KRAS, BRAF genotyping reveals genetic heterogeneity of ovarian borderline tumors and associated implants View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Sabine Heublein, Katinka Grasse, Harald Hessel, Alexander Burges, Miriam Lenhard, Jutta Engel, Thomas Kirchner, Udo Jeschke, Doris Mayr

ABSTRACT

BACKGROUND: Patients diagnosed for a serous ovarian borderline tumor (s-BOT) typically present with an excellent clinical outcome. However there have been controversies concerning the prognostic impact of so-called implants, an extra ovarian spread occurring alongside the s-BOT in certain cases. It remains obscure whether these implants actually resemble metastasis owning the same genetic pattern as the ovarian primary or whether they develop independently. METHODS: The current study, in the aim of further clarifying the genetic origin of implants, assessed BRAF/KRAS hot spot mutations and the p53/p16INK4a immunophenotype of s-BOTs and corresponding implants (n=49) of 15 patients by pyro-sequencing and immunostaining, respectively. RESULTS: A significant proportion of both s-BOTs and implants showed KRAS or BRAF mutation and though p16INK4a was found to be abundantly expressed, p53 immunoreactivity was rather low. When genotypes of BRAF/KRAS mutated s-BOTs and corresponding implants were compared no patient presented with a fully matching mutation profile of s-BOTs and all corresponding implants. CONCLUSIONS: The current study reveals genetic heterogeneity of s-BOTs and implants, as none of the markers examined showed constant reciprocity. Hence, our findings may assist to explain the different clinical presentation of s-BOTs and implants and might encourage to applying more individualized follow up protocols. More... »

PAGES

483

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2407-13-483

DOI

http://dx.doi.org/10.1186/1471-2407-13-483

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016669037

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24139521


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