An aza-macrocycle containing maltolic side-arms (maltonis) as potential drug against human pediatric sarcomas View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Clara Guerzoni, Stefano Amatori, Luca Giorgi, Maria Cristina Manara, Lorena Landuzzi, Pier-Luigi Lollini, Aurora Tassoni, Mauro Balducci, Marco Manfrini, Loredana Pratelli, Massimo Serra, Piero Picci, Mauro Magnani, Vieri Fusi, Mirco Fanelli, Katia Scotlandi

ABSTRACT

BACKGROUND: Identification of new drugs against paediatric sarcomas represents an urgent clinical need that mainly relies on public investments due to the rarity of these diseases. In this paper we evaluated the in vitro and in vivo efficacy of a new maltol derived molecule (maltonis), belonging to the family of molecules named hydroxypyrones. METHODS: Maltonis was screened for its ability to induce structural alteration of DNA molecules in comparison to another maltolic molecule (malten). In vitro antitumour efficacy was tested using a panel of sarcoma cell lines, representative of Ewing sarcoma, osteosarcoma and rhabdomyosarcoma, the three most common paediatric sarcomas, and in normal human mesenchymal primary cell cultures. In vivo efficacy was tested against TC-71 Ewing sarcoma xenografts. RESULTS: Maltonis, a soluble maltol-derived synthetic molecule, was able to alter the DNA structure, inhibit proliferation and induce apoptotic cell death in paediatric sarcoma cells, either sensitive or resistant to some conventional chemotherapeutic drugs, such as doxorubicin and cisplatin. In addition, maltonis was able to induce: i) p21, p15 and Gadd45a mRNA upregulation; ii) Bcl-2, survivin, CDK6 and CDK8 down-regulation; iii) formation of γ-H2AX nuclear foci; iv) cleavage of PARP and Caspase 3. Two independent in vivo experiments demonstrated the tolerability and efficacy of maltonis in the inhibition of tumour growth. Finally maltonis was not extruded by ABCB1, one of the major determinants of chemotherapy failure, nor appeared to be a substrate of the glutathione-related detoxification system. CONCLUSIONS: Considering that treatment of poorly responsive patients still suffers for the paucity of agents able to revert chemoresistance, maltonis may be considered for the future development of new therapeutic approaches for refractory metastatic patients. More... »

PAGES

137

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2407-14-137

DOI

http://dx.doi.org/10.1186/1471-2407-14-137

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005202391

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24575739


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Damage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heterocyclic Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heterografts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inhibitory Concentration 50", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mesenchymal Stromal Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sarcoma", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Istituto Ortopedico Rizzoli", 
          "id": "https://www.grid.ac/institutes/grid.419038.7", 
          "name": [
            "PROMETEO Laboratory, Section of Biomolecular Therapies, RIT Department, Istituto Ortopedico Rizzoli, 40136, Bologna, Italy", 
            "Experimental Oncology Laboratory, CRS Development of Biomolecular Therapies, IstitutoOrtopedico Rizzoli, 40136, Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guerzoni", 
        "givenName": "Clara", 
        "id": "sg:person.01227066027.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227066027.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Urbino", 
          "id": "https://www.grid.ac/institutes/grid.12711.34", 
          "name": [
            "Molecular Pathology Lab. \u201cPaoLa\u201d, Department of Biomolecular Sciences, University of Urbino \u201cCarlo Bo\u201d, via Arco d\u2019Augusto, 2, 61032, Fano (PU), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Amatori", 
        "givenName": "Stefano", 
        "id": "sg:person.0663606015.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663606015.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Urbino", 
          "id": "https://www.grid.ac/institutes/grid.12711.34", 
          "name": [
            "Department of Basic Sciences and Fundamentals, University of Urbino \u201cCarlo Bo\u201d, P.za Rinascimento, 6, 61029, Urbino (PU), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giorgi", 
        "givenName": "Luca", 
        "id": "sg:person.016531410660.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016531410660.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Ortopedico Rizzoli", 
          "id": "https://www.grid.ac/institutes/grid.419038.7", 
          "name": [
            "PROMETEO Laboratory, Section of Biomolecular Therapies, RIT Department, Istituto Ortopedico Rizzoli, 40136, Bologna, Italy", 
            "Experimental Oncology Laboratory, CRS Development of Biomolecular Therapies, IstitutoOrtopedico Rizzoli, 40136, Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Manara", 
        "givenName": "Maria Cristina", 
        "id": "sg:person.01216116770.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216116770.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Ortopedico Rizzoli", 
          "id": "https://www.grid.ac/institutes/grid.419038.7", 
          "name": [
            "PROMETEO Laboratory, Section of Biomolecular Therapies, RIT Department, Istituto Ortopedico Rizzoli, 40136, Bologna, Italy", 
            "Experimental Oncology Laboratory, CRS Development of Biomolecular Therapies, IstitutoOrtopedico Rizzoli, 40136, Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Landuzzi", 
        "givenName": "Lorena", 
        "id": "sg:person.01030263515.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030263515.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bologna", 
          "id": "https://www.grid.ac/institutes/grid.6292.f", 
          "name": [
            "Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lollini", 
        "givenName": "Pier-Luigi", 
        "id": "sg:person.01144245317.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144245317.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Urbino", 
          "id": "https://www.grid.ac/institutes/grid.12711.34", 
          "name": [
            "Molecular Pathology Lab. \u201cPaoLa\u201d, Department of Biomolecular Sciences, University of Urbino \u201cCarlo Bo\u201d, via Arco d\u2019Augusto, 2, 61032, Fano (PU), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tassoni", 
        "givenName": "Aurora", 
        "id": "sg:person.01242137172.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242137172.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Urbino", 
          "id": "https://www.grid.ac/institutes/grid.12711.34", 
          "name": [
            "Molecular Pathology Lab. \u201cPaoLa\u201d, Department of Biomolecular Sciences, University of Urbino \u201cCarlo Bo\u201d, via Arco d\u2019Augusto, 2, 61032, Fano (PU), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Balducci", 
        "givenName": "Mauro", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Ortopedico Rizzoli", 
          "id": "https://www.grid.ac/institutes/grid.419038.7", 
          "name": [
            "Clinica Ortopedica e Traumatologica III, Istituto Ortopedico Rizzoli, 40136, Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Manfrini", 
        "givenName": "Marco", 
        "id": "sg:person.0725016672.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725016672.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Ortopedico Rizzoli", 
          "id": "https://www.grid.ac/institutes/grid.419038.7", 
          "name": [
            "Clinical Pathology, Istituto Ortopedico Rizzoli, 40136, Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pratelli", 
        "givenName": "Loredana", 
        "id": "sg:person.01125076576.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125076576.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Experimental Oncology Laboratory, CRS Development of Biomolecular Therapies, IstitutoOrtopedico Rizzoli, 40136, Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Serra", 
        "givenName": "Massimo", 
        "id": "sg:person.01332345370.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332345370.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Ortopedico Rizzoli", 
          "id": "https://www.grid.ac/institutes/grid.419038.7", 
          "name": [
            "PROMETEO Laboratory, Section of Biomolecular Therapies, RIT Department, Istituto Ortopedico Rizzoli, 40136, Bologna, Italy", 
            "Experimental Oncology Laboratory, CRS Development of Biomolecular Therapies, IstitutoOrtopedico Rizzoli, 40136, Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Picci", 
        "givenName": "Piero", 
        "id": "sg:person.0753274552.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753274552.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Urbino", 
          "id": "https://www.grid.ac/institutes/grid.12711.34", 
          "name": [
            "Department of Biomolecular Sciences, University of Urbino \u201cCarlo Bo\u201d, via Saffi 2, 61029, Urbino (PU), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Magnani", 
        "givenName": "Mauro", 
        "id": "sg:person.0752252542.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752252542.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Urbino", 
          "id": "https://www.grid.ac/institutes/grid.12711.34", 
          "name": [
            "Department of Basic Sciences and Fundamentals, University of Urbino \u201cCarlo Bo\u201d, P.za Rinascimento, 6, 61029, Urbino (PU), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fusi", 
        "givenName": "Vieri", 
        "id": "sg:person.0636462043.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636462043.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Urbino", 
          "id": "https://www.grid.ac/institutes/grid.12711.34", 
          "name": [
            "Molecular Pathology Lab. \u201cPaoLa\u201d, Department of Biomolecular Sciences, University of Urbino \u201cCarlo Bo\u201d, via Arco d\u2019Augusto, 2, 61032, Fano (PU), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fanelli", 
        "givenName": "Mirco", 
        "id": "sg:person.01007647077.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007647077.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Ortopedico Rizzoli", 
          "id": "https://www.grid.ac/institutes/grid.419038.7", 
          "name": [
            "PROMETEO Laboratory, Section of Biomolecular Therapies, RIT Department, Istituto Ortopedico Rizzoli, 40136, Bologna, Italy", 
            "Experimental Oncology Laboratory, CRS Development of Biomolecular Therapies, IstitutoOrtopedico Rizzoli, 40136, Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scotlandi", 
        "givenName": "Katia", 
        "id": "sg:person.01327374561.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327374561.76"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.canlet.2008.09.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002094297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006265436", 
          "https://doi.org/10.1038/nrc1168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006265436", 
          "https://doi.org/10.1038/nrc1168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/neur.1996.0044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007555874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2005.05.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009633411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdt278", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010197645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.24118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010523478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0042985", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012546698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.38.4420", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013071513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6605745", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016311010", 
          "https://doi.org/10.1038/sj.bjc.6605745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.40.3287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016599720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1357-2725(95)00031-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018732166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-3192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022389948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2008.03.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024509301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/stem.5530080644", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027819308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/stem.5530080644", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027819308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19990209)80:4<581::aid-ijc16>3.0.co;2-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028892000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.24458", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029726585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.24458", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029726585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210642", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030862836", 
          "https://doi.org/10.1038/sj.onc.1210642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.27493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030952031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20032247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033131756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-09-0816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033879136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lungcan.2009.01.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035096367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2007.02.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037629381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.20640", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039792051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lungcan.2010.10.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044309585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbmr.1578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045380302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.toxlet.2005.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045471994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-5840", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045535894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m503295200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048697156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10534-005-6998-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049199287", 
          "https://doi.org/10.1007/s10534-005-6998-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10534-005-6998-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049199287", 
          "https://doi.org/10.1007/s10534-005-6998-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdq573", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049439223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0041-008x(69)90062-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049891995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ic9004642", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055584322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ic9004642", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055584322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jo202270j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056026930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7973727", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062650847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.03.144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075201548", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076844285", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077199008", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077841563", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1995.13.8.2123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082444262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082651014", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082708484", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-12", 
    "datePublishedReg": "2014-12-01", 
    "description": "BACKGROUND: Identification of new drugs against paediatric sarcomas represents an urgent clinical need that mainly relies on public investments due to the rarity of these diseases. In this paper we evaluated the in vitro and in vivo efficacy of a new maltol derived molecule (maltonis), belonging to the family of molecules named hydroxypyrones.\nMETHODS: Maltonis was screened for its ability to induce structural alteration of DNA molecules in comparison to another maltolic molecule (malten). In vitro antitumour efficacy was tested using a panel of sarcoma cell lines, representative of Ewing sarcoma, osteosarcoma and rhabdomyosarcoma, the three most common paediatric sarcomas, and in normal human mesenchymal primary cell cultures. In vivo efficacy was tested against TC-71 Ewing sarcoma xenografts.\nRESULTS: Maltonis, a soluble maltol-derived synthetic molecule, was able to alter the DNA structure, inhibit proliferation and induce apoptotic cell death in paediatric sarcoma cells, either sensitive or resistant to some conventional chemotherapeutic drugs, such as doxorubicin and cisplatin. In addition, maltonis was able to induce: i) p21, p15 and Gadd45a mRNA upregulation; ii) Bcl-2, survivin, CDK6 and CDK8 down-regulation; iii) formation of \u03b3-H2AX nuclear foci; iv) cleavage of PARP and Caspase 3. Two independent in vivo experiments demonstrated the tolerability and efficacy of maltonis in the inhibition of tumour growth. Finally maltonis was not extruded by ABCB1, one of the major determinants of chemotherapy failure, nor appeared to be a substrate of the glutathione-related detoxification system.\nCONCLUSIONS: Considering that treatment of poorly responsive patients still suffers for the paucity of agents able to revert chemoresistance, maltonis may be considered for the future development of new therapeutic approaches for refractory metastatic patients.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-2407-14-137", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024632", 
        "issn": [
          "1471-2407"
        ], 
        "name": "BMC Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "An aza-macrocycle containing maltolic side-arms (maltonis) as potential drug against human pediatric sarcomas", 
    "pagination": "137", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "18c92b1ba182db5611fa6c0476249b9240bde3c4026121ceddc341613a1dd307"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24575739"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100967800"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2407-14-137"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005202391"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2407-14-137", 
      "https://app.dimensions.ai/details/publication/pub.1005202391"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-2407-14-137"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-14-137'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-14-137'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-14-137'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-14-137'


 

This table displays all metadata directly associated to this object as RDF triples.

381 TRIPLES      21 PREDICATES      89 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2407-14-137 schema:about N005a92ca737247bf9bf68ca27cdad772
2 N0c26417901ef492989e3936bd7a5009a
3 N4807081dc8664e6b85b84cef24707c31
4 N64d52634c19449efa77547c9425b546f
5 N657ccddbee274be89d476454be3dd6dd
6 N6a59ada2f19249db80391627d82eb8b2
7 N8b972c51e4c34513bf0aa7c7f79aafda
8 N941de18be23b4f73884740a47c5e1ba3
9 N94f0aeb2043b4e42b256da0f6b9c6f5c
10 N96be0361a5af4363af5ac7aed4f605f0
11 N9c525160586045d29a0a1356147aa1e3
12 Na152d8f1fc1c476292381b1fb568dfdd
13 Nae7d4b92f1224f65b28ded3c0f11c757
14 Nc451225efd8543afa2c05b5e19b9d647
15 Ncd639350d9694d5c9017168018126b6c
16 Ne24f3dc262cb424ebebef057c3b22f4a
17 Ne3dc95f470fa4c99a9cbbcbc7e9e15fc
18 Nf6e54a0621834152b1a2afd7314bf1d3
19 anzsrc-for:11
20 anzsrc-for:1112
21 schema:author N62215d6991974fb88ad88331cfc32506
22 schema:citation sg:pub.10.1007/s10534-005-6998-y
23 sg:pub.10.1038/nrc1168
24 sg:pub.10.1038/sj.bjc.6605745
25 sg:pub.10.1038/sj.onc.1210642
26 https://app.dimensions.ai/details/publication/pub.1075201548
27 https://app.dimensions.ai/details/publication/pub.1076844285
28 https://app.dimensions.ai/details/publication/pub.1077199008
29 https://app.dimensions.ai/details/publication/pub.1077841563
30 https://app.dimensions.ai/details/publication/pub.1082651014
31 https://app.dimensions.ai/details/publication/pub.1082708484
32 https://doi.org/10.1002/(sici)1097-0215(19990209)80:4<581::aid-ijc16>3.0.co;2-o
33 https://doi.org/10.1002/cncr.24458
34 https://doi.org/10.1002/cncr.27493
35 https://doi.org/10.1002/gcc.20640
36 https://doi.org/10.1002/jbmr.1578
37 https://doi.org/10.1002/pbc.24118
38 https://doi.org/10.1002/stem.5530080644
39 https://doi.org/10.1006/neur.1996.0044
40 https://doi.org/10.1016/0041-008x(69)90062-3
41 https://doi.org/10.1016/1357-2725(95)00031-j
42 https://doi.org/10.1016/j.bcp.2008.03.025
43 https://doi.org/10.1016/j.canlet.2008.09.039
44 https://doi.org/10.1016/j.ccr.2007.02.027
45 https://doi.org/10.1016/j.lungcan.2009.01.015
46 https://doi.org/10.1016/j.lungcan.2010.10.016
47 https://doi.org/10.1016/j.molcel.2005.05.008
48 https://doi.org/10.1016/j.toxlet.2005.08.002
49 https://doi.org/10.1021/ic9004642
50 https://doi.org/10.1021/jo202270j
51 https://doi.org/10.1074/jbc.m503295200
52 https://doi.org/10.1084/jem.20032247
53 https://doi.org/10.1093/annonc/mdq573
54 https://doi.org/10.1093/annonc/mdt278
55 https://doi.org/10.1126/science.7973727
56 https://doi.org/10.1158/0008-5472.can-04-3192
57 https://doi.org/10.1158/0008-5472.can-07-5840
58 https://doi.org/10.1158/1078-0432.ccr-09-0816
59 https://doi.org/10.1200/jco.1995.13.8.2123
60 https://doi.org/10.1200/jco.2003.03.144
61 https://doi.org/10.1200/jco.2011.38.4420
62 https://doi.org/10.1200/jco.2011.40.3287
63 https://doi.org/10.1371/journal.pone.0042985
64 schema:datePublished 2014-12
65 schema:datePublishedReg 2014-12-01
66 schema:description BACKGROUND: Identification of new drugs against paediatric sarcomas represents an urgent clinical need that mainly relies on public investments due to the rarity of these diseases. In this paper we evaluated the in vitro and in vivo efficacy of a new maltol derived molecule (maltonis), belonging to the family of molecules named hydroxypyrones. METHODS: Maltonis was screened for its ability to induce structural alteration of DNA molecules in comparison to another maltolic molecule (malten). In vitro antitumour efficacy was tested using a panel of sarcoma cell lines, representative of Ewing sarcoma, osteosarcoma and rhabdomyosarcoma, the three most common paediatric sarcomas, and in normal human mesenchymal primary cell cultures. In vivo efficacy was tested against TC-71 Ewing sarcoma xenografts. RESULTS: Maltonis, a soluble maltol-derived synthetic molecule, was able to alter the DNA structure, inhibit proliferation and induce apoptotic cell death in paediatric sarcoma cells, either sensitive or resistant to some conventional chemotherapeutic drugs, such as doxorubicin and cisplatin. In addition, maltonis was able to induce: i) p21, p15 and Gadd45a mRNA upregulation; ii) Bcl-2, survivin, CDK6 and CDK8 down-regulation; iii) formation of γ-H2AX nuclear foci; iv) cleavage of PARP and Caspase 3. Two independent in vivo experiments demonstrated the tolerability and efficacy of maltonis in the inhibition of tumour growth. Finally maltonis was not extruded by ABCB1, one of the major determinants of chemotherapy failure, nor appeared to be a substrate of the glutathione-related detoxification system. CONCLUSIONS: Considering that treatment of poorly responsive patients still suffers for the paucity of agents able to revert chemoresistance, maltonis may be considered for the future development of new therapeutic approaches for refractory metastatic patients.
67 schema:genre research_article
68 schema:inLanguage en
69 schema:isAccessibleForFree true
70 schema:isPartOf Na5b8dc6f2a3c415b9daa6cf9a4f64154
71 Nbdfa7faec4e444049f755d113902b245
72 sg:journal.1024632
73 schema:name An aza-macrocycle containing maltolic side-arms (maltonis) as potential drug against human pediatric sarcomas
74 schema:pagination 137
75 schema:productId N4f7de075e9d5409c9af9aa3b0c14190a
76 N58edc92e6fb24d67a29704cbaf8e6ac8
77 N922da4a3b6c047c3ac10bf0078c2463c
78 Nc6140efa9a13486ca7463c9ea7b66a58
79 Nf5c44d7cffba4328a964c698afeefa9e
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005202391
81 https://doi.org/10.1186/1471-2407-14-137
82 schema:sdDatePublished 2019-04-10T18:20
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher N4ddda34b92ac4ed1a5c3bf5ec9593048
85 schema:url http://link.springer.com/10.1186%2F1471-2407-14-137
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N005a92ca737247bf9bf68ca27cdad772 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Apoptosis
91 rdf:type schema:DefinedTerm
92 N0310758a409c49959a5f18e7f20de01c rdf:first sg:person.016531410660.23
93 rdf:rest Ne06b079f767a4333b160ebd6c4da194c
94 N0c26417901ef492989e3936bd7a5009a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Disease Models, Animal
96 rdf:type schema:DefinedTerm
97 N0c6b33a5df984b0d898e64fd78b0db4d rdf:first sg:person.01007647077.29
98 rdf:rest Nc83029c9197a4d28936a723319ac9adb
99 N19357b140b35447bb51db8fd1b0e05f0 rdf:first sg:person.0725016672.22
100 rdf:rest N7470206745f141c79865b646240a61ad
101 N3e2e46c0ee634d4693644591a0627088 rdf:first N634d1220035e48b6b938728ba9be27aa
102 rdf:rest N19357b140b35447bb51db8fd1b0e05f0
103 N4807081dc8664e6b85b84cef24707c31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Humans
105 rdf:type schema:DefinedTerm
106 N4ddda34b92ac4ed1a5c3bf5ec9593048 schema:name Springer Nature - SN SciGraph project
107 rdf:type schema:Organization
108 N4f7de075e9d5409c9af9aa3b0c14190a schema:name dimensions_id
109 schema:value pub.1005202391
110 rdf:type schema:PropertyValue
111 N58edc92e6fb24d67a29704cbaf8e6ac8 schema:name nlm_unique_id
112 schema:value 100967800
113 rdf:type schema:PropertyValue
114 N62215d6991974fb88ad88331cfc32506 rdf:first sg:person.01227066027.74
115 rdf:rest Nffd4afaed9d14711a12e5f3feeab3faa
116 N634d1220035e48b6b938728ba9be27aa schema:affiliation https://www.grid.ac/institutes/grid.12711.34
117 schema:familyName Balducci
118 schema:givenName Mauro
119 rdf:type schema:Person
120 N64d52634c19449efa77547c9425b546f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Cell Proliferation
122 rdf:type schema:DefinedTerm
123 N657ccddbee274be89d476454be3dd6dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Antineoplastic Agents
125 rdf:type schema:DefinedTerm
126 N6a59ada2f19249db80391627d82eb8b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name DNA Damage
128 rdf:type schema:DefinedTerm
129 N7470206745f141c79865b646240a61ad rdf:first sg:person.01125076576.87
130 rdf:rest Nbba4b3466aae4bac9ef706955f02d752
131 N759ffd14fff546d79c5d99485cc53766 rdf:first sg:person.01242137172.18
132 rdf:rest N3e2e46c0ee634d4693644591a0627088
133 N797f3693104e4bac948d0eeeff0173b2 schema:name Experimental Oncology Laboratory, CRS Development of Biomolecular Therapies, IstitutoOrtopedico Rizzoli, 40136, Bologna, Italy
134 rdf:type schema:Organization
135 N8b972c51e4c34513bf0aa7c7f79aafda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Cell Cycle
137 rdf:type schema:DefinedTerm
138 N8df235a73f7f4bb9b7bcc00ff39a36bb rdf:first sg:person.0636462043.91
139 rdf:rest N0c6b33a5df984b0d898e64fd78b0db4d
140 N922da4a3b6c047c3ac10bf0078c2463c schema:name readcube_id
141 schema:value 18c92b1ba182db5611fa6c0476249b9240bde3c4026121ceddc341613a1dd307
142 rdf:type schema:PropertyValue
143 N941de18be23b4f73884740a47c5e1ba3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Gene Expression Regulation, Neoplastic
145 rdf:type schema:DefinedTerm
146 N94f0aeb2043b4e42b256da0f6b9c6f5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Heterocyclic Compounds
148 rdf:type schema:DefinedTerm
149 N96be0361a5af4363af5ac7aed4f605f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Mesenchymal Stromal Cells
151 rdf:type schema:DefinedTerm
152 N9b0666f5c5a5469cabc62f392f42c503 rdf:first sg:person.0753274552.44
153 rdf:rest Nc6b35ecee31b4d01a96eea7911918e8d
154 N9c525160586045d29a0a1356147aa1e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Heterografts
156 rdf:type schema:DefinedTerm
157 Na152d8f1fc1c476292381b1fb568dfdd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Mice
159 rdf:type schema:DefinedTerm
160 Na5b8dc6f2a3c415b9daa6cf9a4f64154 schema:issueNumber 1
161 rdf:type schema:PublicationIssue
162 Nae7d4b92f1224f65b28ded3c0f11c757 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Animals
164 rdf:type schema:DefinedTerm
165 Nbba4b3466aae4bac9ef706955f02d752 rdf:first sg:person.01332345370.16
166 rdf:rest N9b0666f5c5a5469cabc62f392f42c503
167 Nbdfa7faec4e444049f755d113902b245 schema:volumeNumber 14
168 rdf:type schema:PublicationVolume
169 Nc451225efd8543afa2c05b5e19b9d647 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Child
171 rdf:type schema:DefinedTerm
172 Nc6140efa9a13486ca7463c9ea7b66a58 schema:name pubmed_id
173 schema:value 24575739
174 rdf:type schema:PropertyValue
175 Nc6b35ecee31b4d01a96eea7911918e8d rdf:first sg:person.0752252542.98
176 rdf:rest N8df235a73f7f4bb9b7bcc00ff39a36bb
177 Nc83029c9197a4d28936a723319ac9adb rdf:first sg:person.01327374561.76
178 rdf:rest rdf:nil
179 Ncd639350d9694d5c9017168018126b6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Inhibitory Concentration 50
181 rdf:type schema:DefinedTerm
182 Ne06b079f767a4333b160ebd6c4da194c rdf:first sg:person.01216116770.76
183 rdf:rest Nff520e11d34744a79e973cc12e4b875a
184 Ne24f3dc262cb424ebebef057c3b22f4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Cell Line, Tumor
186 rdf:type schema:DefinedTerm
187 Ne3dc95f470fa4c99a9cbbcbc7e9e15fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Sarcoma
189 rdf:type schema:DefinedTerm
190 Ne7c5956b3da04aa19b755ac1c88a14fa rdf:first sg:person.01144245317.09
191 rdf:rest N759ffd14fff546d79c5d99485cc53766
192 Nf5c44d7cffba4328a964c698afeefa9e schema:name doi
193 schema:value 10.1186/1471-2407-14-137
194 rdf:type schema:PropertyValue
195 Nf6e54a0621834152b1a2afd7314bf1d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Gene Expression Profiling
197 rdf:type schema:DefinedTerm
198 Nff520e11d34744a79e973cc12e4b875a rdf:first sg:person.01030263515.01
199 rdf:rest Ne7c5956b3da04aa19b755ac1c88a14fa
200 Nffd4afaed9d14711a12e5f3feeab3faa rdf:first sg:person.0663606015.00
201 rdf:rest N0310758a409c49959a5f18e7f20de01c
202 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
203 schema:name Medical and Health Sciences
204 rdf:type schema:DefinedTerm
205 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
206 schema:name Oncology and Carcinogenesis
207 rdf:type schema:DefinedTerm
208 sg:journal.1024632 schema:issn 1471-2407
209 schema:name BMC Cancer
210 rdf:type schema:Periodical
211 sg:person.01007647077.29 schema:affiliation https://www.grid.ac/institutes/grid.12711.34
212 schema:familyName Fanelli
213 schema:givenName Mirco
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007647077.29
215 rdf:type schema:Person
216 sg:person.01030263515.01 schema:affiliation https://www.grid.ac/institutes/grid.419038.7
217 schema:familyName Landuzzi
218 schema:givenName Lorena
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030263515.01
220 rdf:type schema:Person
221 sg:person.01125076576.87 schema:affiliation https://www.grid.ac/institutes/grid.419038.7
222 schema:familyName Pratelli
223 schema:givenName Loredana
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125076576.87
225 rdf:type schema:Person
226 sg:person.01144245317.09 schema:affiliation https://www.grid.ac/institutes/grid.6292.f
227 schema:familyName Lollini
228 schema:givenName Pier-Luigi
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144245317.09
230 rdf:type schema:Person
231 sg:person.01216116770.76 schema:affiliation https://www.grid.ac/institutes/grid.419038.7
232 schema:familyName Manara
233 schema:givenName Maria Cristina
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216116770.76
235 rdf:type schema:Person
236 sg:person.01227066027.74 schema:affiliation https://www.grid.ac/institutes/grid.419038.7
237 schema:familyName Guerzoni
238 schema:givenName Clara
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227066027.74
240 rdf:type schema:Person
241 sg:person.01242137172.18 schema:affiliation https://www.grid.ac/institutes/grid.12711.34
242 schema:familyName Tassoni
243 schema:givenName Aurora
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242137172.18
245 rdf:type schema:Person
246 sg:person.01327374561.76 schema:affiliation https://www.grid.ac/institutes/grid.419038.7
247 schema:familyName Scotlandi
248 schema:givenName Katia
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327374561.76
250 rdf:type schema:Person
251 sg:person.01332345370.16 schema:affiliation N797f3693104e4bac948d0eeeff0173b2
252 schema:familyName Serra
253 schema:givenName Massimo
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332345370.16
255 rdf:type schema:Person
256 sg:person.016531410660.23 schema:affiliation https://www.grid.ac/institutes/grid.12711.34
257 schema:familyName Giorgi
258 schema:givenName Luca
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016531410660.23
260 rdf:type schema:Person
261 sg:person.0636462043.91 schema:affiliation https://www.grid.ac/institutes/grid.12711.34
262 schema:familyName Fusi
263 schema:givenName Vieri
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636462043.91
265 rdf:type schema:Person
266 sg:person.0663606015.00 schema:affiliation https://www.grid.ac/institutes/grid.12711.34
267 schema:familyName Amatori
268 schema:givenName Stefano
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663606015.00
270 rdf:type schema:Person
271 sg:person.0725016672.22 schema:affiliation https://www.grid.ac/institutes/grid.419038.7
272 schema:familyName Manfrini
273 schema:givenName Marco
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725016672.22
275 rdf:type schema:Person
276 sg:person.0752252542.98 schema:affiliation https://www.grid.ac/institutes/grid.12711.34
277 schema:familyName Magnani
278 schema:givenName Mauro
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752252542.98
280 rdf:type schema:Person
281 sg:person.0753274552.44 schema:affiliation https://www.grid.ac/institutes/grid.419038.7
282 schema:familyName Picci
283 schema:givenName Piero
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753274552.44
285 rdf:type schema:Person
286 sg:pub.10.1007/s10534-005-6998-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1049199287
287 https://doi.org/10.1007/s10534-005-6998-y
288 rdf:type schema:CreativeWork
289 sg:pub.10.1038/nrc1168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006265436
290 https://doi.org/10.1038/nrc1168
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/sj.bjc.6605745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016311010
293 https://doi.org/10.1038/sj.bjc.6605745
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/sj.onc.1210642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030862836
296 https://doi.org/10.1038/sj.onc.1210642
297 rdf:type schema:CreativeWork
298 https://app.dimensions.ai/details/publication/pub.1075201548 schema:CreativeWork
299 https://app.dimensions.ai/details/publication/pub.1076844285 schema:CreativeWork
300 https://app.dimensions.ai/details/publication/pub.1077199008 schema:CreativeWork
301 https://app.dimensions.ai/details/publication/pub.1077841563 schema:CreativeWork
302 https://app.dimensions.ai/details/publication/pub.1082651014 schema:CreativeWork
303 https://app.dimensions.ai/details/publication/pub.1082708484 schema:CreativeWork
304 https://doi.org/10.1002/(sici)1097-0215(19990209)80:4<581::aid-ijc16>3.0.co;2-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1028892000
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1002/cncr.24458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029726585
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1002/cncr.27493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030952031
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1002/gcc.20640 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039792051
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1002/jbmr.1578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045380302
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1002/pbc.24118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010523478
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1002/stem.5530080644 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027819308
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1006/neur.1996.0044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007555874
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/0041-008x(69)90062-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049891995
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/1357-2725(95)00031-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1018732166
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/j.bcp.2008.03.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024509301
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1016/j.canlet.2008.09.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002094297
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1016/j.ccr.2007.02.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037629381
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1016/j.lungcan.2009.01.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035096367
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1016/j.lungcan.2010.10.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044309585
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1016/j.molcel.2005.05.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009633411
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1016/j.toxlet.2005.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045471994
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1021/ic9004642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055584322
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1021/jo202270j schema:sameAs https://app.dimensions.ai/details/publication/pub.1056026930
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1074/jbc.m503295200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048697156
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1084/jem.20032247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033131756
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1093/annonc/mdq573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049439223
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1093/annonc/mdt278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010197645
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1126/science.7973727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062650847
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1158/0008-5472.can-04-3192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022389948
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1158/0008-5472.can-07-5840 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045535894
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1158/1078-0432.ccr-09-0816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033879136
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1200/jco.1995.13.8.2123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082444262
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1200/jco.2003.03.144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203482
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1200/jco.2011.38.4420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013071513
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1200/jco.2011.40.3287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016599720
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1371/journal.pone.0042985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012546698
367 rdf:type schema:CreativeWork
368 https://www.grid.ac/institutes/grid.12711.34 schema:alternateName University of Urbino
369 schema:name Department of Basic Sciences and Fundamentals, University of Urbino “Carlo Bo”, P.za Rinascimento, 6, 61029, Urbino (PU), Italy
370 Department of Biomolecular Sciences, University of Urbino “Carlo Bo”, via Saffi 2, 61029, Urbino (PU), Italy
371 Molecular Pathology Lab. “PaoLa”, Department of Biomolecular Sciences, University of Urbino “Carlo Bo”, via Arco d’Augusto, 2, 61032, Fano (PU), Italy
372 rdf:type schema:Organization
373 https://www.grid.ac/institutes/grid.419038.7 schema:alternateName Istituto Ortopedico Rizzoli
374 schema:name Clinica Ortopedica e Traumatologica III, Istituto Ortopedico Rizzoli, 40136, Bologna, Italy
375 Clinical Pathology, Istituto Ortopedico Rizzoli, 40136, Bologna, Italy
376 Experimental Oncology Laboratory, CRS Development of Biomolecular Therapies, IstitutoOrtopedico Rizzoli, 40136, Bologna, Italy
377 PROMETEO Laboratory, Section of Biomolecular Therapies, RIT Department, Istituto Ortopedico Rizzoli, 40136, Bologna, Italy
378 rdf:type schema:Organization
379 https://www.grid.ac/institutes/grid.6292.f schema:alternateName University of Bologna
380 schema:name Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
381 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...