Recruitment of focal adhesion kinase and paxillin to β1 integrin promotes cancer cell migration via mitogen activated protein kinase activation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-12

AUTHORS

David L Crowe, Arthur Ohannessian

ABSTRACT

BACKGROUND: Integrin-extracellular matrix interactions activate signaling cascades such as mitogen activated protein kinases (MAPK). Integrin binding to extracellular matrix increases tyrosine phosphorylation of focal adhesion kinase (FAK). Inhibition of FAK activity by expression of its carboxyl terminus decreases cell motility, and cells from FAK deficient mice also show reduced migration. Paxillin is a focal adhesion protein which is also phosphorylated on tyrosine. FAK recruitment of paxillin to the cell membrane correlates with Shc phosphorylation and activation of MAPK. Decreased FAK expression inhibits papilloma formation in a mouse skin carcinogenesis model. We previously demonstrated that MAPK activation was required for growth factor induced in vitro migration and invasion by human squamous cell carcinoma (SCC) lines. METHODS: Adapter protein recruitment to integrin subunits was examined by co-immunoprecipitation in SCC cells attached to type IV collagen or plastic. Stable clones overexpressing FAK or paxillin were created using the lipofection technique. Modified Boyden chambers were used for invasion assays. RESULTS: In the present study, we showed that FAK and paxillin but not Shc are recruited to the beta1 integrin cytoplasmic domain following attachment of SCC cells to type IV collagen. Overexpression of either FAK or paxillin stimulated cancer cell migration on type IV collagen and invasion through reconstituted basement membrane which was dependent on MAPK activity. CONCLUSIONS: We concluded that recruitment of focal adhesion kinase and paxillin to beta1 integrin promoted cancer cell migration via the mitogen activated protein kinase pathway. More... »

PAGES

18

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2407-4-18

DOI

http://dx.doi.org/10.1186/1471-2407-4-18

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036114821

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15132756


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Squamous Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Adhesion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Collagen Type IV", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoskeletal Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Extracellular Matrix", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Focal Adhesion Kinase 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Focal Adhesion Protein-Tyrosine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Integrin beta1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Paxillin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plastics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Tyrosine Kinases", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Southern California", 
          "id": "https://www.grid.ac/institutes/grid.42505.36", 
          "name": [
            "Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, 90033, Los Angeles, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Crowe", 
        "givenName": "David L", 
        "id": "sg:person.01245540461.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245540461.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Southern California", 
          "id": "https://www.grid.ac/institutes/grid.42505.36", 
          "name": [
            "Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, 90033, Los Angeles, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohannessian", 
        "givenName": "Arthur", 
        "id": "sg:person.01231470552.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231470552.60"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/377539a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002285435", 
          "https://doi.org/10.1038/377539a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.43.30738", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002874033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.149.3.741", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002981788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/380538a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005974858", 
          "https://doi.org/10.1038/380538a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.17.12.6906", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008261374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m910027199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011989293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015176868", 
          "https://doi.org/10.1038/sj.bjc.6601050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015176868", 
          "https://doi.org/10.1038/sj.bjc.6601050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.7.8.1209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022916838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.neo.7900135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023858844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200212114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027630093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.134.3.793", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030212510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.107.5.1881", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031530401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.135.4.1109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031877991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m003871200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035435720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.6.6.637", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037592852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1747.2000.00884.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044054320", 
          "https://doi.org/10.1046/j.1523-1747.2000.00884.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/16.18.5592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049008815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.51.36684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051846108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0962-8924(99)01667-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052132529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.13.6.1127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071510868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.15.3.519", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071511119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.2000.278.6.g952", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074655650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074889433", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074961208", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-12", 
    "datePublishedReg": "2004-12-01", 
    "description": "BACKGROUND: Integrin-extracellular matrix interactions activate signaling cascades such as mitogen activated protein kinases (MAPK). Integrin binding to extracellular matrix increases tyrosine phosphorylation of focal adhesion kinase (FAK). Inhibition of FAK activity by expression of its carboxyl terminus decreases cell motility, and cells from FAK deficient mice also show reduced migration. Paxillin is a focal adhesion protein which is also phosphorylated on tyrosine. FAK recruitment of paxillin to the cell membrane correlates with Shc phosphorylation and activation of MAPK. Decreased FAK expression inhibits papilloma formation in a mouse skin carcinogenesis model. We previously demonstrated that MAPK activation was required for growth factor induced in vitro migration and invasion by human squamous cell carcinoma (SCC) lines.\nMETHODS: Adapter protein recruitment to integrin subunits was examined by co-immunoprecipitation in SCC cells attached to type IV collagen or plastic. Stable clones overexpressing FAK or paxillin were created using the lipofection technique. Modified Boyden chambers were used for invasion assays.\nRESULTS: In the present study, we showed that FAK and paxillin but not Shc are recruited to the beta1 integrin cytoplasmic domain following attachment of SCC cells to type IV collagen. Overexpression of either FAK or paxillin stimulated cancer cell migration on type IV collagen and invasion through reconstituted basement membrane which was dependent on MAPK activity.\nCONCLUSIONS: We concluded that recruitment of focal adhesion kinase and paxillin to beta1 integrin promoted cancer cell migration via the mitogen activated protein kinase pathway.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-2407-4-18", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2627308", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1024632", 
        "issn": [
          "1471-2407"
        ], 
        "name": "BMC Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "name": "Recruitment of focal adhesion kinase and paxillin to \u03b21 integrin promotes cancer cell migration via mitogen activated protein kinase activation", 
    "pagination": "18", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ac098cd70d9362298b48d4b086900050b2a746bbd1b6fb762461fd9bec806721"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15132756"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100967800"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2407-4-18"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1036114821"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2407-4-18", 
      "https://app.dimensions.ai/details/publication/pub.1036114821"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:38", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000550.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-2407-4-18"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-4-18'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-4-18'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-4-18'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-4-18'


 

This table displays all metadata directly associated to this object as RDF triples.

219 TRIPLES      21 PREDICATES      70 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2407-4-18 schema:about N0efac6ef253347939e42035deb11a46f
2 N234103f5c9da490ba4bd2b240e3f4bb5
3 N24311341d9664cd4832882103e481622
4 N3a9824db99424142adaf716591bc66ff
5 N542559cb4f914150a47767c5d15531e6
6 N63076a5d63cb4e5f893455065494c9e9
7 N742fe938c8e44cab813f1eacc7efaf09
8 Na119eb4c79a34a00ab7c2ece7b73fa3e
9 Naf012b724f974c428f2ec768f973b795
10 Nc05e1416c93c41c2b88c70ea6f877dfe
11 Ne3e4d16829634a04965579040d3624bc
12 Neca71f588f2044aab1ea08eb0c0a77a5
13 Nf5b50b7d00c6426aa6bdf30d0247e97e
14 Nf8133c3ec872423ab5edf6afef169911
15 Nf9ab84f243464f4eb5374b5f03828894
16 Nfbc41be508554369a21cfb439a5be80b
17 Nfdbe39a565c545b8bbb563ae99a91eea
18 anzsrc-for:06
19 anzsrc-for:0601
20 schema:author N044f42b51121463d82bc9d7a89b51dc8
21 schema:citation sg:pub.10.1038/377539a0
22 sg:pub.10.1038/380538a0
23 sg:pub.10.1038/sj.bjc.6601050
24 sg:pub.10.1046/j.1523-1747.2000.00884.x
25 https://app.dimensions.ai/details/publication/pub.1074889433
26 https://app.dimensions.ai/details/publication/pub.1074961208
27 https://doi.org/10.1016/s0962-8924(99)01667-0
28 https://doi.org/10.1038/sj.neo.7900135
29 https://doi.org/10.1074/jbc.274.43.30738
30 https://doi.org/10.1074/jbc.274.51.36684
31 https://doi.org/10.1074/jbc.m003871200
32 https://doi.org/10.1074/jbc.m910027199
33 https://doi.org/10.1083/jcb.107.5.1881
34 https://doi.org/10.1083/jcb.134.3.793
35 https://doi.org/10.1083/jcb.135.4.1109
36 https://doi.org/10.1083/jcb.149.3.741
37 https://doi.org/10.1083/jcb.200212114
38 https://doi.org/10.1091/mbc.6.6.637
39 https://doi.org/10.1091/mbc.7.8.1209
40 https://doi.org/10.1093/emboj/16.18.5592
41 https://doi.org/10.1128/mcb.17.12.6906
42 https://doi.org/10.1152/ajpgi.2000.278.6.g952
43 https://doi.org/10.3892/ijo.13.6.1127
44 https://doi.org/10.3892/ijo.15.3.519
45 schema:datePublished 2004-12
46 schema:datePublishedReg 2004-12-01
47 schema:description BACKGROUND: Integrin-extracellular matrix interactions activate signaling cascades such as mitogen activated protein kinases (MAPK). Integrin binding to extracellular matrix increases tyrosine phosphorylation of focal adhesion kinase (FAK). Inhibition of FAK activity by expression of its carboxyl terminus decreases cell motility, and cells from FAK deficient mice also show reduced migration. Paxillin is a focal adhesion protein which is also phosphorylated on tyrosine. FAK recruitment of paxillin to the cell membrane correlates with Shc phosphorylation and activation of MAPK. Decreased FAK expression inhibits papilloma formation in a mouse skin carcinogenesis model. We previously demonstrated that MAPK activation was required for growth factor induced in vitro migration and invasion by human squamous cell carcinoma (SCC) lines. METHODS: Adapter protein recruitment to integrin subunits was examined by co-immunoprecipitation in SCC cells attached to type IV collagen or plastic. Stable clones overexpressing FAK or paxillin were created using the lipofection technique. Modified Boyden chambers were used for invasion assays. RESULTS: In the present study, we showed that FAK and paxillin but not Shc are recruited to the beta1 integrin cytoplasmic domain following attachment of SCC cells to type IV collagen. Overexpression of either FAK or paxillin stimulated cancer cell migration on type IV collagen and invasion through reconstituted basement membrane which was dependent on MAPK activity. CONCLUSIONS: We concluded that recruitment of focal adhesion kinase and paxillin to beta1 integrin promoted cancer cell migration via the mitogen activated protein kinase pathway.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree true
51 schema:isPartOf N24aaccbf6e2d4005a00db890235c6718
52 N49ce615e84724e25a4bf4de6b7b809ca
53 sg:journal.1024632
54 schema:name Recruitment of focal adhesion kinase and paxillin to β1 integrin promotes cancer cell migration via mitogen activated protein kinase activation
55 schema:pagination 18
56 schema:productId N39294ec395394920bf5aec51f3e00a79
57 N73d74f4492bf434a83b477927e6a0493
58 Nb30de77c939c46a08d03ac75db7b7bc2
59 Nbd042ad9e97b447cb4d2daefe67bbb42
60 Nf6b45ae4b4af4f83b46ca09502557eab
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036114821
62 https://doi.org/10.1186/1471-2407-4-18
63 schema:sdDatePublished 2019-04-10T17:38
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher Nbe332524f1f846b791ff7642a9539561
66 schema:url http://link.springer.com/10.1186%2F1471-2407-4-18
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N044f42b51121463d82bc9d7a89b51dc8 rdf:first sg:person.01245540461.64
71 rdf:rest N61ed95c4f15645ba8af4c0d72980d85d
72 N0efac6ef253347939e42035deb11a46f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Humans
74 rdf:type schema:DefinedTerm
75 N234103f5c9da490ba4bd2b240e3f4bb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Cell Adhesion
77 rdf:type schema:DefinedTerm
78 N24311341d9664cd4832882103e481622 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Extracellular Matrix
80 rdf:type schema:DefinedTerm
81 N24aaccbf6e2d4005a00db890235c6718 schema:issueNumber 1
82 rdf:type schema:PublicationIssue
83 N39294ec395394920bf5aec51f3e00a79 schema:name readcube_id
84 schema:value ac098cd70d9362298b48d4b086900050b2a746bbd1b6fb762461fd9bec806721
85 rdf:type schema:PropertyValue
86 N3a9824db99424142adaf716591bc66ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Focal Adhesion Kinase 1
88 rdf:type schema:DefinedTerm
89 N49ce615e84724e25a4bf4de6b7b809ca schema:volumeNumber 4
90 rdf:type schema:PublicationVolume
91 N542559cb4f914150a47767c5d15531e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Collagen Type IV
93 rdf:type schema:DefinedTerm
94 N61ed95c4f15645ba8af4c0d72980d85d rdf:first sg:person.01231470552.60
95 rdf:rest rdf:nil
96 N63076a5d63cb4e5f893455065494c9e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Mitogen-Activated Protein Kinases
98 rdf:type schema:DefinedTerm
99 N73d74f4492bf434a83b477927e6a0493 schema:name pubmed_id
100 schema:value 15132756
101 rdf:type schema:PropertyValue
102 N742fe938c8e44cab813f1eacc7efaf09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Cytoskeletal Proteins
104 rdf:type schema:DefinedTerm
105 Na119eb4c79a34a00ab7c2ece7b73fa3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Focal Adhesion Protein-Tyrosine Kinases
107 rdf:type schema:DefinedTerm
108 Naf012b724f974c428f2ec768f973b795 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Integrin beta1
110 rdf:type schema:DefinedTerm
111 Nb30de77c939c46a08d03ac75db7b7bc2 schema:name nlm_unique_id
112 schema:value 100967800
113 rdf:type schema:PropertyValue
114 Nbd042ad9e97b447cb4d2daefe67bbb42 schema:name doi
115 schema:value 10.1186/1471-2407-4-18
116 rdf:type schema:PropertyValue
117 Nbe332524f1f846b791ff7642a9539561 schema:name Springer Nature - SN SciGraph project
118 rdf:type schema:Organization
119 Nc05e1416c93c41c2b88c70ea6f877dfe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Phosphoproteins
121 rdf:type schema:DefinedTerm
122 Ne3e4d16829634a04965579040d3624bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Carcinoma, Squamous Cell
124 rdf:type schema:DefinedTerm
125 Neca71f588f2044aab1ea08eb0c0a77a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Enzyme Activation
127 rdf:type schema:DefinedTerm
128 Nf5b50b7d00c6426aa6bdf30d0247e97e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Cell Movement
130 rdf:type schema:DefinedTerm
131 Nf6b45ae4b4af4f83b46ca09502557eab schema:name dimensions_id
132 schema:value pub.1036114821
133 rdf:type schema:PropertyValue
134 Nf8133c3ec872423ab5edf6afef169911 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Plastics
136 rdf:type schema:DefinedTerm
137 Nf9ab84f243464f4eb5374b5f03828894 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Cell Line, Tumor
139 rdf:type schema:DefinedTerm
140 Nfbc41be508554369a21cfb439a5be80b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Protein-Tyrosine Kinases
142 rdf:type schema:DefinedTerm
143 Nfdbe39a565c545b8bbb563ae99a91eea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Paxillin
145 rdf:type schema:DefinedTerm
146 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
147 schema:name Biological Sciences
148 rdf:type schema:DefinedTerm
149 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
150 schema:name Biochemistry and Cell Biology
151 rdf:type schema:DefinedTerm
152 sg:grant.2627308 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2407-4-18
153 rdf:type schema:MonetaryGrant
154 sg:journal.1024632 schema:issn 1471-2407
155 schema:name BMC Cancer
156 rdf:type schema:Periodical
157 sg:person.01231470552.60 schema:affiliation https://www.grid.ac/institutes/grid.42505.36
158 schema:familyName Ohannessian
159 schema:givenName Arthur
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231470552.60
161 rdf:type schema:Person
162 sg:person.01245540461.64 schema:affiliation https://www.grid.ac/institutes/grid.42505.36
163 schema:familyName Crowe
164 schema:givenName David L
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245540461.64
166 rdf:type schema:Person
167 sg:pub.10.1038/377539a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002285435
168 https://doi.org/10.1038/377539a0
169 rdf:type schema:CreativeWork
170 sg:pub.10.1038/380538a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005974858
171 https://doi.org/10.1038/380538a0
172 rdf:type schema:CreativeWork
173 sg:pub.10.1038/sj.bjc.6601050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015176868
174 https://doi.org/10.1038/sj.bjc.6601050
175 rdf:type schema:CreativeWork
176 sg:pub.10.1046/j.1523-1747.2000.00884.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044054320
177 https://doi.org/10.1046/j.1523-1747.2000.00884.x
178 rdf:type schema:CreativeWork
179 https://app.dimensions.ai/details/publication/pub.1074889433 schema:CreativeWork
180 https://app.dimensions.ai/details/publication/pub.1074961208 schema:CreativeWork
181 https://doi.org/10.1016/s0962-8924(99)01667-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052132529
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1038/sj.neo.7900135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023858844
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1074/jbc.274.43.30738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002874033
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1074/jbc.274.51.36684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051846108
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1074/jbc.m003871200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035435720
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1074/jbc.m910027199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011989293
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1083/jcb.107.5.1881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031530401
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1083/jcb.134.3.793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030212510
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1083/jcb.135.4.1109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031877991
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1083/jcb.149.3.741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002981788
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1083/jcb.200212114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027630093
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1091/mbc.6.6.637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037592852
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1091/mbc.7.8.1209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022916838
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1093/emboj/16.18.5592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049008815
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1128/mcb.17.12.6906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008261374
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1152/ajpgi.2000.278.6.g952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074655650
212 rdf:type schema:CreativeWork
213 https://doi.org/10.3892/ijo.13.6.1127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071510868
214 rdf:type schema:CreativeWork
215 https://doi.org/10.3892/ijo.15.3.519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071511119
216 rdf:type schema:CreativeWork
217 https://www.grid.ac/institutes/grid.42505.36 schema:alternateName University of Southern California
218 schema:name Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, 90033, Los Angeles, CA, USA
219 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...