SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

Jens Neumann, Fiorina Bahr, David Horst, Lydia Kriegl, Jutta Engel, Raquel Mejías-Luque, Markus Gerhard, Thomas Kirchner, Andreas Jung

ABSTRACT

BACKGROUND: The transcription factor SOX2, which is involved in the induction of pluripotent stem cells and contributes to colorectal carcinogenesis, is associated with a poor prognosis in colon cancer (CC). Furthermore, SOX2 is a repressor of the transcriptional activity of β-catenin in vitro. Since the majority of CC develop via an activation of the Wnt/β-catenin signalling pathway, indicated by nuclear expression of β-catenin, we wanted to investigate the expression patterns of SOX2 and β-catenin and correlate them with the occurrence of lymph node and distant metastases as indicators of malignant progression. METHODS: The expression of SOX2 and β-catenin was investigated in a case control study utilizing a matched pair collection (N = 114) of right-sided CCs with either corresponding distant metastases (N = 57) or without distant spread (N = 57) by applying immunohistochemistry. RESULTS: Elevated protein expression of SOX2 significantly correlated with the presence of lymph node- (p = 0.006) and distant metastases (p = 0.022). Nuclear β-catenin expression correlated significantly only with distant metastases (p = 0.001). Less than 10% of cases showed a coexpression of high levels of β-catenin and SOX2. The positivity for both markers was also associated with a very high risk for lymph-node metastases (p = 0.007) and distant spread (p = 0.028). CONCLUSION: We demonstrated that increased expression of either SOX2 or nuclear β-catenin are associated with distant metastases in right-sided CC. Additionally, SOX2 is also associated with lymph-node metastases. These data underline the importance of stemness-associated markers for the identification of CC with high risk for distant spread. More... »

PAGES

518

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2407-11-518

DOI

http://dx.doi.org/10.1186/1471-2407-11-518

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007179784

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22168803


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colonic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphatic Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "SOXB1 Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "beta Catenin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Ludwig Maximilian University of Munich", 
          "id": "https://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Pathologisches Institut, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Neumann", 
        "givenName": "Jens", 
        "id": "sg:person.01300715124.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300715124.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ludwig Maximilian University of Munich", 
          "id": "https://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Pathologisches Institut, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bahr", 
        "givenName": "Fiorina", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ludwig Maximilian University of Munich", 
          "id": "https://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Pathologisches Institut, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany", 
            "Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Horst", 
        "givenName": "David", 
        "id": "sg:person.0625475144.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625475144.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ludwig Maximilian University of Munich", 
          "id": "https://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Pathologisches Institut, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kriegl", 
        "givenName": "Lydia", 
        "id": "sg:person.01121034032.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121034032.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ludwig Maximilian University of Munich", 
          "id": "https://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Tumorregister M\u00fcnchen des Tumorzentrums M\u00fcnchen am Institut f\u00fcr medizinische Informationsverarbeitung, Biometrie und Epidemiologie der Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Engel", 
        "givenName": "Jutta", 
        "id": "sg:person.01064304603.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064304603.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Technical University Munich", 
          "id": "https://www.grid.ac/institutes/grid.6936.a", 
          "name": [
            "Institut f\u00fcr Medizinische Mikrobiologie und Immunologie, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mej\u00edas-Luque", 
        "givenName": "Raquel", 
        "id": "sg:person.0641754765.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641754765.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Technical University Munich", 
          "id": "https://www.grid.ac/institutes/grid.6936.a", 
          "name": [
            "Institut f\u00fcr Medizinische Mikrobiologie und Immunologie, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gerhard", 
        "givenName": "Markus", 
        "id": "sg:person.01000747325.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000747325.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ludwig Maximilian University of Munich", 
          "id": "https://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Pathologisches Institut, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kirchner", 
        "givenName": "Thomas", 
        "id": "sg:person.0650074000.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650074000.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ludwig Maximilian University of Munich", 
          "id": "https://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Pathologisches Institut, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jung", 
        "givenName": "Andreas", 
        "id": "sg:person.01211136300.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211136300.00"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/modpathol.2009.181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000994300", 
          "https://doi.org/10.1038/modpathol.2009.181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2009.04.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001917849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1374", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002744128", 
          "https://doi.org/10.1038/nbt1374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200409182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003899362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvdy.22046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006231505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvdy.22046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006231505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-006-0375-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006660450", 
          "https://doi.org/10.1007/s10120-006-0375-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-006-0375-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006660450", 
          "https://doi.org/10.1007/s10120-006-0375-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/01.mp.0000062859.46942.93", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008652180", 
          "https://doi.org/10.1097/01.mp.0000062859.46942.93"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2008.00819.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009168899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1541-7786.mcr-07-2175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010258302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.11.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010904856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208960", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011398816", 
          "https://doi.org/10.1038/sj.onc.1208960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208960", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011398816", 
          "https://doi.org/10.1038/sj.onc.1208960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.2597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011883086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.2597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011883086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2010.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013647293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.2007.02620.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014426901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.07.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014573758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/mp.56.6.347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015045927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/mp.56.6.347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015045927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.04.0063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016858589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.02179-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018462948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/2789_2007_047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020654823", 
          "https://doi.org/10.1007/2789_2007_047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/2789_2007_047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020654823", 
          "https://doi.org/10.1007/2789_2007_047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-3627-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022411213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.02.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023540354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-009-0617-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024261193", 
          "https://doi.org/10.1245/s10434-009-0617-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-009-0617-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024261193", 
          "https://doi.org/10.1245/s10434-009-0617-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.23225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026592471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-0157-03", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030074112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.2006.02549.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030093906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/jmoldx.2008.070082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031898520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2005.02.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032448722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m808048200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033874737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m802917200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034124256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1694", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039396447", 
          "https://doi.org/10.1038/nrc1694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1694", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039396447", 
          "https://doi.org/10.1038/nrc1694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2008.02.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040053418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041002524", 
          "https://doi.org/10.1038/ncb2048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041002524", 
          "https://doi.org/10.1038/ncb2048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.10.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041684641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.20073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042069193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2008.09.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046580050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1538-7836.2009.03418.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047311394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1538-7836.2009.03418.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047311394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6604664", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047485649", 
          "https://doi.org/10.1038/sj.bjc.6604664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049130438", 
          "https://doi.org/10.1038/ng.127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/omi.2010.0053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059303819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/157488709787047558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069215320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077499611", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-12", 
    "datePublishedReg": "2011-12-01", 
    "description": "BACKGROUND: The transcription factor SOX2, which is involved in the induction of pluripotent stem cells and contributes to colorectal carcinogenesis, is associated with a poor prognosis in colon cancer (CC). Furthermore, SOX2 is a repressor of the transcriptional activity of \u03b2-catenin in vitro. Since the majority of CC develop via an activation of the Wnt/\u03b2-catenin signalling pathway, indicated by nuclear expression of \u03b2-catenin, we wanted to investigate the expression patterns of SOX2 and \u03b2-catenin and correlate them with the occurrence of lymph node and distant metastases as indicators of malignant progression.\nMETHODS: The expression of SOX2 and \u03b2-catenin was investigated in a case control study utilizing a matched pair collection (N = 114) of right-sided CCs with either corresponding distant metastases (N = 57) or without distant spread (N = 57) by applying immunohistochemistry.\nRESULTS: Elevated protein expression of SOX2 significantly correlated with the presence of lymph node- (p = 0.006) and distant metastases (p = 0.022). Nuclear \u03b2-catenin expression correlated significantly only with distant metastases (p = 0.001). Less than 10% of cases showed a coexpression of high levels of \u03b2-catenin and SOX2. The positivity for both markers was also associated with a very high risk for lymph-node metastases (p = 0.007) and distant spread (p = 0.028).\nCONCLUSION: We demonstrated that increased expression of either SOX2 or nuclear \u03b2-catenin are associated with distant metastases in right-sided CC. Additionally, SOX2 is also associated with lymph-node metastases. These data underline the importance of stemness-associated markers for the identification of CC with high risk for distant spread.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-2407-11-518", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024632", 
        "issn": [
          "1471-2407"
        ], 
        "name": "BMC Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "name": "SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer", 
    "pagination": "518", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2232db9b7073ece4e9471b424f77718091c73027b63ad803efe2bbcf34e1cecf"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22168803"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100967800"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2407-11-518"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1007179784"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2407-11-518", 
      "https://app.dimensions.ai/details/publication/pub.1007179784"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-2407-11-518"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-11-518'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-11-518'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-11-518'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-11-518'


 

This table displays all metadata directly associated to this object as RDF triples.

313 TRIPLES      21 PREDICATES      83 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2407-11-518 schema:about N0695c63bc46c48a7887b0a3810b8408f
2 N07a73f21e45f4db9b1c5275742fb161e
3 N2fcf6be069c641bab1239b73b06a95aa
4 N40af0c1532f944f6bb0678ab5d2aa103
5 N5efb64372331435c9b22ee434a9c6966
6 Na096dc4ce03842e694dbdfc94ed3d4a0
7 Na5dbbd26840a424684f6ea652fdaf7bf
8 Nb6c862604ef5440cbe3ec9c75567b3c4
9 Nbaa10d3ce63b4d00bcb98d1636cbf2c6
10 Ndf19a3f0e8fe406c9f3b538f7d4f7faf
11 Nf1c88f1d172948e7af85e33e4bb6b6ac
12 Nf9e7d0129f1741e6a0df778c7a965e4f
13 Nff2f26957a3442aab63a0821f85f2cf6
14 anzsrc-for:11
15 anzsrc-for:1112
16 schema:author N1779bd5d0ba24e179ce0f5dd0bd79500
17 schema:citation sg:pub.10.1007/2789_2007_047
18 sg:pub.10.1007/s10120-006-0375-6
19 sg:pub.10.1038/modpathol.2009.181
20 sg:pub.10.1038/nbt1374
21 sg:pub.10.1038/ncb2048
22 sg:pub.10.1038/ng.127
23 sg:pub.10.1038/nrc1694
24 sg:pub.10.1038/sj.bjc.6604664
25 sg:pub.10.1038/sj.onc.1208960
26 sg:pub.10.1097/01.mp.0000062859.46942.93
27 sg:pub.10.1245/s10434-009-0617-z
28 https://app.dimensions.ai/details/publication/pub.1077499611
29 https://doi.org/10.1002/dvdy.22046
30 https://doi.org/10.1002/ijc.23225
31 https://doi.org/10.1002/path.2597
32 https://doi.org/10.1016/j.cell.2006.07.024
33 https://doi.org/10.1016/j.cell.2006.10.018
34 https://doi.org/10.1016/j.cell.2007.11.019
35 https://doi.org/10.1016/j.cell.2011.02.013
36 https://doi.org/10.1016/j.ejca.2009.04.004
37 https://doi.org/10.1016/j.neuron.2005.02.023
38 https://doi.org/10.1016/j.stem.2008.02.009
39 https://doi.org/10.1016/j.stem.2010.04.001
40 https://doi.org/10.1053/j.gastro.2008.09.019
41 https://doi.org/10.1074/jbc.m802917200
42 https://doi.org/10.1074/jbc.m808048200
43 https://doi.org/10.1083/jcb.200409182
44 https://doi.org/10.1089/omi.2010.0053
45 https://doi.org/10.1111/j.1349-7006.2008.00819.x
46 https://doi.org/10.1111/j.1365-2559.2006.02549.x
47 https://doi.org/10.1111/j.1365-2559.2007.02620.x
48 https://doi.org/10.1111/j.1538-7836.2009.03418.x
49 https://doi.org/10.1128/mcb.02179-06
50 https://doi.org/10.1136/mp.56.6.347
51 https://doi.org/10.1158/0008-5472.can-3627-2
52 https://doi.org/10.1158/1078-0432.ccr-0157-03
53 https://doi.org/10.1158/1541-7786.mcr-07-2175
54 https://doi.org/10.1200/jco.2005.04.0063
55 https://doi.org/10.2174/157488709787047558
56 https://doi.org/10.2353/jmoldx.2008.070082
57 https://doi.org/10.3322/caac.20073
58 schema:datePublished 2011-12
59 schema:datePublishedReg 2011-12-01
60 schema:description BACKGROUND: The transcription factor SOX2, which is involved in the induction of pluripotent stem cells and contributes to colorectal carcinogenesis, is associated with a poor prognosis in colon cancer (CC). Furthermore, SOX2 is a repressor of the transcriptional activity of β-catenin in vitro. Since the majority of CC develop via an activation of the Wnt/β-catenin signalling pathway, indicated by nuclear expression of β-catenin, we wanted to investigate the expression patterns of SOX2 and β-catenin and correlate them with the occurrence of lymph node and distant metastases as indicators of malignant progression. METHODS: The expression of SOX2 and β-catenin was investigated in a case control study utilizing a matched pair collection (N = 114) of right-sided CCs with either corresponding distant metastases (N = 57) or without distant spread (N = 57) by applying immunohistochemistry. RESULTS: Elevated protein expression of SOX2 significantly correlated with the presence of lymph node- (p = 0.006) and distant metastases (p = 0.022). Nuclear β-catenin expression correlated significantly only with distant metastases (p = 0.001). Less than 10% of cases showed a coexpression of high levels of β-catenin and SOX2. The positivity for both markers was also associated with a very high risk for lymph-node metastases (p = 0.007) and distant spread (p = 0.028). CONCLUSION: We demonstrated that increased expression of either SOX2 or nuclear β-catenin are associated with distant metastases in right-sided CC. Additionally, SOX2 is also associated with lymph-node metastases. These data underline the importance of stemness-associated markers for the identification of CC with high risk for distant spread.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree true
64 schema:isPartOf N61eea4220f314125ad96778d3a0ea824
65 Ndc40a27aed4749a283046183ee9e032d
66 sg:journal.1024632
67 schema:name SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer
68 schema:pagination 518
69 schema:productId N20a390ebaa5a4c24a90d98689a91580d
70 N96628e66c16949a6a09812dd41a07d63
71 Nb14cfbc7c3994328afc6d584a8e89c6f
72 Nb78f3c94047c4ade98dc14eba871c98c
73 Ncb14252075954da092df0c042076091d
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007179784
75 https://doi.org/10.1186/1471-2407-11-518
76 schema:sdDatePublished 2019-04-11T01:06
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher Nbcdce2af07ac4328a9de4168e1bd3bb0
79 schema:url http://link.springer.com/10.1186%2F1471-2407-11-518
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N0659a6c2558f4c649972a213f65315a1 rdf:first sg:person.01211136300.00
84 rdf:rest rdf:nil
85 N0695c63bc46c48a7887b0a3810b8408f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Aged
87 rdf:type schema:DefinedTerm
88 N07a73f21e45f4db9b1c5275742fb161e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Neoplasm Proteins
90 rdf:type schema:DefinedTerm
91 N1779bd5d0ba24e179ce0f5dd0bd79500 rdf:first sg:person.01300715124.18
92 rdf:rest N672c126308f144cbbcca19204e7f7c40
93 N20a390ebaa5a4c24a90d98689a91580d schema:name pubmed_id
94 schema:value 22168803
95 rdf:type schema:PropertyValue
96 N2fcf6be069c641bab1239b73b06a95aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Case-Control Studies
98 rdf:type schema:DefinedTerm
99 N3b5c9884fc604252936172846c2a080c rdf:first sg:person.0650074000.01
100 rdf:rest N0659a6c2558f4c649972a213f65315a1
101 N40af0c1532f944f6bb0678ab5d2aa103 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Adenocarcinoma
103 rdf:type schema:DefinedTerm
104 N54cc5b0ce62946b0ab99c8ca5d2169f9 rdf:first sg:person.0625475144.71
105 rdf:rest Nbd08c05c08d949278ee5726838a882d6
106 N5efb64372331435c9b22ee434a9c6966 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name SOXB1 Transcription Factors
108 rdf:type schema:DefinedTerm
109 N61eea4220f314125ad96778d3a0ea824 schema:volumeNumber 11
110 rdf:type schema:PublicationVolume
111 N672c126308f144cbbcca19204e7f7c40 rdf:first N712e1897d18b49bf8e7574b640862cc4
112 rdf:rest N54cc5b0ce62946b0ab99c8ca5d2169f9
113 N712e1897d18b49bf8e7574b640862cc4 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
114 schema:familyName Bahr
115 schema:givenName Fiorina
116 rdf:type schema:Person
117 N8f11fef57a3e4de488256def4defa1d9 rdf:first sg:person.0641754765.24
118 rdf:rest Nf80984543c0743a3a46afc182ad9d4d1
119 N96628e66c16949a6a09812dd41a07d63 schema:name nlm_unique_id
120 schema:value 100967800
121 rdf:type schema:PropertyValue
122 Na096dc4ce03842e694dbdfc94ed3d4a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Middle Aged
124 rdf:type schema:DefinedTerm
125 Na5dbbd26840a424684f6ea652fdaf7bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name beta Catenin
127 rdf:type schema:DefinedTerm
128 Nb14cfbc7c3994328afc6d584a8e89c6f schema:name dimensions_id
129 schema:value pub.1007179784
130 rdf:type schema:PropertyValue
131 Nb6c862604ef5440cbe3ec9c75567b3c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Lymphatic Metastasis
133 rdf:type schema:DefinedTerm
134 Nb78f3c94047c4ade98dc14eba871c98c schema:name doi
135 schema:value 10.1186/1471-2407-11-518
136 rdf:type schema:PropertyValue
137 Nbaa10d3ce63b4d00bcb98d1636cbf2c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Colonic Neoplasms
139 rdf:type schema:DefinedTerm
140 Nbcdce2af07ac4328a9de4168e1bd3bb0 schema:name Springer Nature - SN SciGraph project
141 rdf:type schema:Organization
142 Nbd08c05c08d949278ee5726838a882d6 rdf:first sg:person.01121034032.09
143 rdf:rest Nf00045de14944555afb9e16af624b928
144 Ncb14252075954da092df0c042076091d schema:name readcube_id
145 schema:value 2232db9b7073ece4e9471b424f77718091c73027b63ad803efe2bbcf34e1cecf
146 rdf:type schema:PropertyValue
147 Ndc40a27aed4749a283046183ee9e032d schema:issueNumber 1
148 rdf:type schema:PublicationIssue
149 Ndf19a3f0e8fe406c9f3b538f7d4f7faf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Female
151 rdf:type schema:DefinedTerm
152 Nf00045de14944555afb9e16af624b928 rdf:first sg:person.01064304603.38
153 rdf:rest N8f11fef57a3e4de488256def4defa1d9
154 Nf1c88f1d172948e7af85e33e4bb6b6ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Male
156 rdf:type schema:DefinedTerm
157 Nf80984543c0743a3a46afc182ad9d4d1 rdf:first sg:person.01000747325.87
158 rdf:rest N3b5c9884fc604252936172846c2a080c
159 Nf9e7d0129f1741e6a0df778c7a965e4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Immunohistochemistry
161 rdf:type schema:DefinedTerm
162 Nff2f26957a3442aab63a0821f85f2cf6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Humans
164 rdf:type schema:DefinedTerm
165 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
166 schema:name Medical and Health Sciences
167 rdf:type schema:DefinedTerm
168 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
169 schema:name Oncology and Carcinogenesis
170 rdf:type schema:DefinedTerm
171 sg:journal.1024632 schema:issn 1471-2407
172 schema:name BMC Cancer
173 rdf:type schema:Periodical
174 sg:person.01000747325.87 schema:affiliation https://www.grid.ac/institutes/grid.6936.a
175 schema:familyName Gerhard
176 schema:givenName Markus
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000747325.87
178 rdf:type schema:Person
179 sg:person.01064304603.38 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
180 schema:familyName Engel
181 schema:givenName Jutta
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064304603.38
183 rdf:type schema:Person
184 sg:person.01121034032.09 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
185 schema:familyName Kriegl
186 schema:givenName Lydia
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121034032.09
188 rdf:type schema:Person
189 sg:person.01211136300.00 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
190 schema:familyName Jung
191 schema:givenName Andreas
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211136300.00
193 rdf:type schema:Person
194 sg:person.01300715124.18 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
195 schema:familyName Neumann
196 schema:givenName Jens
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300715124.18
198 rdf:type schema:Person
199 sg:person.0625475144.71 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
200 schema:familyName Horst
201 schema:givenName David
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625475144.71
203 rdf:type schema:Person
204 sg:person.0641754765.24 schema:affiliation https://www.grid.ac/institutes/grid.6936.a
205 schema:familyName Mejías-Luque
206 schema:givenName Raquel
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641754765.24
208 rdf:type schema:Person
209 sg:person.0650074000.01 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
210 schema:familyName Kirchner
211 schema:givenName Thomas
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650074000.01
213 rdf:type schema:Person
214 sg:pub.10.1007/2789_2007_047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020654823
215 https://doi.org/10.1007/2789_2007_047
216 rdf:type schema:CreativeWork
217 sg:pub.10.1007/s10120-006-0375-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006660450
218 https://doi.org/10.1007/s10120-006-0375-6
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/modpathol.2009.181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000994300
221 https://doi.org/10.1038/modpathol.2009.181
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/nbt1374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002744128
224 https://doi.org/10.1038/nbt1374
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/ncb2048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041002524
227 https://doi.org/10.1038/ncb2048
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/ng.127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049130438
230 https://doi.org/10.1038/ng.127
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/nrc1694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039396447
233 https://doi.org/10.1038/nrc1694
234 rdf:type schema:CreativeWork
235 sg:pub.10.1038/sj.bjc.6604664 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047485649
236 https://doi.org/10.1038/sj.bjc.6604664
237 rdf:type schema:CreativeWork
238 sg:pub.10.1038/sj.onc.1208960 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011398816
239 https://doi.org/10.1038/sj.onc.1208960
240 rdf:type schema:CreativeWork
241 sg:pub.10.1097/01.mp.0000062859.46942.93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008652180
242 https://doi.org/10.1097/01.mp.0000062859.46942.93
243 rdf:type schema:CreativeWork
244 sg:pub.10.1245/s10434-009-0617-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1024261193
245 https://doi.org/10.1245/s10434-009-0617-z
246 rdf:type schema:CreativeWork
247 https://app.dimensions.ai/details/publication/pub.1077499611 schema:CreativeWork
248 https://doi.org/10.1002/dvdy.22046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006231505
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1002/ijc.23225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026592471
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1002/path.2597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011883086
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.cell.2006.07.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014573758
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.cell.2006.10.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041684641
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.cell.2007.11.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010904856
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.cell.2011.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023540354
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.ejca.2009.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001917849
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.neuron.2005.02.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032448722
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.stem.2008.02.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040053418
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.stem.2010.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013647293
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1053/j.gastro.2008.09.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046580050
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1074/jbc.m802917200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034124256
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1074/jbc.m808048200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033874737
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1083/jcb.200409182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003899362
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1089/omi.2010.0053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059303819
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1111/j.1349-7006.2008.00819.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009168899
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1111/j.1365-2559.2006.02549.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030093906
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1111/j.1365-2559.2007.02620.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014426901
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1111/j.1538-7836.2009.03418.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047311394
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1128/mcb.02179-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018462948
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1136/mp.56.6.347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015045927
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1158/0008-5472.can-3627-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022411213
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1158/1078-0432.ccr-0157-03 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030074112
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1158/1541-7786.mcr-07-2175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010258302
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1200/jco.2005.04.0063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016858589
299 rdf:type schema:CreativeWork
300 https://doi.org/10.2174/157488709787047558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069215320
301 rdf:type schema:CreativeWork
302 https://doi.org/10.2353/jmoldx.2008.070082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031898520
303 rdf:type schema:CreativeWork
304 https://doi.org/10.3322/caac.20073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042069193
305 rdf:type schema:CreativeWork
306 https://www.grid.ac/institutes/grid.5252.0 schema:alternateName Ludwig Maximilian University of Munich
307 schema:name Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
308 Pathologisches Institut, Ludwig-Maximilians-Universität München, Munich, Germany
309 Tumorregister München des Tumorzentrums München am Institut für medizinische Informationsverarbeitung, Biometrie und Epidemiologie der Ludwig-Maximilians-Universität München, Munich, Germany
310 rdf:type schema:Organization
311 https://www.grid.ac/institutes/grid.6936.a schema:alternateName Technical University Munich
312 schema:name Institut für Medizinische Mikrobiologie und Immunologie, Technische Universität München, Munich, Germany
313 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...