Ontology type: schema:ScholarlyArticle Open Access: True
2014-12
AUTHORSPasquale Aragona, Laura Rania, Anna Maria Roszkowska, Domenico Puzzolo, Antonio Micali, Antonina Pisani, Giuseppina Salzano, Maria Francesca Messina
ABSTRACTBACKGROUND: Allgrove's 4A syndrome determines ocular surface changes. This is the first report providing an up-to-dated analysis of the ocular surface in an affected patient. CASE PRESENTATION: An 18-years-old male Caucasian patient, with a complex progressive gait disorder and adrenal insufficiency, was referred for ophthalmic evaluation, as part of the clinical assessment. He underwent the following tests: best corrected visual acuity, tear osmolarity, tear film break-up time (BUT), corneal fluorescein staining, Schirmer's I test, lid margin assessment, corneal sensitivity, in vivo corneal confocal microscopy, conjunctival impression cytology, tonometry and fundus exam. A dry eye condition was documented by the Schirmer's I test of 0 mm/5' in both eyes, accompanied by tear hyperosmolarity, mild meibomian gland dysfunction, reduced BUT, mucus filaments in the tear film and conjunctival epithelium metaplasic changes. The corneal confocal microscopy showed the presence of activated keratocytes, while the nerve pattern was normal. CONCLUSIONS: The dry eye in this patient appears to be due to tear aqueous deficiency and can be considered as part of the 4A syndrome. The decreased tear production, resulting from a deterioration of the autonomic innervation of the lacrimal glands rather than an impaired corneal innervation, can be considered as part of the systemic autonomic dysfunction present in this disease. More... »
PAGES155
http://scigraph.springernature.com/pub.10.1186/1471-2415-14-155
DOIhttp://dx.doi.org/10.1186/1471-2415-14-155
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1018973645
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/25488127
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1113",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Ophthalmology and Optometry",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adolescent",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adrenal Insufficiency",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Conjunctiva",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Consanguinity",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Corneal Keratocytes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Dry Eye Syndromes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Epithelium, Corneal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Esophageal Achalasia",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Italy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Microscopy, Confocal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Osmolar Concentration",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tears",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Visual Acuity",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Messina",
"id": "https://www.grid.ac/institutes/grid.10438.3e",
"name": [
"Department of Experimental Medical-Surgical Sciences, Ocular Surface Diseases Unit, University of Messina, Via Consolare Valeria 1, I-98125, Messina, Italy"
],
"type": "Organization"
},
"familyName": "Aragona",
"givenName": "Pasquale",
"id": "sg:person.01000245771.23",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000245771.23"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Messina",
"id": "https://www.grid.ac/institutes/grid.10438.3e",
"name": [
"Department of Experimental Medical-Surgical Sciences, Ocular Surface Diseases Unit, University of Messina, Via Consolare Valeria 1, I-98125, Messina, Italy"
],
"type": "Organization"
},
"familyName": "Rania",
"givenName": "Laura",
"id": "sg:person.01052410454.01",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052410454.01"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Messina",
"id": "https://www.grid.ac/institutes/grid.10438.3e",
"name": [
"Department of Experimental Medical-Surgical Sciences, Ocular Surface Diseases Unit, University of Messina, Via Consolare Valeria 1, I-98125, Messina, Italy"
],
"type": "Organization"
},
"familyName": "Roszkowska",
"givenName": "Anna Maria",
"id": "sg:person.01001555663.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001555663.02"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Messina",
"id": "https://www.grid.ac/institutes/grid.10438.3e",
"name": [
"Department of Biomedical Sciences and Morphofunctional Imaging, University of Messina, Via Consolare Valeria 1, I-98125, Messina, Italy"
],
"type": "Organization"
},
"familyName": "Puzzolo",
"givenName": "Domenico",
"id": "sg:person.01353152616.93",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353152616.93"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Messina",
"id": "https://www.grid.ac/institutes/grid.10438.3e",
"name": [
"Department of Biomedical Sciences and Morphofunctional Imaging, University of Messina, Via Consolare Valeria 1, I-98125, Messina, Italy"
],
"type": "Organization"
},
"familyName": "Micali",
"givenName": "Antonio",
"id": "sg:person.01225061671.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225061671.17"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Messina",
"id": "https://www.grid.ac/institutes/grid.10438.3e",
"name": [
"Department of Biomedical Sciences and Morphofunctional Imaging, University of Messina, Via Consolare Valeria 1, I-98125, Messina, Italy"
],
"type": "Organization"
},
"familyName": "Pisani",
"givenName": "Antonina",
"id": "sg:person.01305037416.84",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305037416.84"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Messina",
"id": "https://www.grid.ac/institutes/grid.10438.3e",
"name": [
"Department of Pediatric, Gynecological, Microbiological and Biomedical Sciences, University of Messina, Via Consolare Valeria 1, I-98125, Messina, Italy"
],
"type": "Organization"
},
"familyName": "Salzano",
"givenName": "Giuseppina",
"id": "sg:person.01133322621.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133322621.53"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Messina",
"id": "https://www.grid.ac/institutes/grid.10438.3e",
"name": [
"Department of Pediatric, Gynecological, Microbiological and Biomedical Sciences, University of Messina, Via Consolare Valeria 1, I-98125, Messina, Italy"
],
"type": "Organization"
},
"familyName": "Messina",
"givenName": "Maria Francesca",
"id": "sg:person.01041111212.74",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041111212.74"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/bf03346490",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002253967",
"https://doi.org/10.1007/bf03346490"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/adc.68.6.779",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018919314"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(78)91268-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021502010"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(78)91268-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021502010"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.preteyeres.2009.04.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032076216"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00019605-200107000-00016",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032935751"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1067/mpa.2002.124653",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033325003"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1399-0004.2009.01348.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034288244"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1399-0004.2009.01348.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034288244"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1471-2415-4-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037176723",
"https://doi.org/10.1186/1471-2415-4-7"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/eye.1998.105",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039080259",
"https://doi.org/10.1038/eye.1998.105"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01972967",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039220356",
"https://doi.org/10.1007/bf01972967"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01972967",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039220356",
"https://doi.org/10.1007/bf01972967"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/eye.1996.12",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047581432",
"https://doi.org/10.1038/eye.1996.12"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/eye.1996.12",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047581432",
"https://doi.org/10.1038/eye.1996.12"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/bjophthalmol-2012-302568",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050265835"
],
"type": "CreativeWork"
}
],
"datePublished": "2014-12",
"datePublishedReg": "2014-12-01",
"description": "BACKGROUND: Allgrove's 4A syndrome determines ocular surface changes. This is the first report providing an up-to-dated analysis of the ocular surface in an affected patient.\nCASE PRESENTATION: An 18-years-old male Caucasian patient, with a complex progressive gait disorder and adrenal insufficiency, was referred for ophthalmic evaluation, as part of the clinical assessment. He underwent the following tests: best corrected visual acuity, tear osmolarity, tear film break-up time (BUT), corneal fluorescein staining, Schirmer's I test, lid margin assessment, corneal sensitivity, in vivo corneal confocal microscopy, conjunctival impression cytology, tonometry and fundus exam. A dry eye condition was documented by the Schirmer's I test of 0 mm/5' in both eyes, accompanied by tear hyperosmolarity, mild meibomian gland dysfunction, reduced BUT, mucus filaments in the tear film and conjunctival epithelium metaplasic changes. The corneal confocal microscopy showed the presence of activated keratocytes, while the nerve pattern was normal.\nCONCLUSIONS: The dry eye in this patient appears to be due to tear aqueous deficiency and can be considered as part of the 4A syndrome. The decreased tear production, resulting from a deterioration of the autonomic innervation of the lacrimal glands rather than an impaired corneal innervation, can be considered as part of the systemic autonomic dysfunction present in this disease.",
"genre": "research_article",
"id": "sg:pub.10.1186/1471-2415-14-155",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1024634",
"issn": [
"1471-2415"
],
"name": "BMC Ophthalmology",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "14"
}
],
"name": "4A syndrome: ocular surface investigation in an Italian young patient",
"pagination": "155",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"5a6707f28b2bb9da51c8dab4e5498cf8c320727589e9f8f11119aaa95d4fcf09"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"25488127"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"100967802"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/1471-2415-14-155"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1018973645"
]
}
],
"sameAs": [
"https://doi.org/10.1186/1471-2415-14-155",
"https://app.dimensions.ai/details/publication/pub.1018973645"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T20:47",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000512.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1186%2F1471-2415-14-155"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2415-14-155'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2415-14-155'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2415-14-155'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2415-14-155'
This table displays all metadata directly associated to this object as RDF triples.
220 TRIPLES
21 PREDICATES
56 URIs
36 LITERALS
24 BLANK NODES