UDP-glucuronosyltransferase UGT1A7 genetic polymorphisms in hepatocellular carcinoma: a differential impact according to seropositivity of HBV or HCV markers? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-12

AUTHORS

I Stücker, MA Loriot, G N'Koutchou, S Cénée, L Bodin, C Mulot, M Gelu-Simeon, L Pelletier, JP Bronowicki, F Degos, P Beaune, P Laurent-Puig, D Hémon, JC Trinchet, G Pelletier

ABSTRACT

BACKGROUND: We conducted a case-control study to evaluate the role of UDP-glucuronosyltransferase 1A7 (UGT1A7) polymorphisms in the onset of hepatocellular carcinoma (HCC). METHODS: The study included 165 patients with HCC, 134 with cirrhosis and 142 controls without liver disease, matched for age and hospital. All were men younger than 75 years. HCC and cirrhosis patients were stratified according to time since cirrhosis diagnosis. RESULTS: We found a positive association between the UGT1A7*3/*3 genotype and HCC when the comparison was restricted to patients whose disease was of viral origin [OR = 3.4 (0.3-45)] but a negative association when it included only alcoholic patients [OR = 0.1 (0.02-0.6), p = 0.01]. CONCLUSION: Our study shows that UGT1A7 may play a role in hepatocellular carcinogenesis and that this role may differ according to the primary cause of the cirrhosis. More... »

PAGES

214

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2407-7-214

DOI

http://dx.doi.org/10.1186/1471-2407-7-214

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019127855

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18021430


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-7-214'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-7-214'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-7-214'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-7-214'


 

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331 UMR-S754, IFR69, F-94807, Villejuif, France
332 UMR-S775, F-75005, Paris, France
333 rdf:type schema:Organization
 




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