Preoperative serum carcinoembryonic antigen, albumin and age are supplementary to UICC staging systems in predicting survival for colorectal cancer patients ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-08-20

AUTHORS

Li-Chu Sun, Koung-Shing Chu, Su-Chen Cheng, Chien-Yu Lu, Chao-Hung Kuo, Jan-Sing Hsieh, Ying-Ling Shih, Shun-Jen Chang, Jaw-Yuan Wang

ABSTRACT

BackgroundThe aim of this study was to determine influence of prognostic factors in addition to UICC staging systems, on cancer-specific and overall survival rates for patients with colorectal cancer (CRC) undergoing surgical treatment.MethodsBetween January 1996 and December 2006, a total of 1367 CRC patients who underwent surgical treatment in Kaohsiung Medical University Hospital were analyzed. We retrospectively investigated clinicopathologic features of these patients. All patients were followed up intensively, and their outcomes were investigated completely.ResultsOf 1367 CRC patients, there were seven hundred and fifty-seven males (55.4%) and 610 (44.6%) females. The median follow-up period was 60 months (range, 3–132 months). A multivariate analysis identified that low serum albumin level (P = 0.011), advanced UICC stage (P < 0.001), and high carcinoembryonic antigen (CEA) level (P < 0.001) were independent prognostic factors of cancer-specific survival. Meanwhile, a multivariate analysis showed age over 65 years (P < 0.001), advanced UICC stage (P < 0.001), and high CEA level (P < 0.001) were independent prognostic factors of overall survival. Furthermore, combination of UICC stage, serum CEA and albumin levels as predictors of cancer-specific survival showed that the poorer the prognostic factors involved, the poorer the cancer-specific survival rate. Likewise, combination of UICC stage, age and serum CEA level as predictors of overall survival showed that the poorer the prognostic factors involved, the poorer the overall survival rate. Of these prognostic factors, preoperative serum CEA level was the only significant prognostic factor for patients with stage II and III CRCs in both cancer-specific and overall survival categories.ConclusionPreoperative serum albumin level, CEA level and age could prominently affect postoperative outcome of CRC patients undergoing surgical treatment. In addition to conventional UICC staging system, it might be imperative to take these additional characteristics of factors into account in CRC patients prior to surgical treatment. More... »

PAGES

288

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2407-9-288

DOI

http://dx.doi.org/10.1186/1471-2407-9-288

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013857409

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19691850


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32 schema:description BackgroundThe aim of this study was to determine influence of prognostic factors in addition to UICC staging systems, on cancer-specific and overall survival rates for patients with colorectal cancer (CRC) undergoing surgical treatment.MethodsBetween January 1996 and December 2006, a total of 1367 CRC patients who underwent surgical treatment in Kaohsiung Medical University Hospital were analyzed. We retrospectively investigated clinicopathologic features of these patients. All patients were followed up intensively, and their outcomes were investigated completely.ResultsOf 1367 CRC patients, there were seven hundred and fifty-seven males (55.4%) and 610 (44.6%) females. The median follow-up period was 60 months (range, 3–132 months). A multivariate analysis identified that low serum albumin level (P = 0.011), advanced UICC stage (P < 0.001), and high carcinoembryonic antigen (CEA) level (P < 0.001) were independent prognostic factors of cancer-specific survival. Meanwhile, a multivariate analysis showed age over 65 years (P < 0.001), advanced UICC stage (P < 0.001), and high CEA level (P < 0.001) were independent prognostic factors of overall survival. Furthermore, combination of UICC stage, serum CEA and albumin levels as predictors of cancer-specific survival showed that the poorer the prognostic factors involved, the poorer the cancer-specific survival rate. Likewise, combination of UICC stage, age and serum CEA level as predictors of overall survival showed that the poorer the prognostic factors involved, the poorer the overall survival rate. Of these prognostic factors, preoperative serum CEA level was the only significant prognostic factor for patients with stage II and III CRCs in both cancer-specific and overall survival categories.ConclusionPreoperative serum albumin level, CEA level and age could prominently affect postoperative outcome of CRC patients undergoing surgical treatment. In addition to conventional UICC staging system, it might be imperative to take these additional characteristics of factors into account in CRC patients prior to surgical treatment.
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38 schema:keywords CEA
39 CEA levels
40 CRC patients
41 Kaohsiung Medical University Hospital
42 Medical University Hospital
43 UICC
44 UICC stage
45 UICC staging system
46 University Hospital
47 account
48 addition
49 additional characteristics
50 advanced UICC stage
51 age
52 aim
53 albumin
54 albumin levels
55 analysis
56 antigen
57 antigen levels
58 cancer
59 cancer patients
60 cancer-specific survival
61 cancer-specific survival rates
62 carcinoembryonic antigen
63 carcinoembryonic antigen level
64 categories
65 characteristics
66 clinicopathologic features
67 colorectal cancer
68 colorectal cancer patients
69 combination
70 factors
71 features
72 females
73 follow
74 high CEA levels
75 high carcinoembryonic antigen level
76 hospital
77 independent prognostic factor
78 influence
79 levels
80 low serum albumin level
81 males
82 median follow
83 months
84 multivariate analysis
85 only significant prognostic factor
86 outcomes
87 overall survival
88 overall survival rate
89 patients
90 period
91 postoperative outcomes
92 predictors
93 preoperative serum CEA level
94 preoperative serum carcinoembryonic antigen
95 prognostic factors
96 rate
97 serum CEA
98 serum CEA level
99 serum albumin level
100 serum carcinoembryonic antigen
101 significant prognostic factors
102 stage
103 stage II
104 staging system
105 study
106 surgical treatment
107 survival
108 survival categories
109 survival rate
110 system
111 total
112 treatment
113 years
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