Time course of 25(OH)D3 vitamin D3 as well as PTH (parathyroid hormone) during fracture healing of patients with normal and ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-01-03

AUTHORS

Christoph Wölfl, Sarah Englert, Arash A Moghaddam, Gerald Zimmermann, Gerhard Schmidt-Gayk, Bernd Höner, Aidan Hogan, Marcus Lehnhardt, Paul A Grützner, Leila Kolios

ABSTRACT

BACKGROUND: Until now the exact biochemical processes during healing of metaphyseal fractures of healthy and osteoporotic bone remain unclear. Especially the physiological time courses of 25(OH)D(3) (Vitamin D) as well as PTH (Parathyroid Hormone) the most important modulators of calcium and bone homeostasis are not yet examined sufficiently. The purpose of this study was to focus on the time course of these parameters during fracture healing. METHODS: In the presented study, we analyse the time course of 25(OH)D3 and PTH during fracture healing of low BMD level fractures versus normal BMD level fractures in a matched pair analysis. Between March 2007 and February 2009 30 patients older than 50 years of age who had suffered a metaphyseal fracture of the proximal humerus, the distal radius or the proximal femur were included in our study. Osteoporosis was verified by DEXA measuring. The time courses of 25(OH)D(3) and PTH were examined over an eight week period. Friedmann test, the Wilcoxon signed rank test and the Mann-Withney U test were used as post-hoc tests. A p-value ≤ 0.05 was considered significant. RESULTS: Serum levels of 25(OH)D(3) showed no differences in both groups. In the first phase of fracture healing PTH levels in the low BMD level group remained below those of the normal BMD group in absolute figures. Over all no significant differences between low BMD level bone and normal BMD level bone could be detected in our study. CONCLUSIONS: The time course of 25(OH)D(3) and PTH during fracture healing of patients with normal and low bone mineral density were examined for the first time in humans in this setting and allowing molecular biological insights into fracture healing in metaphyseal bones on a molecural level. There were no significant differences between patients with normal and low BMD levels. Hence further studies will be necessary to obtain more detailed insight into fracture healing in order to provide reliable decision criteria for therapy and the monitoring of fracture healing. More... »

PAGES

6-6

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2474-14-6

DOI

http://dx.doi.org/10.1186/1471-2474-14-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039246825

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23286544


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Absorptiometry, Photon", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Density", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcifediol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Femoral Fractures", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fracture Healing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Matched-Pair Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osteoporosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Parathyroid Hormone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radius Fractures", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Shoulder Fractures", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Trauma- and Orthopaedic Surgery, BG Trauma Centre Ludwigshafen, Ludwig- Guttmann-Str.13, Ludwigshafen 67071, Germany", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Trauma- and Orthopaedic Surgery, BG Trauma Centre Ludwigshafen, Ludwig- Guttmann-Str.13, Ludwigshafen 67071, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "W\u00f6lfl", 
        "givenName": "Christoph", 
        "id": "sg:person.0635517210.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635517210.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Trauma- and Orthopaedic Surgery, BG Trauma Centre Ludwigshafen, Ludwig- Guttmann-Str.13, Ludwigshafen 67071, Germany", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Trauma- and Orthopaedic Surgery, BG Trauma Centre Ludwigshafen, Ludwig- Guttmann-Str.13, Ludwigshafen 67071, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Englert", 
        "givenName": "Sarah", 
        "id": "sg:person.01172322344.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172322344.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Trauma- and Orthopaedic Surgery, BG Trauma Centre Ludwigshafen, Ludwig- Guttmann-Str.13, Ludwigshafen 67071, Germany", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Trauma- and Orthopaedic Surgery, BG Trauma Centre Ludwigshafen, Ludwig- Guttmann-Str.13, Ludwigshafen 67071, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moghaddam", 
        "givenName": "Arash A", 
        "id": "sg:person.01240435544.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240435544.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Trauma and Orthopaedic Surgery, TKH Mannheim, Bassemannstrasse 1, Mannheim, 68156, Germany", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Trauma and Orthopaedic Surgery, TKH Mannheim, Bassemannstrasse 1, Mannheim, 68156, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zimmermann", 
        "givenName": "Gerald", 
        "id": "sg:person.01344220175.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344220175.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Clinical Laboratory Limbach, Im Breitspiel 15, Heidelberg, 69126, Germany", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Clinical Laboratory Limbach, Im Breitspiel 15, Heidelberg, 69126, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schmidt-Gayk", 
        "givenName": "Gerhard", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Social and Legal Sciences, SRH Hochschule, Heidelberg, Ludwig-Guttmann-Str.6, Heidelberg, 69123, Germany", 
          "id": "http://www.grid.ac/institutes/grid.466188.5", 
          "name": [
            "Department of Social and Legal Sciences, SRH Hochschule, Heidelberg, Ludwig-Guttmann-Str.6, Heidelberg, 69123, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "H\u00f6ner", 
        "givenName": "Bernd", 
        "id": "sg:person.0631260044.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631260044.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Trauma- and Orthopaedic Surgery, BG Trauma Centre Ludwigshafen, Ludwig- Guttmann-Str.13, Ludwigshafen 67071, Germany", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Trauma- and Orthopaedic Surgery, BG Trauma Centre Ludwigshafen, Ludwig- Guttmann-Str.13, Ludwigshafen 67071, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hogan", 
        "givenName": "Aidan", 
        "id": "sg:person.01235066325.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235066325.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Plastic-, Reconstructive and Hand surgery, Burn Care Centre, BG Unfallklinik Ludwigshafen, Ludwig-Guttmann-Str.13, Ludwigshafen, 67071, Germany", 
          "id": "http://www.grid.ac/institutes/grid.418303.d", 
          "name": [
            "Department of Plastic-, Reconstructive and Hand surgery, Burn Care Centre, BG Unfallklinik Ludwigshafen, Ludwig-Guttmann-Str.13, Ludwigshafen, 67071, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lehnhardt", 
        "givenName": "Marcus", 
        "id": "sg:person.01276652626.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276652626.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Trauma- and Orthopaedic Surgery, BG Trauma Centre Ludwigshafen, Ludwig- Guttmann-Str.13, Ludwigshafen 67071, Germany", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Trauma- and Orthopaedic Surgery, BG Trauma Centre Ludwigshafen, Ludwig- Guttmann-Str.13, Ludwigshafen 67071, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gr\u00fctzner", 
        "givenName": "Paul A", 
        "id": "sg:person.01060715001.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060715001.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Plastic-, Reconstructive and Hand surgery, Burn Care Centre, BG Unfallklinik Ludwigshafen, Ludwig-Guttmann-Str.13, Ludwigshafen, 67071, Germany", 
          "id": "http://www.grid.ac/institutes/grid.418303.d", 
          "name": [
            "Department of Plastic-, Reconstructive and Hand surgery, Burn Care Centre, BG Unfallklinik Ludwigshafen, Ludwig-Guttmann-Str.13, Ludwigshafen, 67071, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kolios", 
        "givenName": "Leila", 
        "id": "sg:person.01177550105.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177550105.79"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00198-008-0746-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014825395", 
          "https://doi.org/10.1007/s00198-008-0746-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00774-007-0791-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013670967", 
          "https://doi.org/10.1007/s00774-007-0791-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00198-011-1659-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033583882", 
          "https://doi.org/10.1007/s00198-011-1659-1"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-01-03", 
    "datePublishedReg": "2013-01-03", 
    "description": "BACKGROUND: Until now the exact biochemical processes during healing of metaphyseal fractures of healthy and osteoporotic bone remain unclear. Especially the physiological time courses of 25(OH)D(3) (Vitamin D) as well as PTH (Parathyroid Hormone) the most important modulators of calcium and bone homeostasis are not yet examined sufficiently. The purpose of this study was to focus on the time course of these parameters during fracture healing.\nMETHODS: In the presented study, we analyse the time course of 25(OH)D3 and PTH during fracture healing of low BMD level fractures versus normal BMD level fractures in a matched pair analysis. Between March 2007 and February 2009 30 patients older than 50 years of age who had suffered a metaphyseal fracture of the proximal humerus, the distal radius or the proximal femur were included in our study. Osteoporosis was verified by DEXA measuring. The time courses of 25(OH)D(3) and PTH were examined over an eight week period. Friedmann test, the Wilcoxon signed rank test and the Mann-Withney U test were used as post-hoc tests. A p-value \u2264 0.05 was considered significant.\nRESULTS: Serum levels of 25(OH)D(3) showed no differences in both groups. In the first phase of fracture healing PTH levels in the low BMD level group remained below those of the normal BMD group in absolute figures. Over all no significant differences between low BMD level bone and normal BMD level bone could be detected in our study.\nCONCLUSIONS: The time course of 25(OH)D(3) and PTH during fracture healing of patients with normal and low bone mineral density were examined for the first time in humans in this setting and allowing molecular biological insights into fracture healing in metaphyseal bones on a molecural level. There were no significant differences between patients with normal and low BMD levels. Hence further studies will be necessary to obtain more detailed insight into fracture healing in order to provide reliable decision criteria for therapy and the monitoring of fracture healing.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/1471-2474-14-6", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024957", 
        "issn": [
          "1471-2474"
        ], 
        "name": "BMC Musculoskeletal Disorders", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "keywords": [
      "bone mineral density", 
      "low bone mineral density", 
      "fracture healing", 
      "metaphyseal fractures", 
      "mineral density", 
      "time course", 
      "normal BMD group", 
      "lower BMD levels", 
      "matched pair analysis", 
      "years of age", 
      "significant differences", 
      "PTH levels", 
      "serum levels", 
      "BMD levels", 
      "Mann-Withney U test", 
      "proximal humerus", 
      "distal radius", 
      "vitamin D3", 
      "BMD group", 
      "proximal femur", 
      "bone homeostasis", 
      "patients", 
      "PTH", 
      "osteoporotic bone", 
      "metaphyseal bone", 
      "important modulator", 
      "physiological time course", 
      "healing", 
      "rank test", 
      "Friedmann test", 
      "Further studies", 
      "bone", 
      "week period", 
      "level group", 
      "fractures", 
      "pair analysis", 
      "group", 
      "course", 
      "exact biochemical processes", 
      "osteoporosis", 
      "levels", 
      "therapy", 
      "study", 
      "DEXA", 
      "differences", 
      "humerus", 
      "femur", 
      "test", 
      "D3", 
      "absolute figures", 
      "age", 
      "molecular biological insights", 
      "Wilcoxon", 
      "homeostasis", 
      "calcium", 
      "humans", 
      "years", 
      "modulator", 
      "period", 
      "criteria", 
      "first phase", 
      "biological insights", 
      "first time", 
      "monitoring", 
      "purpose", 
      "biochemical processes", 
      "insights", 
      "time", 
      "analysis", 
      "values", 
      "density", 
      "figures", 
      "detailed insight", 
      "phase", 
      "parameters", 
      "order", 
      "process", 
      "decision criteria", 
      "radius", 
      "low BMD level fractures", 
      "BMD level fractures", 
      "level fractures", 
      "normal BMD level fractures", 
      "U test", 
      "fracture healing PTH levels", 
      "healing PTH levels", 
      "low BMD level group", 
      "BMD level group", 
      "low BMD level bone", 
      "BMD level bone", 
      "level bone", 
      "normal BMD level bone", 
      "molecural level", 
      "reliable decision criteria"
    ], 
    "name": "Time course of 25(OH)D3 vitamin D3 as well as PTH (parathyroid hormone) during fracture healing of patients with normal and low bone mineral density (BMD)", 
    "pagination": "6-6", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1039246825"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2474-14-6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23286544"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2474-14-6", 
      "https://app.dimensions.ai/details/publication/pub.1039246825"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_616.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/1471-2474-14-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2474-14-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2474-14-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2474-14-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2474-14-6'


 

This table displays all metadata directly associated to this object as RDF triples.

307 TRIPLES      22 PREDICATES      140 URIs      129 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2474-14-6 schema:about N0e6a1093db6b4223a0b0e0f04a8528ba
2 N1c1bee830f51420e83a8492be63cdc17
3 N23f2db7d011245dfb4d9d17ceb75d5ea
4 N25013e6a03ae45ed9210103e171a76a6
5 N2d4124e75bca4f56a6ed6fbf53052971
6 N3244e822d2ba4c14b9d8f0e65112c5e4
7 N35418cf6540c41b3b0887cf4b90b4803
8 N3c0d6616a27b4601b4ebc5af929511fd
9 N3cf5c78c79384cf08016281c1fa416c1
10 N4dd3fae0798e4472be0f4f835d6c6120
11 N62dfefcaecb2457ca6f24d082a62ad4f
12 N8c07dd12fdd04ffd9130b235cf31011d
13 Nb4ab3530e2e14dffbf0a3399016f7657
14 Nbee1c8709a7a42cfa4b10224bd790ac9
15 Nc9abd4fc290843459cadf385539cff7a
16 Nd013620d3f83423ebc00f26fe3401699
17 Nd987dc7aa87548928cf18782523d932b
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author N64c98cf3475f45c1969b62d35738ab09
21 schema:citation sg:pub.10.1007/s00198-008-0746-4
22 sg:pub.10.1007/s00198-011-1659-1
23 sg:pub.10.1007/s00774-007-0791-7
24 schema:datePublished 2013-01-03
25 schema:datePublishedReg 2013-01-03
26 schema:description BACKGROUND: Until now the exact biochemical processes during healing of metaphyseal fractures of healthy and osteoporotic bone remain unclear. Especially the physiological time courses of 25(OH)D(3) (Vitamin D) as well as PTH (Parathyroid Hormone) the most important modulators of calcium and bone homeostasis are not yet examined sufficiently. The purpose of this study was to focus on the time course of these parameters during fracture healing. METHODS: In the presented study, we analyse the time course of 25(OH)D3 and PTH during fracture healing of low BMD level fractures versus normal BMD level fractures in a matched pair analysis. Between March 2007 and February 2009 30 patients older than 50 years of age who had suffered a metaphyseal fracture of the proximal humerus, the distal radius or the proximal femur were included in our study. Osteoporosis was verified by DEXA measuring. The time courses of 25(OH)D(3) and PTH were examined over an eight week period. Friedmann test, the Wilcoxon signed rank test and the Mann-Withney U test were used as post-hoc tests. A p-value ≤ 0.05 was considered significant. RESULTS: Serum levels of 25(OH)D(3) showed no differences in both groups. In the first phase of fracture healing PTH levels in the low BMD level group remained below those of the normal BMD group in absolute figures. Over all no significant differences between low BMD level bone and normal BMD level bone could be detected in our study. CONCLUSIONS: The time course of 25(OH)D(3) and PTH during fracture healing of patients with normal and low bone mineral density were examined for the first time in humans in this setting and allowing molecular biological insights into fracture healing in metaphyseal bones on a molecural level. There were no significant differences between patients with normal and low BMD levels. Hence further studies will be necessary to obtain more detailed insight into fracture healing in order to provide reliable decision criteria for therapy and the monitoring of fracture healing.
27 schema:genre article
28 schema:inLanguage en
29 schema:isAccessibleForFree true
30 schema:isPartOf N2b5d71abce3c42518bda543aee33d616
31 Na073844ef5ee4b179be880c4d228cfdd
32 sg:journal.1024957
33 schema:keywords BMD group
34 BMD level bone
35 BMD level fractures
36 BMD level group
37 BMD levels
38 D3
39 DEXA
40 Friedmann test
41 Further studies
42 Mann-Withney U test
43 PTH
44 PTH levels
45 U test
46 Wilcoxon
47 absolute figures
48 age
49 analysis
50 biochemical processes
51 biological insights
52 bone
53 bone homeostasis
54 bone mineral density
55 calcium
56 course
57 criteria
58 decision criteria
59 density
60 detailed insight
61 differences
62 distal radius
63 exact biochemical processes
64 femur
65 figures
66 first phase
67 first time
68 fracture healing
69 fracture healing PTH levels
70 fractures
71 group
72 healing
73 healing PTH levels
74 homeostasis
75 humans
76 humerus
77 important modulator
78 insights
79 level bone
80 level fractures
81 level group
82 levels
83 low BMD level bone
84 low BMD level fractures
85 low BMD level group
86 low bone mineral density
87 lower BMD levels
88 matched pair analysis
89 metaphyseal bone
90 metaphyseal fractures
91 mineral density
92 modulator
93 molecular biological insights
94 molecural level
95 monitoring
96 normal BMD group
97 normal BMD level bone
98 normal BMD level fractures
99 order
100 osteoporosis
101 osteoporotic bone
102 pair analysis
103 parameters
104 patients
105 period
106 phase
107 physiological time course
108 process
109 proximal femur
110 proximal humerus
111 purpose
112 radius
113 rank test
114 reliable decision criteria
115 serum levels
116 significant differences
117 study
118 test
119 therapy
120 time
121 time course
122 values
123 vitamin D3
124 week period
125 years
126 years of age
127 schema:name Time course of 25(OH)D3 vitamin D3 as well as PTH (parathyroid hormone) during fracture healing of patients with normal and low bone mineral density (BMD)
128 schema:pagination 6-6
129 schema:productId N18120029d6144fcdb1ce09520d08449e
130 N61ccf68b553b453f841c3ba87cf9e2b8
131 N9636f154fb1b4dabb81a6530551ded7d
132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039246825
133 https://doi.org/10.1186/1471-2474-14-6
134 schema:sdDatePublished 2022-01-01T18:31
135 schema:sdLicense https://scigraph.springernature.com/explorer/license/
136 schema:sdPublisher Nbd589dddf9de44069d73555d606a00b4
137 schema:url https://doi.org/10.1186/1471-2474-14-6
138 sgo:license sg:explorer/license/
139 sgo:sdDataset articles
140 rdf:type schema:ScholarlyArticle
141 N0e6a1093db6b4223a0b0e0f04a8528ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Female
143 rdf:type schema:DefinedTerm
144 N18120029d6144fcdb1ce09520d08449e schema:name doi
145 schema:value 10.1186/1471-2474-14-6
146 rdf:type schema:PropertyValue
147 N1c1bee830f51420e83a8492be63cdc17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Absorptiometry, Photon
149 rdf:type schema:DefinedTerm
150 N23f2db7d011245dfb4d9d17ceb75d5ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Radius Fractures
152 rdf:type schema:DefinedTerm
153 N25013e6a03ae45ed9210103e171a76a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Male
155 rdf:type schema:DefinedTerm
156 N2b5d71abce3c42518bda543aee33d616 schema:volumeNumber 14
157 rdf:type schema:PublicationVolume
158 N2d4124e75bca4f56a6ed6fbf53052971 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Femoral Fractures
160 rdf:type schema:DefinedTerm
161 N3244e822d2ba4c14b9d8f0e65112c5e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Time Factors
163 rdf:type schema:DefinedTerm
164 N35418cf6540c41b3b0887cf4b90b4803 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Parathyroid Hormone
166 rdf:type schema:DefinedTerm
167 N3c0d6616a27b4601b4ebc5af929511fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Biomarkers
169 rdf:type schema:DefinedTerm
170 N3cf5c78c79384cf08016281c1fa416c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Matched-Pair Analysis
172 rdf:type schema:DefinedTerm
173 N4dd3fae0798e4472be0f4f835d6c6120 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Treatment Outcome
175 rdf:type schema:DefinedTerm
176 N542ca9a35c9e4c4b9314ebe3e7742514 rdf:first sg:person.0631260044.30
177 rdf:rest Nedcdb64d95724513bc494bca36a05f0f
178 N552ee425b9f34d688a93438b1e42a8ef rdf:first Na2ad8247ce1746acad7a0e78db3a649a
179 rdf:rest N542ca9a35c9e4c4b9314ebe3e7742514
180 N5962536ba32c45c2b5300159648c5779 rdf:first sg:person.01344220175.24
181 rdf:rest N552ee425b9f34d688a93438b1e42a8ef
182 N61ccf68b553b453f841c3ba87cf9e2b8 schema:name pubmed_id
183 schema:value 23286544
184 rdf:type schema:PropertyValue
185 N62dfefcaecb2457ca6f24d082a62ad4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Middle Aged
187 rdf:type schema:DefinedTerm
188 N64c98cf3475f45c1969b62d35738ab09 rdf:first sg:person.0635517210.18
189 rdf:rest N692ada5c6dba4a25952c04942221af3d
190 N692ada5c6dba4a25952c04942221af3d rdf:first sg:person.01172322344.54
191 rdf:rest Nc1208ef3aaeb4948abdc75dfde654d6a
192 N8c07dd12fdd04ffd9130b235cf31011d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Bone Density
194 rdf:type schema:DefinedTerm
195 N9636f154fb1b4dabb81a6530551ded7d schema:name dimensions_id
196 schema:value pub.1039246825
197 rdf:type schema:PropertyValue
198 Na073844ef5ee4b179be880c4d228cfdd schema:issueNumber 1
199 rdf:type schema:PublicationIssue
200 Na0d3972eb19d498ea274bdd6144c83be rdf:first sg:person.01276652626.26
201 rdf:rest Ne3bec86b7cdb4bc795ee556e663e5db7
202 Na2ad8247ce1746acad7a0e78db3a649a schema:affiliation grid-institutes:None
203 schema:familyName Schmidt-Gayk
204 schema:givenName Gerhard
205 rdf:type schema:Person
206 Nb311cbc7716544a1a34d73ba4db6957f rdf:first sg:person.01177550105.79
207 rdf:rest rdf:nil
208 Nb4ab3530e2e14dffbf0a3399016f7657 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Shoulder Fractures
210 rdf:type schema:DefinedTerm
211 Nbd589dddf9de44069d73555d606a00b4 schema:name Springer Nature - SN SciGraph project
212 rdf:type schema:Organization
213 Nbee1c8709a7a42cfa4b10224bd790ac9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Osteoporosis
215 rdf:type schema:DefinedTerm
216 Nc1208ef3aaeb4948abdc75dfde654d6a rdf:first sg:person.01240435544.36
217 rdf:rest N5962536ba32c45c2b5300159648c5779
218 Nc9abd4fc290843459cadf385539cff7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Calcifediol
220 rdf:type schema:DefinedTerm
221 Nd013620d3f83423ebc00f26fe3401699 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Humans
223 rdf:type schema:DefinedTerm
224 Nd987dc7aa87548928cf18782523d932b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
225 schema:name Fracture Healing
226 rdf:type schema:DefinedTerm
227 Ne3bec86b7cdb4bc795ee556e663e5db7 rdf:first sg:person.01060715001.02
228 rdf:rest Nb311cbc7716544a1a34d73ba4db6957f
229 Nedcdb64d95724513bc494bca36a05f0f rdf:first sg:person.01235066325.31
230 rdf:rest Na0d3972eb19d498ea274bdd6144c83be
231 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
232 schema:name Medical and Health Sciences
233 rdf:type schema:DefinedTerm
234 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
235 schema:name Clinical Sciences
236 rdf:type schema:DefinedTerm
237 sg:journal.1024957 schema:issn 1471-2474
238 schema:name BMC Musculoskeletal Disorders
239 schema:publisher Springer Nature
240 rdf:type schema:Periodical
241 sg:person.01060715001.02 schema:affiliation grid-institutes:None
242 schema:familyName Grützner
243 schema:givenName Paul A
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060715001.02
245 rdf:type schema:Person
246 sg:person.01172322344.54 schema:affiliation grid-institutes:None
247 schema:familyName Englert
248 schema:givenName Sarah
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172322344.54
250 rdf:type schema:Person
251 sg:person.01177550105.79 schema:affiliation grid-institutes:grid.418303.d
252 schema:familyName Kolios
253 schema:givenName Leila
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177550105.79
255 rdf:type schema:Person
256 sg:person.01235066325.31 schema:affiliation grid-institutes:None
257 schema:familyName Hogan
258 schema:givenName Aidan
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235066325.31
260 rdf:type schema:Person
261 sg:person.01240435544.36 schema:affiliation grid-institutes:None
262 schema:familyName Moghaddam
263 schema:givenName Arash A
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240435544.36
265 rdf:type schema:Person
266 sg:person.01276652626.26 schema:affiliation grid-institutes:grid.418303.d
267 schema:familyName Lehnhardt
268 schema:givenName Marcus
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276652626.26
270 rdf:type schema:Person
271 sg:person.01344220175.24 schema:affiliation grid-institutes:None
272 schema:familyName Zimmermann
273 schema:givenName Gerald
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344220175.24
275 rdf:type schema:Person
276 sg:person.0631260044.30 schema:affiliation grid-institutes:grid.466188.5
277 schema:familyName Höner
278 schema:givenName Bernd
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631260044.30
280 rdf:type schema:Person
281 sg:person.0635517210.18 schema:affiliation grid-institutes:None
282 schema:familyName Wölfl
283 schema:givenName Christoph
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635517210.18
285 rdf:type schema:Person
286 sg:pub.10.1007/s00198-008-0746-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014825395
287 https://doi.org/10.1007/s00198-008-0746-4
288 rdf:type schema:CreativeWork
289 sg:pub.10.1007/s00198-011-1659-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033583882
290 https://doi.org/10.1007/s00198-011-1659-1
291 rdf:type schema:CreativeWork
292 sg:pub.10.1007/s00774-007-0791-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013670967
293 https://doi.org/10.1007/s00774-007-0791-7
294 rdf:type schema:CreativeWork
295 grid-institutes:None schema:alternateName Clinical Laboratory Limbach, Im Breitspiel 15, Heidelberg, 69126, Germany
296 Department of Trauma and Orthopaedic Surgery, TKH Mannheim, Bassemannstrasse 1, Mannheim, 68156, Germany
297 Department of Trauma- and Orthopaedic Surgery, BG Trauma Centre Ludwigshafen, Ludwig- Guttmann-Str.13, Ludwigshafen 67071, Germany
298 schema:name Clinical Laboratory Limbach, Im Breitspiel 15, Heidelberg, 69126, Germany
299 Department of Trauma and Orthopaedic Surgery, TKH Mannheim, Bassemannstrasse 1, Mannheim, 68156, Germany
300 Department of Trauma- and Orthopaedic Surgery, BG Trauma Centre Ludwigshafen, Ludwig- Guttmann-Str.13, Ludwigshafen 67071, Germany
301 rdf:type schema:Organization
302 grid-institutes:grid.418303.d schema:alternateName Department of Plastic-, Reconstructive and Hand surgery, Burn Care Centre, BG Unfallklinik Ludwigshafen, Ludwig-Guttmann-Str.13, Ludwigshafen, 67071, Germany
303 schema:name Department of Plastic-, Reconstructive and Hand surgery, Burn Care Centre, BG Unfallklinik Ludwigshafen, Ludwig-Guttmann-Str.13, Ludwigshafen, 67071, Germany
304 rdf:type schema:Organization
305 grid-institutes:grid.466188.5 schema:alternateName Department of Social and Legal Sciences, SRH Hochschule, Heidelberg, Ludwig-Guttmann-Str.6, Heidelberg, 69123, Germany
306 schema:name Department of Social and Legal Sciences, SRH Hochschule, Heidelberg, Ludwig-Guttmann-Str.6, Heidelberg, 69123, Germany
307 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...