Aripiprazole Augmentation in the Treatment of Military-Related PTSD with Major Depression: a retrospective chart review View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

J Don Richardson, Deniz Fikretoglu, Aihua Liu, Diane McIntosh

ABSTRACT

BACKGROUND: In this chart review, we attempted to evaluate the benefits of adding aripiprazole in veterans with military-related PTSD and comorbid depression, who had been minimally or partially responsive to their existing medications. METHODS: A retrospective chart review of patients who received an open-label, flexible-dose, 12- week course of adjunctive aripiprazole was conducted in 27 military veterans meeting DSM-IV criteria for PTSD and comorbid major depression. Concomitant psychiatric medications continued unchanged, except for other antipsychotics which were discontinued prior to initiating aripiprazole. The primary outcome variable was a change from baseline in the PTSD checklist-military version (PCL-M) and the Beck Depression Inventory (BDI-II). RESULTS: PTSD severity (Total PCL scores) decreased from 56.11 at baseline to 46.85 at 12-weeks (p < 0.0001 from Wilcoxon signed rank test) and the depression severity decreased from 30.44 at baseline to 20.67 at 12-weeks (p < 0.0001 from Wilcoxon signed rank test). Thirty seven percent (10/27) were considered responders, as defined by a decrease in total PCL scores of at least 20 percent and 19% (5/27) were considered as responders as defined by a decrease in total BDI score of at least 50%. CONCLUSIONS: The addition of aripiprazole contributed to a reduction in both PTSD and depression symptomatology in a population that has traditionally demonstrated poor pharmacological response. Further investigations, including double-blind, placebo-controlled studies, are essential to confirm and further demonstrate the benefit of aripiprazole augmentation in the treatment of military related PTSD. More... »

PAGES

86

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-244x-11-86

DOI

http://dx.doi.org/10.1186/1471-244x-11-86

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040025118

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21586149


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-244x-11-86'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-244x-11-86'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-244x-11-86'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-244x-11-86'


 

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293 schema:name Department of Psychiatry, Schulich School of Medicine and Dentistry, University of Western Ontario, Canada
294 National Centre for Operational Stress Injuries, Veterans Affairs Canada, Montreal, Quebec, Canada
295 Operational Stress Injury Clinic, St. Joseph's Health Care London - Parkwood Hospital, London, Ontario, Canada
296 rdf:type schema:Organization
 




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