Differential expression of Aquaporin 8 in human colonic epithelial cells and colorectal tumors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-12

AUTHORS

Heléne Fischer, Roger Stenling, Carlos Rubio, Annika Lindblom

ABSTRACT

BACKGROUND: The gene expression pattern in tumor cells differs from that in corresponding normal cells. In order to identify differentially expressed genes in colorectal tumors and normal colorectal epithelium, a differential display experiment was used to compare RNA expression in normal and tumor tissue samples. RESULTS: One gene fragment was expressed only in normal tissue and not, or to a much lesser extent, in the adenomas, carcinomas and cancer cell lines. The isolated gene fragment was identical to Aquaporin 8 (AQP8), a water channel protein. In situ hybridization demonstrated that AQP8 was expressed in the cells facing the lumen in the normal colonic epithelium. CONCLUSION: Our result suggests that the expression of AQP8 is a marker of normal proliferating colonic epithelial cells and suggest these cells to be involved in fluid transport in the colon. More... »

PAGES

1

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1472-6793-1-1

DOI

http://dx.doi.org/10.1186/1472-6793-1-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043880343

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11231887


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