Expression of phosphorylated raf kinase inhibitor protein (pRKIP) is a predictor of lung cancer survival View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-06-21

AUTHORS

Sara Huerta-Yepez, Nam K Yoon, Angeles Hernandez-Cueto, Vei Mah, Clara M Rivera-Pazos, Devasis Chatterjee, Mario I Vega, Erin L Maresh, Steve Horvath, David Chia, Benjamin Bonavida, Lee Goodglick

ABSTRACT

BackgroundRaf-1 kinase inhibitor protein (RKIP) has been reported to negatively regulate signal kinases of major survival pathways. RKIP activity is modulated in part by phosphorylation on Serine 153 by protein kinase C, which leads to dissociation of RKIP from Raf-1. RKIP expression is low in many human cancers and represents an indicator of poor prognosis and/or induction of metastasis. The prognostic power has typically been based on total RKIP expression and has not considered the significance of phospho-RKIP.MethodsThe present study examined the expression levels of both RKIP and phospho-RKIP in human lung cancer tissue microarray proteomics technology.ResultsTotal RKIP and phospho-RKIP expression levels were similar in normal and cancerous tissues. phospho-RKIP levels slightly decreased in metastatic lesions. However, the expression levels of phospho-RKIP, in contrast to total RKIP, displayed significant predictive power for outcome with normal expression of phospho-RKIP predicting a more favorable survival compared to lower levels (P = 0.0118); this was even more pronounced in more senior individuals and in those with early stage lung cancer.ConclusionsThis study examines for the first time, the expression profile of RKIP and phospho-RKIP in lung cancer. Significantly, we found that phospho-RKIP was a predictive indicator of survival. More... »

PAGES

259

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2407-11-259

DOI

http://dx.doi.org/10.1186/1471-2407-11-259

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037521550

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21689459


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29 schema:description BackgroundRaf-1 kinase inhibitor protein (RKIP) has been reported to negatively regulate signal kinases of major survival pathways. RKIP activity is modulated in part by phosphorylation on Serine 153 by protein kinase C, which leads to dissociation of RKIP from Raf-1. RKIP expression is low in many human cancers and represents an indicator of poor prognosis and/or induction of metastasis. The prognostic power has typically been based on total RKIP expression and has not considered the significance of phospho-RKIP.MethodsThe present study examined the expression levels of both RKIP and phospho-RKIP in human lung cancer tissue microarray proteomics technology.ResultsTotal RKIP and phospho-RKIP expression levels were similar in normal and cancerous tissues. phospho-RKIP levels slightly decreased in metastatic lesions. However, the expression levels of phospho-RKIP, in contrast to total RKIP, displayed significant predictive power for outcome with normal expression of phospho-RKIP predicting a more favorable survival compared to lower levels (P = 0.0118); this was even more pronounced in more senior individuals and in those with early stage lung cancer.ConclusionsThis study examines for the first time, the expression profile of RKIP and phospho-RKIP in lung cancer. Significantly, we found that phospho-RKIP was a predictive indicator of survival.
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36 schema:keywords ConclusionsThis study
37 MethodsThe present study
38 RKIP
39 RKIP activity
40 RKIP expression
41 Raf kinase inhibitor protein
42 Raf-1
43 activity
44 cancer
45 cancer survival
46 cancerous tissues
47 contrast
48 dissociation
49 early-stage lung cancer
50 expression
51 expression levels
52 expression profiles
53 favorable survival
54 first time
55 human cancers
56 indicators
57 individuals
58 induction
59 induction of metastasis
60 inhibitor protein
61 kinase
62 kinase C
63 kinase inhibitor protein
64 lesions
65 levels
66 low levels
67 lung cancer
68 lung cancer survival
69 major survival pathways
70 metastasis
71 metastatic lesions
72 normal expression
73 outcomes
74 part
75 pathway
76 phosphorylation
77 poor prognosis
78 power
79 predictive indicator
80 predictive power
81 predictors
82 present study
83 profile
84 prognosis
85 prognostic power
86 protein
87 protein kinase C
88 proteomic technologies
89 senior individuals
90 serine 153
91 signal kinase
92 significance
93 significant predictive power
94 stage lung cancer
95 study
96 survival
97 survival pathways
98 technology
99 time
100 tissue
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