Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-12

AUTHORS

Joshua Z Press, Alessandro De Luca, Niki Boyd, Sean Young, Armelle Troussard, Yolanda Ridge, Pardeep Kaurah, Steve E Kalloger, Katherine A Blood, Margaret Smith, Paul T Spellman, Yuker Wang, Dianne M Miller, Doug Horsman, Malek Faham, C Blake Gilks, Joe Gray, David G Huntsman

ABSTRACT

BACKGROUND: Subclassification of ovarian carcinomas can be used to guide treatment and determine prognosis. Germline and somatic mutations, loss of heterozygosity (LOH), and epigenetic events such as promoter hypermethylation can lead to decreased expression of BRCA1/2 in ovarian cancers. The mechanism of BRCA1/2 loss is a potential method of subclassifying high grade serous carcinomas. METHODS: A consecutive series of 49 ovarian cancers was assessed for mutations status of BRCA1 and BRCA2, LOH at the BRCA1 and BRCA2 loci, methylation of the BRCA1 promoter, BRCA1, BRCA2, PTEN, and PIK3CA transcript levels, PIK3CA gene copy number, and BRCA1, p21, p53, and WT-1 immunohistochemistry. RESULTS: Eighteen (37%) of the ovarian carcinomas had germline or somatic BRCA1 mutations, or epigenetic loss of BRCA1. All of these tumours were high-grade serous or undifferentiated type. None of the endometrioid (n = 5), clear cell (n = 4), or low grade serous (n = 2) carcinomas showed loss of BRCA1, whereas 47% of the 38 high-grade serous or undifferentiated carcinomas had loss of BRCA1. It was possible to distinguish high grade serous carcinomas with BRCA1 mutations from those with epigenetic BRCA1 loss: tumours with BRCA1 mutations typically had decreased PTEN mRNA levels while those with epigenetic loss of BRCA1 had copy number gain of PIK3CA. Overexpression of p53 with loss of p21 expression occurred significantly more frequently in high grade serous carcinomas with epigenetic loss of BRCA1, compared to high grade serous tumors without loss of BRCA1. CONCLUSION: High grade serous carcinomas can be subclassified into three groups: BRCA1 loss (genetic), BRCA1 loss (epigenetic), and no BRCA1 loss. Tumors in these groups show distinct molecular alterations involving the PI3K/AKT and p53 pathways. More... »

PAGES

17

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2407-8-17

DOI

http://dx.doi.org/10.1186/1471-2407-8-17

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003338054

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18208621


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "BRCA1 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epigenesis, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Deletion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome, Human", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ovarian Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "PTEN Phosphohydrolase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Protein p53", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Press", 
        "givenName": "Joshua Z", 
        "id": "sg:person.0657267337.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657267337.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Luca", 
        "givenName": "Alessandro", 
        "id": "sg:person.0743205140.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743205140.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boyd", 
        "givenName": "Niki", 
        "id": "sg:person.013452370272.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013452370272.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada", 
            "Hereditary Cancer Program, British Columbia Cancer Agency, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Young", 
        "givenName": "Sean", 
        "id": "sg:person.01116275315.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116275315.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Troussard", 
        "givenName": "Armelle", 
        "id": "sg:person.01122533136.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122533136.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Hereditary Cancer Program, British Columbia Cancer Agency, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ridge", 
        "givenName": "Yolanda", 
        "id": "sg:person.01061440173.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061440173.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Hereditary Cancer Program, British Columbia Cancer Agency, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kaurah", 
        "givenName": "Pardeep", 
        "id": "sg:person.01317605274.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317605274.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vancouver General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412541.7", 
          "name": [
            "Genetic Pathology Evaluation Centre of the Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kalloger", 
        "givenName": "Steve E", 
        "id": "sg:person.0762426613.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762426613.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blood", 
        "givenName": "Katherine A", 
        "id": "sg:person.01310236620.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310236620.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Melbourne Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416153.4", 
          "name": [
            "Molecular Genetics, The Royal Melbourne Hospital, Parkville, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smith", 
        "givenName": "Margaret", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, San Francisco, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spellman", 
        "givenName": "Paul T", 
        "id": "sg:person.01064253031.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064253031.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affymetrix (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417703.6", 
          "name": [
            "Affymetrix Inc, 7300 Shoreline Blvd South, San FranciscoCalifornia, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Yuker", 
        "id": "sg:person.012263040417.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012263040417.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Gynecologic Oncology, University of British Columbia, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miller", 
        "givenName": "Dianne M", 
        "id": "sg:person.011077447057.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011077447057.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Melbourne Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416153.4", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada", 
            "Molecular Genetics, The Royal Melbourne Hospital, Parkville, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Horsman", 
        "givenName": "Doug", 
        "id": "sg:person.010106740464.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010106740464.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affymetrix (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417703.6", 
          "name": [
            "Affymetrix Inc, 7300 Shoreline Blvd South, San FranciscoCalifornia, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Faham", 
        "givenName": "Malek", 
        "id": "sg:person.01230770417.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230770417.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vancouver General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412541.7", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada", 
            "Genetic Pathology Evaluation Centre of the Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gilks", 
        "givenName": "C Blake", 
        "id": "sg:person.01120560217.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120560217.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, San Francisco, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gray", 
        "givenName": "Joe", 
        "id": "sg:person.014525340267.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014525340267.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vancouver General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412541.7", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada", 
            "Hereditary Cancer Program, British Columbia Cancer Agency, Vancouver, British Columbia, Canada", 
            "Genetic Pathology Evaluation Centre of the Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huntsman", 
        "givenName": "David G", 
        "id": "sg:person.015140454124.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015140454124.62"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0889-8588(03)00061-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000265301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/b:fame.0000039861.30651.c8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002166811", 
          "https://doi.org/10.1023/b:fame.0000039861.30651.c8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.21992", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002843968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(02)00615-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003706567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-1170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003861547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004484245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(02)00041-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005948625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.21.10148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006403818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004347-200210000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006554022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004347-200210000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006554022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006625148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008238042", 
          "https://doi.org/10.1038/sj.onc.1206176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008238042", 
          "https://doi.org/10.1038/sj.onc.1206176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/94.13.990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008897588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.2004.01787.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008911407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472-can-04-3913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011326721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2005.10.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011600196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.21276", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011674754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.21276", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011674754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.21536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011828352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.21536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011828352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0396-333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013077376", 
          "https://doi.org/10.1038/ng0396-333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2202/1544-6115.1095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013708845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1997.526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013836365", 
          "https://doi.org/10.1038/bjc.1997.526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1997.526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013836365", 
          "https://doi.org/10.1038/bjc.1997.526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/5042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015487157", 
          "https://doi.org/10.1038/5042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/5042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015487157", 
          "https://doi.org/10.1038/5042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.11310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016295307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004347-199804000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016814605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004347-199804000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016814605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004347-199804000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016814605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m203636200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017982027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm852", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019055785", 
          "https://doi.org/10.1038/nm852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm852", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019055785", 
          "https://doi.org/10.1038/nm852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004347-200001000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020007633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004347-200001000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020007633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-06-1375", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022108262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.283.17.2260", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023526030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027289274", 
          "https://doi.org/10.1038/modpathol.3800306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027289274", 
          "https://doi.org/10.1038/modpathol.3800306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(20010815)92:4<787::aid-cncr1384>3.0.co;2-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027511713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2007.02.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027587031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.3185605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029969824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0495-439", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029999728", 
          "https://doi.org/10.1038/ng0495-439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molmed.2006.07.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032059219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910640412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032190816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-2620", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032388482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200404000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036053529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200404000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036053529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036499081", 
          "https://doi.org/10.1038/nature03443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036499081", 
          "https://doi.org/10.1038/nature03443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1054/bjoc.2000.1581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037306339", 
          "https://doi.org/10.1054/bjoc.2000.1581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90500-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038576682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)61714-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038820521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03445", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039649759", 
          "https://doi.org/10.1038/nature03445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03445", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039649759", 
          "https://doi.org/10.1038/nature03445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7545954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041365117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042257134", 
          "https://doi.org/10.1038/nrc1457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042257134", 
          "https://doi.org/10.1038/nrc1457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/26.6.1396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043803354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/92.7.564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044385773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gni177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044827446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2362.2003.01116.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045019580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0894-472", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046324905", 
          "https://doi.org/10.1038/ng0894-472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1525-1438.2006.00504.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046837371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pgp.0000101080.35393.16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048334618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pgp.0000101080.35393.16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048334618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.19.9267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048848467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00313020220147113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049352850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00313020220147113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049352850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coph.2006.02.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049862846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/95.6.484", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049943179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.11080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049973628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1432-1327.2001.01936.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051367437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0340633", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051372982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0340633", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051372982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pgp.0000101083.35393.cd", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051600189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pgp.0000101083.35393.cd", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051600189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.5.2077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051736465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1525-1438.2000.010004289.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056744084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/318787", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058622528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2270482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062529993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7939630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062650649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8091231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062652236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.20.5.1248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064202847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2002.09.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.07.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.13.1.101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071510724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.16.3.567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071511284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074613540", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074624822", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074708118", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074801138", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075003246", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075087966", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075262312", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076852340", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077213523", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082557887", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082825732", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-12", 
    "datePublishedReg": "2008-12-01", 
    "description": "BACKGROUND: Subclassification of ovarian carcinomas can be used to guide treatment and determine prognosis. Germline and somatic mutations, loss of heterozygosity (LOH), and epigenetic events such as promoter hypermethylation can lead to decreased expression of BRCA1/2 in ovarian cancers. The mechanism of BRCA1/2 loss is a potential method of subclassifying high grade serous carcinomas.\nMETHODS: A consecutive series of 49 ovarian cancers was assessed for mutations status of BRCA1 and BRCA2, LOH at the BRCA1 and BRCA2 loci, methylation of the BRCA1 promoter, BRCA1, BRCA2, PTEN, and PIK3CA transcript levels, PIK3CA gene copy number, and BRCA1, p21, p53, and WT-1 immunohistochemistry.\nRESULTS: Eighteen (37%) of the ovarian carcinomas had germline or somatic BRCA1 mutations, or epigenetic loss of BRCA1. All of these tumours were high-grade serous or undifferentiated type. None of the endometrioid (n = 5), clear cell (n = 4), or low grade serous (n = 2) carcinomas showed loss of BRCA1, whereas 47% of the 38 high-grade serous or undifferentiated carcinomas had loss of BRCA1. It was possible to distinguish high grade serous carcinomas with BRCA1 mutations from those with epigenetic BRCA1 loss: tumours with BRCA1 mutations typically had decreased PTEN mRNA levels while those with epigenetic loss of BRCA1 had copy number gain of PIK3CA. Overexpression of p53 with loss of p21 expression occurred significantly more frequently in high grade serous carcinomas with epigenetic loss of BRCA1, compared to high grade serous tumors without loss of BRCA1.\nCONCLUSION: High grade serous carcinomas can be subclassified into three groups: BRCA1 loss (genetic), BRCA1 loss (epigenetic), and no BRCA1 loss. Tumors in these groups show distinct molecular alterations involving the PI3K/AKT and p53 pathways.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-2407-8-17", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2440138", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2435643", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4109929", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2440150", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1024632", 
        "issn": [
          "1471-2407"
        ], 
        "name": "BMC Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities", 
    "pagination": "17", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0fe6a19c997d18e7d3e9df0959067a6628155aec2eda040e802cddb9ac0b7162"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18208621"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100967800"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2407-8-17"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1003338054"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2407-8-17", 
      "https://app.dimensions.ai/details/publication/pub.1003338054"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:41", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-2407-8-17"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-8-17'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-8-17'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-8-17'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-8-17'


 

This table displays all metadata directly associated to this object as RDF triples.

520 TRIPLES      21 PREDICATES      125 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2407-8-17 schema:about N030fde2878964b5aa2a94ded73167dc1
2 N268be9bdc2394dcbb36c0978f48dc26d
3 N39a99bb2571f467c85c868444d999faa
4 N4259fa3dc0bc49f8b7063779d21903e8
5 N54426fbc93044745876b0b7c4213a2b2
6 N605595d7f21c4fec8e46e4585bfb14b3
7 N7fb5b5b6fc8a4f6b8e0caad3a2db0789
8 N83ff98a1430742058902b9b6858748ce
9 N9c36337dadc7411f8bf14d9666d790e4
10 Nb0d2b1857c1b4eda844cd885540a756b
11 Nb9dfbbb0aa414f5fa43be91a23d99e9c
12 Nc9b950da1a44441696dc5bf9b9a130b8
13 Nc9fa2325e4894bab8e40c84d52c53a69
14 Nd39bc09f98f24ed8b3ad41f820431907
15 Nda936cd47e3a49ecba3bba43c90d51b2
16 anzsrc-for:11
17 anzsrc-for:1112
18 schema:author Na627662735e64162895786bb4d4d7e31
19 schema:citation sg:pub.10.1023/b:fame.0000039861.30651.c8
20 sg:pub.10.1038/5042
21 sg:pub.10.1038/bjc.1997.526
22 sg:pub.10.1038/modpathol.3800306
23 sg:pub.10.1038/nature03443
24 sg:pub.10.1038/nature03445
25 sg:pub.10.1038/ng0396-333
26 sg:pub.10.1038/ng0495-439
27 sg:pub.10.1038/ng0894-472
28 sg:pub.10.1038/nm852
29 sg:pub.10.1038/nrc1457
30 sg:pub.10.1038/sj.onc.1206176
31 sg:pub.10.1054/bjoc.2000.1581
32 https://app.dimensions.ai/details/publication/pub.1074613540
33 https://app.dimensions.ai/details/publication/pub.1074624822
34 https://app.dimensions.ai/details/publication/pub.1074708118
35 https://app.dimensions.ai/details/publication/pub.1074801138
36 https://app.dimensions.ai/details/publication/pub.1075003246
37 https://app.dimensions.ai/details/publication/pub.1075087966
38 https://app.dimensions.ai/details/publication/pub.1075262312
39 https://app.dimensions.ai/details/publication/pub.1076852340
40 https://app.dimensions.ai/details/publication/pub.1077213523
41 https://app.dimensions.ai/details/publication/pub.1082557887
42 https://app.dimensions.ai/details/publication/pub.1082825732
43 https://doi.org/10.1001/jama.283.17.2260
44 https://doi.org/10.1002/1097-0142(20010815)92:4<787::aid-cncr1384>3.0.co;2-4
45 https://doi.org/10.1002/cncr.11080
46 https://doi.org/10.1002/cncr.11310
47 https://doi.org/10.1002/cncr.21276
48 https://doi.org/10.1002/cncr.21536
49 https://doi.org/10.1002/cncr.21992
50 https://doi.org/10.1002/ijc.2910640412
51 https://doi.org/10.1002/path.1193
52 https://doi.org/10.1002/path.1507
53 https://doi.org/10.1016/0092-8674(93)90500-p
54 https://doi.org/10.1016/j.ccr.2007.02.016
55 https://doi.org/10.1016/j.coph.2006.02.007
56 https://doi.org/10.1016/j.molmed.2006.07.007
57 https://doi.org/10.1016/j.ygyno.2005.10.034
58 https://doi.org/10.1016/s0002-9440(10)61714-2
59 https://doi.org/10.1016/s0092-8674(02)00615-3
60 https://doi.org/10.1016/s0889-8588(03)00061-3
61 https://doi.org/10.1016/s0959-8049(02)00041-2
62 https://doi.org/10.1042/bst0340633
63 https://doi.org/10.1046/j.1365-2362.2003.01116.x
64 https://doi.org/10.1046/j.1432-1327.2001.01936.x
65 https://doi.org/10.1046/j.1525-1438.2000.010004289.x
66 https://doi.org/10.1073/pnas.89.19.9267
67 https://doi.org/10.1073/pnas.91.21.10148
68 https://doi.org/10.1073/pnas.96.5.2077
69 https://doi.org/10.1074/jbc.m203636200
70 https://doi.org/10.1080/00313020220147113
71 https://doi.org/10.1086/318787
72 https://doi.org/10.1093/jnci/92.7.564
73 https://doi.org/10.1093/jnci/94.13.990
74 https://doi.org/10.1093/jnci/95.6.484
75 https://doi.org/10.1093/nar/26.6.1396
76 https://doi.org/10.1093/nar/gni177
77 https://doi.org/10.1097/00000478-200404000-00009
78 https://doi.org/10.1097/00004347-199804000-00006
79 https://doi.org/10.1097/00004347-200001000-00003
80 https://doi.org/10.1097/00004347-200210000-00011
81 https://doi.org/10.1097/01.pgp.0000101080.35393.16
82 https://doi.org/10.1097/01.pgp.0000101083.35393.cd
83 https://doi.org/10.1101/gr.3185605
84 https://doi.org/10.1111/j.1365-2559.2004.01787.x
85 https://doi.org/10.1111/j.1525-1438.2006.00504.x
86 https://doi.org/10.1126/science.2270482
87 https://doi.org/10.1126/science.7545954
88 https://doi.org/10.1126/science.7939630
89 https://doi.org/10.1126/science.8091231
90 https://doi.org/10.1158/0008-5472-can-04-3913
91 https://doi.org/10.1158/0008-5472.can-04-1170
92 https://doi.org/10.1158/0008-5472.can-05-2620
93 https://doi.org/10.1158/1078-0432.ccr-06-1375
94 https://doi.org/10.1200/jco.20.5.1248
95 https://doi.org/10.1200/jco.2002.09.023
96 https://doi.org/10.1200/jco.2003.07.013
97 https://doi.org/10.2202/1544-6115.1095
98 https://doi.org/10.3892/ijo.13.1.101
99 https://doi.org/10.3892/ijo.16.3.567
100 schema:datePublished 2008-12
101 schema:datePublishedReg 2008-12-01
102 schema:description BACKGROUND: Subclassification of ovarian carcinomas can be used to guide treatment and determine prognosis. Germline and somatic mutations, loss of heterozygosity (LOH), and epigenetic events such as promoter hypermethylation can lead to decreased expression of BRCA1/2 in ovarian cancers. The mechanism of BRCA1/2 loss is a potential method of subclassifying high grade serous carcinomas. METHODS: A consecutive series of 49 ovarian cancers was assessed for mutations status of BRCA1 and BRCA2, LOH at the BRCA1 and BRCA2 loci, methylation of the BRCA1 promoter, BRCA1, BRCA2, PTEN, and PIK3CA transcript levels, PIK3CA gene copy number, and BRCA1, p21, p53, and WT-1 immunohistochemistry. RESULTS: Eighteen (37%) of the ovarian carcinomas had germline or somatic BRCA1 mutations, or epigenetic loss of BRCA1. All of these tumours were high-grade serous or undifferentiated type. None of the endometrioid (n = 5), clear cell (n = 4), or low grade serous (n = 2) carcinomas showed loss of BRCA1, whereas 47% of the 38 high-grade serous or undifferentiated carcinomas had loss of BRCA1. It was possible to distinguish high grade serous carcinomas with BRCA1 mutations from those with epigenetic BRCA1 loss: tumours with BRCA1 mutations typically had decreased PTEN mRNA levels while those with epigenetic loss of BRCA1 had copy number gain of PIK3CA. Overexpression of p53 with loss of p21 expression occurred significantly more frequently in high grade serous carcinomas with epigenetic loss of BRCA1, compared to high grade serous tumors without loss of BRCA1. CONCLUSION: High grade serous carcinomas can be subclassified into three groups: BRCA1 loss (genetic), BRCA1 loss (epigenetic), and no BRCA1 loss. Tumors in these groups show distinct molecular alterations involving the PI3K/AKT and p53 pathways.
103 schema:genre research_article
104 schema:inLanguage en
105 schema:isAccessibleForFree true
106 schema:isPartOf N2e716911d8194adc9b0a8cef6ea69ed2
107 Nf921d2fbbf3a49168d07b59858606cb0
108 sg:journal.1024632
109 schema:name Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities
110 schema:pagination 17
111 schema:productId N1c8b1b0eb18f4acaa74a03d754c2ca18
112 N57944a50b783437592ffe916c81717ad
113 N7530cab9e5914a93a9fb9318a23ab260
114 Na03e73bcc60f4e99aef238e26686a147
115 Ne17e6a85b45846c886a194589626afe5
116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003338054
117 https://doi.org/10.1186/1471-2407-8-17
118 schema:sdDatePublished 2019-04-10T16:41
119 schema:sdLicense https://scigraph.springernature.com/explorer/license/
120 schema:sdPublisher Nb60e04c37e1b4bc5a92b973d9c83e77e
121 schema:url http://link.springer.com/10.1186%2F1471-2407-8-17
122 sgo:license sg:explorer/license/
123 sgo:sdDataset articles
124 rdf:type schema:ScholarlyArticle
125 N01e799e938fa41d89b91aacda3fa4ee3 rdf:first sg:person.015140454124.62
126 rdf:rest rdf:nil
127 N030fde2878964b5aa2a94ded73167dc1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name RNA, Messenger
129 rdf:type schema:DefinedTerm
130 N1bf11d3e9be24d479221f0844bba5e7f schema:affiliation https://www.grid.ac/institutes/grid.416153.4
131 schema:familyName Smith
132 schema:givenName Margaret
133 rdf:type schema:Person
134 N1c8b1b0eb18f4acaa74a03d754c2ca18 schema:name dimensions_id
135 schema:value pub.1003338054
136 rdf:type schema:PropertyValue
137 N268be9bdc2394dcbb36c0978f48dc26d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Nuclear Proteins
139 rdf:type schema:DefinedTerm
140 N2a1f22296b9549f7a4fce1f09ea78e45 rdf:first sg:person.01122533136.29
141 rdf:rest N6257f0ced0044aabb72d1c3f5dd342c8
142 N2bfec06f5038494da7c3268c582667ac rdf:first sg:person.014525340267.00
143 rdf:rest N01e799e938fa41d89b91aacda3fa4ee3
144 N2e716911d8194adc9b0a8cef6ea69ed2 schema:issueNumber 1
145 rdf:type schema:PublicationIssue
146 N33c861a9810443b19ec036944ed93654 rdf:first sg:person.010106740464.33
147 rdf:rest Nab459b4b33f3458baf996c73ff7d9dfe
148 N36ba636ebb864feeb52f38964e83a2c5 rdf:first sg:person.01064253031.26
149 rdf:rest Nfa91e64aaf5d42e3b0bd67ec31ffe0fd
150 N39a99bb2571f467c85c868444d999faa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Transcription Factors
152 rdf:type schema:DefinedTerm
153 N4259fa3dc0bc49f8b7063779d21903e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Epigenesis, Genetic
155 rdf:type schema:DefinedTerm
156 N54426fbc93044745876b0b7c4213a2b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Female
158 rdf:type schema:DefinedTerm
159 N57944a50b783437592ffe916c81717ad schema:name nlm_unique_id
160 schema:value 100967800
161 rdf:type schema:PropertyValue
162 N5db3de3e9a6e45d69e346bbf24ff81cf rdf:first sg:person.013452370272.66
163 rdf:rest Ndc2b4d9282f141ddb7b55d98252baea2
164 N605595d7f21c4fec8e46e4585bfb14b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Humans
166 rdf:type schema:DefinedTerm
167 N6257f0ced0044aabb72d1c3f5dd342c8 rdf:first sg:person.01061440173.67
168 rdf:rest N744ec16d126e4f278bd65ffc21957f45
169 N66acb8066ba747dba49a2f0fd329de76 rdf:first sg:person.0762426613.24
170 rdf:rest N737307f3288e4d9cb51c3248108951b2
171 N737307f3288e4d9cb51c3248108951b2 rdf:first sg:person.01310236620.83
172 rdf:rest Nebafc5622f9f4cd9a06a0d67719ae690
173 N744ec16d126e4f278bd65ffc21957f45 rdf:first sg:person.01317605274.52
174 rdf:rest N66acb8066ba747dba49a2f0fd329de76
175 N7530cab9e5914a93a9fb9318a23ab260 schema:name pubmed_id
176 schema:value 18208621
177 rdf:type schema:PropertyValue
178 N7ef21d260a584954bc52f573ac1c4215 rdf:first sg:person.0743205140.47
179 rdf:rest N5db3de3e9a6e45d69e346bbf24ff81cf
180 N7fb5b5b6fc8a4f6b8e0caad3a2db0789 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Gene Deletion
182 rdf:type schema:DefinedTerm
183 N83ff98a1430742058902b9b6858748ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Ovarian Neoplasms
185 rdf:type schema:DefinedTerm
186 N8ebd4ca17bc64bd29bd95fef1cf8b75a rdf:first sg:person.011077447057.72
187 rdf:rest N33c861a9810443b19ec036944ed93654
188 N9c36337dadc7411f8bf14d9666d790e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Tumor Suppressor Protein p53
190 rdf:type schema:DefinedTerm
191 N9d27eb0c7a44451898768e40f4f2bae7 rdf:first sg:person.01120560217.98
192 rdf:rest N2bfec06f5038494da7c3268c582667ac
193 Na03e73bcc60f4e99aef238e26686a147 schema:name readcube_id
194 schema:value 0fe6a19c997d18e7d3e9df0959067a6628155aec2eda040e802cddb9ac0b7162
195 rdf:type schema:PropertyValue
196 Na627662735e64162895786bb4d4d7e31 rdf:first sg:person.0657267337.09
197 rdf:rest N7ef21d260a584954bc52f573ac1c4215
198 Nab459b4b33f3458baf996c73ff7d9dfe rdf:first sg:person.01230770417.44
199 rdf:rest N9d27eb0c7a44451898768e40f4f2bae7
200 Nb0d2b1857c1b4eda844cd885540a756b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name PTEN Phosphohydrolase
202 rdf:type schema:DefinedTerm
203 Nb60e04c37e1b4bc5a92b973d9c83e77e schema:name Springer Nature - SN SciGraph project
204 rdf:type schema:Organization
205 Nb9dfbbb0aa414f5fa43be91a23d99e9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Genome, Human
207 rdf:type schema:DefinedTerm
208 Nc9b950da1a44441696dc5bf9b9a130b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Base Sequence
210 rdf:type schema:DefinedTerm
211 Nc9fa2325e4894bab8e40c84d52c53a69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Immunohistochemistry
213 rdf:type schema:DefinedTerm
214 Nd39bc09f98f24ed8b3ad41f820431907 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name BRCA1 Protein
216 rdf:type schema:DefinedTerm
217 Nda936cd47e3a49ecba3bba43c90d51b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
218 schema:name Gene Expression Regulation, Neoplastic
219 rdf:type schema:DefinedTerm
220 Ndc2b4d9282f141ddb7b55d98252baea2 rdf:first sg:person.01116275315.53
221 rdf:rest N2a1f22296b9549f7a4fce1f09ea78e45
222 Ne17e6a85b45846c886a194589626afe5 schema:name doi
223 schema:value 10.1186/1471-2407-8-17
224 rdf:type schema:PropertyValue
225 Nebafc5622f9f4cd9a06a0d67719ae690 rdf:first N1bf11d3e9be24d479221f0844bba5e7f
226 rdf:rest N36ba636ebb864feeb52f38964e83a2c5
227 Nf921d2fbbf3a49168d07b59858606cb0 schema:volumeNumber 8
228 rdf:type schema:PublicationVolume
229 Nfa91e64aaf5d42e3b0bd67ec31ffe0fd rdf:first sg:person.012263040417.40
230 rdf:rest N8ebd4ca17bc64bd29bd95fef1cf8b75a
231 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
232 schema:name Medical and Health Sciences
233 rdf:type schema:DefinedTerm
234 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
235 schema:name Oncology and Carcinogenesis
236 rdf:type schema:DefinedTerm
237 sg:grant.2435643 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2407-8-17
238 rdf:type schema:MonetaryGrant
239 sg:grant.2440138 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2407-8-17
240 rdf:type schema:MonetaryGrant
241 sg:grant.2440150 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2407-8-17
242 rdf:type schema:MonetaryGrant
243 sg:grant.4109929 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2407-8-17
244 rdf:type schema:MonetaryGrant
245 sg:journal.1024632 schema:issn 1471-2407
246 schema:name BMC Cancer
247 rdf:type schema:Periodical
248 sg:person.010106740464.33 schema:affiliation https://www.grid.ac/institutes/grid.416153.4
249 schema:familyName Horsman
250 schema:givenName Doug
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010106740464.33
252 rdf:type schema:Person
253 sg:person.01061440173.67 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
254 schema:familyName Ridge
255 schema:givenName Yolanda
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061440173.67
257 rdf:type schema:Person
258 sg:person.01064253031.26 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
259 schema:familyName Spellman
260 schema:givenName Paul T
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064253031.26
262 rdf:type schema:Person
263 sg:person.011077447057.72 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
264 schema:familyName Miller
265 schema:givenName Dianne M
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011077447057.72
267 rdf:type schema:Person
268 sg:person.01116275315.53 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
269 schema:familyName Young
270 schema:givenName Sean
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116275315.53
272 rdf:type schema:Person
273 sg:person.01120560217.98 schema:affiliation https://www.grid.ac/institutes/grid.412541.7
274 schema:familyName Gilks
275 schema:givenName C Blake
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120560217.98
277 rdf:type schema:Person
278 sg:person.01122533136.29 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
279 schema:familyName Troussard
280 schema:givenName Armelle
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122533136.29
282 rdf:type schema:Person
283 sg:person.012263040417.40 schema:affiliation https://www.grid.ac/institutes/grid.417703.6
284 schema:familyName Wang
285 schema:givenName Yuker
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012263040417.40
287 rdf:type schema:Person
288 sg:person.01230770417.44 schema:affiliation https://www.grid.ac/institutes/grid.417703.6
289 schema:familyName Faham
290 schema:givenName Malek
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230770417.44
292 rdf:type schema:Person
293 sg:person.01310236620.83 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
294 schema:familyName Blood
295 schema:givenName Katherine A
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310236620.83
297 rdf:type schema:Person
298 sg:person.01317605274.52 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
299 schema:familyName Kaurah
300 schema:givenName Pardeep
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317605274.52
302 rdf:type schema:Person
303 sg:person.013452370272.66 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
304 schema:familyName Boyd
305 schema:givenName Niki
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013452370272.66
307 rdf:type schema:Person
308 sg:person.014525340267.00 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
309 schema:familyName Gray
310 schema:givenName Joe
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014525340267.00
312 rdf:type schema:Person
313 sg:person.015140454124.62 schema:affiliation https://www.grid.ac/institutes/grid.412541.7
314 schema:familyName Huntsman
315 schema:givenName David G
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015140454124.62
317 rdf:type schema:Person
318 sg:person.0657267337.09 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
319 schema:familyName Press
320 schema:givenName Joshua Z
321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657267337.09
322 rdf:type schema:Person
323 sg:person.0743205140.47 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
324 schema:familyName De Luca
325 schema:givenName Alessandro
326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743205140.47
327 rdf:type schema:Person
328 sg:person.0762426613.24 schema:affiliation https://www.grid.ac/institutes/grid.412541.7
329 schema:familyName Kalloger
330 schema:givenName Steve E
331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762426613.24
332 rdf:type schema:Person
333 sg:pub.10.1023/b:fame.0000039861.30651.c8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002166811
334 https://doi.org/10.1023/b:fame.0000039861.30651.c8
335 rdf:type schema:CreativeWork
336 sg:pub.10.1038/5042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015487157
337 https://doi.org/10.1038/5042
338 rdf:type schema:CreativeWork
339 sg:pub.10.1038/bjc.1997.526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013836365
340 https://doi.org/10.1038/bjc.1997.526
341 rdf:type schema:CreativeWork
342 sg:pub.10.1038/modpathol.3800306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027289274
343 https://doi.org/10.1038/modpathol.3800306
344 rdf:type schema:CreativeWork
345 sg:pub.10.1038/nature03443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036499081
346 https://doi.org/10.1038/nature03443
347 rdf:type schema:CreativeWork
348 sg:pub.10.1038/nature03445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039649759
349 https://doi.org/10.1038/nature03445
350 rdf:type schema:CreativeWork
351 sg:pub.10.1038/ng0396-333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013077376
352 https://doi.org/10.1038/ng0396-333
353 rdf:type schema:CreativeWork
354 sg:pub.10.1038/ng0495-439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029999728
355 https://doi.org/10.1038/ng0495-439
356 rdf:type schema:CreativeWork
357 sg:pub.10.1038/ng0894-472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046324905
358 https://doi.org/10.1038/ng0894-472
359 rdf:type schema:CreativeWork
360 sg:pub.10.1038/nm852 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019055785
361 https://doi.org/10.1038/nm852
362 rdf:type schema:CreativeWork
363 sg:pub.10.1038/nrc1457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042257134
364 https://doi.org/10.1038/nrc1457
365 rdf:type schema:CreativeWork
366 sg:pub.10.1038/sj.onc.1206176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008238042
367 https://doi.org/10.1038/sj.onc.1206176
368 rdf:type schema:CreativeWork
369 sg:pub.10.1054/bjoc.2000.1581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037306339
370 https://doi.org/10.1054/bjoc.2000.1581
371 rdf:type schema:CreativeWork
372 https://app.dimensions.ai/details/publication/pub.1074613540 schema:CreativeWork
373 https://app.dimensions.ai/details/publication/pub.1074624822 schema:CreativeWork
374 https://app.dimensions.ai/details/publication/pub.1074708118 schema:CreativeWork
375 https://app.dimensions.ai/details/publication/pub.1074801138 schema:CreativeWork
376 https://app.dimensions.ai/details/publication/pub.1075003246 schema:CreativeWork
377 https://app.dimensions.ai/details/publication/pub.1075087966 schema:CreativeWork
378 https://app.dimensions.ai/details/publication/pub.1075262312 schema:CreativeWork
379 https://app.dimensions.ai/details/publication/pub.1076852340 schema:CreativeWork
380 https://app.dimensions.ai/details/publication/pub.1077213523 schema:CreativeWork
381 https://app.dimensions.ai/details/publication/pub.1082557887 schema:CreativeWork
382 https://app.dimensions.ai/details/publication/pub.1082825732 schema:CreativeWork
383 https://doi.org/10.1001/jama.283.17.2260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023526030
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1002/1097-0142(20010815)92:4<787::aid-cncr1384>3.0.co;2-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027511713
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1002/cncr.11080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049973628
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1002/cncr.11310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016295307
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1002/cncr.21276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011674754
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1002/cncr.21536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011828352
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1002/cncr.21992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002843968
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1002/ijc.2910640412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032190816
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1002/path.1193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004484245
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1002/path.1507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006625148
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1016/0092-8674(93)90500-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1038576682
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1016/j.ccr.2007.02.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027587031
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1016/j.coph.2006.02.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049862846
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1016/j.molmed.2006.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032059219
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1016/j.ygyno.2005.10.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011600196
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1016/s0002-9440(10)61714-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038820521
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1016/s0092-8674(02)00615-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003706567
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1016/s0889-8588(03)00061-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000265301
418 rdf:type schema:CreativeWork
419 https://doi.org/10.1016/s0959-8049(02)00041-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005948625
420 rdf:type schema:CreativeWork
421 https://doi.org/10.1042/bst0340633 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051372982
422 rdf:type schema:CreativeWork
423 https://doi.org/10.1046/j.1365-2362.2003.01116.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045019580
424 rdf:type schema:CreativeWork
425 https://doi.org/10.1046/j.1432-1327.2001.01936.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051367437
426 rdf:type schema:CreativeWork
427 https://doi.org/10.1046/j.1525-1438.2000.010004289.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1056744084
428 rdf:type schema:CreativeWork
429 https://doi.org/10.1073/pnas.89.19.9267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048848467
430 rdf:type schema:CreativeWork
431 https://doi.org/10.1073/pnas.91.21.10148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006403818
432 rdf:type schema:CreativeWork
433 https://doi.org/10.1073/pnas.96.5.2077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051736465
434 rdf:type schema:CreativeWork
435 https://doi.org/10.1074/jbc.m203636200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017982027
436 rdf:type schema:CreativeWork
437 https://doi.org/10.1080/00313020220147113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049352850
438 rdf:type schema:CreativeWork
439 https://doi.org/10.1086/318787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058622528
440 rdf:type schema:CreativeWork
441 https://doi.org/10.1093/jnci/92.7.564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044385773
442 rdf:type schema:CreativeWork
443 https://doi.org/10.1093/jnci/94.13.990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008897588
444 rdf:type schema:CreativeWork
445 https://doi.org/10.1093/jnci/95.6.484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049943179
446 rdf:type schema:CreativeWork
447 https://doi.org/10.1093/nar/26.6.1396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043803354
448 rdf:type schema:CreativeWork
449 https://doi.org/10.1093/nar/gni177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044827446
450 rdf:type schema:CreativeWork
451 https://doi.org/10.1097/00000478-200404000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036053529
452 rdf:type schema:CreativeWork
453 https://doi.org/10.1097/00004347-199804000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016814605
454 rdf:type schema:CreativeWork
455 https://doi.org/10.1097/00004347-200001000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020007633
456 rdf:type schema:CreativeWork
457 https://doi.org/10.1097/00004347-200210000-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006554022
458 rdf:type schema:CreativeWork
459 https://doi.org/10.1097/01.pgp.0000101080.35393.16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048334618
460 rdf:type schema:CreativeWork
461 https://doi.org/10.1097/01.pgp.0000101083.35393.cd schema:sameAs https://app.dimensions.ai/details/publication/pub.1051600189
462 rdf:type schema:CreativeWork
463 https://doi.org/10.1101/gr.3185605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029969824
464 rdf:type schema:CreativeWork
465 https://doi.org/10.1111/j.1365-2559.2004.01787.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008911407
466 rdf:type schema:CreativeWork
467 https://doi.org/10.1111/j.1525-1438.2006.00504.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046837371
468 rdf:type schema:CreativeWork
469 https://doi.org/10.1126/science.2270482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062529993
470 rdf:type schema:CreativeWork
471 https://doi.org/10.1126/science.7545954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041365117
472 rdf:type schema:CreativeWork
473 https://doi.org/10.1126/science.7939630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062650649
474 rdf:type schema:CreativeWork
475 https://doi.org/10.1126/science.8091231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062652236
476 rdf:type schema:CreativeWork
477 https://doi.org/10.1158/0008-5472-can-04-3913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011326721
478 rdf:type schema:CreativeWork
479 https://doi.org/10.1158/0008-5472.can-04-1170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003861547
480 rdf:type schema:CreativeWork
481 https://doi.org/10.1158/0008-5472.can-05-2620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032388482
482 rdf:type schema:CreativeWork
483 https://doi.org/10.1158/1078-0432.ccr-06-1375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022108262
484 rdf:type schema:CreativeWork
485 https://doi.org/10.1200/jco.20.5.1248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064202847
486 rdf:type schema:CreativeWork
487 https://doi.org/10.1200/jco.2002.09.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203120
488 rdf:type schema:CreativeWork
489 https://doi.org/10.1200/jco.2003.07.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203714
490 rdf:type schema:CreativeWork
491 https://doi.org/10.2202/1544-6115.1095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013708845
492 rdf:type schema:CreativeWork
493 https://doi.org/10.3892/ijo.13.1.101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071510724
494 rdf:type schema:CreativeWork
495 https://doi.org/10.3892/ijo.16.3.567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071511284
496 rdf:type schema:CreativeWork
497 https://www.grid.ac/institutes/grid.17091.3e schema:alternateName University of British Columbia
498 schema:name Department of Gynecologic Oncology, University of British Columbia, Vancouver, British Columbia, Canada
499 Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada
500 Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
501 rdf:type schema:Organization
502 https://www.grid.ac/institutes/grid.248762.d schema:alternateName BC Cancer Agency
503 schema:name Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
504 Hereditary Cancer Program, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
505 rdf:type schema:Organization
506 https://www.grid.ac/institutes/grid.266102.1 schema:alternateName University of California, San Francisco
507 schema:name Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, San Francisco, California, USA
508 rdf:type schema:Organization
509 https://www.grid.ac/institutes/grid.412541.7 schema:alternateName Vancouver General Hospital
510 schema:name Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
511 Genetic Pathology Evaluation Centre of the Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia, Canada
512 Hereditary Cancer Program, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
513 rdf:type schema:Organization
514 https://www.grid.ac/institutes/grid.416153.4 schema:alternateName Royal Melbourne Hospital
515 schema:name Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
516 Molecular Genetics, The Royal Melbourne Hospital, Parkville, Australia
517 rdf:type schema:Organization
518 https://www.grid.ac/institutes/grid.417703.6 schema:alternateName Affymetrix (United States)
519 schema:name Affymetrix Inc, 7300 Shoreline Blvd South, San FranciscoCalifornia, USA
520 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...