Functional characterization of E- and P-cadherin in invasive breast cancer cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-03-03

AUTHORS

David Sarrió, José Palacios, Marta Hergueta-Redondo, Gonzalo Gómez-López, Amparo Cano, Gema Moreno-Bueno

ABSTRACT

BACKGROUND: Alterations in the cadherin-catenin adhesion complexes are involved in tumor initiation, progression and metastasis. However, the functional implication of distinct cadherin types in breast cancer biology is still poorly understood. METHODS: To compare the functional role of E-cadherin and P-cadherin in invasive breast cancer, we stably transfected these molecules into the MDA-MB-231 cell line, and investigated their effects on motility, invasion and gene expression regulation. RESULTS: Expression of either E- and P-cadherin significantly increased cell aggregation and induced a switch from fibroblastic to epithelial morphology. Although expression of these cadherins did not completely reverse the mesenchymal phenotype of MDA-MB-231 cells, both E- and P-cadherin decreased fibroblast-like migration and invasion through extracellular matrix in a similar way. Moreover, microarray gene expression analysis of MDA-MB-231 cells after expression of E- and P-cadherins revealed that these molecules can activate signaling pathways leading to significant changes in gene expression. Although the expression patterns induced by E- and P-cadherin showed more similarities than differences, 40 genes were differentially modified by the expression of either cadherin type. CONCLUSION: E- and P-cadherin have similar functional consequences on the phenotype and invasive behavior of MDA-MB-231 cells. Moreover, we demonstrate for the first time that these cadherins can induce both common and specific gene expression programs on invasive breast cancer cells. Importantly, these identified genes are potential targets for future studies on the functional consequences of altered cadherin expression in human breast cancer. More... »

PAGES

74-74

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2407-9-74

DOI

http://dx.doi.org/10.1186/1471-2407-9-74

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032723844

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19257890


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cadherins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, SW3 6JB, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Department of Biochemistry UAM, Instituto de Investigaciones Biom\u00e9dicas \"Alberto Sols\" (CSIC-UAM), C/Arturo Duperier 4. 28029, Madrid, Spain", 
            "Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, SW3 6JB, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sarri\u00f3", 
        "givenName": "David", 
        "id": "sg:person.0734435312.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734435312.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Servicio de Anatom\u00eda Patol\u00f3gica, Hospital Virgen del Roc\u00edo, Avda, Manuel Siurot S/N, 41013, Sevilla, Spain", 
          "id": "http://www.grid.ac/institutes/grid.411109.c", 
          "name": [
            "Servicio de Anatom\u00eda Patol\u00f3gica, Hospital Virgen del Roc\u00edo, Avda, Manuel Siurot S/N, 41013, Sevilla, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Palacios", 
        "givenName": "Jos\u00e9", 
        "id": "sg:person.0712056620.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712056620.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry UAM, Instituto de Investigaciones Biom\u00e9dicas \"Alberto Sols\" (CSIC-UAM), C/Arturo Duperier 4. 28029, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.466793.9", 
          "name": [
            "Department of Biochemistry UAM, Instituto de Investigaciones Biom\u00e9dicas \"Alberto Sols\" (CSIC-UAM), C/Arturo Duperier 4. 28029, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hergueta-Redondo", 
        "givenName": "Marta", 
        "id": "sg:person.01000265421.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000265421.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bioinformatics Unit, UBio, Spanish National Cancer Research Center, CNIO, C/Melchor Fern\u00e1ndez Almagro, 28029 Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Bioinformatics Unit, UBio, Spanish National Cancer Research Center, CNIO, C/Melchor Fern\u00e1ndez Almagro, 28029 Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "G\u00f3mez-L\u00f3pez", 
        "givenName": "Gonzalo", 
        "id": "sg:person.0700636421.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700636421.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry UAM, Instituto de Investigaciones Biom\u00e9dicas \"Alberto Sols\" (CSIC-UAM), C/Arturo Duperier 4. 28029, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.466793.9", 
          "name": [
            "Department of Biochemistry UAM, Instituto de Investigaciones Biom\u00e9dicas \"Alberto Sols\" (CSIC-UAM), C/Arturo Duperier 4. 28029, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cano", 
        "givenName": "Amparo", 
        "id": "sg:person.01321371146.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321371146.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry UAM, Instituto de Investigaciones Biom\u00e9dicas \"Alberto Sols\" (CSIC-UAM), C/Arturo Duperier 4. 28029, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.466793.9", 
          "name": [
            "Department of Biochemistry UAM, Instituto de Investigaciones Biom\u00e9dicas \"Alberto Sols\" (CSIC-UAM), C/Arturo Duperier 4. 28029, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moreno-Bueno", 
        "givenName": "Gema", 
        "id": "sg:person.01067577224.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067577224.00"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s004280100516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031441774", 
          "https://doi.org/10.1007/s004280100516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3700158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045004530", 
          "https://doi.org/10.1038/labinvest.3700158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3880367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029826182", 
          "https://doi.org/10.1038/modpathol.3880367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1276", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003923555", 
          "https://doi.org/10.1038/nrc1276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207439", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021772643", 
          "https://doi.org/10.1038/sj.onc.1207439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035761697", 
          "https://doi.org/10.1038/sj.onc.1209396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052733880", 
          "https://doi.org/10.1186/bcr309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc822", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020528453", 
          "https://doi.org/10.1038/nrc822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025092385", 
          "https://doi.org/10.1038/nrc2131"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-03-03", 
    "datePublishedReg": "2009-03-03", 
    "description": "BACKGROUND: Alterations in the cadherin-catenin adhesion complexes are involved in tumor initiation, progression and metastasis. However, the functional implication of distinct cadherin types in breast cancer biology is still poorly understood.\nMETHODS: To compare the functional role of E-cadherin and P-cadherin in invasive breast cancer, we stably transfected these molecules into the MDA-MB-231 cell line, and investigated their effects on motility, invasion and gene expression regulation.\nRESULTS: Expression of either E- and P-cadherin significantly increased cell aggregation and induced a switch from fibroblastic to epithelial morphology. Although expression of these cadherins did not completely reverse the mesenchymal phenotype of MDA-MB-231 cells, both E- and P-cadherin decreased fibroblast-like migration and invasion through extracellular matrix in a similar way. Moreover, microarray gene expression analysis of MDA-MB-231 cells after expression of E- and P-cadherins revealed that these molecules can activate signaling pathways leading to significant changes in gene expression. Although the expression patterns induced by E- and P-cadherin showed more similarities than differences, 40 genes were differentially modified by the expression of either cadherin type.\nCONCLUSION: E- and P-cadherin have similar functional consequences on the phenotype and invasive behavior of MDA-MB-231 cells. Moreover, we demonstrate for the first time that these cadherins can induce both common and specific gene expression programs on invasive breast cancer cells. Importantly, these identified genes are potential targets for future studies on the functional consequences of altered cadherin expression in human breast cancer.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/1471-2407-9-74", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.8483119", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1024632", 
        "issn": [
          "1471-2407"
        ], 
        "name": "BMC Cancer", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "keywords": [
      "invasive breast cancer cells", 
      "MDA-MB-231 cells", 
      "cadherin types", 
      "specific gene expression programs", 
      "cadherin-catenin adhesion complex", 
      "breast cancer cells", 
      "gene expression regulation", 
      "gene expression programs", 
      "functional consequences", 
      "microarray gene expression analysis", 
      "similar functional consequences", 
      "gene expression analysis", 
      "cancer cells", 
      "expression programs", 
      "expression regulation", 
      "adhesion complexes", 
      "functional characterization", 
      "expression analysis", 
      "gene expression", 
      "expression patterns", 
      "mesenchymal phenotype", 
      "cancer biology", 
      "functional role", 
      "extracellular matrix", 
      "cell aggregation", 
      "functional implications", 
      "tumor initiation", 
      "cadherin", 
      "invasive behavior", 
      "cadherin expression", 
      "MDA-MB-231 cell line", 
      "cell lines", 
      "epithelial morphology", 
      "potential target", 
      "genes", 
      "breast cancer biology", 
      "expression", 
      "human breast cancer", 
      "phenotype", 
      "cells", 
      "invasion", 
      "biology", 
      "more similarities", 
      "molecules", 
      "regulation", 
      "pathway", 
      "first time", 
      "motility", 
      "future studies", 
      "complexes", 
      "similarity", 
      "breast cancer", 
      "similar way", 
      "migration", 
      "target", 
      "aggregation", 
      "cancer", 
      "alterations", 
      "consequences", 
      "role", 
      "lines", 
      "initiation", 
      "characterization", 
      "progression", 
      "switch", 
      "patterns", 
      "types", 
      "morphology", 
      "significant changes", 
      "metastasis", 
      "changes", 
      "analysis", 
      "implications", 
      "effect", 
      "differences", 
      "study", 
      "matrix", 
      "program", 
      "time", 
      "behavior", 
      "way", 
      "invasive breast cancer", 
      "distinct cadherin types", 
      "fibroblast-like migration"
    ], 
    "name": "Functional characterization of E- and P-cadherin in invasive breast cancer cells", 
    "pagination": "74-74", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032723844"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2407-9-74"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19257890"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2407-9-74", 
      "https://app.dimensions.ai/details/publication/pub.1032723844"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_501.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/1471-2407-9-74"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-9-74'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-9-74'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-9-74'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-9-74'


 

This table displays all metadata directly associated to this object as RDF triples.

264 TRIPLES      22 PREDICATES      128 URIs      111 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2407-9-74 schema:about N00a8a5599ecf42fa8366fe9b08b78974
2 N0a1222335de44d3d8d69116270dffe68
3 N3cbdd440bf5545349c0a1b50e78b5ce8
4 N4d5bed90cfdb4a52bcd35ff7828de26e
5 N69f42f046a4440f292ed51ef43bef13a
6 N895d7129f2f744a094e84fa742faf8a2
7 Na23e6c2cd3794648b225a841b18b70c3
8 Nb89fd682be4d4106b1c3c4d02f7c21d3
9 Nf6be32e2e77a4dbd9579ff0891a96ad0
10 anzsrc-for:11
11 anzsrc-for:1112
12 schema:author Nc7bc1ee289a54f9b84040081ce5d5b04
13 schema:citation sg:pub.10.1007/s004280100516
14 sg:pub.10.1038/labinvest.3700158
15 sg:pub.10.1038/modpathol.3880367
16 sg:pub.10.1038/nrc1276
17 sg:pub.10.1038/nrc2131
18 sg:pub.10.1038/nrc822
19 sg:pub.10.1038/sj.onc.1207439
20 sg:pub.10.1038/sj.onc.1209396
21 sg:pub.10.1186/bcr309
22 schema:datePublished 2009-03-03
23 schema:datePublishedReg 2009-03-03
24 schema:description BACKGROUND: Alterations in the cadherin-catenin adhesion complexes are involved in tumor initiation, progression and metastasis. However, the functional implication of distinct cadherin types in breast cancer biology is still poorly understood. METHODS: To compare the functional role of E-cadherin and P-cadherin in invasive breast cancer, we stably transfected these molecules into the MDA-MB-231 cell line, and investigated their effects on motility, invasion and gene expression regulation. RESULTS: Expression of either E- and P-cadherin significantly increased cell aggregation and induced a switch from fibroblastic to epithelial morphology. Although expression of these cadherins did not completely reverse the mesenchymal phenotype of MDA-MB-231 cells, both E- and P-cadherin decreased fibroblast-like migration and invasion through extracellular matrix in a similar way. Moreover, microarray gene expression analysis of MDA-MB-231 cells after expression of E- and P-cadherins revealed that these molecules can activate signaling pathways leading to significant changes in gene expression. Although the expression patterns induced by E- and P-cadherin showed more similarities than differences, 40 genes were differentially modified by the expression of either cadherin type. CONCLUSION: E- and P-cadherin have similar functional consequences on the phenotype and invasive behavior of MDA-MB-231 cells. Moreover, we demonstrate for the first time that these cadherins can induce both common and specific gene expression programs on invasive breast cancer cells. Importantly, these identified genes are potential targets for future studies on the functional consequences of altered cadherin expression in human breast cancer.
25 schema:genre article
26 schema:inLanguage en
27 schema:isAccessibleForFree true
28 schema:isPartOf N24102b032b97440cb8650fd11cf877d7
29 Ndf60075814d64df4b4115c793949e931
30 sg:journal.1024632
31 schema:keywords MDA-MB-231 cell line
32 MDA-MB-231 cells
33 adhesion complexes
34 aggregation
35 alterations
36 analysis
37 behavior
38 biology
39 breast cancer
40 breast cancer biology
41 breast cancer cells
42 cadherin
43 cadherin expression
44 cadherin types
45 cadherin-catenin adhesion complex
46 cancer
47 cancer biology
48 cancer cells
49 cell aggregation
50 cell lines
51 cells
52 changes
53 characterization
54 complexes
55 consequences
56 differences
57 distinct cadherin types
58 effect
59 epithelial morphology
60 expression
61 expression analysis
62 expression patterns
63 expression programs
64 expression regulation
65 extracellular matrix
66 fibroblast-like migration
67 first time
68 functional characterization
69 functional consequences
70 functional implications
71 functional role
72 future studies
73 gene expression
74 gene expression analysis
75 gene expression programs
76 gene expression regulation
77 genes
78 human breast cancer
79 implications
80 initiation
81 invasion
82 invasive behavior
83 invasive breast cancer
84 invasive breast cancer cells
85 lines
86 matrix
87 mesenchymal phenotype
88 metastasis
89 microarray gene expression analysis
90 migration
91 molecules
92 more similarities
93 morphology
94 motility
95 pathway
96 patterns
97 phenotype
98 potential target
99 program
100 progression
101 regulation
102 role
103 significant changes
104 similar functional consequences
105 similar way
106 similarity
107 specific gene expression programs
108 study
109 switch
110 target
111 time
112 tumor initiation
113 types
114 way
115 schema:name Functional characterization of E- and P-cadherin in invasive breast cancer cells
116 schema:pagination 74-74
117 schema:productId N75fe720087ca4ebbbc08cfde87222634
118 Na2ebf364b04745dc95ddbb4125a1679f
119 Nc166a2fbbd5740f4aaeaefc430dddeec
120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032723844
121 https://doi.org/10.1186/1471-2407-9-74
122 schema:sdDatePublished 2022-01-01T18:22
123 schema:sdLicense https://scigraph.springernature.com/explorer/license/
124 schema:sdPublisher N8251482665dd44058afec75eb98837ff
125 schema:url https://doi.org/10.1186/1471-2407-9-74
126 sgo:license sg:explorer/license/
127 sgo:sdDataset articles
128 rdf:type schema:ScholarlyArticle
129 N00a8a5599ecf42fa8366fe9b08b78974 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Cell Movement
131 rdf:type schema:DefinedTerm
132 N02dfaed0e2f44f68a61c2773c5ba3a9a rdf:first sg:person.01000265421.21
133 rdf:rest N23e41014d27e41d28b3e04c24cfa4fd8
134 N0a1222335de44d3d8d69116270dffe68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Breast Neoplasms
136 rdf:type schema:DefinedTerm
137 N23e41014d27e41d28b3e04c24cfa4fd8 rdf:first sg:person.0700636421.39
138 rdf:rest N88dc8ede8a994317aec277db62396eeb
139 N24102b032b97440cb8650fd11cf877d7 schema:volumeNumber 9
140 rdf:type schema:PublicationVolume
141 N3cbdd440bf5545349c0a1b50e78b5ce8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Transfection
143 rdf:type schema:DefinedTerm
144 N4d5bed90cfdb4a52bcd35ff7828de26e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Humans
146 rdf:type schema:DefinedTerm
147 N69f42f046a4440f292ed51ef43bef13a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Cell Line, Tumor
149 rdf:type schema:DefinedTerm
150 N6bee0db2f0464205b1077aec1d1026a3 rdf:first sg:person.01067577224.00
151 rdf:rest rdf:nil
152 N75fe720087ca4ebbbc08cfde87222634 schema:name doi
153 schema:value 10.1186/1471-2407-9-74
154 rdf:type schema:PropertyValue
155 N8251482665dd44058afec75eb98837ff schema:name Springer Nature - SN SciGraph project
156 rdf:type schema:Organization
157 N88dc8ede8a994317aec277db62396eeb rdf:first sg:person.01321371146.38
158 rdf:rest N6bee0db2f0464205b1077aec1d1026a3
159 N895d7129f2f744a094e84fa742faf8a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Cadherins
161 rdf:type schema:DefinedTerm
162 Na23e6c2cd3794648b225a841b18b70c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Transcription, Genetic
164 rdf:type schema:DefinedTerm
165 Na2ebf364b04745dc95ddbb4125a1679f schema:name dimensions_id
166 schema:value pub.1032723844
167 rdf:type schema:PropertyValue
168 Nb89fd682be4d4106b1c3c4d02f7c21d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Neoplasm Invasiveness
170 rdf:type schema:DefinedTerm
171 Nc166a2fbbd5740f4aaeaefc430dddeec schema:name pubmed_id
172 schema:value 19257890
173 rdf:type schema:PropertyValue
174 Nc7bc1ee289a54f9b84040081ce5d5b04 rdf:first sg:person.0734435312.17
175 rdf:rest Ne6c92be923474ab58f26b14f9e5460d9
176 Ndf60075814d64df4b4115c793949e931 schema:issueNumber 1
177 rdf:type schema:PublicationIssue
178 Ne6c92be923474ab58f26b14f9e5460d9 rdf:first sg:person.0712056620.00
179 rdf:rest N02dfaed0e2f44f68a61c2773c5ba3a9a
180 Nf6be32e2e77a4dbd9579ff0891a96ad0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Gene Expression Regulation, Neoplastic
182 rdf:type schema:DefinedTerm
183 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
184 schema:name Medical and Health Sciences
185 rdf:type schema:DefinedTerm
186 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
187 schema:name Oncology and Carcinogenesis
188 rdf:type schema:DefinedTerm
189 sg:grant.8483119 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2407-9-74
190 rdf:type schema:MonetaryGrant
191 sg:journal.1024632 schema:issn 1471-2407
192 schema:name BMC Cancer
193 schema:publisher Springer Nature
194 rdf:type schema:Periodical
195 sg:person.01000265421.21 schema:affiliation grid-institutes:grid.466793.9
196 schema:familyName Hergueta-Redondo
197 schema:givenName Marta
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000265421.21
199 rdf:type schema:Person
200 sg:person.01067577224.00 schema:affiliation grid-institutes:grid.466793.9
201 schema:familyName Moreno-Bueno
202 schema:givenName Gema
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067577224.00
204 rdf:type schema:Person
205 sg:person.01321371146.38 schema:affiliation grid-institutes:grid.466793.9
206 schema:familyName Cano
207 schema:givenName Amparo
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321371146.38
209 rdf:type schema:Person
210 sg:person.0700636421.39 schema:affiliation grid-institutes:grid.7719.8
211 schema:familyName Gómez-López
212 schema:givenName Gonzalo
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700636421.39
214 rdf:type schema:Person
215 sg:person.0712056620.00 schema:affiliation grid-institutes:grid.411109.c
216 schema:familyName Palacios
217 schema:givenName José
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712056620.00
219 rdf:type schema:Person
220 sg:person.0734435312.17 schema:affiliation grid-institutes:grid.18886.3f
221 schema:familyName Sarrió
222 schema:givenName David
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734435312.17
224 rdf:type schema:Person
225 sg:pub.10.1007/s004280100516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031441774
226 https://doi.org/10.1007/s004280100516
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/labinvest.3700158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045004530
229 https://doi.org/10.1038/labinvest.3700158
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/modpathol.3880367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029826182
232 https://doi.org/10.1038/modpathol.3880367
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/nrc1276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003923555
235 https://doi.org/10.1038/nrc1276
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/nrc2131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025092385
238 https://doi.org/10.1038/nrc2131
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/nrc822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020528453
241 https://doi.org/10.1038/nrc822
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/sj.onc.1207439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021772643
244 https://doi.org/10.1038/sj.onc.1207439
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/sj.onc.1209396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035761697
247 https://doi.org/10.1038/sj.onc.1209396
248 rdf:type schema:CreativeWork
249 sg:pub.10.1186/bcr309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052733880
250 https://doi.org/10.1186/bcr309
251 rdf:type schema:CreativeWork
252 grid-institutes:grid.18886.3f schema:alternateName Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, SW3 6JB, London, UK
253 schema:name Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, SW3 6JB, London, UK
254 Department of Biochemistry UAM, Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), C/Arturo Duperier 4. 28029, Madrid, Spain
255 rdf:type schema:Organization
256 grid-institutes:grid.411109.c schema:alternateName Servicio de Anatomía Patológica, Hospital Virgen del Rocío, Avda, Manuel Siurot S/N, 41013, Sevilla, Spain
257 schema:name Servicio de Anatomía Patológica, Hospital Virgen del Rocío, Avda, Manuel Siurot S/N, 41013, Sevilla, Spain
258 rdf:type schema:Organization
259 grid-institutes:grid.466793.9 schema:alternateName Department of Biochemistry UAM, Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), C/Arturo Duperier 4. 28029, Madrid, Spain
260 schema:name Department of Biochemistry UAM, Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), C/Arturo Duperier 4. 28029, Madrid, Spain
261 rdf:type schema:Organization
262 grid-institutes:grid.7719.8 schema:alternateName Bioinformatics Unit, UBio, Spanish National Cancer Research Center, CNIO, C/Melchor Fernández Almagro, 28029 Madrid, Spain
263 schema:name Bioinformatics Unit, UBio, Spanish National Cancer Research Center, CNIO, C/Melchor Fernández Almagro, 28029 Madrid, Spain
264 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...