Retrospective exploratory analysis of VEGF polymorphisms in the prediction of benefit from first-line FOLFIRI plus bevacizumab in metastatic colorectal cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

Fotios Loupakis, Annamaria Ruzzo, Lisa Salvatore, Chiara Cremolini, Gianluca Masi, Paolo Frumento, Marta Schirripa, Vincenzo Catalano, Nadia Galluccio, Emanuele Canestrari, Bruno Vincenzi, Daniele Santini, Katia Bencardino, Vincenzo Ricci, Mariangela Manzoni, Marco Danova, Giuseppe Tonini, Mauro Magnani, Alfredo Falcone, Francesco Graziano

ABSTRACT

BACKGROUND: Molecular predictors of bevacizumab efficacy in colorectal cancer have not been identified yet. Specific VEGF polymorphisms may affect gene transcription and therefore indirectly influence the efficacy of bevacizumab. METHODS: Genomic DNA of 111 consecutive metastatic colorectal cancer patients treated with first-line FOLFIRI plus bevacizumab was obtained from blood samples. VEGF -2578 C/A, -1498 C/T, + 405 C/G, + 936 C/T polymorphisms were analyzed by means of PCR-RFLP. DNA samples from 107 patients treated with FOLFIRI alone served as historical control group. The relation of VEGF polymorphisms with PFS, evaluated through Kaplan-Meier method and log-rank test, was the primary end-point. An interaction test with a Cox model has been performed in order to demonstrate the heterogeneity of the effect of VEGF -1498 C/T polymorphism between bevacizumab-and control group. RESULTS: In the bevacizumab-group median PFS and OS of patients carrying VEGF -1498 C/C, C/T and T/T allelic variants were, respectively, 12.8, 10.5, 7.5 months (p = 0.0046, log-rank test) and 27.3, 20.5, 18.6 months (p = 0.038, log-rank test). VEGF -1498 T/T genotype was associated with shorter PFS (HR = 2.13, [1.41-5.10], p = 0.0027). In the control group no significant association of VEGF -1498 C/T allelic variants and PFS or OS was found. Interaction between VEGF -1498 C/T variants and treatment effect suggested that the relation of VEGF -1498 T/T genotype with shorter PFS was caused by the effect of bevacizumab (p = 0.011). Other investigated polymorphisms did not affect the outcome. CONCLUSIONS: These data suggest a possible role for VEGF -1498 C/T variants in predicting the efficacy of bevacizumab in the up-front treatment of metastatic colorectal cancer patients. A molecular tool for selecting subjects candidate to benefit from the anti-VEGF could be important for clinical practice. The retrospective and exploratory design of the present study, coupled with the non-randomized nature of the comparison between treated and untreated patients, imply that these results should be considered as hypothesis generators. A prospective validating trial is currently ongoing. More... »

PAGES

247

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2407-11-247

DOI

http://dx.doi.org/10.1186/1471-2407-11-247

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049074019

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21669012


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal, Humanized", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bevacizumab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Camptothecin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorouracil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leucovorin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Statistical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vascular Endothelial Growth Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "U.O. Oncologia Medica 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano Tumori and Dipartimento di Oncologia, dei Trapianti e delle Nuove Tecnologie in Medicina, Universit\u00e0 di Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Loupakis", 
        "givenName": "Fotios", 
        "id": "sg:person.01175106504.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175106504.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Dipartimento di Scienze Biomolecolari, Universit\u00e0 degli Studi \"Carlo Bo\", Urbino, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ruzzo", 
        "givenName": "Annamaria", 
        "id": "sg:person.0577005525.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577005525.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "U.O. Oncologia Medica 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano Tumori and Dipartimento di Oncologia, dei Trapianti e delle Nuove Tecnologie in Medicina, Universit\u00e0 di Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salvatore", 
        "givenName": "Lisa", 
        "id": "sg:person.01157052153.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157052153.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "U.O. Oncologia Medica 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano Tumori and Dipartimento di Oncologia, dei Trapianti e delle Nuove Tecnologie in Medicina, Universit\u00e0 di Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cremolini", 
        "givenName": "Chiara", 
        "id": "sg:person.01257327771.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257327771.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "U.O. Oncologia Medica 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano Tumori and Dipartimento di Oncologia, dei Trapianti e delle Nuove Tecnologie in Medicina, Universit\u00e0 di Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Masi", 
        "givenName": "Gianluca", 
        "id": "sg:person.01062670207.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062670207.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sant'Anna School of Advanced Studies", 
          "id": "https://www.grid.ac/institutes/grid.263145.7", 
          "name": [
            "Scuola Superiore di Studi Universitari e Perfezionamento \"Sant'Anna\", Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Frumento", 
        "givenName": "Paolo", 
        "id": "sg:person.01257271757.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257271757.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "U.O. Oncologia Medica 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano Tumori and Dipartimento di Oncologia, dei Trapianti e delle Nuove Tecnologie in Medicina, Universit\u00e0 di Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schirripa", 
        "givenName": "Marta", 
        "id": "sg:person.01225165353.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225165353.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "U.O. Oncologia Medica, Ospedale di Pesaro, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Catalano", 
        "givenName": "Vincenzo", 
        "id": "sg:person.0645354261.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645354261.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Dipartimento di Scienze Biomolecolari, Universit\u00e0 degli Studi \"Carlo Bo\", Urbino, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Galluccio", 
        "givenName": "Nadia", 
        "id": "sg:person.0777022717.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777022717.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Dipartimento di Scienze Biomolecolari, Universit\u00e0 degli Studi \"Carlo Bo\", Urbino, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Canestrari", 
        "givenName": "Emanuele", 
        "id": "sg:person.0656451363.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656451363.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e0 Campus Bio-Medico", 
          "id": "https://www.grid.ac/institutes/grid.9657.d", 
          "name": [
            "U.O. Oncologia Medica, Universit\u00e0 Campus Biomedico, Roma, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vincenzi", 
        "givenName": "Bruno", 
        "id": "sg:person.0602665555.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602665555.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e0 Campus Bio-Medico", 
          "id": "https://www.grid.ac/institutes/grid.9657.d", 
          "name": [
            "U.O. Oncologia Medica, Universit\u00e0 Campus Biomedico, Roma, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Santini", 
        "givenName": "Daniele", 
        "id": "sg:person.0700665677.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700665677.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Unit\u00e0 di Oncologia, Istituto Scientifico San Raffaele, Milano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bencardino", 
        "givenName": "Katia", 
        "id": "sg:person.01242020722.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242020722.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Unit\u00e0 di Oncologia, Istituto Scientifico San Raffaele, Milano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ricci", 
        "givenName": "Vincenzo", 
        "id": "sg:person.0722070557.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722070557.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Policlinico San Matteo Fondazione", 
          "id": "https://www.grid.ac/institutes/grid.419425.f", 
          "name": [
            "U.O. Oncologia Medica, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Manzoni", 
        "givenName": "Mariangela", 
        "id": "sg:person.01053611156.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053611156.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Policlinico San Matteo Fondazione", 
          "id": "https://www.grid.ac/institutes/grid.419425.f", 
          "name": [
            "U.O. Oncologia Medica, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Danova", 
        "givenName": "Marco", 
        "id": "sg:person.0601356435.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601356435.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e0 Campus Bio-Medico", 
          "id": "https://www.grid.ac/institutes/grid.9657.d", 
          "name": [
            "U.O. Oncologia Medica, Universit\u00e0 Campus Biomedico, Roma, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tonini", 
        "givenName": "Giuseppe", 
        "id": "sg:person.01236745400.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236745400.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Dipartimento di Scienze Biomolecolari, Universit\u00e0 degli Studi \"Carlo Bo\", Urbino, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Magnani", 
        "givenName": "Mauro", 
        "id": "sg:person.0752252542.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752252542.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "U.O. Oncologia Medica 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano Tumori and Dipartimento di Oncologia, dei Trapianti e delle Nuove Tecnologie in Medicina, Universit\u00e0 di Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Falcone", 
        "givenName": "Alfredo", 
        "id": "sg:person.01006230145.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006230145.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "U.O. Oncologia Medica, Ospedale di Pesaro, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Graziano", 
        "givenName": "Francesco", 
        "id": "sg:person.01027716061.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027716061.05"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s10549-005-9003-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002360352", 
          "https://doi.org/10.1007/s10549-005-9003-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr1400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005230005", 
          "https://doi.org/10.1186/bcr1400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.16.1612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006396374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/14622416.8.1.49", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006422698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6604955", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008988272", 
          "https://doi.org/10.1038/sj.bjc.6604955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/cyto.2000.0692", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009866177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/16.3.1215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012912024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.2008-0213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015589842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-0351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017695176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.05.113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025767346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.20.7175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027665051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1359-6349(09)72051-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027830304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.20.6359", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029712075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.01.5388", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031716816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/92.3.205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032301848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa072113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033842397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.21.9170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035426871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/dji174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037639061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6605061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037820966", 
          "https://doi.org/10.1038/sj.bjc.6605061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6605061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037820966", 
          "https://doi.org/10.1038/sj.bjc.6605061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000054076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042325625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2010.1535", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043560351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdf034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045240563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdp233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047295095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdp233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047295095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2008.656", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048505634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdi244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051303692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.28.15_suppl.3587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083943073"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-12", 
    "datePublishedReg": "2011-12-01", 
    "description": "BACKGROUND: Molecular predictors of bevacizumab efficacy in colorectal cancer have not been identified yet. Specific VEGF polymorphisms may affect gene transcription and therefore indirectly influence the efficacy of bevacizumab.\nMETHODS: Genomic DNA of 111 consecutive metastatic colorectal cancer patients treated with first-line FOLFIRI plus bevacizumab was obtained from blood samples. VEGF -2578 C/A, -1498 C/T, + 405 C/G, + 936 C/T polymorphisms were analyzed by means of PCR-RFLP. DNA samples from 107 patients treated with FOLFIRI alone served as historical control group. The relation of VEGF polymorphisms with PFS, evaluated through Kaplan-Meier method and log-rank test, was the primary end-point. An interaction test with a Cox model has been performed in order to demonstrate the heterogeneity of the effect of VEGF -1498 C/T polymorphism between bevacizumab-and control group.\nRESULTS: In the bevacizumab-group median PFS and OS of patients carrying VEGF -1498 C/C, C/T and T/T allelic variants were, respectively, 12.8, 10.5, 7.5 months (p = 0.0046, log-rank test) and 27.3, 20.5, 18.6 months (p = 0.038, log-rank test). VEGF -1498 T/T genotype was associated with shorter PFS (HR = 2.13, [1.41-5.10], p = 0.0027). In the control group no significant association of VEGF -1498 C/T allelic variants and PFS or OS was found. Interaction between VEGF -1498 C/T variants and treatment effect suggested that the relation of VEGF -1498 T/T genotype with shorter PFS was caused by the effect of bevacizumab (p = 0.011). Other investigated polymorphisms did not affect the outcome.\nCONCLUSIONS: These data suggest a possible role for VEGF -1498 C/T variants in predicting the efficacy of bevacizumab in the up-front treatment of metastatic colorectal cancer patients. A molecular tool for selecting subjects candidate to benefit from the anti-VEGF could be important for clinical practice. The retrospective and exploratory design of the present study, coupled with the non-randomized nature of the comparison between treated and untreated patients, imply that these results should be considered as hypothesis generators. A prospective validating trial is currently ongoing.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-2407-11-247", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024632", 
        "issn": [
          "1471-2407"
        ], 
        "name": "BMC Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "name": "Retrospective exploratory analysis of VEGF polymorphisms in the prediction of benefit from first-line FOLFIRI plus bevacizumab in metastatic colorectal cancer", 
    "pagination": "247", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e9c7cffd55cd80d1bcd27f5c655c7c7e4c9c67f0cc45afa2244b94d11767c26e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21669012"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100967800"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2407-11-247"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1049074019"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2407-11-247", 
      "https://app.dimensions.ai/details/publication/pub.1049074019"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000516.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-2407-11-247"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-11-247'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-11-247'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-11-247'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-11-247'


 

This table displays all metadata directly associated to this object as RDF triples.

412 TRIPLES      21 PREDICATES      79 URIs      45 LITERALS      33 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2407-11-247 schema:about N12a2ed60db3a418587a0f9602e33a934
2 N340f5e640a6a48b8a70769742fd3b57d
3 N3695f700f0fa4edea717f9bed5832a00
4 N41a876aecb09470ab36ec1fe9f7b9ab0
5 N420f873d603c4724ae4bc4cae134225b
6 N48360590ffa4466e8271ed2c71700e51
7 N589014a85ecb464dbfa7a55d3469add0
8 N5d981875408441729e2c2a4c7cda89b7
9 N5f4d5b6c96b6489a89bbce58d6b5b0ce
10 N69d76e31044a48b0acfa9514e617fc5f
11 N6d954186804c4024bc82a0aef0280fc3
12 N70dcb026dab340e589607625ad867f1a
13 N76bffeb93ae2443e9d2ab9fd18213e06
14 N80a7152bd20b41d7a8646c72d4edffcf
15 N8af5b98bcefc4ccf8d6c497280ac5c23
16 Naee25fef9db445f88d5e12784279be80
17 Nb564df551a544dda91c96ccc690cb042
18 Nba4e02de875f4f68bebbecc0394b0101
19 Nbef72be427724362af24d705abac57e3
20 Nbf6240e75470410487bcb69ecd513f32
21 Nc5edb7ff42764ade8322ddec72d227a4
22 Nca4ade1ce09a456f86f59684f1021669
23 Ne026038e1bcb4e09aed7a93d041e3727
24 Ne05d3fb17d9447f093c57f8b58d21d70
25 anzsrc-for:11
26 anzsrc-for:1112
27 schema:author Nc1e31c3e06fc448d919e01ae6ae0b667
28 schema:citation sg:pub.10.1007/s10549-005-9003-0
29 sg:pub.10.1038/sj.bjc.6604955
30 sg:pub.10.1038/sj.bjc.6605061
31 sg:pub.10.1186/bcr1400
32 https://doi.org/10.1001/jama.2008.656
33 https://doi.org/10.1001/jama.2010.1535
34 https://doi.org/10.1006/cyto.2000.0692
35 https://doi.org/10.1016/s1359-6349(09)72051-8
36 https://doi.org/10.1056/nejmoa072113
37 https://doi.org/10.1093/annonc/mdf034
38 https://doi.org/10.1093/annonc/mdi244
39 https://doi.org/10.1093/annonc/mdp233
40 https://doi.org/10.1093/jnci/92.3.205
41 https://doi.org/10.1093/jnci/dji174
42 https://doi.org/10.1093/nar/16.3.1215
43 https://doi.org/10.1158/1078-0432.ccr-08-0351
44 https://doi.org/10.1159/000054076
45 https://doi.org/10.1200/jco.2004.05.113
46 https://doi.org/10.1200/jco.2005.01.5388
47 https://doi.org/10.1200/jco.2008.16.1612
48 https://doi.org/10.1200/jco.2008.20.6359
49 https://doi.org/10.1200/jco.2008.20.7175
50 https://doi.org/10.1200/jco.2009.21.9170
51 https://doi.org/10.1200/jco.2010.28.15_suppl.3587
52 https://doi.org/10.1634/theoncologist.2008-0213
53 https://doi.org/10.2217/14622416.8.1.49
54 schema:datePublished 2011-12
55 schema:datePublishedReg 2011-12-01
56 schema:description BACKGROUND: Molecular predictors of bevacizumab efficacy in colorectal cancer have not been identified yet. Specific VEGF polymorphisms may affect gene transcription and therefore indirectly influence the efficacy of bevacizumab. METHODS: Genomic DNA of 111 consecutive metastatic colorectal cancer patients treated with first-line FOLFIRI plus bevacizumab was obtained from blood samples. VEGF -2578 C/A, -1498 C/T, + 405 C/G, + 936 C/T polymorphisms were analyzed by means of PCR-RFLP. DNA samples from 107 patients treated with FOLFIRI alone served as historical control group. The relation of VEGF polymorphisms with PFS, evaluated through Kaplan-Meier method and log-rank test, was the primary end-point. An interaction test with a Cox model has been performed in order to demonstrate the heterogeneity of the effect of VEGF -1498 C/T polymorphism between bevacizumab-and control group. RESULTS: In the bevacizumab-group median PFS and OS of patients carrying VEGF -1498 C/C, C/T and T/T allelic variants were, respectively, 12.8, 10.5, 7.5 months (p = 0.0046, log-rank test) and 27.3, 20.5, 18.6 months (p = 0.038, log-rank test). VEGF -1498 T/T genotype was associated with shorter PFS (HR = 2.13, [1.41-5.10], p = 0.0027). In the control group no significant association of VEGF -1498 C/T allelic variants and PFS or OS was found. Interaction between VEGF -1498 C/T variants and treatment effect suggested that the relation of VEGF -1498 T/T genotype with shorter PFS was caused by the effect of bevacizumab (p = 0.011). Other investigated polymorphisms did not affect the outcome. CONCLUSIONS: These data suggest a possible role for VEGF -1498 C/T variants in predicting the efficacy of bevacizumab in the up-front treatment of metastatic colorectal cancer patients. A molecular tool for selecting subjects candidate to benefit from the anti-VEGF could be important for clinical practice. The retrospective and exploratory design of the present study, coupled with the non-randomized nature of the comparison between treated and untreated patients, imply that these results should be considered as hypothesis generators. A prospective validating trial is currently ongoing.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree true
60 schema:isPartOf N40d218ca09194a89bb5c72d740f765c3
61 Nbf0b7c146fba40299c2d9031b7f6bec7
62 sg:journal.1024632
63 schema:name Retrospective exploratory analysis of VEGF polymorphisms in the prediction of benefit from first-line FOLFIRI plus bevacizumab in metastatic colorectal cancer
64 schema:pagination 247
65 schema:productId N3c3b5f4592b643b6b12ad8a2911a85bc
66 N62b39d7f48e94bd49cfad948ed8e535e
67 N690afa5b24964849b608254f1f45bdbb
68 N7de1272533a8481facce346e0efd3d91
69 Nab8594f0f58c4e05b1718131c1417be4
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049074019
71 https://doi.org/10.1186/1471-2407-11-247
72 schema:sdDatePublished 2019-04-10T20:48
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher Nec3a3d67e5d647b5bbe5a45cbe60d6b9
75 schema:url http://link.springer.com/10.1186%2F1471-2407-11-247
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N12a2ed60db3a418587a0f9602e33a934 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Middle Aged
81 rdf:type schema:DefinedTerm
82 N17bc29bc66a74ee4bfe006feeb36a760 rdf:first sg:person.01157052153.90
83 rdf:rest Nf3980c6a0b8345a9ae17fb8a7cdf8954
84 N1aef16978026467b9b342cf36245f6e0 schema:name Dipartimento di Scienze Biomolecolari, Università degli Studi "Carlo Bo", Urbino, Italy
85 rdf:type schema:Organization
86 N299b46149a694cb8b8038a33b1d77d61 rdf:first sg:person.0577005525.74
87 rdf:rest N17bc29bc66a74ee4bfe006feeb36a760
88 N340f5e640a6a48b8a70769742fd3b57d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Polymorphism, Genetic
90 rdf:type schema:DefinedTerm
91 N3695f700f0fa4edea717f9bed5832a00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Aged
93 rdf:type schema:DefinedTerm
94 N381fa9f4b3da4b09b4d4747c6fe74c20 schema:name Dipartimento di Scienze Biomolecolari, Università degli Studi "Carlo Bo", Urbino, Italy
95 rdf:type schema:Organization
96 N3c3b5f4592b643b6b12ad8a2911a85bc schema:name doi
97 schema:value 10.1186/1471-2407-11-247
98 rdf:type schema:PropertyValue
99 N40d218ca09194a89bb5c72d740f765c3 schema:volumeNumber 11
100 rdf:type schema:PublicationVolume
101 N41a876aecb09470ab36ec1fe9f7b9ab0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Colorectal Neoplasms
103 rdf:type schema:DefinedTerm
104 N420f873d603c4724ae4bc4cae134225b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Prognosis
106 rdf:type schema:DefinedTerm
107 N48360590ffa4466e8271ed2c71700e51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Adenocarcinoma
109 rdf:type schema:DefinedTerm
110 N4f4b1a27e3574ed5b8b25a61168dbe66 rdf:first sg:person.0602665555.11
111 rdf:rest N62a3c842a4e546d7a0a6cf794afc1baf
112 N589014a85ecb464dbfa7a55d3469add0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Bevacizumab
114 rdf:type schema:DefinedTerm
115 N5d981875408441729e2c2a4c7cda89b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Male
117 rdf:type schema:DefinedTerm
118 N5f4d5b6c96b6489a89bbce58d6b5b0ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Genotype
120 rdf:type schema:DefinedTerm
121 N62a3c842a4e546d7a0a6cf794afc1baf rdf:first sg:person.0700665677.08
122 rdf:rest N777749514863468085e17bffcd2c0197
123 N62b39d7f48e94bd49cfad948ed8e535e schema:name dimensions_id
124 schema:value pub.1049074019
125 rdf:type schema:PropertyValue
126 N690afa5b24964849b608254f1f45bdbb schema:name readcube_id
127 schema:value e9c7cffd55cd80d1bcd27f5c655c7c7e4c9c67f0cc45afa2244b94d11767c26e
128 rdf:type schema:PropertyValue
129 N69d76e31044a48b0acfa9514e617fc5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Antineoplastic Combined Chemotherapy Protocols
131 rdf:type schema:DefinedTerm
132 N6d954186804c4024bc82a0aef0280fc3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Retrospective Studies
134 rdf:type schema:DefinedTerm
135 N70dcb026dab340e589607625ad867f1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Models, Statistical
137 rdf:type schema:DefinedTerm
138 N71077d1a45584603929cfdac318892e4 rdf:first sg:person.01006230145.44
139 rdf:rest N9a73457257d0471e902e1e0c60a3310d
140 N72cf241e8234432a97de2c272506cc9a rdf:first sg:person.01053611156.12
141 rdf:rest Ndbe1d3a6e0b242d58efd3d70c0273228
142 N73463aed61cc43d2a7c2b87e1ca6e45a rdf:first sg:person.01062670207.83
143 rdf:rest Nf44616313b7a4e0ebe419038e7d603e1
144 N76bffeb93ae2443e9d2ab9fd18213e06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Camptothecin
146 rdf:type schema:DefinedTerm
147 N777749514863468085e17bffcd2c0197 rdf:first sg:person.01242020722.16
148 rdf:rest Ndc844f4fbbd0403385f017339087bcbc
149 N7ca8b181e2da40bb8fc8c03fe7d35181 schema:name U.O. Oncologia Medica 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano Tumori and Dipartimento di Oncologia, dei Trapianti e delle Nuove Tecnologie in Medicina, Università di Pisa, Italy
150 rdf:type schema:Organization
151 N7de1272533a8481facce346e0efd3d91 schema:name nlm_unique_id
152 schema:value 100967800
153 rdf:type schema:PropertyValue
154 N80a7152bd20b41d7a8646c72d4edffcf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Humans
156 rdf:type schema:DefinedTerm
157 N82474653a26a4b539222ca207b7eea88 schema:name Dipartimento di Scienze Biomolecolari, Università degli Studi "Carlo Bo", Urbino, Italy
158 rdf:type schema:Organization
159 N8557d69ccb1c40b893686349b691e745 rdf:first sg:person.01225165353.57
160 rdf:rest N913fa89dfdce4f788c1c60b9910d126d
161 N88e263e4f0454bdf923403401ac994d7 rdf:first sg:person.0777022717.28
162 rdf:rest Nd57ea47e30ba45bf99fccf3e1ab8ddaa
163 N8af5b98bcefc4ccf8d6c497280ac5c23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Alleles
165 rdf:type schema:DefinedTerm
166 N913fa89dfdce4f788c1c60b9910d126d rdf:first sg:person.0645354261.22
167 rdf:rest N88e263e4f0454bdf923403401ac994d7
168 N99c07d16864742e5a6b1914c4f5bfab4 schema:name U.O. Oncologia Medica, Ospedale di Pesaro, Italy
169 rdf:type schema:Organization
170 N9a73457257d0471e902e1e0c60a3310d rdf:first sg:person.01027716061.05
171 rdf:rest rdf:nil
172 Na3bf5ed5416f4b95b6680e172f2f2a6f schema:name U.O. Oncologia Medica 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano Tumori and Dipartimento di Oncologia, dei Trapianti e delle Nuove Tecnologie in Medicina, Università di Pisa, Italy
173 rdf:type schema:Organization
174 Nab8594f0f58c4e05b1718131c1417be4 schema:name pubmed_id
175 schema:value 21669012
176 rdf:type schema:PropertyValue
177 Naee25fef9db445f88d5e12784279be80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Leucovorin
179 rdf:type schema:DefinedTerm
180 Nb2c6b51fb5e1414f93360f4b7035fab0 schema:name U.O. Oncologia Medica 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano Tumori and Dipartimento di Oncologia, dei Trapianti e delle Nuove Tecnologie in Medicina, Università di Pisa, Italy
181 rdf:type schema:Organization
182 Nb564df551a544dda91c96ccc690cb042 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Vascular Endothelial Growth Factors
184 rdf:type schema:DefinedTerm
185 Nba4e02de875f4f68bebbecc0394b0101 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Fluorouracil
187 rdf:type schema:DefinedTerm
188 Nbef72be427724362af24d705abac57e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Antineoplastic Agents
190 rdf:type schema:DefinedTerm
191 Nbf0b7c146fba40299c2d9031b7f6bec7 schema:issueNumber 1
192 rdf:type schema:PublicationIssue
193 Nbf6240e75470410487bcb69ecd513f32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Antibodies, Monoclonal, Humanized
195 rdf:type schema:DefinedTerm
196 Nc1e31c3e06fc448d919e01ae6ae0b667 rdf:first sg:person.01175106504.32
197 rdf:rest N299b46149a694cb8b8038a33b1d77d61
198 Nc5edb7ff42764ade8322ddec72d227a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Female
200 rdf:type schema:DefinedTerm
201 Nc86c6ead419d444691eeb72893c67d6d rdf:first sg:person.0752252542.98
202 rdf:rest N71077d1a45584603929cfdac318892e4
203 Nca4ade1ce09a456f86f59684f1021669 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Survival Analysis
205 rdf:type schema:DefinedTerm
206 Ncd7314f1675a43e0be0d1c58e60a83f5 schema:name U.O. Oncologia Medica, Ospedale di Pesaro, Italy
207 rdf:type schema:Organization
208 Nd57ea47e30ba45bf99fccf3e1ab8ddaa rdf:first sg:person.0656451363.23
209 rdf:rest N4f4b1a27e3574ed5b8b25a61168dbe66
210 Ndbe1d3a6e0b242d58efd3d70c0273228 rdf:first sg:person.0601356435.31
211 rdf:rest Nfdfd86389dcf4ec087756a6e132f896e
212 Ndc844f4fbbd0403385f017339087bcbc rdf:first sg:person.0722070557.52
213 rdf:rest N72cf241e8234432a97de2c272506cc9a
214 Ndd3103f9a33b48bfbe634c688f034e76 schema:name U.O. Oncologia Medica 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano Tumori and Dipartimento di Oncologia, dei Trapianti e delle Nuove Tecnologie in Medicina, Università di Pisa, Italy
215 rdf:type schema:Organization
216 Ne026038e1bcb4e09aed7a93d041e3727 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Treatment Outcome
218 rdf:type schema:DefinedTerm
219 Ne05d3fb17d9447f093c57f8b58d21d70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
220 schema:name Antibodies, Monoclonal
221 rdf:type schema:DefinedTerm
222 Nec3a3d67e5d647b5bbe5a45cbe60d6b9 schema:name Springer Nature - SN SciGraph project
223 rdf:type schema:Organization
224 Nf3980c6a0b8345a9ae17fb8a7cdf8954 rdf:first sg:person.01257327771.59
225 rdf:rest N73463aed61cc43d2a7c2b87e1ca6e45a
226 Nf44616313b7a4e0ebe419038e7d603e1 rdf:first sg:person.01257271757.35
227 rdf:rest N8557d69ccb1c40b893686349b691e745
228 Nf9d8d174afe947cc81b1933c4d217f47 schema:name Dipartimento di Scienze Biomolecolari, Università degli Studi "Carlo Bo", Urbino, Italy
229 rdf:type schema:Organization
230 Nfdcfa4eddcf44f949edbc82c8eb1d8c2 schema:name U.O. Oncologia Medica 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano Tumori and Dipartimento di Oncologia, dei Trapianti e delle Nuove Tecnologie in Medicina, Università di Pisa, Italy
231 rdf:type schema:Organization
232 Nfdfd86389dcf4ec087756a6e132f896e rdf:first sg:person.01236745400.24
233 rdf:rest Nc86c6ead419d444691eeb72893c67d6d
234 Nff23ed50db594b7cafa1611b3b456b09 schema:name U.O. Oncologia Medica 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano Tumori and Dipartimento di Oncologia, dei Trapianti e delle Nuove Tecnologie in Medicina, Università di Pisa, Italy
235 rdf:type schema:Organization
236 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
237 schema:name Medical and Health Sciences
238 rdf:type schema:DefinedTerm
239 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
240 schema:name Oncology and Carcinogenesis
241 rdf:type schema:DefinedTerm
242 sg:journal.1024632 schema:issn 1471-2407
243 schema:name BMC Cancer
244 rdf:type schema:Periodical
245 sg:person.01006230145.44 schema:affiliation Na3bf5ed5416f4b95b6680e172f2f2a6f
246 schema:familyName Falcone
247 schema:givenName Alfredo
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006230145.44
249 rdf:type schema:Person
250 sg:person.01027716061.05 schema:affiliation N99c07d16864742e5a6b1914c4f5bfab4
251 schema:familyName Graziano
252 schema:givenName Francesco
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027716061.05
254 rdf:type schema:Person
255 sg:person.01053611156.12 schema:affiliation https://www.grid.ac/institutes/grid.419425.f
256 schema:familyName Manzoni
257 schema:givenName Mariangela
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053611156.12
259 rdf:type schema:Person
260 sg:person.01062670207.83 schema:affiliation Nfdcfa4eddcf44f949edbc82c8eb1d8c2
261 schema:familyName Masi
262 schema:givenName Gianluca
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062670207.83
264 rdf:type schema:Person
265 sg:person.01157052153.90 schema:affiliation Ndd3103f9a33b48bfbe634c688f034e76
266 schema:familyName Salvatore
267 schema:givenName Lisa
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157052153.90
269 rdf:type schema:Person
270 sg:person.01175106504.32 schema:affiliation N7ca8b181e2da40bb8fc8c03fe7d35181
271 schema:familyName Loupakis
272 schema:givenName Fotios
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175106504.32
274 rdf:type schema:Person
275 sg:person.01225165353.57 schema:affiliation Nb2c6b51fb5e1414f93360f4b7035fab0
276 schema:familyName Schirripa
277 schema:givenName Marta
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225165353.57
279 rdf:type schema:Person
280 sg:person.01236745400.24 schema:affiliation https://www.grid.ac/institutes/grid.9657.d
281 schema:familyName Tonini
282 schema:givenName Giuseppe
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236745400.24
284 rdf:type schema:Person
285 sg:person.01242020722.16 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
286 schema:familyName Bencardino
287 schema:givenName Katia
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242020722.16
289 rdf:type schema:Person
290 sg:person.01257271757.35 schema:affiliation https://www.grid.ac/institutes/grid.263145.7
291 schema:familyName Frumento
292 schema:givenName Paolo
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257271757.35
294 rdf:type schema:Person
295 sg:person.01257327771.59 schema:affiliation Nff23ed50db594b7cafa1611b3b456b09
296 schema:familyName Cremolini
297 schema:givenName Chiara
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257327771.59
299 rdf:type schema:Person
300 sg:person.0577005525.74 schema:affiliation Nf9d8d174afe947cc81b1933c4d217f47
301 schema:familyName Ruzzo
302 schema:givenName Annamaria
303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577005525.74
304 rdf:type schema:Person
305 sg:person.0601356435.31 schema:affiliation https://www.grid.ac/institutes/grid.419425.f
306 schema:familyName Danova
307 schema:givenName Marco
308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601356435.31
309 rdf:type schema:Person
310 sg:person.0602665555.11 schema:affiliation https://www.grid.ac/institutes/grid.9657.d
311 schema:familyName Vincenzi
312 schema:givenName Bruno
313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602665555.11
314 rdf:type schema:Person
315 sg:person.0645354261.22 schema:affiliation Ncd7314f1675a43e0be0d1c58e60a83f5
316 schema:familyName Catalano
317 schema:givenName Vincenzo
318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645354261.22
319 rdf:type schema:Person
320 sg:person.0656451363.23 schema:affiliation N1aef16978026467b9b342cf36245f6e0
321 schema:familyName Canestrari
322 schema:givenName Emanuele
323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656451363.23
324 rdf:type schema:Person
325 sg:person.0700665677.08 schema:affiliation https://www.grid.ac/institutes/grid.9657.d
326 schema:familyName Santini
327 schema:givenName Daniele
328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700665677.08
329 rdf:type schema:Person
330 sg:person.0722070557.52 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
331 schema:familyName Ricci
332 schema:givenName Vincenzo
333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722070557.52
334 rdf:type schema:Person
335 sg:person.0752252542.98 schema:affiliation N82474653a26a4b539222ca207b7eea88
336 schema:familyName Magnani
337 schema:givenName Mauro
338 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752252542.98
339 rdf:type schema:Person
340 sg:person.0777022717.28 schema:affiliation N381fa9f4b3da4b09b4d4747c6fe74c20
341 schema:familyName Galluccio
342 schema:givenName Nadia
343 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777022717.28
344 rdf:type schema:Person
345 sg:pub.10.1007/s10549-005-9003-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002360352
346 https://doi.org/10.1007/s10549-005-9003-0
347 rdf:type schema:CreativeWork
348 sg:pub.10.1038/sj.bjc.6604955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008988272
349 https://doi.org/10.1038/sj.bjc.6604955
350 rdf:type schema:CreativeWork
351 sg:pub.10.1038/sj.bjc.6605061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037820966
352 https://doi.org/10.1038/sj.bjc.6605061
353 rdf:type schema:CreativeWork
354 sg:pub.10.1186/bcr1400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005230005
355 https://doi.org/10.1186/bcr1400
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1001/jama.2008.656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048505634
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1001/jama.2010.1535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043560351
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1006/cyto.2000.0692 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009866177
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1016/s1359-6349(09)72051-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027830304
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1056/nejmoa072113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033842397
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1093/annonc/mdf034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045240563
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1093/annonc/mdi244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051303692
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1093/annonc/mdp233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047295095
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1093/jnci/92.3.205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032301848
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1093/jnci/dji174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037639061
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1093/nar/16.3.1215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012912024
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1158/1078-0432.ccr-08-0351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017695176
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1159/000054076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042325625
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1200/jco.2004.05.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025767346
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1200/jco.2005.01.5388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031716816
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1200/jco.2008.16.1612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006396374
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1200/jco.2008.20.6359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029712075
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1200/jco.2008.20.7175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027665051
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1200/jco.2009.21.9170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035426871
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1200/jco.2010.28.15_suppl.3587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083943073
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1634/theoncologist.2008-0213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015589842
398 rdf:type schema:CreativeWork
399 https://doi.org/10.2217/14622416.8.1.49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006422698
400 rdf:type schema:CreativeWork
401 https://www.grid.ac/institutes/grid.18887.3e schema:alternateName San Raffaele Hospital
402 schema:name Unità di Oncologia, Istituto Scientifico San Raffaele, Milano, Italy
403 rdf:type schema:Organization
404 https://www.grid.ac/institutes/grid.263145.7 schema:alternateName Sant'Anna School of Advanced Studies
405 schema:name Scuola Superiore di Studi Universitari e Perfezionamento "Sant'Anna", Pisa, Italy
406 rdf:type schema:Organization
407 https://www.grid.ac/institutes/grid.419425.f schema:alternateName Policlinico San Matteo Fondazione
408 schema:name U.O. Oncologia Medica, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy
409 rdf:type schema:Organization
410 https://www.grid.ac/institutes/grid.9657.d schema:alternateName Università Campus Bio-Medico
411 schema:name U.O. Oncologia Medica, Università Campus Biomedico, Roma, Italy
412 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...