S-allylmercaptocysteine scavenges hydroxyl radical and singlet oxygen in vitro and attenuates gentamicin-induced oxidative and nitrosative stress and renal damage in ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-04-30

AUTHORS

José Pedraza-Chaverrí, Diana Barrera, Perla D Maldonado, Yolanda I Chirino, Norma A Macías-Ruvalcaba, Omar N Medina-Campos, Leticia Castro, Marcos I Salcedo, Rogelio Hernández-Pando

ABSTRACT

BackgroundOxidative and nitrosative stress have been involved in gentamicin-induced nephrotoxicity. The purpose of this work was to study the effect of S-allylmercaptocysteine, a garlic derived compound, on gentamicin-induced oxidative and nitrosative stress and nephrotoxicity. In addition, the in vitro reactive oxygen species scavenging properties of S-allylmercaptocysteine were studied.ResultsS-allylmercaptocysteine was able to scavenge hydroxyl radicals and singlet oxygen in vitro. In rats treated with gentamicin (70 mg/Kg body weight, subcutaneously, every 12 h, for 4 days), renal oxidative stress was made evident by the increase in protein carbonyl content and 4-hydroxy-2-nonenal, and the nitrosative stress was made evident by the increase in 3-nitrotyrosine. In addition, gentamicin-induced nephrotoxicity was evident by the: (1) decrease in creatinine clearance and in activity of circulating glutathione peroxidase, and (2) increase in urinary excretion of N-acetyl-β-D-glucosaminidase, and (3) necrosis of proximal tubular cells. Gentamicin-induced oxidative and nitrosative stress and nephrotoxicity were attenuated by S-allylmercaptocysteine treatment (100 mg/Kg body weight, intragastrically, 24 h before the first dose of gentamicin and 50 mg/Kg body weight, intragastrically, every 12 h, for 4 days along gentamicin-treatment).ConclusionIn conclusion, S-allylmercaptocysteine is able to scavenge hydroxyl radicals and singlet oxygen in vitro and to ameliorate the gentamicin-induced nephrotoxicity and oxidative and nitrosative stress in vivo. More... »

PAGES

5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1472-6904-4-5

DOI

http://dx.doi.org/10.1186/1472-6904-4-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052259312

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15119956


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31 schema:description BackgroundOxidative and nitrosative stress have been involved in gentamicin-induced nephrotoxicity. The purpose of this work was to study the effect of S-allylmercaptocysteine, a garlic derived compound, on gentamicin-induced oxidative and nitrosative stress and nephrotoxicity. In addition, the in vitro reactive oxygen species scavenging properties of S-allylmercaptocysteine were studied.ResultsS-allylmercaptocysteine was able to scavenge hydroxyl radicals and singlet oxygen in vitro. In rats treated with gentamicin (70 mg/Kg body weight, subcutaneously, every 12 h, for 4 days), renal oxidative stress was made evident by the increase in protein carbonyl content and 4-hydroxy-2-nonenal, and the nitrosative stress was made evident by the increase in 3-nitrotyrosine. In addition, gentamicin-induced nephrotoxicity was evident by the: (1) decrease in creatinine clearance and in activity of circulating glutathione peroxidase, and (2) increase in urinary excretion of N-acetyl-β-D-glucosaminidase, and (3) necrosis of proximal tubular cells. Gentamicin-induced oxidative and nitrosative stress and nephrotoxicity were attenuated by S-allylmercaptocysteine treatment (100 mg/Kg body weight, intragastrically, 24 h before the first dose of gentamicin and 50 mg/Kg body weight, intragastrically, every 12 h, for 4 days along gentamicin-treatment).ConclusionIn conclusion, S-allylmercaptocysteine is able to scavenge hydroxyl radicals and singlet oxygen in vitro and to ameliorate the gentamicin-induced nephrotoxicity and oxidative and nitrosative stress in vivo.
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38 schema:keywords ConclusionIn conclusion
39 D-glucosaminidase
40 S-allylmercaptocysteine
41 activity
42 addition
43 carbonyl content
44 cells
45 clearance
46 compounds
47 conclusion
48 content
49 creatinine clearance
50 damage
51 decrease
52 effect
53 excretion
54 garlic
55 gentamicin
56 glutathione peroxidase
57 hydroxyl
58 hydroxyl radicals
59 increase
60 necrosis
61 nephrotoxicity
62 nitrosative stress
63 oxidative stress
64 oxygen
65 peroxidase
66 properties
67 protein carbonyl content
68 proximal tubular cells
69 purpose
70 radicals
71 rats
72 reactive oxygen species scavenging properties
73 renal damage
74 renal oxidative stress
75 scavenging properties
76 stress
77 treatment
78 tubular cells
79 urinary excretion
80 vitro
81 vivo
82 work
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