Anamnestic risk factor questionnaire as reliable diagnostic instrument for osteoporosis (reduced bone morphogenic density) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-08-17

AUTHORS

Leila Kolios, Caner Takur, Arash Moghaddam, Mirjam Hitzler, Heinrich Schmidt-Gayk, Arnold J Suda, Bernd Höner, Paul A Grützner, Christoph Wölfl

ABSTRACT

BACKGROUND: Osteoporosis is a major health problem worldwide, and is included in the WHO list of the top 10 major diseases. However, it is often undiagnosed until the first fracture occurs, due to inadequate patient education and lack of insurance coverage for screening tests. Anamnestic risk factors like positive family anamnesis or early menopause are assumed to correlate with reduced BMD. METHODS: In our study of 78 patients with metaphyseal long bone fractures, we searched for a correlation between anamnestic risk factors, bone specific laboratory values, and the bone morphogenic density (BMD). Each indicator was examined as a possible diagnostic instrument for osteoporosis. The secondary aim of this study was to demonstrate the high prevalence of osteoporosis in patients with metaphyseal fractures. RESULTS: 76.9% of our fracture patients had decreased bone density and 43.6% showed manifest osteoporosis in DXA (densitometry) measurements. Our questionnaire, identifying anamnestic risk factors, correlated highly significantly (p = 0.01) with reduced BMD, whereas seven bone-specific laboratory values (p = 0.046) correlated significantly. CONCLUSIONS: Anamnestic risk factors correlate with pathological BMD. The medical questionnaire used in this study would therefore function as a cost-effective primary diagnostic instrument for identification of osteoporosis patients. More... »

PAGES

187-187

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    http://scigraph.springernature.com/pub.10.1186/1471-2474-12-187

    DOI

    http://dx.doi.org/10.1186/1471-2474-12-187

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1012857304

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21849030


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    353 rdf:type schema:Organization
     




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