Circulating soluble Fas levels and risk of ovarian cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-12-22

AUTHORS

Arslan Akhmedkhanov, Eva Lundin, Seth Guller, Annekatrin Lukanova, Andrea Micheli, Yuehong Ma, Yelena Afanasyeva, Anne Zeleniuch-Jacquotte, Vittorio Krogh, Per Lenner, Paola Muti, Sabina Rinaldi, Rudolf Kaaks, Franco Berrino, Göran Hallmans, Paolo Toniolo

ABSTRACT

BackgroundDysregulation of apoptosis, specifically overexpression of soluble Fas (sFas), has been proposed to play a role in the development of ovarian cancer. The main objective of the present study was to evaluate serum sFas as a potential biomarker of ovarian cancer risk.MethodsThe association between serum sFas levels and the risk of ovarian cancer was examined in a case-control study nested within three prospective cohorts in New York (USA), Umeå (Sweden), and Milan (Italy). Case subjects were 138 women with primary invasive epithelial ovarian cancer diagnosed between 2 months and 13.2 years after the initial blood donation. Control subjects were 263 women who were free of cancer, and matched the case on cohort, menopausal status, age, and enrollment date. Serum sFas levels were determined using a quantitative sandwich enzyme immunoassay.ResultsSerum sFas levels were similar in women subsequently diagnosed with ovarian cancer (median, 6.5 ng/mL; range, 4.4 – 10.2) and in controls (median, 6.8 ng/mL; range, 4.5 – 10.1). Statistically significant trends of increasing serum sFas with age were observed among cases (r = 0.39, p < 0.0001) and controls (r = 0.42, p < 0.0001). Compared to women in the lowest third, women in the highest third of serum sFas were not at increased risk of ovarian cancer after adjustment for potential confounders (odd ratio (OR), 0.87; 95% confidence interval (CI), 0.42 – 1.82).ConclusionThe results suggest that serum sFas may not be a suitable marker for identification of women at increased risk of ovarian cancer. More... »

PAGES

33

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URI

http://scigraph.springernature.com/pub.10.1186/1471-2407-3-33

DOI

http://dx.doi.org/10.1186/1471-2407-3-33

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https://app.dimensions.ai/details/publication/pub.1019768660

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14690548


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24 FA
25 FA levels
26 MethodsThe association
27 Milan
28 New York
29 SFA
30 Umeå
31 York
32 adjustment
33 age
34 apoptosis
35 association
36 biomarkers
37 blood donation
38 cancer
39 cancer risk
40 case subjects
41 case-control study
42 cases
43 cohort
44 confounders
45 control
46 control subjects
47 date
48 development
49 donation
50 enrollment date
51 enzyme immunoassay
52 epithelial ovarian cancer
53 highest third
54 identification
55 identification of women
56 immunoassay
57 invasive epithelial ovarian cancer
58 levels
59 main objective
60 markers
61 menopausal status
62 months
63 objective
64 ovarian cancer
65 ovarian cancer risk
66 overexpression
67 potential biomarkers
68 potential confounders
69 present study
70 primary invasive epithelial ovarian cancer
71 prospective cohort
72 quantitative sandwich enzyme immunoassay
73 results
74 risk
75 role
76 sFas levels
77 sandwich enzyme immunoassay
78 serum sFas
79 serum sFas levels
80 significant trend
81 soluble Fas
82 soluble Fas levels
83 status
84 study
85 subjects
86 suitable marker
87 third
88 trends
89 women
90 years
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