Targeting HOX transcription factors in prostate cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Richard Morgan, Angie Boxall, Kevin J Harrington, Guy R Simpson, Agnieszka Michael, Hardev S Pandha

ABSTRACT

BACKGROUND: The HOX genes are a family of transcription factors that help to determine cell and tissue identity during early development, and which are also over-expressed in a number of malignancies where they have been shown to promote cell proliferation and survival. The purpose of this study was to evaluate the expression of HOX genes in prostate cancer and to establish whether prostate cancer cells are sensitive to killing by HXR9, an inhibitor of HOX function. METHODS: HOX function was inhibited using the HXR9 peptide. HOX gene expression was assessed by RNA extraction from cells or tissues followed by quantitative PCR, and siRNA was used to block the expression of the HOX target gene, cFos. In vivo modelling involved a mouse flank tumour induced by inoculation with LNCaP cells. RESULTS: In this study we show that the expression of HOX genes in prostate tumours is greatly increased with respect to normal prostate tissue. Targeting the interaction between HOX proteins and their PBX cofactor induces apoptosis in the prostate cancer derived cell lines PC3, DU145 and LNCaP, through a mechanism that involves a rapid increase in the expression of cFos, an oncogenic transcription factor. Furthermore, disrupting HOX/PBX binding using the HXR9 antagonist blocks the growth of LNCaP tumours in a xenograft model over an extended period. CONCLUSION: Many HOX genes are highly over-expressed in prostate cancer, and prostate cancer cells are sensitive to killing by HXR9 both in vitro and in vivo. The HOX genes are therefore a potential therapeutic target in prostate cancer. More... »

PAGES

17

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2490-14-17

DOI

http://dx.doi.org/10.1186/1471-2490-14-17

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000686900

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24499138


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homeodomain Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Targeted Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Surrey", 
          "id": "https://www.grid.ac/institutes/grid.5475.3", 
          "name": [
            "Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morgan", 
        "givenName": "Richard", 
        "id": "sg:person.010032116317.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010032116317.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Surrey", 
          "id": "https://www.grid.ac/institutes/grid.5475.3", 
          "name": [
            "Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boxall", 
        "givenName": "Angie", 
        "id": "sg:person.0604322634.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604322634.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Targeted Therapy Team, Chester Beatty Laboratories, The Institute of Cancer Research, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harrington", 
        "givenName": "Kevin J", 
        "id": "sg:person.01167312032.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167312032.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Surrey", 
          "id": "https://www.grid.ac/institutes/grid.5475.3", 
          "name": [
            "Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Simpson", 
        "givenName": "Guy R", 
        "id": "sg:person.0763301135.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763301135.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Surrey", 
          "id": "https://www.grid.ac/institutes/grid.5475.3", 
          "name": [
            "Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Michael", 
        "givenName": "Agnieszka", 
        "id": "sg:person.01034777634.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034777634.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Surrey", 
          "id": "https://www.grid.ac/institutes/grid.5475.3", 
          "name": [
            "Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pandha", 
        "givenName": "Hardev S", 
        "id": "sg:person.01215757170.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215757170.08"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/0008-5472.can-09-2408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000364620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-4231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001603934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910210305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006704074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.25516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008443664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.25516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008443664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/mt.2009.80", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010309613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-9525(99)01881-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010955172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(92)90471-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011293717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1258/002367788780746467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013737421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1258/002367788780746467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013737421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.10045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014849692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/27.18.3752", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015701382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.juro.2008.07.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016298401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0045(19970101)30:1<58::aid-pros9>3.0.co;2-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016355548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2826", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018749149", 
          "https://doi.org/10.1038/nrc2826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2826", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018749149", 
          "https://doi.org/10.1038/nrc2826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/11633360-000000000-00000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020710510", 
          "https://doi.org/10.2165/11633360-000000000-00000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m400932200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021614490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-10-89", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022137095", 
          "https://doi.org/10.1186/1471-2407-10-89"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-012-2259-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022188194", 
          "https://doi.org/10.1007/s10549-012-2259-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/moh.0b013e32801684b6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024044643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/moh.0b013e32801684b6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024044643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/moh.0b013e32801684b6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024044643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.28097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026677655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-410x.2009.08593.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027037503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-410x.2009.08593.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027037503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2009.10.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033128345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-013-2316-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036748569", 
          "https://doi.org/10.1007/s00280-013-2316-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2012-07-442004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039008462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2010.142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039993211", 
          "https://doi.org/10.1038/leu.2010.142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2010.142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039993211", 
          "https://doi.org/10.1038/leu.2010.142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-1899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041390512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.16.4.1734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043698804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206781", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043751276", 
          "https://doi.org/10.1038/sj.onc.1206781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206781", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043751276", 
          "https://doi.org/10.1038/sj.onc.1206781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.25.12223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044882666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1997.6364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053033130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6604857", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053403090", 
          "https://doi.org/10.1038/sj.bjc.6604857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2006-1250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064248327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076575067", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080373651", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081983028", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-12", 
    "datePublishedReg": "2014-12-01", 
    "description": "BACKGROUND: The HOX genes are a family of transcription factors that help to determine cell and tissue identity during early development, and which are also over-expressed in a number of malignancies where they have been shown to promote cell proliferation and survival. The purpose of this study was to evaluate the expression of HOX genes in prostate cancer and to establish whether prostate cancer cells are sensitive to killing by HXR9, an inhibitor of HOX function.\nMETHODS: HOX function was inhibited using the HXR9 peptide. HOX gene expression was assessed by RNA extraction from cells or tissues followed by quantitative PCR, and siRNA was used to block the expression of the HOX target gene, cFos. In vivo modelling involved a mouse flank tumour induced by inoculation with LNCaP cells.\nRESULTS: In this study we show that the expression of HOX genes in prostate tumours is greatly increased with respect to normal prostate tissue. Targeting the interaction between HOX proteins and their PBX cofactor induces apoptosis in the prostate cancer derived cell lines PC3, DU145 and LNCaP, through a mechanism that involves a rapid increase in the expression of cFos, an oncogenic transcription factor. Furthermore, disrupting HOX/PBX binding using the HXR9 antagonist blocks the growth of LNCaP tumours in a xenograft model over an extended period.\nCONCLUSION: Many HOX genes are highly over-expressed in prostate cancer, and prostate cancer cells are sensitive to killing by HXR9 both in vitro and in vivo. The HOX genes are therefore a potential therapeutic target in prostate cancer.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-2490-14-17", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024960", 
        "issn": [
          "1471-2490"
        ], 
        "name": "BMC Urology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "Targeting HOX transcription factors in prostate cancer", 
    "pagination": "17", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "03457cacdf50e9d8639c25ce87f281680ccb266acebd90faedbd85645792ceec"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24499138"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100968571"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2490-14-17"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1000686900"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2490-14-17", 
      "https://app.dimensions.ai/details/publication/pub.1000686900"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000509.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-2490-14-17"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2490-14-17'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2490-14-17'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2490-14-17'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2490-14-17'


 

This table displays all metadata directly associated to this object as RDF triples.

265 TRIPLES      21 PREDICATES      76 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2490-14-17 schema:about N1e26878bb8474cc5bc2dea9aa7e1295c
2 N2f126c626cba46749afd9fcfb0451a06
3 N3136336940364c2f99bece596578e768
4 N4e041139033f4bb8b7db5c249811f2b0
5 N60e02313511b4a13832386c6b4addcf4
6 N6916d25e09494ff8a41ef1a3caace356
7 N9f357a0a0b2643709b72955c27653e60
8 Na18a73997b554ab38e7dcc541005b676
9 Nb379fa2504ce415699618295d824210a
10 Nc4167fd0f2934509a993c8fa1d0b13a7
11 Nc5adf90c36374a25a2482fc778e14aa4
12 Nd024e6f8951d461e8ff7013be90c0d31
13 Nd3721020c31645be920d22c4ece69f14
14 anzsrc-for:11
15 anzsrc-for:1112
16 schema:author N9a8f427d6c4b45df91690a64d625ebb1
17 schema:citation sg:pub.10.1007/s00280-013-2316-5
18 sg:pub.10.1007/s10549-012-2259-2
19 sg:pub.10.1038/leu.2010.142
20 sg:pub.10.1038/nrc2826
21 sg:pub.10.1038/sj.bjc.6604857
22 sg:pub.10.1038/sj.onc.1206781
23 sg:pub.10.1186/1471-2407-10-89
24 sg:pub.10.2165/11633360-000000000-00000
25 https://app.dimensions.ai/details/publication/pub.1076575067
26 https://app.dimensions.ai/details/publication/pub.1080373651
27 https://app.dimensions.ai/details/publication/pub.1081983028
28 https://doi.org/10.1002/(sici)1097-0045(19970101)30:1<58::aid-pros9>3.0.co;2-h
29 https://doi.org/10.1002/ijc.25516
30 https://doi.org/10.1002/ijc.28097
31 https://doi.org/10.1002/ijc.2910210305
32 https://doi.org/10.1002/pros.10045
33 https://doi.org/10.1006/bbrc.1997.6364
34 https://doi.org/10.1016/0092-8674(92)90471-n
35 https://doi.org/10.1016/j.juro.2008.07.018
36 https://doi.org/10.1016/j.molcel.2009.10.020
37 https://doi.org/10.1016/s0168-9525(99)01881-8
38 https://doi.org/10.1038/mt.2009.80
39 https://doi.org/10.1073/pnas.91.25.12223
40 https://doi.org/10.1074/jbc.m400932200
41 https://doi.org/10.1093/nar/27.18.3752
42 https://doi.org/10.1097/moh.0b013e32801684b6
43 https://doi.org/10.1111/j.1464-410x.2009.08593.x
44 https://doi.org/10.1128/mcb.16.4.1734
45 https://doi.org/10.1158/0008-5472.can-06-4231
46 https://doi.org/10.1158/0008-5472.can-09-2408
47 https://doi.org/10.1158/1078-0432.ccr-11-1899
48 https://doi.org/10.1182/blood-2012-07-442004
49 https://doi.org/10.1210/en.2006-1250
50 https://doi.org/10.1258/002367788780746467
51 schema:datePublished 2014-12
52 schema:datePublishedReg 2014-12-01
53 schema:description BACKGROUND: The HOX genes are a family of transcription factors that help to determine cell and tissue identity during early development, and which are also over-expressed in a number of malignancies where they have been shown to promote cell proliferation and survival. The purpose of this study was to evaluate the expression of HOX genes in prostate cancer and to establish whether prostate cancer cells are sensitive to killing by HXR9, an inhibitor of HOX function. METHODS: HOX function was inhibited using the HXR9 peptide. HOX gene expression was assessed by RNA extraction from cells or tissues followed by quantitative PCR, and siRNA was used to block the expression of the HOX target gene, cFos. In vivo modelling involved a mouse flank tumour induced by inoculation with LNCaP cells. RESULTS: In this study we show that the expression of HOX genes in prostate tumours is greatly increased with respect to normal prostate tissue. Targeting the interaction between HOX proteins and their PBX cofactor induces apoptosis in the prostate cancer derived cell lines PC3, DU145 and LNCaP, through a mechanism that involves a rapid increase in the expression of cFos, an oncogenic transcription factor. Furthermore, disrupting HOX/PBX binding using the HXR9 antagonist blocks the growth of LNCaP tumours in a xenograft model over an extended period. CONCLUSION: Many HOX genes are highly over-expressed in prostate cancer, and prostate cancer cells are sensitive to killing by HXR9 both in vitro and in vivo. The HOX genes are therefore a potential therapeutic target in prostate cancer.
54 schema:genre research_article
55 schema:inLanguage en
56 schema:isAccessibleForFree true
57 schema:isPartOf N141deb1c52bd4dcb88a9fa9ec34b4be4
58 N576e24a32bf247dd841e358397c58d2f
59 sg:journal.1024960
60 schema:name Targeting HOX transcription factors in prostate cancer
61 schema:pagination 17
62 schema:productId N48d3abbb7f144874acc72bf57f81dfc2
63 N66b75332b7784fb2aceea23900d4325f
64 N7c6865060ffd4f5ba28832b235634f60
65 N7d020822cf3140f8b3da8a99ea77730a
66 Nda63bb94e437487bb4ad3c93c224e9cc
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000686900
68 https://doi.org/10.1186/1471-2490-14-17
69 schema:sdDatePublished 2019-04-11T00:15
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher Ndca5ad9fc04e45ed813e8aa0d6291c30
72 schema:url http://link.springer.com/10.1186%2F1471-2490-14-17
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N141deb1c52bd4dcb88a9fa9ec34b4be4 schema:volumeNumber 14
77 rdf:type schema:PublicationVolume
78 N1e26878bb8474cc5bc2dea9aa7e1295c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Treatment Outcome
80 rdf:type schema:DefinedTerm
81 N2cf06655e0ba4881afd5cb2657d72799 rdf:first sg:person.01167312032.35
82 rdf:rest Nd5c413a03ccf46a8ba5254b7ecd9b7fd
83 N2f126c626cba46749afd9fcfb0451a06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Homeodomain Proteins
85 rdf:type schema:DefinedTerm
86 N3136336940364c2f99bece596578e768 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Male
88 rdf:type schema:DefinedTerm
89 N48d3abbb7f144874acc72bf57f81dfc2 schema:name nlm_unique_id
90 schema:value 100968571
91 rdf:type schema:PropertyValue
92 N4ae2f6a77734463197de44c94ab22ef6 rdf:first sg:person.01034777634.08
93 rdf:rest Nf5d6c3655fa74ae587a872e3a1694af3
94 N4e041139033f4bb8b7db5c249811f2b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Cell Survival
96 rdf:type schema:DefinedTerm
97 N576e24a32bf247dd841e358397c58d2f schema:issueNumber 1
98 rdf:type schema:PublicationIssue
99 N60e02313511b4a13832386c6b4addcf4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Peptides
101 rdf:type schema:DefinedTerm
102 N6313cf16793d4dd0aefce76f768a1bfe rdf:first sg:person.0604322634.44
103 rdf:rest N2cf06655e0ba4881afd5cb2657d72799
104 N66b75332b7784fb2aceea23900d4325f schema:name doi
105 schema:value 10.1186/1471-2490-14-17
106 rdf:type schema:PropertyValue
107 N6916d25e09494ff8a41ef1a3caace356 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Molecular Targeted Therapy
109 rdf:type schema:DefinedTerm
110 N7c6865060ffd4f5ba28832b235634f60 schema:name dimensions_id
111 schema:value pub.1000686900
112 rdf:type schema:PropertyValue
113 N7d020822cf3140f8b3da8a99ea77730a schema:name pubmed_id
114 schema:value 24499138
115 rdf:type schema:PropertyValue
116 N9a8f427d6c4b45df91690a64d625ebb1 rdf:first sg:person.010032116317.42
117 rdf:rest N6313cf16793d4dd0aefce76f768a1bfe
118 N9f357a0a0b2643709b72955c27653e60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Cell Line, Tumor
120 rdf:type schema:DefinedTerm
121 Na18a73997b554ab38e7dcc541005b676 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Female
123 rdf:type schema:DefinedTerm
124 Nb379fa2504ce415699618295d824210a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Humans
126 rdf:type schema:DefinedTerm
127 Nc4167fd0f2934509a993c8fa1d0b13a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Antineoplastic Agents
129 rdf:type schema:DefinedTerm
130 Nc5adf90c36374a25a2482fc778e14aa4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Prostatic Neoplasms
132 rdf:type schema:DefinedTerm
133 Nd024e6f8951d461e8ff7013be90c0d31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Apoptosis
135 rdf:type schema:DefinedTerm
136 Nd3721020c31645be920d22c4ece69f14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Transcription Factors
138 rdf:type schema:DefinedTerm
139 Nd5c413a03ccf46a8ba5254b7ecd9b7fd rdf:first sg:person.0763301135.56
140 rdf:rest N4ae2f6a77734463197de44c94ab22ef6
141 Nda63bb94e437487bb4ad3c93c224e9cc schema:name readcube_id
142 schema:value 03457cacdf50e9d8639c25ce87f281680ccb266acebd90faedbd85645792ceec
143 rdf:type schema:PropertyValue
144 Ndca5ad9fc04e45ed813e8aa0d6291c30 schema:name Springer Nature - SN SciGraph project
145 rdf:type schema:Organization
146 Nf5d6c3655fa74ae587a872e3a1694af3 rdf:first sg:person.01215757170.08
147 rdf:rest rdf:nil
148 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
149 schema:name Medical and Health Sciences
150 rdf:type schema:DefinedTerm
151 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
152 schema:name Oncology and Carcinogenesis
153 rdf:type schema:DefinedTerm
154 sg:journal.1024960 schema:issn 1471-2490
155 schema:name BMC Urology
156 rdf:type schema:Periodical
157 sg:person.010032116317.42 schema:affiliation https://www.grid.ac/institutes/grid.5475.3
158 schema:familyName Morgan
159 schema:givenName Richard
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010032116317.42
161 rdf:type schema:Person
162 sg:person.01034777634.08 schema:affiliation https://www.grid.ac/institutes/grid.5475.3
163 schema:familyName Michael
164 schema:givenName Agnieszka
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034777634.08
166 rdf:type schema:Person
167 sg:person.01167312032.35 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
168 schema:familyName Harrington
169 schema:givenName Kevin J
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167312032.35
171 rdf:type schema:Person
172 sg:person.01215757170.08 schema:affiliation https://www.grid.ac/institutes/grid.5475.3
173 schema:familyName Pandha
174 schema:givenName Hardev S
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215757170.08
176 rdf:type schema:Person
177 sg:person.0604322634.44 schema:affiliation https://www.grid.ac/institutes/grid.5475.3
178 schema:familyName Boxall
179 schema:givenName Angie
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604322634.44
181 rdf:type schema:Person
182 sg:person.0763301135.56 schema:affiliation https://www.grid.ac/institutes/grid.5475.3
183 schema:familyName Simpson
184 schema:givenName Guy R
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763301135.56
186 rdf:type schema:Person
187 sg:pub.10.1007/s00280-013-2316-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036748569
188 https://doi.org/10.1007/s00280-013-2316-5
189 rdf:type schema:CreativeWork
190 sg:pub.10.1007/s10549-012-2259-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022188194
191 https://doi.org/10.1007/s10549-012-2259-2
192 rdf:type schema:CreativeWork
193 sg:pub.10.1038/leu.2010.142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039993211
194 https://doi.org/10.1038/leu.2010.142
195 rdf:type schema:CreativeWork
196 sg:pub.10.1038/nrc2826 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018749149
197 https://doi.org/10.1038/nrc2826
198 rdf:type schema:CreativeWork
199 sg:pub.10.1038/sj.bjc.6604857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053403090
200 https://doi.org/10.1038/sj.bjc.6604857
201 rdf:type schema:CreativeWork
202 sg:pub.10.1038/sj.onc.1206781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043751276
203 https://doi.org/10.1038/sj.onc.1206781
204 rdf:type schema:CreativeWork
205 sg:pub.10.1186/1471-2407-10-89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022137095
206 https://doi.org/10.1186/1471-2407-10-89
207 rdf:type schema:CreativeWork
208 sg:pub.10.2165/11633360-000000000-00000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020710510
209 https://doi.org/10.2165/11633360-000000000-00000
210 rdf:type schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1076575067 schema:CreativeWork
212 https://app.dimensions.ai/details/publication/pub.1080373651 schema:CreativeWork
213 https://app.dimensions.ai/details/publication/pub.1081983028 schema:CreativeWork
214 https://doi.org/10.1002/(sici)1097-0045(19970101)30:1<58::aid-pros9>3.0.co;2-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1016355548
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1002/ijc.25516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008443664
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1002/ijc.28097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026677655
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1002/ijc.2910210305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006704074
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1002/pros.10045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014849692
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1006/bbrc.1997.6364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053033130
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/0092-8674(92)90471-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1011293717
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.juro.2008.07.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016298401
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.molcel.2009.10.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033128345
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/s0168-9525(99)01881-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010955172
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1038/mt.2009.80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010309613
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1073/pnas.91.25.12223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044882666
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1074/jbc.m400932200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021614490
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1093/nar/27.18.3752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015701382
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1097/moh.0b013e32801684b6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024044643
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1111/j.1464-410x.2009.08593.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027037503
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1128/mcb.16.4.1734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043698804
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1158/0008-5472.can-06-4231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001603934
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1158/0008-5472.can-09-2408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000364620
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1158/1078-0432.ccr-11-1899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041390512
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1182/blood-2012-07-442004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039008462
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1210/en.2006-1250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064248327
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1258/002367788780746467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013737421
259 rdf:type schema:CreativeWork
260 https://www.grid.ac/institutes/grid.18886.3f schema:alternateName Institute of Cancer Research
261 schema:name Targeted Therapy Team, Chester Beatty Laboratories, The Institute of Cancer Research, London, UK
262 rdf:type schema:Organization
263 https://www.grid.ac/institutes/grid.5475.3 schema:alternateName University of Surrey
264 schema:name Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
265 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...