Implications of a RAD54L polymorphism (2290C/T) in human meningiomas as a risk factor and/or a genetic marker View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-03-04

AUTHORS

Paola E Leone, Marta Mendiola, Javier Alonso, César Paz-y-Miño, Angel Pestaña

ABSTRACT

BackgroundRAD54L (OMIM 603615, Locus Link 8438) has been proposed as a candidate oncosupressor in tumours bearing a non-random deletion of 1p32, such as breast or colon carcinomas, lymphomas and meningiomas. In a search for RAD54L mutations in 29 menigiomas with allelic deletions in 1p, the only genetic change observed was a silent C/T transition at nucleotide 2290 in exon 18. In this communication the possible association of the 2290C/T polymorphism with the risk of meningiomas was examined. In addition, the usefulness of this polymorphism as a genetic marker within the meningioma consensus deletion region in 1p32 was also verified. The present study comprises 287 blood control samples and 70 meningiomas from Spain and Ecuador. Matched blood samples were only available from Spanish patients.ResultsThe frequency of the rare allele-T and heterozygotes for the 2290C/T polymorphism in the blood of Spanish meningioma patients and in the Ecuadorian meningioma tumours was higher than in the control population (P < 0.05). Four other rare variants (2290C/G, 2299C/G, 2313G/A, 2344A/G) were found within 50 bp at the 3' end of RAD54L. Frequent loss of heterozygosity for the 2290C/T SNP in meningiomas allowed to further narrow the 1p32 consensus region of deletion in meningiomas to either 2.08 Mbp – within D1S2713 (44.35 Mbp) and RAD54L (46.43 Mbp) – or to 1.47 Mbp – within RAD54L and D1S2134 (47.90 Mbp) – according to recent gene mapping results.ConclusionThe statistical analysis of genotypes at the 2290C/T polymorphism suggest an association between the rare T allele and the development of meningeal tumours. This polymorphism can be used as a genetic marker inside the consensus deletion region at 1p32 in meningiomas. More... »

PAGES

6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2407-3-6

DOI

http://dx.doi.org/10.1186/1471-2407-3-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027676345

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12614485


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenosine Triphosphatases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytosine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Helicases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Repair", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Frequency", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Carrier Screening", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Meningioma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sex Distribution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thymine", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Laboratorio de Gen\u00e9tica Molecular y Citogen\u00e9tica Humana, Pontificia Universidad Cat\u00f3lica de Ecuador, P.O. Box 17-1-2184, Quito, Ecuador", 
          "id": "http://www.grid.ac/institutes/grid.412527.7", 
          "name": [
            "Laboratorio de Gen\u00e9tica Molecular y Citogen\u00e9tica Humana, Pontificia Universidad Cat\u00f3lica de Ecuador, P.O. Box 17-1-2184, Quito, Ecuador"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leone", 
        "givenName": "Paola E", 
        "id": "sg:person.01134527433.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134527433.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto de Investigaciones Biom\u00e9dicas \"A. Sols\", CSIC-UAM, Unidad de Biolog\u00eda Molecular y Celular del C\u00e1ncer, C/ Arturo Duperier 4, 28029, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.4711.3", 
          "name": [
            "Instituto de Investigaciones Biom\u00e9dicas \"A. Sols\", CSIC-UAM, Unidad de Biolog\u00eda Molecular y Celular del C\u00e1ncer, C/ Arturo Duperier 4, 28029, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mendiola", 
        "givenName": "Marta", 
        "id": "sg:person.0703577124.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703577124.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto de Investigaciones Biom\u00e9dicas \"A. Sols\", CSIC-UAM, Unidad de Biolog\u00eda Molecular y Celular del C\u00e1ncer, C/ Arturo Duperier 4, 28029, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.4711.3", 
          "name": [
            "Instituto de Investigaciones Biom\u00e9dicas \"A. Sols\", CSIC-UAM, Unidad de Biolog\u00eda Molecular y Celular del C\u00e1ncer, C/ Arturo Duperier 4, 28029, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alonso", 
        "givenName": "Javier", 
        "id": "sg:person.012571320022.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012571320022.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratorio de Gen\u00e9tica Molecular y Citogen\u00e9tica Humana, Pontificia Universidad Cat\u00f3lica de Ecuador, P.O. Box 17-1-2184, Quito, Ecuador", 
          "id": "http://www.grid.ac/institutes/grid.412527.7", 
          "name": [
            "Laboratorio de Gen\u00e9tica Molecular y Citogen\u00e9tica Humana, Pontificia Universidad Cat\u00f3lica de Ecuador, P.O. Box 17-1-2184, Quito, Ecuador"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paz-y-Mi\u00f1o", 
        "givenName": "C\u00e9sar", 
        "id": "sg:person.01053750670.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053750670.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto de Investigaciones Biom\u00e9dicas \"A. Sols\", CSIC-UAM, Unidad de Biolog\u00eda Molecular y Celular del C\u00e1ncer, C/ Arturo Duperier 4, 28029, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.4711.3", 
          "name": [
            "Instituto de Investigaciones Biom\u00e9dicas \"A. Sols\", CSIC-UAM, Unidad de Biolog\u00eda Molecular y Celular del C\u00e1ncer, C/ Arturo Duperier 4, 28029, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pesta\u00f1a", 
        "givenName": "Angel", 
        "id": "sg:person.01257537002.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257537002.15"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1203696", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023696469", 
          "https://doi.org/10.1038/sj.onc.1203696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202692", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028009495", 
          "https://doi.org/10.1038/sj.onc.1202692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1006400723490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019445264", 
          "https://doi.org/10.1023/a:1006400723490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202531", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029521389", 
          "https://doi.org/10.1038/sj.onc.1202531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00165649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001878423", 
          "https://doi.org/10.1007/bf00165649"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-03-04", 
    "datePublishedReg": "2003-03-04", 
    "description": "BackgroundRAD54L (OMIM 603615, Locus Link 8438) has been proposed as a candidate oncosupressor in tumours bearing a non-random deletion of 1p32, such as breast or colon carcinomas, lymphomas and meningiomas. In a search for RAD54L mutations in 29 menigiomas with allelic deletions in 1p, the only genetic change observed was a silent C/T transition at nucleotide 2290 in exon 18. In this communication the possible association of the 2290C/T polymorphism with the risk of meningiomas was examined. In addition, the usefulness of this polymorphism as a genetic marker within the meningioma consensus deletion region in 1p32 was also verified. The present study comprises 287 blood control samples and 70 meningiomas from Spain and Ecuador. Matched blood samples were only available from Spanish patients.ResultsThe frequency of the rare allele-T and heterozygotes for the 2290C/T polymorphism in the blood of Spanish meningioma patients and in the Ecuadorian meningioma tumours was higher than in the control population (P < 0.05). Four other rare variants (2290C/G, 2299C/G, 2313G/A, 2344A/G) were found within 50 bp at the 3' end of RAD54L. Frequent loss of heterozygosity for the 2290C/T SNP in meningiomas allowed to further narrow the 1p32 consensus region of deletion in meningiomas to either 2.08 Mbp \u2013 within D1S2713 (44.35 Mbp) and RAD54L (46.43 Mbp) \u2013 or to 1.47 Mbp \u2013 within RAD54L and D1S2134 (47.90 Mbp) \u2013 according to recent gene mapping results.ConclusionThe statistical analysis of genotypes at the 2290C/T polymorphism suggest an association between the rare T allele and the development of meningeal tumours. This polymorphism can be used as a genetic marker inside the consensus deletion region at 1p32 in meningiomas.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/1471-2407-3-6", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024632", 
        "issn": [
          "1471-2407"
        ], 
        "name": "BMC Cancer", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "3"
      }
    ], 
    "keywords": [
      "T polymorphism", 
      "risk of meningioma", 
      "Matched blood samples", 
      "rare T allele", 
      "meningeal tumors", 
      "risk factors", 
      "Spanish patients", 
      "meningioma patients", 
      "blood samples", 
      "non-random deletion", 
      "blood control samples", 
      "possible association", 
      "T allele", 
      "meningiomas", 
      "control population", 
      "colon carcinoma", 
      "human meningiomas", 
      "tumors", 
      "exon 18", 
      "meningioma tumors", 
      "allelic deletions", 
      "patients", 
      "deletion region", 
      "rare variants", 
      "T SNP", 
      "frequent loss", 
      "only genetic change", 
      "markers", 
      "present study", 
      "genetic markers", 
      "polymorphism", 
      "association", 
      "RAD54L", 
      "genetic changes", 
      "carcinoma", 
      "statistical analysis", 
      "lymphoma", 
      "T transition", 
      "breast", 
      "deletion", 
      "menigiomas", 
      "control samples", 
      "blood", 
      "alleles", 
      "risk", 
      "rare alleles", 
      "heterozygotes", 
      "oncosupressor", 
      "population", 
      "mutations", 
      "genotypes", 
      "samples", 
      "factors", 
      "variants", 
      "study", 
      "usefulness", 
      "end", 
      "SNPs", 
      "consensus region", 
      "loss", 
      "changes", 
      "MBP", 
      "search", 
      "heterozygosity", 
      "region", 
      "frequency", 
      "addition", 
      "development", 
      "BP", 
      "analysis", 
      "implications", 
      "results", 
      "gene mapping results", 
      "Spain", 
      "communication", 
      "mapping results", 
      "Ecuador", 
      "transition"
    ], 
    "name": "Implications of a RAD54L polymorphism (2290C/T) in human meningiomas as a risk factor and/or a genetic marker", 
    "pagination": "6", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1027676345"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2407-3-6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12614485"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2407-3-6", 
      "https://app.dimensions.ai/details/publication/pub.1027676345"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_364.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/1471-2407-3-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-3-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-3-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-3-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-3-6'


 

This table displays all metadata directly associated to this object as RDF triples.

278 TRIPLES      22 PREDICATES      131 URIs      117 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2407-3-6 schema:about N016f42f1fb4b46e6a5a2da8962e3d890
2 N07cbe292b50e4d08a66b06aaeb5ad8dc
3 N0e014a1068d94780bb914256b8aecf8a
4 N25f606ccbc294763b56f7d069369e6e3
5 N2bec8525491c4a3192aeac5458e78a86
6 N2d9b5c50bfc34f10bc2946e20d27f069
7 N368bd4cac8ff4b7fbc26bf64ce577ed6
8 N38f7cea754b84231ba1f22a6ca719022
9 N4932f2d939d441db822dca5c602a80d7
10 N56bb6e83daf74335a7f99242b02692ed
11 N602a93ff8c934ccd853080e5057493e9
12 N62040e3326a24f2d9c9bb7d16bcc0507
13 N86f13dbdb21d4bb7b81403c295fc663a
14 N888150f8a5c449a6a0670b4677988907
15 Nabadd67dfe914069bdeeb028c9936989
16 Nb4f35c7a079b4110993958b4d3d056ba
17 Nbc12061022204d728d4137d42c539ac3
18 Ncaa1df2e1aec4e53988946c97b85048a
19 Ncd7672d0f0314c4c90a1e59a0131e2b0
20 Nd0ddb7237c864e73a7505cfcf2f58827
21 Nf2e5d3bde53e4cc4ab85141ee1573716
22 anzsrc-for:11
23 anzsrc-for:1112
24 anzsrc-for:1117
25 schema:author N2e8f3ec02e5e46dab17733b16c80b8c1
26 schema:citation sg:pub.10.1007/bf00165649
27 sg:pub.10.1023/a:1006400723490
28 sg:pub.10.1038/sj.onc.1202531
29 sg:pub.10.1038/sj.onc.1202692
30 sg:pub.10.1038/sj.onc.1203696
31 schema:datePublished 2003-03-04
32 schema:datePublishedReg 2003-03-04
33 schema:description BackgroundRAD54L (OMIM 603615, Locus Link 8438) has been proposed as a candidate oncosupressor in tumours bearing a non-random deletion of 1p32, such as breast or colon carcinomas, lymphomas and meningiomas. In a search for RAD54L mutations in 29 menigiomas with allelic deletions in 1p, the only genetic change observed was a silent C/T transition at nucleotide 2290 in exon 18. In this communication the possible association of the 2290C/T polymorphism with the risk of meningiomas was examined. In addition, the usefulness of this polymorphism as a genetic marker within the meningioma consensus deletion region in 1p32 was also verified. The present study comprises 287 blood control samples and 70 meningiomas from Spain and Ecuador. Matched blood samples were only available from Spanish patients.ResultsThe frequency of the rare allele-T and heterozygotes for the 2290C/T polymorphism in the blood of Spanish meningioma patients and in the Ecuadorian meningioma tumours was higher than in the control population (P < 0.05). Four other rare variants (2290C/G, 2299C/G, 2313G/A, 2344A/G) were found within 50 bp at the 3' end of RAD54L. Frequent loss of heterozygosity for the 2290C/T SNP in meningiomas allowed to further narrow the 1p32 consensus region of deletion in meningiomas to either 2.08 Mbp – within D1S2713 (44.35 Mbp) and RAD54L (46.43 Mbp) – or to 1.47 Mbp – within RAD54L and D1S2134 (47.90 Mbp) – according to recent gene mapping results.ConclusionThe statistical analysis of genotypes at the 2290C/T polymorphism suggest an association between the rare T allele and the development of meningeal tumours. This polymorphism can be used as a genetic marker inside the consensus deletion region at 1p32 in meningiomas.
34 schema:genre article
35 schema:inLanguage en
36 schema:isAccessibleForFree true
37 schema:isPartOf N5a14cb5b650540159a8a0ef6a2107fdb
38 Ne82373642c964d15b5657144bbd02c81
39 sg:journal.1024632
40 schema:keywords BP
41 Ecuador
42 MBP
43 Matched blood samples
44 RAD54L
45 SNPs
46 Spain
47 Spanish patients
48 T SNP
49 T allele
50 T polymorphism
51 T transition
52 addition
53 alleles
54 allelic deletions
55 analysis
56 association
57 blood
58 blood control samples
59 blood samples
60 breast
61 carcinoma
62 changes
63 colon carcinoma
64 communication
65 consensus region
66 control population
67 control samples
68 deletion
69 deletion region
70 development
71 end
72 exon 18
73 factors
74 frequency
75 frequent loss
76 gene mapping results
77 genetic changes
78 genetic markers
79 genotypes
80 heterozygosity
81 heterozygotes
82 human meningiomas
83 implications
84 loss
85 lymphoma
86 mapping results
87 markers
88 menigiomas
89 meningeal tumors
90 meningioma patients
91 meningioma tumors
92 meningiomas
93 mutations
94 non-random deletion
95 oncosupressor
96 only genetic change
97 patients
98 polymorphism
99 population
100 possible association
101 present study
102 rare T allele
103 rare alleles
104 rare variants
105 region
106 results
107 risk
108 risk factors
109 risk of meningioma
110 samples
111 search
112 statistical analysis
113 study
114 transition
115 tumors
116 usefulness
117 variants
118 schema:name Implications of a RAD54L polymorphism (2290C/T) in human meningiomas as a risk factor and/or a genetic marker
119 schema:pagination 6
120 schema:productId N8d5e416f7dde402fb9a5ab155786efa9
121 Nbb4cc1f368b747dcb2af27c334123501
122 Nea02fe5db5e8430282c9d315179ed26d
123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027676345
124 https://doi.org/10.1186/1471-2407-3-6
125 schema:sdDatePublished 2022-05-20T07:22
126 schema:sdLicense https://scigraph.springernature.com/explorer/license/
127 schema:sdPublisher Nfd7be08655ef4b978d3060e6f1cfa3b4
128 schema:url https://doi.org/10.1186/1471-2407-3-6
129 sgo:license sg:explorer/license/
130 sgo:sdDataset articles
131 rdf:type schema:ScholarlyArticle
132 N016f42f1fb4b46e6a5a2da8962e3d890 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Male
134 rdf:type schema:DefinedTerm
135 N07cbe292b50e4d08a66b06aaeb5ad8dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Cytosine
137 rdf:type schema:DefinedTerm
138 N0cbbeb2dc95b49858fbe5f73cefc57e2 rdf:first sg:person.01053750670.55
139 rdf:rest N7c01bc3f8c9f4752807edd3edb964de3
140 N0e014a1068d94780bb914256b8aecf8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Nuclear Proteins
142 rdf:type schema:DefinedTerm
143 N25f606ccbc294763b56f7d069369e6e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name DNA Helicases
145 rdf:type schema:DefinedTerm
146 N2bec8525491c4a3192aeac5458e78a86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Spain
148 rdf:type schema:DefinedTerm
149 N2d9b5c50bfc34f10bc2946e20d27f069 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name DNA Repair
151 rdf:type schema:DefinedTerm
152 N2e8f3ec02e5e46dab17733b16c80b8c1 rdf:first sg:person.01134527433.08
153 rdf:rest Nf74fd07ac291418f9a268c97e6e519ce
154 N368bd4cac8ff4b7fbc26bf64ce577ed6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Sex Distribution
156 rdf:type schema:DefinedTerm
157 N38f7cea754b84231ba1f22a6ca719022 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Biomarkers, Tumor
159 rdf:type schema:DefinedTerm
160 N4932f2d939d441db822dca5c602a80d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Alleles
162 rdf:type schema:DefinedTerm
163 N56bb6e83daf74335a7f99242b02692ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Female
165 rdf:type schema:DefinedTerm
166 N5a14cb5b650540159a8a0ef6a2107fdb schema:issueNumber 1
167 rdf:type schema:PublicationIssue
168 N5cbce86c8f004af79f38f6460d73c073 rdf:first sg:person.012571320022.50
169 rdf:rest N0cbbeb2dc95b49858fbe5f73cefc57e2
170 N602a93ff8c934ccd853080e5057493e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Gene Frequency
172 rdf:type schema:DefinedTerm
173 N62040e3326a24f2d9c9bb7d16bcc0507 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Meningioma
175 rdf:type schema:DefinedTerm
176 N7c01bc3f8c9f4752807edd3edb964de3 rdf:first sg:person.01257537002.15
177 rdf:rest rdf:nil
178 N86f13dbdb21d4bb7b81403c295fc663a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Middle Aged
180 rdf:type schema:DefinedTerm
181 N888150f8a5c449a6a0670b4677988907 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Polymorphism, Single Nucleotide
183 rdf:type schema:DefinedTerm
184 N8d5e416f7dde402fb9a5ab155786efa9 schema:name doi
185 schema:value 10.1186/1471-2407-3-6
186 rdf:type schema:PropertyValue
187 Nabadd67dfe914069bdeeb028c9936989 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Genetic Carrier Screening
189 rdf:type schema:DefinedTerm
190 Nb4f35c7a079b4110993958b4d3d056ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Humans
192 rdf:type schema:DefinedTerm
193 Nbb4cc1f368b747dcb2af27c334123501 schema:name dimensions_id
194 schema:value pub.1027676345
195 rdf:type schema:PropertyValue
196 Nbc12061022204d728d4137d42c539ac3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Risk Factors
198 rdf:type schema:DefinedTerm
199 Ncaa1df2e1aec4e53988946c97b85048a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Polymorphism, Genetic
201 rdf:type schema:DefinedTerm
202 Ncd7672d0f0314c4c90a1e59a0131e2b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Adenosine Triphosphatases
204 rdf:type schema:DefinedTerm
205 Nd0ddb7237c864e73a7505cfcf2f58827 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name DNA-Binding Proteins
207 rdf:type schema:DefinedTerm
208 Ne82373642c964d15b5657144bbd02c81 schema:volumeNumber 3
209 rdf:type schema:PublicationVolume
210 Nea02fe5db5e8430282c9d315179ed26d schema:name pubmed_id
211 schema:value 12614485
212 rdf:type schema:PropertyValue
213 Nf2e5d3bde53e4cc4ab85141ee1573716 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Thymine
215 rdf:type schema:DefinedTerm
216 Nf74fd07ac291418f9a268c97e6e519ce rdf:first sg:person.0703577124.63
217 rdf:rest N5cbce86c8f004af79f38f6460d73c073
218 Nfd7be08655ef4b978d3060e6f1cfa3b4 schema:name Springer Nature - SN SciGraph project
219 rdf:type schema:Organization
220 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
221 schema:name Medical and Health Sciences
222 rdf:type schema:DefinedTerm
223 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
224 schema:name Oncology and Carcinogenesis
225 rdf:type schema:DefinedTerm
226 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
227 schema:name Public Health and Health Services
228 rdf:type schema:DefinedTerm
229 sg:journal.1024632 schema:issn 1471-2407
230 schema:name BMC Cancer
231 schema:publisher Springer Nature
232 rdf:type schema:Periodical
233 sg:person.01053750670.55 schema:affiliation grid-institutes:grid.412527.7
234 schema:familyName Paz-y-Miño
235 schema:givenName César
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053750670.55
237 rdf:type schema:Person
238 sg:person.01134527433.08 schema:affiliation grid-institutes:grid.412527.7
239 schema:familyName Leone
240 schema:givenName Paola E
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134527433.08
242 rdf:type schema:Person
243 sg:person.012571320022.50 schema:affiliation grid-institutes:grid.4711.3
244 schema:familyName Alonso
245 schema:givenName Javier
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012571320022.50
247 rdf:type schema:Person
248 sg:person.01257537002.15 schema:affiliation grid-institutes:grid.4711.3
249 schema:familyName Pestaña
250 schema:givenName Angel
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257537002.15
252 rdf:type schema:Person
253 sg:person.0703577124.63 schema:affiliation grid-institutes:grid.4711.3
254 schema:familyName Mendiola
255 schema:givenName Marta
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703577124.63
257 rdf:type schema:Person
258 sg:pub.10.1007/bf00165649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001878423
259 https://doi.org/10.1007/bf00165649
260 rdf:type schema:CreativeWork
261 sg:pub.10.1023/a:1006400723490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019445264
262 https://doi.org/10.1023/a:1006400723490
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/sj.onc.1202531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029521389
265 https://doi.org/10.1038/sj.onc.1202531
266 rdf:type schema:CreativeWork
267 sg:pub.10.1038/sj.onc.1202692 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028009495
268 https://doi.org/10.1038/sj.onc.1202692
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/sj.onc.1203696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023696469
271 https://doi.org/10.1038/sj.onc.1203696
272 rdf:type schema:CreativeWork
273 grid-institutes:grid.412527.7 schema:alternateName Laboratorio de Genética Molecular y Citogenética Humana, Pontificia Universidad Católica de Ecuador, P.O. Box 17-1-2184, Quito, Ecuador
274 schema:name Laboratorio de Genética Molecular y Citogenética Humana, Pontificia Universidad Católica de Ecuador, P.O. Box 17-1-2184, Quito, Ecuador
275 rdf:type schema:Organization
276 grid-institutes:grid.4711.3 schema:alternateName Instituto de Investigaciones Biomédicas "A. Sols", CSIC-UAM, Unidad de Biología Molecular y Celular del Cáncer, C/ Arturo Duperier 4, 28029, Madrid, Spain
277 schema:name Instituto de Investigaciones Biomédicas "A. Sols", CSIC-UAM, Unidad de Biología Molecular y Celular del Cáncer, C/ Arturo Duperier 4, 28029, Madrid, Spain
278 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...