) and cancer patients (Sample 3, N\u2009=\u200938) for different attributes of a hypothetical genomic test for guiding cancer treatment. Samples 1 and 3 considered the test/treatment in the context of an aggressive curable cancer (scenario A) while the scenario for sample 2 was based on a non-aggressive incurable cancer (scenario B).\nRESULTS: In aggressive curable cancer (scenario A), everything else being equal, the odds ratio (OR) of choosing a test with 95% sensitivity was 1.41 (versus a test with 50% sensitivity) and willingness to pay (WTP) was $1331, on average, for this amount of improvement in test sensitivity. In this scenario, the OR of choosing a test with 95% specificity was 1.24 times that of a test with 50% specificity (WTP\u2009=\u2009$827). In non-aggressive incurable cancer (scenario B), the OR of choosing a test with 95% sensitivity was 1.65 (WTP\u2009=\u2009$1344), and the OR of choosing a test with 95% specificity was 1.50 (WTP\u2009=\u2009$1080). Reducing severity of treatment side effects from severe to mild was associated with large ORs in both scenarios (OR\u2009=\u20092.10 and 2.24 in scenario A and B, respectively). In contrast, patients had a very large preference for 95% sensitivity of the test (OR\u2009=\u20095.23).\nCONCLUSION: The type and prognosis of cancer affected preferences for genomically-guided treatment. In aggressive curable cancer, individuals emphasized more on the sensitivity rather than the specificity of the test. In contrast, for a non-aggressive incurable cancer, individuals put similar emphasis on sensitivity and specificity of the test. While the public expressed strong preference toward lowering severity of side effects, improving sensitivity of the test had by far the largest influence on patients' decision to use genomic testing.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1472-6963-13-454", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1327417", 
        "issn": [
          "1472-6963"
        ], 
        "name": "BMC Health Services Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "name": "Genomic testing to determine drug response: measuring preferences of the public and patients using Discrete Choice Experiment (DCE)", 
    "pagination": "454", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7940d4d25fc4a61d5a911851527da93cdaa2b2a67948229dfd7adbf40f1c9342"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24176050"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101088677"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1472-6963-13-454"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1025451400"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1472-6963-13-454", 
      "https://app.dimensions.ai/details/publication/pub.1025451400"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:42", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000512.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1472-6963-13-454"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1472-6963-13-454'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1472-6963-13-454'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1472-6963-13-454'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1472-6963-13-454'


 

This table displays all metadata directly associated to this object as RDF triples.

289 TRIPLES      21 PREDICATES      77 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1472-6963-13-454 schema:about N09ea612d028f49c29bf8e6b46a31121d
2 N26d02041d3fb4cc79a588f0ee686437c
3 N274f64d77add485b8bf262507088792e
4 N3d8819fd7f0d4adaa0922ce1728bf83e
5 N40fd987d031841feb44175fd6acbb351
6 N759b89d18b504219b4c9d735c5af526b
7 N8ba8b4ba95284ebeaa474773f0706308
8 N8fd29fb3430b4603b043d4dc63d10c1a
9 N99c7ac7057d24962b9ad2049ec4239bb
10 Ncc669848517d431b887509e3ba440b74
11 Ndda0c285ce8b4556860ead18b177e301
12 Nea3601e8d456475daa06ae1a0243d495
13 Neafb78d3e56841b08876f9e4772dcde2
14 Nf92ec2fb974b4b548b8322cf07bf8d1c
15 Nfb6f84fa21524e5095ab4ecdae9ef0d1
16 anzsrc-for:11
17 anzsrc-for:1112
18 schema:author N3b5d8d10b03c428ba4fadb8a566e8c06
19 schema:citation sg:pub.10.1007/s10640-005-4817-0
20 sg:pub.10.1007/s10689-008-9217-5
21 sg:pub.10.1038/nbt0508-509
22 sg:pub.10.1097/gim.0b013e3181837217
23 sg:pub.10.2165/00019053-200826080-00004
24 sg:pub.10.2165/11530660-000000000-00000
25 https://doi.org/10.1001/jama.304.14.1628
26 https://doi.org/10.1002/ajmg.a.35811
27 https://doi.org/10.1002/hec.1563
28 https://doi.org/10.1002/hec.845
29 https://doi.org/10.1002/hec.984
30 https://doi.org/10.1016/j.jhealeco.2005.09.002
31 https://doi.org/10.1016/j.jhealeco.2008.11.003
32 https://doi.org/10.1016/j.jval.2010.10.007
33 https://doi.org/10.1016/j.jval.2012.08.2223
34 https://doi.org/10.1016/s0191-2615(02)00046-2
35 https://doi.org/10.1016/s0959-8049(02)80607-4
36 https://doi.org/10.1016/s1470-2045(11)70141-3
37 https://doi.org/10.1017/cbo9780511753831
38 https://doi.org/10.1017/cbo9780511753930
39 https://doi.org/10.1017/s0266462307080129
40 https://doi.org/10.1086/296093
41 https://doi.org/10.1086/586913
42 https://doi.org/10.1097gim.0b013e3181837217
43 https://doi.org/10.1111/j.1399-0004.2012.01908.x
44 https://doi.org/10.1111/j.1524-4733.2007.00196.x
45 https://doi.org/10.1158/1078-0432.ccr-10-1203
46 https://doi.org/10.1159/000189629
47 https://doi.org/10.1159/000226595
48 https://doi.org/10.1177/0272989x0102100505
49 https://doi.org/10.1177/0272989x09347014
50 https://doi.org/10.1634/theoncologist.8-suppl_2-25
51 https://doi.org/10.2217/14622416.7.1.49
52 schema:datePublished 2013-12
53 schema:datePublishedReg 2013-12-01
54 schema:description BACKGROUND: The extent to which a genomic test will be used in practice is affected by factors such as ability of the test to correctly predict response to treatment (i.e. sensitivity and specificity of the test), invasiveness of the testing procedure, test cost, and the probability and severity of side effects associated with treatment. METHODS: Using discrete choice experimentation (DCE), we elicited preferences of the public (Sample 1, N = 533 and Sample 2, N = 525) and cancer patients (Sample 3, N = 38) for different attributes of a hypothetical genomic test for guiding cancer treatment. Samples 1 and 3 considered the test/treatment in the context of an aggressive curable cancer (scenario A) while the scenario for sample 2 was based on a non-aggressive incurable cancer (scenario B). RESULTS: In aggressive curable cancer (scenario A), everything else being equal, the odds ratio (OR) of choosing a test with 95% sensitivity was 1.41 (versus a test with 50% sensitivity) and willingness to pay (WTP) was $1331, on average, for this amount of improvement in test sensitivity. In this scenario, the OR of choosing a test with 95% specificity was 1.24 times that of a test with 50% specificity (WTP = $827). In non-aggressive incurable cancer (scenario B), the OR of choosing a test with 95% sensitivity was 1.65 (WTP = $1344), and the OR of choosing a test with 95% specificity was 1.50 (WTP = $1080). Reducing severity of treatment side effects from severe to mild was associated with large ORs in both scenarios (OR = 2.10 and 2.24 in scenario A and B, respectively). In contrast, patients had a very large preference for 95% sensitivity of the test (OR = 5.23). CONCLUSION: The type and prognosis of cancer affected preferences for genomically-guided treatment. In aggressive curable cancer, individuals emphasized more on the sensitivity rather than the specificity of the test. In contrast, for a non-aggressive incurable cancer, individuals put similar emphasis on sensitivity and specificity of the test. While the public expressed strong preference toward lowering severity of side effects, improving sensitivity of the test had by far the largest influence on patients' decision to use genomic testing.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree true
58 schema:isPartOf N30ddbad50fdd43a88a20ee4eef81278e
59 Ne5c463a6f60549e188be6d47a48e67a6
60 sg:journal.1327417
61 schema:name Genomic testing to determine drug response: measuring preferences of the public and patients using Discrete Choice Experiment (DCE)
62 schema:pagination 454
63 schema:productId N02ef37333ad348d197ad7af9d2083f76
64 N10a7f49830db4e9f9d264b9d867c44a8
65 N128b8eda4a884dc4888cea51e0d00624
66 N8259d09f168e4ad0adef535a197c077a
67 Nbc5d18862cfe4879aa15dae2b7e7ff08
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025451400
69 https://doi.org/10.1186/1472-6963-13-454
70 schema:sdDatePublished 2019-04-10T16:42
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher N399021589c1a48a796f8f3d8e20a5f54
73 schema:url http://link.springer.com/10.1186%2F1472-6963-13-454
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N02ef37333ad348d197ad7af9d2083f76 schema:name dimensions_id
78 schema:value pub.1025451400
79 rdf:type schema:PropertyValue
80 N09ea612d028f49c29bf8e6b46a31121d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Pharmacogenetics
82 rdf:type schema:DefinedTerm
83 N10a7f49830db4e9f9d264b9d867c44a8 schema:name nlm_unique_id
84 schema:value 101088677
85 rdf:type schema:PropertyValue
86 N128b8eda4a884dc4888cea51e0d00624 schema:name readcube_id
87 schema:value 7940d4d25fc4a61d5a911851527da93cdaa2b2a67948229dfd7adbf40f1c9342
88 rdf:type schema:PropertyValue
89 N26d02041d3fb4cc79a588f0ee686437c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Prognosis
91 rdf:type schema:DefinedTerm
92 N274f64d77add485b8bf262507088792e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Consumer Behavior
94 rdf:type schema:DefinedTerm
95 N30ddbad50fdd43a88a20ee4eef81278e schema:volumeNumber 13
96 rdf:type schema:PublicationVolume
97 N399021589c1a48a796f8f3d8e20a5f54 schema:name Springer Nature - SN SciGraph project
98 rdf:type schema:Organization
99 N39dd6b63db9b42fda8239571784ca5d4 rdf:first sg:person.0732333256.41
100 rdf:rest Nce5a33f54ba145359f75560a8fc6df9f
101 N3b5d8d10b03c428ba4fadb8a566e8c06 rdf:first sg:person.01006746763.27
102 rdf:rest Nc7b9deece7344466b3873ad21e4f6e4c
103 N3d8819fd7f0d4adaa0922ce1728bf83e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Female
105 rdf:type schema:DefinedTerm
106 N40fd987d031841feb44175fd6acbb351 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Male
108 rdf:type schema:DefinedTerm
109 N759b89d18b504219b4c9d735c5af526b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Surveys and Questionnaires
111 rdf:type schema:DefinedTerm
112 N8259d09f168e4ad0adef535a197c077a schema:name pubmed_id
113 schema:value 24176050
114 rdf:type schema:PropertyValue
115 N8ba8b4ba95284ebeaa474773f0706308 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Patient Preference
117 rdf:type schema:DefinedTerm
118 N8fd29fb3430b4603b043d4dc63d10c1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Genetic Testing
120 rdf:type schema:DefinedTerm
121 N99c7ac7057d24962b9ad2049ec4239bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Treatment Outcome
123 rdf:type schema:DefinedTerm
124 Nae13d5c6e4f74ca0bada55f3eb8a307c rdf:first sg:person.01076161056.09
125 rdf:rest Nb3213e962b694374b15d8d26d8ee72cc
126 Nb3213e962b694374b15d8d26d8ee72cc rdf:first sg:person.0677574517.97
127 rdf:rest Nb90e7fd5abed46159909df6abc74f6ac
128 Nb90e7fd5abed46159909df6abc74f6ac rdf:first sg:person.01150455763.02
129 rdf:rest N39dd6b63db9b42fda8239571784ca5d4
130 Nbc5d18862cfe4879aa15dae2b7e7ff08 schema:name doi
131 schema:value 10.1186/1472-6963-13-454
132 rdf:type schema:PropertyValue
133 Nc7b9deece7344466b3873ad21e4f6e4c rdf:first sg:person.01065267143.31
134 rdf:rest Nae13d5c6e4f74ca0bada55f3eb8a307c
135 Ncc669848517d431b887509e3ba440b74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Sensitivity and Specificity
137 rdf:type schema:DefinedTerm
138 Nce5a33f54ba145359f75560a8fc6df9f rdf:first sg:person.01021612012.88
139 rdf:rest rdf:nil
140 Ndda0c285ce8b4556860ead18b177e301 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Neoplasms
142 rdf:type schema:DefinedTerm
143 Ne5c463a6f60549e188be6d47a48e67a6 schema:issueNumber 1
144 rdf:type schema:PublicationIssue
145 Nea3601e8d456475daa06ae1a0243d495 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Middle Aged
147 rdf:type schema:DefinedTerm
148 Neafb78d3e56841b08876f9e4772dcde2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Humans
150 rdf:type schema:DefinedTerm
151 Nf92ec2fb974b4b548b8322cf07bf8d1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Choice Behavior
153 rdf:type schema:DefinedTerm
154 Nfb6f84fa21524e5095ab4ecdae9ef0d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Antineoplastic Agents
156 rdf:type schema:DefinedTerm
157 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
158 schema:name Medical and Health Sciences
159 rdf:type schema:DefinedTerm
160 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
161 schema:name Oncology and Carcinogenesis
162 rdf:type schema:DefinedTerm
163 sg:journal.1327417 schema:issn 1472-6963
164 schema:name BMC Health Services Research
165 rdf:type schema:Periodical
166 sg:person.01006746763.27 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
167 schema:familyName Najafzadeh
168 schema:givenName Mehdi
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006746763.27
170 rdf:type schema:Person
171 sg:person.01021612012.88 schema:affiliation https://www.grid.ac/institutes/grid.416553.0
172 schema:familyName Marra
173 schema:givenName Carlo A
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021612012.88
175 rdf:type schema:Person
176 sg:person.01065267143.31 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
177 schema:familyName Johnston
178 schema:givenName Karissa M
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065267143.31
180 rdf:type schema:Person
181 sg:person.01076161056.09 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
182 schema:familyName Peacock
183 schema:givenName Stuart J
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076161056.09
185 rdf:type schema:Person
186 sg:person.01150455763.02 schema:affiliation https://www.grid.ac/institutes/grid.434706.2
187 schema:familyName Marra
188 schema:givenName Marco A
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150455763.02
190 rdf:type schema:Person
191 sg:person.0677574517.97 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
192 schema:familyName Connors
193 schema:givenName Joseph M
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677574517.97
195 rdf:type schema:Person
196 sg:person.0732333256.41 schema:affiliation https://www.grid.ac/institutes/grid.416553.0
197 schema:familyName Lynd
198 schema:givenName Larry D
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732333256.41
200 rdf:type schema:Person
201 sg:pub.10.1007/s10640-005-4817-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027707441
202 https://doi.org/10.1007/s10640-005-4817-0
203 rdf:type schema:CreativeWork
204 sg:pub.10.1007/s10689-008-9217-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004538244
205 https://doi.org/10.1007/s10689-008-9217-5
206 rdf:type schema:CreativeWork
207 sg:pub.10.1038/nbt0508-509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037865970
208 https://doi.org/10.1038/nbt0508-509
209 rdf:type schema:CreativeWork
210 sg:pub.10.1097/gim.0b013e3181837217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005331293
211 https://doi.org/10.1097/gim.0b013e3181837217
212 rdf:type schema:CreativeWork
213 sg:pub.10.2165/00019053-200826080-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008806799
214 https://doi.org/10.2165/00019053-200826080-00004
215 rdf:type schema:CreativeWork
216 sg:pub.10.2165/11530660-000000000-00000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033746385
217 https://doi.org/10.2165/11530660-000000000-00000
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1001/jama.304.14.1628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012409313
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1002/ajmg.a.35811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039018594
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1002/hec.1563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024360320
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1002/hec.845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003146658
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1002/hec.984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024016537
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/j.jhealeco.2005.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036680627
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/j.jhealeco.2008.11.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020651763
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/j.jval.2010.10.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042098931
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/j.jval.2012.08.2223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037115565
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/s0191-2615(02)00046-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025239775
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/s0959-8049(02)80607-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015491951
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/s1470-2045(11)70141-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015138258
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1017/cbo9780511753831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1098665042
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1017/cbo9780511753930 schema:sameAs https://app.dimensions.ai/details/publication/pub.1098721478
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1017/s0266462307080129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043410941
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1086/296093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058605919
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1086/586913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058800148
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1097gim.0b013e3181837217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077804733
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1111/j.1399-0004.2012.01908.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014741774
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1111/j.1524-4733.2007.00196.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030199644
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1158/1078-0432.ccr-10-1203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007664124
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1159/000189629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012485133
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1159/000226595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003087032
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1177/0272989x0102100505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039623479
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1177/0272989x09347014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036728087
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1634/theoncologist.8-suppl_2-25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044892184
270 rdf:type schema:CreativeWork
271 https://doi.org/10.2217/14622416.7.1.49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022245456
272 rdf:type schema:CreativeWork
273 https://www.grid.ac/institutes/grid.17091.3e schema:alternateName University of British Columbia
274 schema:name British Columbia Cancer Agency, Vancouver, BC, Canada
275 Faculty of Medicine, University of British Columbia, Vancouver, Canada
276 rdf:type schema:Organization
277 https://www.grid.ac/institutes/grid.248762.d schema:alternateName BC Cancer Agency
278 schema:name British Columbia Cancer Agency, Vancouver, BC, Canada
279 rdf:type schema:Organization
280 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
281 schema:name Department of Medicine, Harvard Medical School, Boston, MA, USA
282 rdf:type schema:Organization
283 https://www.grid.ac/institutes/grid.416553.0 schema:alternateName St. Paul's Hospital
284 schema:name Centre for Health Evaluation and Outcome Sciences (CHEOS), St. Paul’s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
285 Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada
286 rdf:type schema:Organization
287 https://www.grid.ac/institutes/grid.434706.2 schema:alternateName Canada's Michael Smith Genome Sciences Centre
288 schema:name Genome Sciences Centre, Vancouver, BC, Canada
289 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...