In vitro metabolism studies of erythraline, the major spiroalkaloid from Erythrina verna View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-02-18

AUTHORS

Thais Guaratini, Denise Brentan Silva, Aline Cavalli Bizaro, Lucas Rossi Sartori, Hans-Ulrich Humpf, Norberto Peporine Lopes, Letícia Veras Costa-Lotufo, João Luis Callegari Lopes

ABSTRACT

BACKGROUND: Erythrina verna, popularly known as "mulungu", is a Brazilian medicinal plant used to treat anxiety. Erythrina alkaloids have been described in several species of Erythrina, which have biological and therapeutic properties well known that include anxiolytic and sedative effects. METHODS: In this work, in vitro metabolism of erythraline (1), the major spirocyclic alkaloid of Erythrina verna, was studied in the pig cecum model and by biomimetic phase I reactions. The biomimetic reactions were performed with Jacobsen catalyst to produce oxidative metabolites and one metabolite was isolated and evaluated against cancer cells, as HL-60 (promyelocytic leukemia), SF-295 (Glioblastoma) and OVCAR-8 (ovarian carcinoma). RESULTS: Erythraline exhibited no metabolization by the pig microbiota and a main putative metabolite was formed in a biomimetic model using Jacobsen catalyst. This metabolite was isolated and identified as 8-oxo-erythraline (2). Finally, erythraline and the putative metabolite were tested in MTT model and both compounds showed no important cytotoxic activity against tumor cells. CONCLUSIONS: The alkaloid erythraline was not metabolized by intestinal microbiota, but it was possible to identify its oxidative metabolite from biomimetic reactions. So these data are interesting and stimulate other studies involving this alkaloid, since it is present in phytomedicine products and there are not reported data about the metabolism of erythrina alkaloids. More... »

PAGES

61-61

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1472-6882-14-61

DOI

http://dx.doi.org/10.1186/1472-6882-14-61

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048989624

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24548728


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