Efficacy of strength and aerobic exercise on patient-reported outcomes and structural changes in patients with knee osteoarthritis: study protocol for ... View Full Text


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Article Info

DATE

2013-12

AUTHORS

Britt Elin Øiestad, Nina Østerås, Richard Frobell, Margreth Grotle, Helga Brøgger, May Arna Risberg

ABSTRACT

BACKGROUND: Despite an extensive literature on treatment interventions for patients with knee osteoarthritis, studies comparing the efficacy of different exercise interventions and living the life as usual on quality of life, cartilage quality and cost-effectiveness are lacking. The aim of the present study is to compare the efficacy of two different exercise programs compared to a control group in individuals with established radiographic and symptomatic knee osteoarthritis on self-reported knee-related quality of life, knee pain, physical function, and cartilage quality. METHODS/DESIGN: A three-armed randomized controlled trial involving two exercise interventions and a control group of individuals doing as they usually do is described. The patients will have mild to moderate radiographic osteoarthritis according to the Kellgren and Lawrence classification (grade 2-3), and fulfill the American College of Rheumatology clinical criteria, be aged between 45 and 65 years, and have no other serious physical or mental illnesses. The patients will be randomly allocated to a strength exercise group; a cycling group, or a control group. The primary outcome is the Knee injury and Osteoarthritis Outcome Score knee-related quality of life subscale. Secondary outcomes include all five Knee Injury and Osteoarthritis Outcome Score subscales, morphological evaluation of cartilage including focal thickness, subchondral bone marrow edema, proteoglycan content and collagen degradation (measured using magnetic resonance imaging clinical sequences, T2 mapping and T1ρ), specific serum biomarkers, isokinetic muscle strength, maximal oxygen uptake, quality of life (EuroQol 5D), and self-efficacy (Arthritis Self-Efficacy Scale). A sample size calculation on the primary outcome showed that 207 individuals, 69 in each group, is needed to detect a clinically relevant difference of 10 points with 80% power and a significance level of 5%. Assessments will be conducted at baseline, 14 weeks, 1 year and 2 years post-randomization. The interventions will be a 14 weeks exercise program. DISCUSSION: Although exercise therapy has been found to be effective in knee osteoarthritis, the knowledge of the underlying mechanisms for why exercise works is lacking. This study will contribute with knowledge on the efficacy of strength exercise versus cycling on patient-reported outcomes, cartilage quality and cost-effectiveness. TRIAL REGISTRATION: Clinicaltrial.gov Identifier: NCT01682980. More... »

PAGES

266

References to SciGraph publications

  • 2012-12. The implementation of a community-based aerobic walking program for mild to moderate knee osteoarthritis: A knowledge translation randomized controlled trial: Part II: Clinical outcomes in BMC PUBLIC HEALTH
  • 2008-12. Cutpoints for mild, moderate and severe pain in patients with osteoarthritis of the hip or knee ready for joint replacement surgery in BMC MUSCULOSKELETAL DISORDERS
  • 2012-04. Moderate loading of the human osteoarthritic knee joint leads to lowering of intraarticular cartilage oligomeric matrix protein in RHEUMATOLOGY INTERNATIONAL
  • 2010-08. Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial in ARTHRITIS RESEARCH & THERAPY
  • 2011-12. Comparison of neuromuscular and quadriceps strengthening exercise in the treatment of varus malaligned knees with medial knee osteoarthritis: a randomised controlled trial protocol in BMC MUSCULOSKELETAL DISORDERS
  • 2004-09. Fixed-flexion radiography of the knee provides reproducible joint space width measurements in osteoarthritis in EUROPEAN RADIOLOGY
  • 2013-12. Hand, hip and knee osteoarthritis in a Norwegian population-based study - The MUST protocol in BMC MUSCULOSKELETAL DISORDERS
  • 2003-12. The Knee injury and Osteoarthritis Outcome Score (KOOS): from joint injury to osteoarthritis in HEALTH AND QUALITY OF LIFE OUTCOMES
  • 2010-11. Early osteoarthritis and microdialysis: a novel in vivo approach for measurements of biochemical markers in the perisynovium and intraarticularly in KNEE SURGERY, SPORTS TRAUMATOLOGY, ARTHROSCOPY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1471-2474-14-266

    DOI

    http://dx.doi.org/10.1186/1471-2474-14-266

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049354362

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24028201


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