Time series analysis of demographic and temporal trends of tuberculosis in Singapore View Full Text


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Article Info

DATE

2014-12

AUTHORS

Win Wah, Sourav Das, Arul Earnest, Leo Kang Yang Lim, Cynthia Bin Eng Chee, Alex Richard Cook, Yee Tang Wang, Khin Mar Kyi Win, Marcus Eng Hock Ong, Li Yang Hsu

ABSTRACT

BACKGROUND: Singapore is an intermediate tuberculosis (TB) incidence country, with a recent rise in TB incidence from 2008, after a fall in incidence since 1998. This study identified population characteristics that were associated with the recent increase in TB cases, and built a predictive model of TB risk in Singapore. METHODS: Retrospective time series analysis was used to study TB notification data collected from 1995 to 2011 from the Singapore Tuberculosis Elimination Program (STEP) registry. A predictive model was developed based on the data collected from 1995 to 2010 and validated using the data collected in 2011. RESULTS: There was a significant difference in demographic characteristics between resident and non-resident TB cases. TB risk was higher in non-residents than in residents throughout the period. We found no significant association between demographic and macro-economic factors and annual incidence of TB with or without adjusting for the population-at-risk. Despite growing non-resident population, there was a significant decrease in the non-resident TB risk (p < 0.0001). However, there was no evidence of trend in the resident TB risk over this time period, though differences between different demographic groups were apparent with ethnic minorities experiencing higher incidence rates. CONCLUSION: The study found that despite an increasing size of non-resident population, TB risk among non-residents was decreasing at a rate of about 3% per year. There was an apparent seasonality in the TB reporting. More... »

PAGES

1121

References to SciGraph publications

  • 2000-05. A statistical analysis of the seasonality in pulmonary tuberculosis in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2011-03-15. Performance of Univariate Forecasting on Seasonal Diseases: The Case of Tuberculosis in SOFTWARE TOOLS AND ALGORITHMS FOR BIOLOGICAL SYSTEMS
  • 2011. Springer Texts in Statistics in NONE
  • 1966. Cancer Incidence in Five Continents in NONE
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    http://dx.doi.org/10.1186/1471-2458-14-1121

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25359711


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