Additional diagnostic value of tumor markers in cytological fluid for diagnosis of non-small-cell lung cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-09-07

AUTHORS

Jin Hur, Hye-Jeong Lee, Ji Eun Nam, Young Jin Kim, Yoo Jin Hong, Hee Yeong Kim, Se Kyu Kim, Joon Chang, Joo-Hang Kim, Kyung Young Chung, Hye Sun Lee, Byoung Wook Choi

ABSTRACT

BackgroundCytological fluid from a needle aspiration biopsy (NAB) is obtained directly from tumor tissue, therefore many biomarker candidates will be present in high concentrations. The aim of this study was to prospectively assess and validate the tumor markers CYFRA 21–1, CEA, and SCC in cytological fluid obtained from NAB samples to determine if they improved the performance of NAB for diagnosing non-small cell lung cancer (NSCLC).MethodsA total of 194 patients (M:F = 128:66, mean age 63.7 years) with suspected malignant pulmonary lesions were prospectively enrolled and underwent percutaneous NAB. Levels of CYFRA 21–1, CEA, and SCC were measured by immunoassay in serum and cytological fluid obtained during aspiration biopsy. Cut-off values to determined malignancy were 3.3 ng/mL in serum and 15.7 ng/mL in cytological fluid for CYFRA 21–1, 5 ng/mL and 0.6 ng/mL for CEA, and 2 ng/mL and 0.86 ng/mL for SCC.ResultsOf 194 patients, 139 patients (71.6%) had NSCLC and 55 (28.4%) had benign lesions. Sensitivity increased significantly for NAB combined with cytological tumor markers compared with NAB alone (CYFRA 21–1: 95% versus 83.5%, p < 0.001, CEA: 92.1% versus 83.5%, p = 0.002, SCC: 91.4% versus 83.5%, p = 0.003). Accuracy improved significantly for NAB combined with cytological CYFRA 21–1 compared with NAB alone (95.9% versus 88.1%, p < 0.001). The area under curve (AUC) of NAB with cytological CYFRA 21–1 was significantly larger than for NAB alone (0.966 versus 0.917, p = 0.009).ConclusionOf the tested tumor markers, cytological fluid measurements of CYFRA 21–1 improved the diagnostic performance of NAB for NSCLC. More... »

PAGES

392

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2407-12-392

DOI

http://dx.doi.org/10.1186/1471-2407-12-392

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019479966

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22954172


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28 schema:description BackgroundCytological fluid from a needle aspiration biopsy (NAB) is obtained directly from tumor tissue, therefore many biomarker candidates will be present in high concentrations. The aim of this study was to prospectively assess and validate the tumor markers CYFRA 21–1, CEA, and SCC in cytological fluid obtained from NAB samples to determine if they improved the performance of NAB for diagnosing non-small cell lung cancer (NSCLC).MethodsA total of 194 patients (M:F = 128:66, mean age 63.7 years) with suspected malignant pulmonary lesions were prospectively enrolled and underwent percutaneous NAB. Levels of CYFRA 21–1, CEA, and SCC were measured by immunoassay in serum and cytological fluid obtained during aspiration biopsy. Cut-off values to determined malignancy were 3.3 ng/mL in serum and 15.7 ng/mL in cytological fluid for CYFRA 21–1, 5 ng/mL and 0.6 ng/mL for CEA, and 2 ng/mL and 0.86 ng/mL for SCC.ResultsOf 194 patients, 139 patients (71.6%) had NSCLC and 55 (28.4%) had benign lesions. Sensitivity increased significantly for NAB combined with cytological tumor markers compared with NAB alone (CYFRA 21–1: 95% versus 83.5%, p < 0.001, CEA: 92.1% versus 83.5%, p = 0.002, SCC: 91.4% versus 83.5%, p = 0.003). Accuracy improved significantly for NAB combined with cytological CYFRA 21–1 compared with NAB alone (95.9% versus 88.1%, p < 0.001). The area under curve (AUC) of NAB with cytological CYFRA 21–1 was significantly larger than for NAB alone (0.966 versus 0.917, p = 0.009).ConclusionOf the tested tumor markers, cytological fluid measurements of CYFRA 21–1 improved the diagnostic performance of NAB for NSCLC.
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35 CYFRA 21
36 ConclusionOf
37 NAB samples
38 SCC
39 accuracy
40 additional diagnostic value
41 aim
42 area
43 aspiration biopsy
44 benign lesions
45 biomarker candidates
46 biopsy
47 cancer
48 candidates
49 cell lung cancer
50 concentration
51 curves
52 cytological fluid
53 diagnosis
54 diagnostic performance
55 diagnostic value
56 fluid
57 fluid measurements
58 high concentrations
59 immunoassay
60 lesions
61 levels
62 lung cancer
63 malignancy
64 malignant pulmonary lesions
65 markers
66 measurements
67 needle aspiration biopsy
68 non-small cell lung cancer
69 patients
70 percutaneous needle aspiration biopsy
71 performance
72 pulmonary lesions
73 samples
74 sensitivity
75 serum
76 study
77 tissue
78 total
79 tumor markers
80 tumor markers CYFRA 21
81 tumor tissue
82 values
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