A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: A case control study in an Italian population View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-12

AUTHORS

Soroush Nasri, Helen More, Francesco Graziano, Annamaria Ruzzo, Emily Wilson, Anita Dunbier, Cushla McKinney, Tony Merriman, Parry Guilford, Mauro Magnani, Bostjan Humar

ABSTRACT

BACKGROUND: Inherited genetic factors such as E-cadherin (CDH1) promoter variants are believed to influence the risk towards sporadic diffuse gastric cancer (DGC). Recently, a new regulatory region essential for CDH1 transcription has been identified in CDH1 intron 2. METHODS: We genotyped all known polymorphisms located within conserved sequences of CDH1 intron 2 (rs10673765, rs9932686, rs1125557, rs9282650, rs9931853) in an Italian population consisting of 134 DGC cases and 100 healthy controls (55 patient relatives and 45 unrelated, matched individuals). The influence of individual variants on DGC risk was assessed using chi2-tests and logistic regression. The relative contribution of alleles was estimated by haplotype analysis. RESULTS: We observed a significant (p < 0.0004) association of the CDH1 163+37235G>A variant (rs1125557) with DGC risk. Odds ratios were 4.55 (95%CI = 2.09-9.93) and 1.38 (95%CI = 0.75-2.55) for AA and GA carriers, respectively. When adjusted for age, sex, smoking status, alcohol intake and H. pylori infection, the risk estimates remained largely significant for AA carriers. Haplotype analysis suggested the 163+37235A-allele contributes to disease risk independently of the other variants studied. CONCLUSION: The CDH1 163+37235G>A polymorphism may represent a novel susceptibility variant for sporadic DGC if confirmed in other populations. Considering the broad expression of E-cadherin in epithelia, this exploratory study encourages further evaluation of the 163+37235A-allele as a susceptibility variant in other carcinomas. More... »

PAGES

138

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2407-8-138

DOI

http://dx.doi.org/10.1186/1471-2407-8-138

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009897570

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18482459


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cadherins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Introns", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Italy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Regulatory Elements, Transcriptional", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stomach Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Otago", 
          "id": "https://www.grid.ac/institutes/grid.29980.3a", 
          "name": [
            "Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, 9054, Dunedin, Aotearoa, New Zealand"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nasri", 
        "givenName": "Soroush", 
        "id": "sg:person.01036255453.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036255453.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Otago", 
          "id": "https://www.grid.ac/institutes/grid.29980.3a", 
          "name": [
            "Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, 9054, Dunedin, Aotearoa, New Zealand"
          ], 
          "type": "Organization"
        }, 
        "familyName": "More", 
        "givenName": "Helen", 
        "id": "sg:person.0675355755.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675355755.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "San Salvatore Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415103.2", 
          "name": [
            "Medical Oncology Unit, Azienda Ospedale \"S. Salvatore\", 61100, Pesaro, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Graziano", 
        "givenName": "Francesco", 
        "id": "sg:person.01027716061.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027716061.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Urbino", 
          "id": "https://www.grid.ac/institutes/grid.12711.34", 
          "name": [
            "Institute of Biochemistry, University of Urbino, 61029, Urbino, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ruzzo", 
        "givenName": "Annamaria", 
        "id": "sg:person.0577005525.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577005525.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Auckland", 
          "id": "https://www.grid.ac/institutes/grid.9654.e", 
          "name": [
            "Department of Molecular Medicine & Pathology, University of Auckland, 1142, Auckland, Aotearoa, New Zealand"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wilson", 
        "givenName": "Emily", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Institute of Cancer Research, SW3 6JB, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dunbier", 
        "givenName": "Anita", 
        "id": "sg:person.01220051520.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220051520.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Otago", 
          "id": "https://www.grid.ac/institutes/grid.29980.3a", 
          "name": [
            "Department of Biochemistry, University of Otago, 9054, Dunedin, Aotearoa, New Zealand"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McKinney", 
        "givenName": "Cushla", 
        "id": "sg:person.0756571601.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756571601.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Otago", 
          "id": "https://www.grid.ac/institutes/grid.29980.3a", 
          "name": [
            "Department of Biochemistry, University of Otago, 9054, Dunedin, Aotearoa, New Zealand"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Merriman", 
        "givenName": "Tony", 
        "id": "sg:person.0641412005.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641412005.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Otago", 
          "id": "https://www.grid.ac/institutes/grid.29980.3a", 
          "name": [
            "Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, 9054, Dunedin, Aotearoa, New Zealand"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guilford", 
        "givenName": "Parry", 
        "id": "sg:person.0743471155.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743471155.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Urbino", 
          "id": "https://www.grid.ac/institutes/grid.12711.34", 
          "name": [
            "Institute of Biochemistry, University of Urbino, 61029, Urbino, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Magnani", 
        "givenName": "Mauro", 
        "id": "sg:person.0752252542.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752252542.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Otago", 
          "id": "https://www.grid.ac/institutes/grid.29980.3a", 
          "name": [
            "Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, 9054, Dunedin, Aotearoa, New Zealand"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Humar", 
        "givenName": "Bostjan", 
        "id": "sg:person.0627242555.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627242555.55"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.3346/jkms.2003.18.4.501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000300624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00365520701478436", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003554974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1276", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003923555", 
          "https://doi.org/10.1038/nrc1276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1276", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003923555", 
          "https://doi.org/10.1038/nrc1276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cr.7290272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006534318", 
          "https://doi.org/10.1038/sj.cr.7290272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cr.7290272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006534318", 
          "https://doi.org/10.1038/sj.cr.7290272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cr.7290286", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006552091", 
          "https://doi.org/10.1038/sj.cr.7290286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cr.7290286", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006552091", 
          "https://doi.org/10.1038/sj.cr.7290286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-006-9054-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006594498", 
          "https://doi.org/10.1245/s10434-006-9054-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/aje/kwm264", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009636566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(04)00033-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009712886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1057/9780230504523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010061477", 
          "https://doi.org/10.1057/9780230504523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1057/9780230504523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010061477", 
          "https://doi.org/10.1057/9780230504523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.2085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011570885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.10541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016586082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-005-0060-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016777908", 
          "https://doi.org/10.1007/s00439-005-0060-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-005-0060-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016777908", 
          "https://doi.org/10.1007/s00439-005-0060-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-005-0060-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016777908", 
          "https://doi.org/10.1007/s00439-005-0060-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.01662", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019119058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-3021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025623282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ju.0000084297.43710.e9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025631423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ju.0000084297.43710.e9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025631423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.02293-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026645737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19930515)71:10<2926::aid-cncr2820711007>3.0.co;2-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028142774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1897-4287-5-4-183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029040478", 
          "https://doi.org/10.1186/1897-4287-5-4-183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0177(199703)208:3<313::aid-aja3>3.0.co;2-l", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030378522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/21.3.334", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032582441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-1004(1998)12:4<226::aid-humu2>3.0.co;2-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035321665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1205921", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036825163", 
          "https://doi.org/10.1038/sj.onc.1205921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1205921", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036825163", 
          "https://doi.org/10.1038/sj.onc.1205921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.10590", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040287473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/92.7.569", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040831945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2004/454238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042544156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/humu.10067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043875133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3835(03)00130-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043898135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3835(03)00130-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043898135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.17.8263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044031236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11373-006-9069-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044061922", 
          "https://doi.org/10.1007/s11373-006-9069-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11373-006-9069-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044061922", 
          "https://doi.org/10.1007/s11373-006-9069-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/32918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044664817", 
          "https://doi.org/10.1038/32918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/32918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044664817", 
          "https://doi.org/10.1038/32918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m303530200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045255100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgh223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047996729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkl861", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050083956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or.15.6.1491", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071530030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077051871", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077343666", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082511013", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083387777", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-12", 
    "datePublishedReg": "2008-12-01", 
    "description": "BACKGROUND: Inherited genetic factors such as E-cadherin (CDH1) promoter variants are believed to influence the risk towards sporadic diffuse gastric cancer (DGC). Recently, a new regulatory region essential for CDH1 transcription has been identified in CDH1 intron 2.\nMETHODS: We genotyped all known polymorphisms located within conserved sequences of CDH1 intron 2 (rs10673765, rs9932686, rs1125557, rs9282650, rs9931853) in an Italian population consisting of 134 DGC cases and 100 healthy controls (55 patient relatives and 45 unrelated, matched individuals). The influence of individual variants on DGC risk was assessed using chi2-tests and logistic regression. The relative contribution of alleles was estimated by haplotype analysis.\nRESULTS: We observed a significant (p < 0.0004) association of the CDH1 163+37235G>A variant (rs1125557) with DGC risk. Odds ratios were 4.55 (95%CI = 2.09-9.93) and 1.38 (95%CI = 0.75-2.55) for AA and GA carriers, respectively. When adjusted for age, sex, smoking status, alcohol intake and H. pylori infection, the risk estimates remained largely significant for AA carriers. Haplotype analysis suggested the 163+37235A-allele contributes to disease risk independently of the other variants studied.\nCONCLUSION: The CDH1 163+37235G>A polymorphism may represent a novel susceptibility variant for sporadic DGC if confirmed in other populations. Considering the broad expression of E-cadherin in epithelia, this exploratory study encourages further evaluation of the 163+37235A-allele as a susceptibility variant in other carcinomas.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-2407-8-138", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024632", 
        "issn": [
          "1471-2407"
        ], 
        "name": "BMC Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: A case control study in an Italian population", 
    "pagination": "138", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2f26bc57c5192b3d4e8746a7280cb45229a82ed92203e669fa03fd8a6ba9faf5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18482459"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100967800"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2407-8-138"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1009897570"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2407-8-138", 
      "https://app.dimensions.ai/details/publication/pub.1009897570"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:46", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-2407-8-138"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-8-138'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-8-138'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-8-138'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-8-138'


 

This table displays all metadata directly associated to this object as RDF triples.

330 TRIPLES      21 PREDICATES      82 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2407-8-138 schema:about N1d8bee2a275a472f87d1ceceb59cbd94
2 N23bd92bf37ca4a1eb9262a6ad10919b0
3 N2ad4cdf9edd841798f13902304d17230
4 N3fcf3facaa7a49ad93fbb8bafee93c26
5 N4405f7e9111b4991b2f3a6b97685573f
6 N543a4c5e75084b36a4179c8601d289ef
7 N6feb32e23e734405842a8f36dae65c59
8 N70ec370439e0443a939e4d022ec3e974
9 Nb59944b527d640f0ba447dc15d06b9f4
10 Nd0e617f19b724882a71f2fc64516a960
11 Ne2a49b851a994a82b45fb4896b6731a7
12 Ne33c864fd697464b99497d34c098209e
13 Ne61f83b15fbe46e18b32ad2da6dc5728
14 Nf253fd6640bc4b8bb501e2c69c469651
15 Nf3f8f6e659264786938b95ded929d27e
16 anzsrc-for:06
17 anzsrc-for:0604
18 schema:author N11d408d163b84230b0d4089117badb5d
19 schema:citation sg:pub.10.1007/s00439-005-0060-6
20 sg:pub.10.1007/s11373-006-9069-7
21 sg:pub.10.1038/32918
22 sg:pub.10.1038/nrc1276
23 sg:pub.10.1038/sj.cr.7290272
24 sg:pub.10.1038/sj.cr.7290286
25 sg:pub.10.1038/sj.onc.1205921
26 sg:pub.10.1057/9780230504523
27 sg:pub.10.1186/1897-4287-5-4-183
28 sg:pub.10.1245/s10434-006-9054-4
29 https://app.dimensions.ai/details/publication/pub.1077051871
30 https://app.dimensions.ai/details/publication/pub.1077343666
31 https://app.dimensions.ai/details/publication/pub.1082511013
32 https://app.dimensions.ai/details/publication/pub.1083387777
33 https://doi.org/10.1002/(sici)1097-0177(199703)208:3<313::aid-aja3>3.0.co;2-l
34 https://doi.org/10.1002/(sici)1098-1004(1998)12:4<226::aid-humu2>3.0.co;2-d
35 https://doi.org/10.1002/1097-0142(19930515)71:10<2926::aid-cncr2820711007>3.0.co;2-x
36 https://doi.org/10.1002/humu.10067
37 https://doi.org/10.1002/ijc.10541
38 https://doi.org/10.1002/ijc.10590
39 https://doi.org/10.1002/path.2085
40 https://doi.org/10.1016/s0304-3835(03)00130-7
41 https://doi.org/10.1016/s1535-6108(04)00033-9
42 https://doi.org/10.1073/pnas.91.17.8263
43 https://doi.org/10.1074/jbc.m303530200
44 https://doi.org/10.1080/00365520701478436
45 https://doi.org/10.1093/aje/kwm264
46 https://doi.org/10.1093/carcin/bgh223
47 https://doi.org/10.1093/emboj/21.3.334
48 https://doi.org/10.1093/jnci/92.7.569
49 https://doi.org/10.1093/nar/gkl861
50 https://doi.org/10.1097/01.ju.0000084297.43710.e9
51 https://doi.org/10.1128/mcb.02293-06
52 https://doi.org/10.1155/2004/454238
53 https://doi.org/10.1158/0008-5472.can-06-3021
54 https://doi.org/10.1242/dev.01662
55 https://doi.org/10.3346/jkms.2003.18.4.501
56 https://doi.org/10.3892/or.15.6.1491
57 schema:datePublished 2008-12
58 schema:datePublishedReg 2008-12-01
59 schema:description BACKGROUND: Inherited genetic factors such as E-cadherin (CDH1) promoter variants are believed to influence the risk towards sporadic diffuse gastric cancer (DGC). Recently, a new regulatory region essential for CDH1 transcription has been identified in CDH1 intron 2. METHODS: We genotyped all known polymorphisms located within conserved sequences of CDH1 intron 2 (rs10673765, rs9932686, rs1125557, rs9282650, rs9931853) in an Italian population consisting of 134 DGC cases and 100 healthy controls (55 patient relatives and 45 unrelated, matched individuals). The influence of individual variants on DGC risk was assessed using chi2-tests and logistic regression. The relative contribution of alleles was estimated by haplotype analysis. RESULTS: We observed a significant (p < 0.0004) association of the CDH1 163+37235G>A variant (rs1125557) with DGC risk. Odds ratios were 4.55 (95%CI = 2.09-9.93) and 1.38 (95%CI = 0.75-2.55) for AA and GA carriers, respectively. When adjusted for age, sex, smoking status, alcohol intake and H. pylori infection, the risk estimates remained largely significant for AA carriers. Haplotype analysis suggested the 163+37235A-allele contributes to disease risk independently of the other variants studied. CONCLUSION: The CDH1 163+37235G>A polymorphism may represent a novel susceptibility variant for sporadic DGC if confirmed in other populations. Considering the broad expression of E-cadherin in epithelia, this exploratory study encourages further evaluation of the 163+37235A-allele as a susceptibility variant in other carcinomas.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree true
63 schema:isPartOf N9132055da11448caadf4d80f4a6215d7
64 Nbfbe5f5c40ff44b0955847b3d74e7aa5
65 sg:journal.1024632
66 schema:name A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: A case control study in an Italian population
67 schema:pagination 138
68 schema:productId N451cf0f5d45d4bdd80055245026ccd7e
69 N461e8878594748eb8e896dd49e323dd4
70 N4983d6cdec84493aaab683685aff50ce
71 N7c7d7f8cd1c8425996e89f59f771b14b
72 Na53696f4084a4558bc3711b25ff10553
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009897570
74 https://doi.org/10.1186/1471-2407-8-138
75 schema:sdDatePublished 2019-04-10T20:46
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher N09bca01289cd4123aa98c12203fecd6d
78 schema:url http://link.springer.com/10.1186%2F1471-2407-8-138
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N053e92ae71bc4340acf95214e64a7548 rdf:first sg:person.0627242555.55
83 rdf:rest rdf:nil
84 N09bca01289cd4123aa98c12203fecd6d schema:name Springer Nature - SN SciGraph project
85 rdf:type schema:Organization
86 N11d408d163b84230b0d4089117badb5d rdf:first sg:person.01036255453.10
87 rdf:rest N882e2291f0c1470ca2de4e2c4ca6c9f7
88 N1bdf01ce28224f5c85d2aabd68aac795 rdf:first sg:person.0743471155.46
89 rdf:rest N9c00ab7f66724030990e2cfacfdbfa57
90 N1d8bee2a275a472f87d1ceceb59cbd94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Adult
92 rdf:type schema:DefinedTerm
93 N23bd92bf37ca4a1eb9262a6ad10919b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Humans
95 rdf:type schema:DefinedTerm
96 N25fc7026d0b24c34aab365bed8e5fd34 rdf:first N575ea750d9e04f0795320de4475bfde9
97 rdf:rest N8e11b2efeea24999b89b0c4759cf05bf
98 N2ad4cdf9edd841798f13902304d17230 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Cadherins
100 rdf:type schema:DefinedTerm
101 N3dc7e86b901d4102b08d23e92ec91f3c rdf:first sg:person.01027716061.05
102 rdf:rest Nadc91284b39447c2842756be1f78b03c
103 N3fcf3facaa7a49ad93fbb8bafee93c26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Middle Aged
105 rdf:type schema:DefinedTerm
106 N4405f7e9111b4991b2f3a6b97685573f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Italy
108 rdf:type schema:DefinedTerm
109 N451cf0f5d45d4bdd80055245026ccd7e schema:name readcube_id
110 schema:value 2f26bc57c5192b3d4e8746a7280cb45229a82ed92203e669fa03fd8a6ba9faf5
111 rdf:type schema:PropertyValue
112 N461e8878594748eb8e896dd49e323dd4 schema:name pubmed_id
113 schema:value 18482459
114 rdf:type schema:PropertyValue
115 N4983d6cdec84493aaab683685aff50ce schema:name dimensions_id
116 schema:value pub.1009897570
117 rdf:type schema:PropertyValue
118 N543a4c5e75084b36a4179c8601d289ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Female
120 rdf:type schema:DefinedTerm
121 N575ea750d9e04f0795320de4475bfde9 schema:affiliation https://www.grid.ac/institutes/grid.9654.e
122 schema:familyName Wilson
123 schema:givenName Emily
124 rdf:type schema:Person
125 N6feb32e23e734405842a8f36dae65c59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Male
127 rdf:type schema:DefinedTerm
128 N70ec370439e0443a939e4d022ec3e974 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Genetic Predisposition to Disease
130 rdf:type schema:DefinedTerm
131 N7c7d7f8cd1c8425996e89f59f771b14b schema:name doi
132 schema:value 10.1186/1471-2407-8-138
133 rdf:type schema:PropertyValue
134 N882e2291f0c1470ca2de4e2c4ca6c9f7 rdf:first sg:person.0675355755.16
135 rdf:rest N3dc7e86b901d4102b08d23e92ec91f3c
136 N8cfdf767a273475baddbd3f0ee6bee64 rdf:first sg:person.0756571601.07
137 rdf:rest Nc0894dd345f24db8a925100f0c57dab7
138 N8e11b2efeea24999b89b0c4759cf05bf rdf:first sg:person.01220051520.72
139 rdf:rest N8cfdf767a273475baddbd3f0ee6bee64
140 N9132055da11448caadf4d80f4a6215d7 schema:volumeNumber 8
141 rdf:type schema:PublicationVolume
142 N9c00ab7f66724030990e2cfacfdbfa57 rdf:first sg:person.0752252542.98
143 rdf:rest N053e92ae71bc4340acf95214e64a7548
144 Na53696f4084a4558bc3711b25ff10553 schema:name nlm_unique_id
145 schema:value 100967800
146 rdf:type schema:PropertyValue
147 Nadc91284b39447c2842756be1f78b03c rdf:first sg:person.0577005525.74
148 rdf:rest N25fc7026d0b24c34aab365bed8e5fd34
149 Nb59944b527d640f0ba447dc15d06b9f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Regulatory Elements, Transcriptional
151 rdf:type schema:DefinedTerm
152 Nbfbe5f5c40ff44b0955847b3d74e7aa5 schema:issueNumber 1
153 rdf:type schema:PublicationIssue
154 Nc0894dd345f24db8a925100f0c57dab7 rdf:first sg:person.0641412005.79
155 rdf:rest N1bdf01ce28224f5c85d2aabd68aac795
156 Nd0e617f19b724882a71f2fc64516a960 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Introns
158 rdf:type schema:DefinedTerm
159 Ne2a49b851a994a82b45fb4896b6731a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Stomach Neoplasms
161 rdf:type schema:DefinedTerm
162 Ne33c864fd697464b99497d34c098209e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Polymorphism, Genetic
164 rdf:type schema:DefinedTerm
165 Ne61f83b15fbe46e18b32ad2da6dc5728 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Aged
167 rdf:type schema:DefinedTerm
168 Nf253fd6640bc4b8bb501e2c69c469651 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Genotype
170 rdf:type schema:DefinedTerm
171 Nf3f8f6e659264786938b95ded929d27e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Case-Control Studies
173 rdf:type schema:DefinedTerm
174 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
175 schema:name Biological Sciences
176 rdf:type schema:DefinedTerm
177 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
178 schema:name Genetics
179 rdf:type schema:DefinedTerm
180 sg:journal.1024632 schema:issn 1471-2407
181 schema:name BMC Cancer
182 rdf:type schema:Periodical
183 sg:person.01027716061.05 schema:affiliation https://www.grid.ac/institutes/grid.415103.2
184 schema:familyName Graziano
185 schema:givenName Francesco
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027716061.05
187 rdf:type schema:Person
188 sg:person.01036255453.10 schema:affiliation https://www.grid.ac/institutes/grid.29980.3a
189 schema:familyName Nasri
190 schema:givenName Soroush
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036255453.10
192 rdf:type schema:Person
193 sg:person.01220051520.72 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
194 schema:familyName Dunbier
195 schema:givenName Anita
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220051520.72
197 rdf:type schema:Person
198 sg:person.0577005525.74 schema:affiliation https://www.grid.ac/institutes/grid.12711.34
199 schema:familyName Ruzzo
200 schema:givenName Annamaria
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577005525.74
202 rdf:type schema:Person
203 sg:person.0627242555.55 schema:affiliation https://www.grid.ac/institutes/grid.29980.3a
204 schema:familyName Humar
205 schema:givenName Bostjan
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627242555.55
207 rdf:type schema:Person
208 sg:person.0641412005.79 schema:affiliation https://www.grid.ac/institutes/grid.29980.3a
209 schema:familyName Merriman
210 schema:givenName Tony
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641412005.79
212 rdf:type schema:Person
213 sg:person.0675355755.16 schema:affiliation https://www.grid.ac/institutes/grid.29980.3a
214 schema:familyName More
215 schema:givenName Helen
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675355755.16
217 rdf:type schema:Person
218 sg:person.0743471155.46 schema:affiliation https://www.grid.ac/institutes/grid.29980.3a
219 schema:familyName Guilford
220 schema:givenName Parry
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743471155.46
222 rdf:type schema:Person
223 sg:person.0752252542.98 schema:affiliation https://www.grid.ac/institutes/grid.12711.34
224 schema:familyName Magnani
225 schema:givenName Mauro
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752252542.98
227 rdf:type schema:Person
228 sg:person.0756571601.07 schema:affiliation https://www.grid.ac/institutes/grid.29980.3a
229 schema:familyName McKinney
230 schema:givenName Cushla
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756571601.07
232 rdf:type schema:Person
233 sg:pub.10.1007/s00439-005-0060-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016777908
234 https://doi.org/10.1007/s00439-005-0060-6
235 rdf:type schema:CreativeWork
236 sg:pub.10.1007/s11373-006-9069-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044061922
237 https://doi.org/10.1007/s11373-006-9069-7
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/32918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044664817
240 https://doi.org/10.1038/32918
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/nrc1276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003923555
243 https://doi.org/10.1038/nrc1276
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/sj.cr.7290272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006534318
246 https://doi.org/10.1038/sj.cr.7290272
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/sj.cr.7290286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006552091
249 https://doi.org/10.1038/sj.cr.7290286
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/sj.onc.1205921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036825163
252 https://doi.org/10.1038/sj.onc.1205921
253 rdf:type schema:CreativeWork
254 sg:pub.10.1057/9780230504523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010061477
255 https://doi.org/10.1057/9780230504523
256 rdf:type schema:CreativeWork
257 sg:pub.10.1186/1897-4287-5-4-183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029040478
258 https://doi.org/10.1186/1897-4287-5-4-183
259 rdf:type schema:CreativeWork
260 sg:pub.10.1245/s10434-006-9054-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006594498
261 https://doi.org/10.1245/s10434-006-9054-4
262 rdf:type schema:CreativeWork
263 https://app.dimensions.ai/details/publication/pub.1077051871 schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1077343666 schema:CreativeWork
265 https://app.dimensions.ai/details/publication/pub.1082511013 schema:CreativeWork
266 https://app.dimensions.ai/details/publication/pub.1083387777 schema:CreativeWork
267 https://doi.org/10.1002/(sici)1097-0177(199703)208:3<313::aid-aja3>3.0.co;2-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1030378522
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1002/(sici)1098-1004(1998)12:4<226::aid-humu2>3.0.co;2-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1035321665
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1002/1097-0142(19930515)71:10<2926::aid-cncr2820711007>3.0.co;2-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028142774
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1002/humu.10067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043875133
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1002/ijc.10541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016586082
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1002/ijc.10590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040287473
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1002/path.2085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011570885
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/s0304-3835(03)00130-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043898135
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/s1535-6108(04)00033-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009712886
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1073/pnas.91.17.8263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044031236
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1074/jbc.m303530200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045255100
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1080/00365520701478436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003554974
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1093/aje/kwm264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009636566
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1093/carcin/bgh223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047996729
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1093/emboj/21.3.334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032582441
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1093/jnci/92.7.569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040831945
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1093/nar/gkl861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050083956
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1097/01.ju.0000084297.43710.e9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025631423
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1128/mcb.02293-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026645737
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1155/2004/454238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042544156
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1158/0008-5472.can-06-3021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025623282
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1242/dev.01662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019119058
310 rdf:type schema:CreativeWork
311 https://doi.org/10.3346/jkms.2003.18.4.501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000300624
312 rdf:type schema:CreativeWork
313 https://doi.org/10.3892/or.15.6.1491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071530030
314 rdf:type schema:CreativeWork
315 https://www.grid.ac/institutes/grid.12711.34 schema:alternateName University of Urbino
316 schema:name Institute of Biochemistry, University of Urbino, 61029, Urbino, Italy
317 rdf:type schema:Organization
318 https://www.grid.ac/institutes/grid.18886.3f schema:alternateName Institute of Cancer Research
319 schema:name Institute of Cancer Research, SW3 6JB, London, UK
320 rdf:type schema:Organization
321 https://www.grid.ac/institutes/grid.29980.3a schema:alternateName University of Otago
322 schema:name Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, 9054, Dunedin, Aotearoa, New Zealand
323 Department of Biochemistry, University of Otago, 9054, Dunedin, Aotearoa, New Zealand
324 rdf:type schema:Organization
325 https://www.grid.ac/institutes/grid.415103.2 schema:alternateName San Salvatore Hospital
326 schema:name Medical Oncology Unit, Azienda Ospedale "S. Salvatore", 61100, Pesaro, Italy
327 rdf:type schema:Organization
328 https://www.grid.ac/institutes/grid.9654.e schema:alternateName University of Auckland
329 schema:name Department of Molecular Medicine & Pathology, University of Auckland, 1142, Auckland, Aotearoa, New Zealand
330 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...