Zosuquidar restores drug sensitivity in P-glycoprotein expressing acute myeloid leukemia (AML) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-02-13

AUTHORS

Ruoping Tang, Anne-Marie Faussat, Jean-Yves Perrot, Zora Marjanovic, Simy Cohen, Thomas Storme, Hamid Morjani, Ollivier Legrand, Jean-Pierre Marie

ABSTRACT

BackgroundChemotherapeutic drug efflux via the P-glycoprotein (P-gp) transporter encoded by the MDR1/ABCB1 gene is a significant cause of drug resistance in numerous malignancies, including acute leukemias, especially in older patients with acute myeloid leukemia (AML). Therefore, the P-gp modulators that block P-gp-mediated drug efflux have been developed, and used in combination with standard chemotherapy. In this paper, the capacity of zosuquidar, a specific P-gp modulator, to reverse chemoresistance was examined in both leukemia cell lines and primary AML blasts.MethodsThe transporter protein expressions were analyzed by flow cytometry using their specific antibodies. The protein functionalities were assessed by the uptake of their fluorescence substrates in presence or absence their specific modulators. The drug cytotoxicity was evaluated by MTT test.ResultsZosuquidar completely or partially restored drug sensitivity in all P-gp-expressing leukemia cell lines tested and enhanced the cytotoxicity of anthracyclines (daunorubicin, idarubicin, mitoxantrone) and gemtuzumab ozogamicin (Mylotarg) in primary AML blasts with active P-gp. In addition, P-gp inhibition by zosuquidar was found to be more potent than cyclosporine A in cells with highly active P-gp.ConclusionThese in vitro studies suggest that zosuquidar may be an effective adjunct to cytotoxic chemotherapy for AML patients whose blasts express P-gp, especially for older patients. More... »

PAGES

51

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2407-8-51

DOI

http://dx.doi.org/10.1186/1471-2407-8-51

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037051589

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18271955


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ATP Binding Cassette Transporter, Subfamily B, Member 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dibenzocycloheptenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Resistance, Multiple", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HL-60 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia, Myeloid, Acute", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quinolines", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Assistance Publique \u2013 H\u00f4pitaux de Paris; H\u00f4pital H\u00f4tel Dieu, 1 place du Parvis de Notre-Dame, 75181 Paris cedex 04, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "INSERM, U872 Equipe 18 Paris, F-75006, France", 
            "Centre de Recherche des Cordeliers, Universit\u00e9 Pierre et Marie Curie \u2013 Paris6, UMR S U872, F-75006, Paris, France", 
            "Assistance Publique \u2013 H\u00f4pitaux de Paris; H\u00f4pital H\u00f4tel Dieu, 1 place du Parvis de Notre-Dame, 75181 Paris cedex 04, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tang", 
        "givenName": "Ruoping", 
        "id": "sg:person.010467152312.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010467152312.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre de Recherche des Cordeliers, Universit\u00e9 Pierre et Marie Curie \u2013 Paris6, UMR S U872, F-75006, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.417925.c", 
          "name": [
            "INSERM, U872 Equipe 18 Paris, F-75006, France", 
            "Centre de Recherche des Cordeliers, Universit\u00e9 Pierre et Marie Curie \u2013 Paris6, UMR S U872, F-75006, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Faussat", 
        "givenName": "Anne-Marie", 
        "id": "sg:person.015436354754.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015436354754.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Assistance Publique \u2013 H\u00f4pitaux de Paris; H\u00f4pital H\u00f4tel Dieu, 1 place du Parvis de Notre-Dame, 75181 Paris cedex 04, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Assistance Publique \u2013 H\u00f4pitaux de Paris; H\u00f4pital H\u00f4tel Dieu, 1 place du Parvis de Notre-Dame, 75181 Paris cedex 04, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Perrot", 
        "givenName": "Jean-Yves", 
        "id": "sg:person.0632736606.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632736606.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Assistance Publique \u2013 H\u00f4pitaux de Paris; H\u00f4pital H\u00f4tel Dieu, 1 place du Parvis de Notre-Dame, 75181 Paris cedex 04, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Assistance Publique \u2013 H\u00f4pitaux de Paris; H\u00f4pital H\u00f4tel Dieu, 1 place du Parvis de Notre-Dame, 75181 Paris cedex 04, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marjanovic", 
        "givenName": "Zora", 
        "id": "sg:person.01143206732.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143206732.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre de Recherche des Cordeliers, Universit\u00e9 Pierre et Marie Curie \u2013 Paris6, UMR S U872, F-75006, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.417925.c", 
          "name": [
            "INSERM, U872 Equipe 18 Paris, F-75006, France", 
            "Centre de Recherche des Cordeliers, Universit\u00e9 Pierre et Marie Curie \u2013 Paris6, UMR S U872, F-75006, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cohen", 
        "givenName": "Simy", 
        "id": "sg:person.01224074527.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224074527.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Assistance Publique \u2013 H\u00f4pitaux de Paris; H\u00f4pital H\u00f4tel Dieu, 1 place du Parvis de Notre-Dame, 75181 Paris cedex 04, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Assistance Publique \u2013 H\u00f4pitaux de Paris; H\u00f4pital H\u00f4tel Dieu, 1 place du Parvis de Notre-Dame, 75181 Paris cedex 04, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Storme", 
        "givenName": "Thomas", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "JE Onco-Pharmacologie, IFR53; UFR de Pharmacie, 51096, Reims cedex, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "JE Onco-Pharmacologie, IFR53; UFR de Pharmacie, 51096, Reims cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morjani", 
        "givenName": "Hamid", 
        "id": "sg:person.01233046747.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233046747.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Assistance Publique \u2013 H\u00f4pitaux de Paris; H\u00f4pital H\u00f4tel Dieu, 1 place du Parvis de Notre-Dame, 75181 Paris cedex 04, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "INSERM, U872 Equipe 18 Paris, F-75006, France", 
            "Centre de Recherche des Cordeliers, Universit\u00e9 Pierre et Marie Curie \u2013 Paris6, UMR S U872, F-75006, Paris, France", 
            "Assistance Publique \u2013 H\u00f4pitaux de Paris; H\u00f4pital H\u00f4tel Dieu, 1 place du Parvis de Notre-Dame, 75181 Paris cedex 04, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Legrand", 
        "givenName": "Ollivier", 
        "id": "sg:person.0752753564.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752753564.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Assistance Publique \u2013 H\u00f4pitaux de Paris; H\u00f4pital H\u00f4tel Dieu, 1 place du Parvis de Notre-Dame, 75181 Paris cedex 04, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "INSERM, U872 Equipe 18 Paris, F-75006, France", 
            "Centre de Recherche des Cordeliers, Universit\u00e9 Pierre et Marie Curie \u2013 Paris6, UMR S U872, F-75006, Paris, France", 
            "Assistance Publique \u2013 H\u00f4pitaux de Paris; H\u00f4pital H\u00f4tel Dieu, 1 place du Parvis de Notre-Dame, 75181 Paris cedex 04, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marie", 
        "givenName": "Jean-Pierre", 
        "id": "sg:person.01064502270.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064502270.46"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.thj.6200050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056649323", 
          "https://doi.org/10.1038/sj.thj.6200050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4615-4811-9_1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050675331", 
          "https://doi.org/10.1007/978-1-4615-4811-9_1"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-02-13", 
    "datePublishedReg": "2008-02-13", 
    "description": "BackgroundChemotherapeutic drug efflux via the P-glycoprotein (P-gp) transporter encoded by the MDR1/ABCB1 gene is a significant cause of drug resistance in numerous malignancies, including acute leukemias, especially in older patients with acute myeloid leukemia (AML). Therefore, the P-gp modulators that block P-gp-mediated drug efflux have been developed, and used in combination with standard chemotherapy. In this paper, the capacity of zosuquidar, a specific P-gp modulator, to reverse chemoresistance was examined in both leukemia cell lines and primary AML blasts.MethodsThe transporter protein expressions were analyzed by flow cytometry using their specific antibodies. The protein functionalities were assessed by the uptake of their fluorescence substrates in presence or absence their specific modulators. The drug cytotoxicity was evaluated by MTT test.ResultsZosuquidar completely or partially restored drug sensitivity in all P-gp-expressing leukemia cell lines tested and enhanced the cytotoxicity of anthracyclines (daunorubicin, idarubicin, mitoxantrone) and gemtuzumab ozogamicin (Mylotarg) in primary AML blasts with active P-gp. In addition, P-gp inhibition by zosuquidar was found to be more potent than cyclosporine A in cells with highly active P-gp.ConclusionThese in vitro studies suggest that zosuquidar may be an effective adjunct to cytotoxic chemotherapy for AML patients whose blasts express P-gp, especially for older patients.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/1471-2407-8-51", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024632", 
        "issn": [
          "1471-2407"
        ], 
        "name": "BMC Cancer", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "keywords": [
      "acute myeloid leukemia", 
      "P-gp modulators", 
      "primary AML blasts", 
      "P-gp", 
      "older patients", 
      "myeloid leukemia", 
      "AML blasts", 
      "leukemia cell lines", 
      "active P-gp", 
      "P-gp-mediated drug efflux", 
      "drug efflux", 
      "drug sensitivity", 
      "MDR1/ABCB1 gene", 
      "cytotoxicity of anthracyclines", 
      "P-gp inhibition", 
      "cell lines", 
      "P-glycoprotein transporter", 
      "gemtuzumab ozogamicin", 
      "standard chemotherapy", 
      "AML patients", 
      "transporter protein expression", 
      "acute leukemia", 
      "effective adjunct", 
      "ABCB1 gene", 
      "significant cause", 
      "numerous malignancies", 
      "P-glycoprotein", 
      "drug resistance", 
      "flow cytometry", 
      "drug cytotoxicity", 
      "patients", 
      "zosuquidar", 
      "leukemia", 
      "protein expression", 
      "specific antibodies", 
      "chemotherapy", 
      "MTT test", 
      "specific modulators", 
      "efflux", 
      "cytotoxicity", 
      "blasts", 
      "ozogamicin", 
      "modulator", 
      "malignancy", 
      "anthracyclines", 
      "chemoresistance", 
      "adjunct", 
      "antibodies", 
      "cytometry", 
      "ConclusionThese", 
      "inhibition", 
      "cause", 
      "sensitivity", 
      "cells", 
      "expression", 
      "transporters", 
      "uptake", 
      "fluorescence substrate", 
      "lines", 
      "genes", 
      "study", 
      "test", 
      "resistance", 
      "presence", 
      "combination", 
      "addition", 
      "capacity", 
      "protein functionality", 
      "functionality", 
      "substrate", 
      "paper"
    ], 
    "name": "Zosuquidar restores drug sensitivity in P-glycoprotein expressing acute myeloid leukemia (AML)", 
    "pagination": "51", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1037051589"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2407-8-51"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18271955"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2407-8-51", 
      "https://app.dimensions.ai/details/publication/pub.1037051589"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-06-01T22:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_466.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/1471-2407-8-51"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-8-51'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-8-51'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-8-51'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-8-51'


 

This table displays all metadata directly associated to this object as RDF triples.

239 TRIPLES      22 PREDICATES      108 URIs      98 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2407-8-51 schema:about N106b6c4e5108457f991a07e9c9fc5d0b
2 N4dcb97b4a0824c489b0206a99e53c415
3 N915494c150544629b51dd5dc8bee4eb9
4 Na4d8796c6843420aaefcbbb81b6ce161
5 Nd326fc0b956047b992d6ca5c9941d6d0
6 Nde8a7e5e2d164fdd9930cea600545624
7 Ne02c3d1c8ebb4c909083c6dbb11beaff
8 Ne10324e1196f47199566966d624a1c45
9 Nea76a95e81ac4c1da146b6553120dde8
10 anzsrc-for:11
11 anzsrc-for:1112
12 schema:author N27b7af3e83a74f01a4072247ea24a6a5
13 schema:citation sg:pub.10.1007/978-1-4615-4811-9_1
14 sg:pub.10.1038/sj.thj.6200050
15 schema:datePublished 2008-02-13
16 schema:datePublishedReg 2008-02-13
17 schema:description BackgroundChemotherapeutic drug efflux via the P-glycoprotein (P-gp) transporter encoded by the MDR1/ABCB1 gene is a significant cause of drug resistance in numerous malignancies, including acute leukemias, especially in older patients with acute myeloid leukemia (AML). Therefore, the P-gp modulators that block P-gp-mediated drug efflux have been developed, and used in combination with standard chemotherapy. In this paper, the capacity of zosuquidar, a specific P-gp modulator, to reverse chemoresistance was examined in both leukemia cell lines and primary AML blasts.MethodsThe transporter protein expressions were analyzed by flow cytometry using their specific antibodies. The protein functionalities were assessed by the uptake of their fluorescence substrates in presence or absence their specific modulators. The drug cytotoxicity was evaluated by MTT test.ResultsZosuquidar completely or partially restored drug sensitivity in all P-gp-expressing leukemia cell lines tested and enhanced the cytotoxicity of anthracyclines (daunorubicin, idarubicin, mitoxantrone) and gemtuzumab ozogamicin (Mylotarg) in primary AML blasts with active P-gp. In addition, P-gp inhibition by zosuquidar was found to be more potent than cyclosporine A in cells with highly active P-gp.ConclusionThese in vitro studies suggest that zosuquidar may be an effective adjunct to cytotoxic chemotherapy for AML patients whose blasts express P-gp, especially for older patients.
18 schema:genre article
19 schema:inLanguage en
20 schema:isAccessibleForFree true
21 schema:isPartOf N759cefda8b12495e9eddce1d6384b5c8
22 Nb00a0ae6b6a94937aa6f030e95436602
23 sg:journal.1024632
24 schema:keywords ABCB1 gene
25 AML blasts
26 AML patients
27 ConclusionThese
28 MDR1/ABCB1 gene
29 MTT test
30 P-glycoprotein
31 P-glycoprotein transporter
32 P-gp
33 P-gp inhibition
34 P-gp modulators
35 P-gp-mediated drug efflux
36 active P-gp
37 acute leukemia
38 acute myeloid leukemia
39 addition
40 adjunct
41 anthracyclines
42 antibodies
43 blasts
44 capacity
45 cause
46 cell lines
47 cells
48 chemoresistance
49 chemotherapy
50 combination
51 cytometry
52 cytotoxicity
53 cytotoxicity of anthracyclines
54 drug cytotoxicity
55 drug efflux
56 drug resistance
57 drug sensitivity
58 effective adjunct
59 efflux
60 expression
61 flow cytometry
62 fluorescence substrate
63 functionality
64 gemtuzumab ozogamicin
65 genes
66 inhibition
67 leukemia
68 leukemia cell lines
69 lines
70 malignancy
71 modulator
72 myeloid leukemia
73 numerous malignancies
74 older patients
75 ozogamicin
76 paper
77 patients
78 presence
79 primary AML blasts
80 protein expression
81 protein functionality
82 resistance
83 sensitivity
84 significant cause
85 specific antibodies
86 specific modulators
87 standard chemotherapy
88 study
89 substrate
90 test
91 transporter protein expression
92 transporters
93 uptake
94 zosuquidar
95 schema:name Zosuquidar restores drug sensitivity in P-glycoprotein expressing acute myeloid leukemia (AML)
96 schema:pagination 51
97 schema:productId N397e746339e845ec86dd63ed098297de
98 N405a36925db24508932c27a2ad09a3b6
99 Nd42c8769c96249eab1585a9d028db0ae
100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037051589
101 https://doi.org/10.1186/1471-2407-8-51
102 schema:sdDatePublished 2022-06-01T22:06
103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
104 schema:sdPublisher N70849cf2bf3641278cb8e3f644642784
105 schema:url https://doi.org/10.1186/1471-2407-8-51
106 sgo:license sg:explorer/license/
107 sgo:sdDataset articles
108 rdf:type schema:ScholarlyArticle
109 N106b6c4e5108457f991a07e9c9fc5d0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name ATP Binding Cassette Transporter, Subfamily B, Member 1
111 rdf:type schema:DefinedTerm
112 N188a1f3770b64ba1abc0051b973c0e67 rdf:first sg:person.01233046747.24
113 rdf:rest N47a8f2c29a8e4f08bcd983c725333c51
114 N27b7af3e83a74f01a4072247ea24a6a5 rdf:first sg:person.010467152312.87
115 rdf:rest N6ce2bd9a322241bca61c96c991b8b5e9
116 N397e746339e845ec86dd63ed098297de schema:name dimensions_id
117 schema:value pub.1037051589
118 rdf:type schema:PropertyValue
119 N3b851f2214314059b9c2a050bf754fa6 rdf:first sg:person.01064502270.46
120 rdf:rest rdf:nil
121 N405a36925db24508932c27a2ad09a3b6 schema:name doi
122 schema:value 10.1186/1471-2407-8-51
123 rdf:type schema:PropertyValue
124 N47a8f2c29a8e4f08bcd983c725333c51 rdf:first sg:person.0752753564.08
125 rdf:rest N3b851f2214314059b9c2a050bf754fa6
126 N4dcb97b4a0824c489b0206a99e53c415 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Leukemia, Myeloid, Acute
128 rdf:type schema:DefinedTerm
129 N5ea32459305b4afa88a4003703b4237a rdf:first Nc30501afa56a47828b1b72725297c340
130 rdf:rest N188a1f3770b64ba1abc0051b973c0e67
131 N6ce2bd9a322241bca61c96c991b8b5e9 rdf:first sg:person.015436354754.08
132 rdf:rest Ncc257b8f6e6f4aa9a4d182192555006e
133 N70849cf2bf3641278cb8e3f644642784 schema:name Springer Nature - SN SciGraph project
134 rdf:type schema:Organization
135 N759cefda8b12495e9eddce1d6384b5c8 schema:issueNumber 1
136 rdf:type schema:PublicationIssue
137 N83f3cd431f794c6d9a461cdf67643d0c rdf:first sg:person.01224074527.17
138 rdf:rest N5ea32459305b4afa88a4003703b4237a
139 N915494c150544629b51dd5dc8bee4eb9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Dibenzocycloheptenes
141 rdf:type schema:DefinedTerm
142 Na4d8796c6843420aaefcbbb81b6ce161 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Quinolines
144 rdf:type schema:DefinedTerm
145 Nb00a0ae6b6a94937aa6f030e95436602 schema:volumeNumber 8
146 rdf:type schema:PublicationVolume
147 Nc30501afa56a47828b1b72725297c340 schema:affiliation grid-institutes:None
148 schema:familyName Storme
149 schema:givenName Thomas
150 rdf:type schema:Person
151 Ncc257b8f6e6f4aa9a4d182192555006e rdf:first sg:person.0632736606.03
152 rdf:rest Nd73d11a697414d89b881754e6ca93f36
153 Nd326fc0b956047b992d6ca5c9941d6d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Gene Expression Regulation, Neoplastic
155 rdf:type schema:DefinedTerm
156 Nd42c8769c96249eab1585a9d028db0ae schema:name pubmed_id
157 schema:value 18271955
158 rdf:type schema:PropertyValue
159 Nd73d11a697414d89b881754e6ca93f36 rdf:first sg:person.01143206732.01
160 rdf:rest N83f3cd431f794c6d9a461cdf67643d0c
161 Nde8a7e5e2d164fdd9930cea600545624 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Drug Resistance, Multiple
163 rdf:type schema:DefinedTerm
164 Ne02c3d1c8ebb4c909083c6dbb11beaff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name HL-60 Cells
166 rdf:type schema:DefinedTerm
167 Ne10324e1196f47199566966d624a1c45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Cell Line, Tumor
169 rdf:type schema:DefinedTerm
170 Nea76a95e81ac4c1da146b6553120dde8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Humans
172 rdf:type schema:DefinedTerm
173 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
174 schema:name Medical and Health Sciences
175 rdf:type schema:DefinedTerm
176 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
177 schema:name Oncology and Carcinogenesis
178 rdf:type schema:DefinedTerm
179 sg:journal.1024632 schema:issn 1471-2407
180 schema:name BMC Cancer
181 schema:publisher Springer Nature
182 rdf:type schema:Periodical
183 sg:person.010467152312.87 schema:affiliation grid-institutes:None
184 schema:familyName Tang
185 schema:givenName Ruoping
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010467152312.87
187 rdf:type schema:Person
188 sg:person.01064502270.46 schema:affiliation grid-institutes:None
189 schema:familyName Marie
190 schema:givenName Jean-Pierre
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064502270.46
192 rdf:type schema:Person
193 sg:person.01143206732.01 schema:affiliation grid-institutes:None
194 schema:familyName Marjanovic
195 schema:givenName Zora
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143206732.01
197 rdf:type schema:Person
198 sg:person.01224074527.17 schema:affiliation grid-institutes:grid.417925.c
199 schema:familyName Cohen
200 schema:givenName Simy
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224074527.17
202 rdf:type schema:Person
203 sg:person.01233046747.24 schema:affiliation grid-institutes:None
204 schema:familyName Morjani
205 schema:givenName Hamid
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233046747.24
207 rdf:type schema:Person
208 sg:person.015436354754.08 schema:affiliation grid-institutes:grid.417925.c
209 schema:familyName Faussat
210 schema:givenName Anne-Marie
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015436354754.08
212 rdf:type schema:Person
213 sg:person.0632736606.03 schema:affiliation grid-institutes:None
214 schema:familyName Perrot
215 schema:givenName Jean-Yves
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632736606.03
217 rdf:type schema:Person
218 sg:person.0752753564.08 schema:affiliation grid-institutes:None
219 schema:familyName Legrand
220 schema:givenName Ollivier
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752753564.08
222 rdf:type schema:Person
223 sg:pub.10.1007/978-1-4615-4811-9_1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050675331
224 https://doi.org/10.1007/978-1-4615-4811-9_1
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/sj.thj.6200050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056649323
227 https://doi.org/10.1038/sj.thj.6200050
228 rdf:type schema:CreativeWork
229 grid-institutes:None schema:alternateName Assistance Publique – Hôpitaux de Paris; Hôpital Hôtel Dieu, 1 place du Parvis de Notre-Dame, 75181 Paris cedex 04, France
230 JE Onco-Pharmacologie, IFR53; UFR de Pharmacie, 51096, Reims cedex, France
231 schema:name Assistance Publique – Hôpitaux de Paris; Hôpital Hôtel Dieu, 1 place du Parvis de Notre-Dame, 75181 Paris cedex 04, France
232 Centre de Recherche des Cordeliers, Université Pierre et Marie Curie – Paris6, UMR S U872, F-75006, Paris, France
233 INSERM, U872 Equipe 18 Paris, F-75006, France
234 JE Onco-Pharmacologie, IFR53; UFR de Pharmacie, 51096, Reims cedex, France
235 rdf:type schema:Organization
236 grid-institutes:grid.417925.c schema:alternateName Centre de Recherche des Cordeliers, Université Pierre et Marie Curie – Paris6, UMR S U872, F-75006, Paris, France
237 schema:name Centre de Recherche des Cordeliers, Université Pierre et Marie Curie – Paris6, UMR S U872, F-75006, Paris, France
238 INSERM, U872 Equipe 18 Paris, F-75006, France
239 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...