Systemic alendronate prevents resorption of necrotic bone during revascularization. A bone chamber study in rats View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-12

AUTHORS

Jörgen Åstrand, Per Aspenberg

ABSTRACT

BACKGROUND: Avascular necrosis of bone (osteonecrosis) can cause structural failure and subsequent deformation, leading to joint dysfunction and pain. Structural failure is the result of resorption of necrotic bone during revascularization, before new bone has formed or consolidated enough for loadbearing. Bone resorption can be reduced by bisphosphonates. If resorption of the necrotic bone could be reduced during the revascularization phase until sufficient new bone has formed, it would appear that structural failure could be avoided. METHODS: To test whether resorption of necrotic bone can be prevented, structural grafts were subjected to new bone ingrowth during systemic bisphosphonate treatment in a rat model. RESULTS: In rats treated with alendronate the necrotic bone was not resorbed, whereas it was almost entirely resorbed in the controls. CONCLUSION: Systemic alendronate treatment prevents resorption of necrotic bone during revascularization. In patients with osteonecrosis, bisphosphonates may therefore prevent collapse of the necrotic bone. More... »

PAGES

19

References to SciGraph publications

  • 1995-04. Increased bone ingrowth distance into lipid-extracted bank bone at 6 weeks in ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1186/1471-2474-3-19

    DOI

    http://dx.doi.org/10.1186/1471-2474-3-19

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12165099


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