Decreased expression of RNA-binding motif protein 3 correlates with tumour progression and poor prognosis in urothelial bladder cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Karolina Boman, Ulrika Segersten, Göran Ahlgren, Jakob Eberhard, Mathias Uhlén, Karin Jirström, Per-Uno Malmström

ABSTRACT

BACKGROUND: Low nuclear expression of the RNA-binding motif protein 3 (RBM3) has previously been found to be associated with poor prognosis in several cancer forms e.g. breast, ovarian, colorectal, prostate cancer and malignant melanoma. The aim of this study was to examine the prognostic impact of RBM3 expression in urinary bladder cancer. METHODS: Immunohistochemical RBM3 expression was examined in tumours from 343 patients with urothelial bladder cancer. Chi-square and Spearman's correlation tests were applied to explore associations between RBM3 expression and clinicopathological characteristics. The impact of RBM3 expression on disease-specific survival (DSS), 5-year overall survival (OS) and progression-free survival (PFS) was assessed by Kaplan-Meier analysis and Cox proportional hazards modelling. RESULTS: Reduced nuclear RBM3 expression was significantly associated with more advanced tumour (T) stage (p <0.001) and high grade tumours (p=0.004). Negative RBM3 expression was associated with a significantly shorter DSS (HR=2.55; 95% CI 1.68-3.86)) and 5-year OS (HR=2.10; 95% CI 1.56-2.82), also in multivariable analysis (HR=1.65; 95% CI 1.07-2.53 for DSS and HR=1.54; 95% CI 1.13-2.10 for 5-year OS). In patients with Ta and T1 tumours expressing reduced RBM3 levels, Kaplan-Meier analysis revealed a significantly shorter PFS (p=0.048) and 5-year OS (p=0.006). CONCLUSION: Loss of RBM3 expression is associated with clinically more aggressive tumours and an independent factor of poor prognosis in patients with urothelial bladder cancer and a potentially useful biomarker for treatment stratification and surveillance of disease progression. More... »

PAGES

17

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2490-13-17

DOI

http://dx.doi.org/10.1186/1471-2490-13-17

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012583994

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23565664


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Transitional Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kaplan-Meier Estimate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Grading", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proportional Hazards Models", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Urinary Bladder Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Clinical Sciences, Division of Pathology, Lund University, Sk\u00e5ne University Hospital, 221 85, Lund, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boman", 
        "givenName": "Karolina", 
        "id": "sg:person.01022703216.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022703216.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Uppsala University", 
          "id": "https://www.grid.ac/institutes/grid.8993.b", 
          "name": [
            "Department of Surgical Sciences, Uppsala University, 751 85, Uppsala, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Segersten", 
        "givenName": "Ulrika", 
        "id": "sg:person.01335550563.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335550563.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Clinical Sciences, Division of Urological Cancers, Lund University, Sk\u00e5ne University Hospital, 205 02, Malm\u00f6, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ahlgren", 
        "givenName": "G\u00f6ran", 
        "id": "sg:person.01015707364.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015707364.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Clinical Sciences, Division of Oncology, Lund University, Sk\u00e5ne University Hospital, 221 85, Lund, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eberhard", 
        "givenName": "Jakob", 
        "id": "sg:person.0767340254.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767340254.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Institute of Technology", 
          "id": "https://www.grid.ac/institutes/grid.5037.1", 
          "name": [
            "Science for Life Laboratory and School of Biotechnology, AlbaNova University Center, Royal Institute of Technology, 106 91, Stockholm, Sweden", 
            "School of Biotechnology, AlbaNova University Center, Royal Institute of Technology, 106 91, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uhl\u00e9n", 
        "givenName": "Mathias", 
        "id": "sg:person.01023367713.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023367713.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Clinical Sciences, Division of Pathology, Lund University, Sk\u00e5ne University Hospital, 221 85, Lund, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jirstr\u00f6m", 
        "givenName": "Karin", 
        "id": "sg:person.0773201354.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773201354.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Uppsala University", 
          "id": "https://www.grid.ac/institutes/grid.8993.b", 
          "name": [
            "Department of Surgical Sciences, Uppsala University, 751 85, Uppsala, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Malmstr\u00f6m", 
        "givenName": "Per-Uno", 
        "id": "sg:person.01046006513.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046006513.02"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1309/xuvxfxmfpl7telce", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004026435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/pdr.0b013e3181c13326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010208528", 
          "https://doi.org/10.1203/pdr.0b013e3181c13326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/pdr.0b013e3181c13326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010208528", 
          "https://doi.org/10.1203/pdr.0b013e3181c13326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/pdr.0b013e3181c13326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010208528", 
          "https://doi.org/10.1203/pdr.0b013e3181c13326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2012.08.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011281266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2009.124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017485839", 
          "https://doi.org/10.1038/modpathol.2009.124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2009.124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017485839", 
          "https://doi.org/10.1038/modpathol.2009.124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19940401)73:7<1926::aid-cncr2820730725>3.0.co;2-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019094025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1593/tlo.11106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020414603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1746-1596-6-91", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020520237", 
          "https://doi.org/10.1186/1746-1596-6-91"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1746-1596-6-91", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020520237", 
          "https://doi.org/10.1186/1746-1596-6-91"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-9-114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020851919", 
          "https://doi.org/10.1186/1479-5876-9-114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-8-78", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024363411", 
          "https://doi.org/10.1186/1479-5876-8-78"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prca.201100020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030580534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2605.2007.00772.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031557112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037091000", 
          "https://doi.org/10.1038/nature03482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037091000", 
          "https://doi.org/10.1038/nature03482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2006.06.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040285942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2012.05.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042736096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00345-009-0395-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044452132", 
          "https://doi.org/10.1007/s00345-009-0395-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00345-009-0395-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044452132", 
          "https://doi.org/10.1007/s00345-009-0395-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/b:urol.0000032688.37789.7c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044997848", 
          "https://doi.org/10.1023/b:urol.0000032688.37789.7c"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199004193221607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048539000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2008.97", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050040643", 
          "https://doi.org/10.1038/onc.2008.97"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2000.18.17.3068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074702294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1992.10.7.1066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077093351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.annonc.a059105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082507228"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-12", 
    "datePublishedReg": "2013-12-01", 
    "description": "BACKGROUND: Low nuclear expression of the RNA-binding motif protein 3 (RBM3) has previously been found to be associated with poor prognosis in several cancer forms e.g. breast, ovarian, colorectal, prostate cancer and malignant melanoma. The aim of this study was to examine the prognostic impact of RBM3 expression in urinary bladder cancer.\nMETHODS: Immunohistochemical RBM3 expression was examined in tumours from 343 patients with urothelial bladder cancer. Chi-square and Spearman's correlation tests were applied to explore associations between RBM3 expression and clinicopathological characteristics. The impact of RBM3 expression on disease-specific survival (DSS), 5-year overall survival (OS) and progression-free survival (PFS) was assessed by Kaplan-Meier analysis and Cox proportional hazards modelling.\nRESULTS: Reduced nuclear RBM3 expression was significantly associated with more advanced tumour (T) stage (p <0.001) and high grade tumours (p=0.004). Negative RBM3 expression was associated with a significantly shorter DSS (HR=2.55; 95% CI 1.68-3.86)) and 5-year OS (HR=2.10; 95% CI 1.56-2.82), also in multivariable analysis (HR=1.65; 95% CI 1.07-2.53 for DSS and HR=1.54; 95% CI 1.13-2.10 for 5-year OS). In patients with Ta and T1 tumours expressing reduced RBM3 levels, Kaplan-Meier analysis revealed a significantly shorter PFS (p=0.048) and 5-year OS (p=0.006).\nCONCLUSION: Loss of RBM3 expression is associated with clinically more aggressive tumours and an independent factor of poor prognosis in patients with urothelial bladder cancer and a potentially useful biomarker for treatment stratification and surveillance of disease progression.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-2490-13-17", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024960", 
        "issn": [
          "1471-2490"
        ], 
        "name": "BMC Urology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "name": "Decreased expression of RNA-binding motif protein 3 correlates with tumour progression and poor prognosis in urothelial bladder cancer", 
    "pagination": "17", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3bf3cdfdfa6ad1a4bda0baad7cc7f6a0c747aa31e62f93090ee409b1087af90d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23565664"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100968571"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2490-13-17"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1012583994"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2490-13-17", 
      "https://app.dimensions.ai/details/publication/pub.1012583994"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000511.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-2490-13-17"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2490-13-17'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2490-13-17'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2490-13-17'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2490-13-17'


 

This table displays all metadata directly associated to this object as RDF triples.

282 TRIPLES      21 PREDICATES      72 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2490-13-17 schema:about N054e2faf2fcc4ec78a397c8b0b0e9e0d
2 N06c6c16c050f4ef9a435896bbc70e6d5
3 N0cb301244b41494bac7baba19bb3cfb5
4 N0de10c5ac6424e5d949d3d44612a2635
5 N163894a3bfb142899269e03191eebd8d
6 N2173c480172f440ea1d15b063e949886
7 N2253e67e8b0d4dc5808ba6dec61f143d
8 N44c38292ce304de38a514f2f9e870368
9 N45d630d53fbe4b5fbefe7f2d198b83dc
10 N45dc4b9830a14d4c8a14a53b26997a91
11 N489e1342c01d4dea8a3306d0d02f49a2
12 N5635013b524e449bb640e5a3f5ef8d8e
13 N76bfc5b520f54fc7b14f55267c5cbfa6
14 N8cb4422e649348288b4b6b5c24eb39ac
15 N8d5a9ed4e5024323b91994bab8ba3854
16 N99b84c90659a42f99530f81c22df1a06
17 N9b368fe10f6e44c197beb1fd222cf43e
18 Na8b62c12c3b849899a09361e4decf94b
19 Nc0d6a292806244d4b7dfcca1b6c20610
20 Nc294c99e243a46bdbf56f55c11217ac4
21 Nf34694ae9d6d4159a458cd1834b283cc
22 Nfee2e93521c24a7eb550a3c6013cdb7d
23 anzsrc-for:11
24 anzsrc-for:1112
25 schema:author N9b8a2ebd48d34152a5f2884c78c9bb46
26 schema:citation sg:pub.10.1007/s00345-009-0395-z
27 sg:pub.10.1023/b:urol.0000032688.37789.7c
28 sg:pub.10.1038/modpathol.2009.124
29 sg:pub.10.1038/nature03482
30 sg:pub.10.1038/onc.2008.97
31 sg:pub.10.1186/1479-5876-8-78
32 sg:pub.10.1186/1479-5876-9-114
33 sg:pub.10.1186/1746-1596-6-91
34 sg:pub.10.1203/pdr.0b013e3181c13326
35 https://doi.org/10.1002/1097-0142(19940401)73:7<1926::aid-cncr2820730725>3.0.co;2-q
36 https://doi.org/10.1002/prca.201100020
37 https://doi.org/10.1016/j.eururo.2006.06.006
38 https://doi.org/10.1016/j.eururo.2012.05.048
39 https://doi.org/10.1016/j.eururo.2012.08.010
40 https://doi.org/10.1056/nejm199004193221607
41 https://doi.org/10.1093/oxfordjournals.annonc.a059105
42 https://doi.org/10.1111/j.1365-2605.2007.00772.x
43 https://doi.org/10.1200/jco.1992.10.7.1066
44 https://doi.org/10.1200/jco.2000.18.17.3068
45 https://doi.org/10.1309/xuvxfxmfpl7telce
46 https://doi.org/10.1593/tlo.11106
47 schema:datePublished 2013-12
48 schema:datePublishedReg 2013-12-01
49 schema:description BACKGROUND: Low nuclear expression of the RNA-binding motif protein 3 (RBM3) has previously been found to be associated with poor prognosis in several cancer forms e.g. breast, ovarian, colorectal, prostate cancer and malignant melanoma. The aim of this study was to examine the prognostic impact of RBM3 expression in urinary bladder cancer. METHODS: Immunohistochemical RBM3 expression was examined in tumours from 343 patients with urothelial bladder cancer. Chi-square and Spearman's correlation tests were applied to explore associations between RBM3 expression and clinicopathological characteristics. The impact of RBM3 expression on disease-specific survival (DSS), 5-year overall survival (OS) and progression-free survival (PFS) was assessed by Kaplan-Meier analysis and Cox proportional hazards modelling. RESULTS: Reduced nuclear RBM3 expression was significantly associated with more advanced tumour (T) stage (p <0.001) and high grade tumours (p=0.004). Negative RBM3 expression was associated with a significantly shorter DSS (HR=2.55; 95% CI 1.68-3.86)) and 5-year OS (HR=2.10; 95% CI 1.56-2.82), also in multivariable analysis (HR=1.65; 95% CI 1.07-2.53 for DSS and HR=1.54; 95% CI 1.13-2.10 for 5-year OS). In patients with Ta and T1 tumours expressing reduced RBM3 levels, Kaplan-Meier analysis revealed a significantly shorter PFS (p=0.048) and 5-year OS (p=0.006). CONCLUSION: Loss of RBM3 expression is associated with clinically more aggressive tumours and an independent factor of poor prognosis in patients with urothelial bladder cancer and a potentially useful biomarker for treatment stratification and surveillance of disease progression.
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree true
53 schema:isPartOf N28b6087c29c045bcbe72b8e213498c39
54 Nd34604432c5c4791b95431f906b52a61
55 sg:journal.1024960
56 schema:name Decreased expression of RNA-binding motif protein 3 correlates with tumour progression and poor prognosis in urothelial bladder cancer
57 schema:pagination 17
58 schema:productId N1a8e989115c740c6af34dde98bb6b6cc
59 N3ab92a8a274f4faab2d3013c2775a552
60 N4f4f499f91b24b03a12c02558f6a74c9
61 Na3c617348d3c4a56b0533ee2f4e73212
62 Nd297fdfc06154c1e86b95e8f2a7ea7b9
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012583994
64 https://doi.org/10.1186/1471-2490-13-17
65 schema:sdDatePublished 2019-04-11T00:15
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher N293ffa79eb8f4e118403a24efea4b1ad
68 schema:url http://link.springer.com/10.1186%2F1471-2490-13-17
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N054e2faf2fcc4ec78a397c8b0b0e9e0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Female
74 rdf:type schema:DefinedTerm
75 N06c6c16c050f4ef9a435896bbc70e6d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Middle Aged
77 rdf:type schema:DefinedTerm
78 N0cb301244b41494bac7baba19bb3cfb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Biomarkers
80 rdf:type schema:DefinedTerm
81 N0de10c5ac6424e5d949d3d44612a2635 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Neoplasm Staging
83 rdf:type schema:DefinedTerm
84 N163894a3bfb142899269e03191eebd8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Neoplasm Grading
86 rdf:type schema:DefinedTerm
87 N1a8e989115c740c6af34dde98bb6b6cc schema:name dimensions_id
88 schema:value pub.1012583994
89 rdf:type schema:PropertyValue
90 N2173c480172f440ea1d15b063e949886 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Prospective Studies
92 rdf:type schema:DefinedTerm
93 N2253e67e8b0d4dc5808ba6dec61f143d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Aged
95 rdf:type schema:DefinedTerm
96 N28b6087c29c045bcbe72b8e213498c39 schema:volumeNumber 13
97 rdf:type schema:PublicationVolume
98 N293ffa79eb8f4e118403a24efea4b1ad schema:name Springer Nature - SN SciGraph project
99 rdf:type schema:Organization
100 N2cb2e9f853264fb18f02a8bd63a134ce schema:name Department of Clinical Sciences, Division of Pathology, Lund University, Skåne University Hospital, 221 85, Lund, Sweden
101 rdf:type schema:Organization
102 N370ad1e7592c4998b6f1327b59337d76 rdf:first sg:person.0767340254.86
103 rdf:rest N8cb1b8c4671c4e1bbcebebc9cff810f3
104 N3ab92a8a274f4faab2d3013c2775a552 schema:name doi
105 schema:value 10.1186/1471-2490-13-17
106 rdf:type schema:PropertyValue
107 N3ccf65a82a8a4c10a084b70d81e78677 schema:name Department of Clinical Sciences, Division of Urological Cancers, Lund University, Skåne University Hospital, 205 02, Malmö, Sweden
108 rdf:type schema:Organization
109 N44c38292ce304de38a514f2f9e870368 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Urinary Bladder Neoplasms
111 rdf:type schema:DefinedTerm
112 N45d630d53fbe4b5fbefe7f2d198b83dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Male
114 rdf:type schema:DefinedTerm
115 N45dc4b9830a14d4c8a14a53b26997a91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Kaplan-Meier Estimate
117 rdf:type schema:DefinedTerm
118 N489e1342c01d4dea8a3306d0d02f49a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name RNA-Binding Proteins
120 rdf:type schema:DefinedTerm
121 N4f4f499f91b24b03a12c02558f6a74c9 schema:name readcube_id
122 schema:value 3bf3cdfdfa6ad1a4bda0baad7cc7f6a0c747aa31e62f93090ee409b1087af90d
123 rdf:type schema:PropertyValue
124 N5172b3ea72b64984b137e12ac9a1e84b rdf:first sg:person.01046006513.02
125 rdf:rest rdf:nil
126 N5635013b524e449bb640e5a3f5ef8d8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Disease-Free Survival
128 rdf:type schema:DefinedTerm
129 N5cdd067e5f1c4b4eb8512532e22a185e schema:name Department of Clinical Sciences, Division of Oncology, Lund University, Skåne University Hospital, 221 85, Lund, Sweden
130 rdf:type schema:Organization
131 N76bfc5b520f54fc7b14f55267c5cbfa6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Carcinoma, Transitional Cell
133 rdf:type schema:DefinedTerm
134 N79ed78ed42314d0697423f861cf07b54 rdf:first sg:person.01335550563.36
135 rdf:rest Nf15b886c309148739b77adb09275ba69
136 N8cb1b8c4671c4e1bbcebebc9cff810f3 rdf:first sg:person.01023367713.91
137 rdf:rest Nc808dc2bb9404ba8868da6c1e2ea87b8
138 N8cb4422e649348288b4b6b5c24eb39ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Proportional Hazards Models
140 rdf:type schema:DefinedTerm
141 N8d5a9ed4e5024323b91994bab8ba3854 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Immunohistochemistry
143 rdf:type schema:DefinedTerm
144 N99b84c90659a42f99530f81c22df1a06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Adult
146 rdf:type schema:DefinedTerm
147 N9b368fe10f6e44c197beb1fd222cf43e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Cohort Studies
149 rdf:type schema:DefinedTerm
150 N9b8a2ebd48d34152a5f2884c78c9bb46 rdf:first sg:person.01022703216.55
151 rdf:rest N79ed78ed42314d0697423f861cf07b54
152 Na3c617348d3c4a56b0533ee2f4e73212 schema:name pubmed_id
153 schema:value 23565664
154 rdf:type schema:PropertyValue
155 Na8b62c12c3b849899a09361e4decf94b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Aged, 80 and over
157 rdf:type schema:DefinedTerm
158 Nbfca936e92c243898aa531002ee95624 schema:name Department of Clinical Sciences, Division of Pathology, Lund University, Skåne University Hospital, 221 85, Lund, Sweden
159 rdf:type schema:Organization
160 Nc0d6a292806244d4b7dfcca1b6c20610 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Retrospective Studies
162 rdf:type schema:DefinedTerm
163 Nc294c99e243a46bdbf56f55c11217ac4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Disease Progression
165 rdf:type schema:DefinedTerm
166 Nc808dc2bb9404ba8868da6c1e2ea87b8 rdf:first sg:person.0773201354.68
167 rdf:rest N5172b3ea72b64984b137e12ac9a1e84b
168 Nd297fdfc06154c1e86b95e8f2a7ea7b9 schema:name nlm_unique_id
169 schema:value 100968571
170 rdf:type schema:PropertyValue
171 Nd34604432c5c4791b95431f906b52a61 schema:issueNumber 1
172 rdf:type schema:PublicationIssue
173 Nf15b886c309148739b77adb09275ba69 rdf:first sg:person.01015707364.80
174 rdf:rest N370ad1e7592c4998b6f1327b59337d76
175 Nf34694ae9d6d4159a458cd1834b283cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Prognosis
177 rdf:type schema:DefinedTerm
178 Nfee2e93521c24a7eb550a3c6013cdb7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Humans
180 rdf:type schema:DefinedTerm
181 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
182 schema:name Medical and Health Sciences
183 rdf:type schema:DefinedTerm
184 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
185 schema:name Oncology and Carcinogenesis
186 rdf:type schema:DefinedTerm
187 sg:journal.1024960 schema:issn 1471-2490
188 schema:name BMC Urology
189 rdf:type schema:Periodical
190 sg:person.01015707364.80 schema:affiliation N3ccf65a82a8a4c10a084b70d81e78677
191 schema:familyName Ahlgren
192 schema:givenName Göran
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015707364.80
194 rdf:type schema:Person
195 sg:person.01022703216.55 schema:affiliation Nbfca936e92c243898aa531002ee95624
196 schema:familyName Boman
197 schema:givenName Karolina
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022703216.55
199 rdf:type schema:Person
200 sg:person.01023367713.91 schema:affiliation https://www.grid.ac/institutes/grid.5037.1
201 schema:familyName Uhlén
202 schema:givenName Mathias
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023367713.91
204 rdf:type schema:Person
205 sg:person.01046006513.02 schema:affiliation https://www.grid.ac/institutes/grid.8993.b
206 schema:familyName Malmström
207 schema:givenName Per-Uno
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046006513.02
209 rdf:type schema:Person
210 sg:person.01335550563.36 schema:affiliation https://www.grid.ac/institutes/grid.8993.b
211 schema:familyName Segersten
212 schema:givenName Ulrika
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335550563.36
214 rdf:type schema:Person
215 sg:person.0767340254.86 schema:affiliation N5cdd067e5f1c4b4eb8512532e22a185e
216 schema:familyName Eberhard
217 schema:givenName Jakob
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767340254.86
219 rdf:type schema:Person
220 sg:person.0773201354.68 schema:affiliation N2cb2e9f853264fb18f02a8bd63a134ce
221 schema:familyName Jirström
222 schema:givenName Karin
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773201354.68
224 rdf:type schema:Person
225 sg:pub.10.1007/s00345-009-0395-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1044452132
226 https://doi.org/10.1007/s00345-009-0395-z
227 rdf:type schema:CreativeWork
228 sg:pub.10.1023/b:urol.0000032688.37789.7c schema:sameAs https://app.dimensions.ai/details/publication/pub.1044997848
229 https://doi.org/10.1023/b:urol.0000032688.37789.7c
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/modpathol.2009.124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017485839
232 https://doi.org/10.1038/modpathol.2009.124
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/nature03482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037091000
235 https://doi.org/10.1038/nature03482
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/onc.2008.97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050040643
238 https://doi.org/10.1038/onc.2008.97
239 rdf:type schema:CreativeWork
240 sg:pub.10.1186/1479-5876-8-78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024363411
241 https://doi.org/10.1186/1479-5876-8-78
242 rdf:type schema:CreativeWork
243 sg:pub.10.1186/1479-5876-9-114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020851919
244 https://doi.org/10.1186/1479-5876-9-114
245 rdf:type schema:CreativeWork
246 sg:pub.10.1186/1746-1596-6-91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020520237
247 https://doi.org/10.1186/1746-1596-6-91
248 rdf:type schema:CreativeWork
249 sg:pub.10.1203/pdr.0b013e3181c13326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010208528
250 https://doi.org/10.1203/pdr.0b013e3181c13326
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1002/1097-0142(19940401)73:7<1926::aid-cncr2820730725>3.0.co;2-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1019094025
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1002/prca.201100020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030580534
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.eururo.2006.06.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040285942
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.eururo.2012.05.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042736096
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.eururo.2012.08.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011281266
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1056/nejm199004193221607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048539000
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1093/oxfordjournals.annonc.a059105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082507228
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1111/j.1365-2605.2007.00772.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031557112
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1200/jco.1992.10.7.1066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077093351
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1200/jco.2000.18.17.3068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074702294
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1309/xuvxfxmfpl7telce schema:sameAs https://app.dimensions.ai/details/publication/pub.1004026435
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1593/tlo.11106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020414603
275 rdf:type schema:CreativeWork
276 https://www.grid.ac/institutes/grid.5037.1 schema:alternateName Royal Institute of Technology
277 schema:name School of Biotechnology, AlbaNova University Center, Royal Institute of Technology, 106 91, Stockholm, Sweden
278 Science for Life Laboratory and School of Biotechnology, AlbaNova University Center, Royal Institute of Technology, 106 91, Stockholm, Sweden
279 rdf:type schema:Organization
280 https://www.grid.ac/institutes/grid.8993.b schema:alternateName Uppsala University
281 schema:name Department of Surgical Sciences, Uppsala University, 751 85, Uppsala, Sweden
282 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...