YKL-40 tissue expression and plasma levels in patients with ovarian cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-01-09

AUTHORS

Estrid VS Høgdall, Merete Ringsholt, Claus K Høgdall, Ib Jarle Christensen, Julia S Johansen, Susanne K Kjaer, Jan Blaakaer, Lene Ostenfeld-Møller, Paul A Price, Lise H Christensen

ABSTRACT

BACKGROUND: YKL-40 (chitinase-3-like-1) is a member of "mammalian chitinase-like proteins". The protein is expressed in many types of cancer cells and the highest plasma YKL-40 levels have been found in patients with metastatic disease, short recurrence/progression-free intervals, and short overall survival. The aim of the study was to determine the expression of YKL-40 in tumor tissue and plasma in patients with borderline ovarian tumor or epithelial ovarian cancer (OC), and investigate prognostic value of this marker. METHODS: YKL-40 protein expression was determined by immunohistochemistry in tissue arrays from 181 borderline tumors and 473 OC. Plasma YKL-40 was determined by ELISA in preoperative samples from 19 patients with borderline tumor and 76 OC patients. RESULTS: YKL-40 protein expression was found in cancer cells, tumor associated macrophages, neutrophils and mast cells. The tumor cell expression was higher in OC than in borderline tumors (p = 0.001), and associated with FIGO stage (p < 0.0001) and histological subtype (p = 0.0009). Positive YKL-40 expression (>or= 5% staining) was not associated with reduced survival. Plasma YKL-40 was also higher in patients with OC than in patients with borderline tumors (p < 0.0001), and it was positively correlated to serum CA-125 (p < 0.0001) and FIGO stage (p = 0.0001). Univariate Cox analysis of plasma YKL-40 showed association with overall survival (p < 0.0001). Multivariate Cox analysis, including plasma YKL-40, serum CA125, FIGO stage, age and radicality after primary surgery as variables, showed that elevated plasma YKL-40 was associated with a shorter survival (HR = 2.13, 95% CI: 1.40-3.25, p = 0.0004). CONCLUSION: YKL-40 in OC tissue and plasma are related to stage and histology, but only plasma YKL-40 is a prognostic biomarker in patients with OC. More... »

PAGES

8-8

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2407-9-8

DOI

http://dx.doi.org/10.1186/1471-2407-9-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008247985

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19134206


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83 plasma YKL-40 levels
84 plasma levels
85 preoperative samples
86 primary surgery
87 prognostic biomarker
88 prognostic value
89 progression-free interval
90 protein
91 protein expression
92 radicality
93 recurrence/progression-free intervals
94 samples
95 serum CA125
96 short recurrence/progression-free intervals
97 shorter overall survival
98 shorter survival
99 stage
100 study
101 subtypes
102 surgery
103 survival
104 tissue
105 tissue arrays
106 tissue expression
107 tumor cell expression
108 tumor tissue
109 tumors
110 types
111 values
112 variables
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