Gross genomic alterations and gene expression profiles of high- grade serous carcinoma of the ovary with and without BRCA1 inactivation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-12

AUTHORS

Manohar Pradhan, Björn Å Risberg, Claes G Tropé, Matt van de Rijn, C Blake Gilks, Cheng-Han Lee

ABSTRACT

BACKGROUND: BRCA1 gene inactivation causes chromosomal instability, leading to rapid accumulation of chromosomal rearrangements and mutations. The loss of BRCA1 function due to either germline/somatic mutation or epigenetic silencing is observed in most high-grade serous carcinomas of the ovary. METHODS: DNA ploidy and gene expression profile were used in order to compare gross genomic alteration and gene expression pattern between cases with BRCA1 loss through mutation, BRCA1 epigenetic loss, and no BRCA1 loss in cases of high-grade serous carcinoma with known BRCA1 and BRCA 2 status. RESULTS: Using image cytometry and oligonucleotide microarrays, we analyzed DNA ploidy, S-phase fraction and gene expression profile of 28 consecutive cases of ovarian high-grade serous adenocarcinomas, which included 8 tumor samples with BRCA1 somatic or germline mutation, 9 samples with promoter hypermethylation of BRCA1, and 11 samples with no BRCA1 loss. None had BRCA2 mutations. The prevalence of aneuploidy and tetraploidy was not statistically different in the three groups with different BRCA1 status. The gene expression profiles were also very similar between the groups, with only two genes showing significant differential expression when comparison was made between the group with BRCA1 mutation and the group with no demonstrable BRCA1 loss. There were no genes showing significant differences in expression when the group with BRCA1 loss through epigenetic silencing was compared to either of the other two groups. CONCLUSIONS: In this series of 28 high-grade serous carcinomas, gross genomic alteration characterized by aneuploidy did not correlate with BRCA1 status. In addition, the gene expression profiles of the tumors showed negligible differences between the three defined groups based on BRCA1 status. This suggests that all ovarian high-grade serous carcinomas arise through oncogenic mechanisms that result in chromosomal instability, irrespective of BRCA status; the molecular abnormalities underlying this in the BRCA intact tumors remains unknown. More... »

PAGES

493

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2407-10-493

DOI

http://dx.doi.org/10.1186/1471-2407-10-493

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021183604

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20843305


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "BRCA1 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "BRCA2 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cystadenocarcinoma, Serous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Methylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epigenesis, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genomic Instability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Germ-Line Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligonucleotide Array Sequence Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ovarian Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ploidies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "S Phase", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Oslo University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.55325.34", 
          "name": [
            "Division of Pathology, Oslo University Hospital, Oslo, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pradhan", 
        "givenName": "Manohar", 
        "id": "sg:person.0756710342.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756710342.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oslo University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.55325.34", 
          "name": [
            "Division of Pathology, Oslo University Hospital, Oslo, Norway", 
            "Institute for Medical Informatics, Oslo University Hospital, Oslo, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Risberg", 
        "givenName": "Bj\u00f6rn \u00c5", 
        "id": "sg:person.01356130201.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356130201.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oslo University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.55325.34", 
          "name": [
            "Department of Gynecologic Oncology, Oslo University Hospital, Oslo, Norway", 
            "Faculty Division the Norwegian Radium Hospital, University of Oslo, Oslo, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trop\u00e9", 
        "givenName": "Claes G", 
        "id": "sg:person.01131314301.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131314301.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford Medicine", 
          "id": "https://www.grid.ac/institutes/grid.240952.8", 
          "name": [
            "Department of Pathology, Stanford University Medical Center, Stanford, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van de Rijn", 
        "givenName": "Matt", 
        "id": "sg:person.0737427052.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737427052.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia and Vancouver General Hospital, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gilks", 
        "givenName": "C Blake", 
        "id": "sg:person.01120560217.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120560217.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia and Vancouver General Hospital, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Cheng-Han", 
        "id": "sg:person.0777615543.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777615543.62"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.091062498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001631710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-8-17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003338054", 
          "https://doi.org/10.1186/1471-2407-8-17"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-03-2451", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004918539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203334", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005228794", 
          "https://doi.org/10.1038/sj.onc.1203334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203334", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005228794", 
          "https://doi.org/10.1038/sj.onc.1203334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coph.2005.03.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006121543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0007314", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007427601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/94.13.990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008897588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2005.10.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011600196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(01)00174-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018212723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pap.0b013e3181b4fffa", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019505999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pap.0b013e3181b4fffa", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019505999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pap.0b013e3181b4fffa", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019505999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.25.14863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020882317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.20006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022825825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80466-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023088089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2718", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024297992", 
          "https://doi.org/10.1038/nrm2718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.pathol.3.121806.151422", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024864484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-009-0778-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028591112", 
          "https://doi.org/10.1007/s00428-009-0778-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-009-0778-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028591112", 
          "https://doi.org/10.1007/s00428-009-0778-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-009-0778-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028591112", 
          "https://doi.org/10.1007/s00428-009-0778-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-4608(03)00003-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029863262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-4608(03)00003-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029863262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1940-6207.capr-09-0078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030626163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0900212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036199013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(02)08270-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036340611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036499081", 
          "https://doi.org/10.1038/nature03443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036499081", 
          "https://doi.org/10.1038/nature03443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-07-4959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037188385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03445", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039649759", 
          "https://doi.org/10.1038/nature03445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03445", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039649759", 
          "https://doi.org/10.1038/nature03445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209874", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041645442", 
          "https://doi.org/10.1038/sj.onc.1209874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209874", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041645442", 
          "https://doi.org/10.1038/sj.onc.1209874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042100427", 
          "https://doi.org/10.1038/sj.onc.1208056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042100427", 
          "https://doi.org/10.1038/sj.onc.1208056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s146239940800077x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042317114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/gyno.2002.6646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042896670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800641", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044883893", 
          "https://doi.org/10.1038/modpathol.3800641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800641", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044883893", 
          "https://doi.org/10.1038/modpathol.3800641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80035-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045196719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80202-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047827768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(03)00424-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048378076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-09-2842", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048542747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pgp.0b013e3181c042b6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049244574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pgp.0b013e3181c042b6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049244574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pgp.0b013e3181c042b6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049244574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1525-1438.2000.010004289.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056744084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/318787", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058622528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075087966", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083071638", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-12", 
    "datePublishedReg": "2010-12-01", 
    "description": "BACKGROUND: BRCA1 gene inactivation causes chromosomal instability, leading to rapid accumulation of chromosomal rearrangements and mutations. The loss of BRCA1 function due to either germline/somatic mutation or epigenetic silencing is observed in most high-grade serous carcinomas of the ovary.\nMETHODS: DNA ploidy and gene expression profile were used in order to compare gross genomic alteration and gene expression pattern between cases with BRCA1 loss through mutation, BRCA1 epigenetic loss, and no BRCA1 loss in cases of high-grade serous carcinoma with known BRCA1 and BRCA 2 status.\nRESULTS: Using image cytometry and oligonucleotide microarrays, we analyzed DNA ploidy, S-phase fraction and gene expression profile of 28 consecutive cases of ovarian high-grade serous adenocarcinomas, which included 8 tumor samples with BRCA1 somatic or germline mutation, 9 samples with promoter hypermethylation of BRCA1, and 11 samples with no BRCA1 loss. None had BRCA2 mutations. The prevalence of aneuploidy and tetraploidy was not statistically different in the three groups with different BRCA1 status. The gene expression profiles were also very similar between the groups, with only two genes showing significant differential expression when comparison was made between the group with BRCA1 mutation and the group with no demonstrable BRCA1 loss. There were no genes showing significant differences in expression when the group with BRCA1 loss through epigenetic silencing was compared to either of the other two groups.\nCONCLUSIONS: In this series of 28 high-grade serous carcinomas, gross genomic alteration characterized by aneuploidy did not correlate with BRCA1 status. In addition, the gene expression profiles of the tumors showed negligible differences between the three defined groups based on BRCA1 status. This suggests that all ovarian high-grade serous carcinomas arise through oncogenic mechanisms that result in chromosomal instability, irrespective of BRCA status; the molecular abnormalities underlying this in the BRCA intact tumors remains unknown.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-2407-10-493", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024632", 
        "issn": [
          "1471-2407"
        ], 
        "name": "BMC Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "Gross genomic alterations and gene expression profiles of high- grade serous carcinoma of the ovary with and without BRCA1 inactivation", 
    "pagination": "493", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "64edb0d7117ea8842891a4fccdbe780117e2c4a645f023fa6de6d9a6ea68f823"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20843305"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100967800"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2407-10-493"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021183604"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2407-10-493", 
      "https://app.dimensions.ai/details/publication/pub.1021183604"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000512.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-2407-10-493"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-10-493'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-10-493'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-10-493'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-10-493'


 

This table displays all metadata directly associated to this object as RDF triples.

302 TRIPLES      21 PREDICATES      84 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2407-10-493 schema:about N01d8d0c81179440ca6c28bc61a97ab9a
2 N1ae78627aa85443b81ae4ce6d873c9fb
3 N455bb8445cc64b6daa8bdd067fd82ba0
4 N560c0076cd084c3684cf427a217f6052
5 N67c217a29c9546f486b3bb446b1d5ec1
6 N724bcd81728446e4a5ca86e70e1e76ce
7 N7f3f1afde2f540008926e62c42bc1296
8 N97d71fa8681548fdbb3f86a8e0d3a1d1
9 N9fbe7e2e2d444da8842f6ce0018601eb
10 Na4239784cc474b56859e2aba0ee80bf7
11 Nae1695d21dd44193b5e0aa032c602b85
12 Nb2c2926541b84ac9b9fe722cacce747a
13 Nbc1e08bf1d044b4e8df0083ac0e62363
14 Nd4f04674908f485db3d263facd55e09e
15 Nde44bf2efd5c4d19985a3dffa2946bf3
16 Ne0ad09982aeb4ac7a63c498f55c5eda7
17 Ne287edca90004fed946f27a51178cc00
18 Nf0958c69ae2146f1920a2425f8bd2309
19 anzsrc-for:06
20 anzsrc-for:0604
21 schema:author Nba99e8ccb2094687add37525049f7cd4
22 schema:citation sg:pub.10.1007/s00428-009-0778-y
23 sg:pub.10.1038/modpathol.3800641
24 sg:pub.10.1038/nature03443
25 sg:pub.10.1038/nature03445
26 sg:pub.10.1038/nrm2718
27 sg:pub.10.1038/sj.onc.1203334
28 sg:pub.10.1038/sj.onc.1208056
29 sg:pub.10.1038/sj.onc.1209874
30 sg:pub.10.1186/1471-2407-8-17
31 https://app.dimensions.ai/details/publication/pub.1075087966
32 https://app.dimensions.ai/details/publication/pub.1083071638
33 https://doi.org/10.1006/gyno.2002.6646
34 https://doi.org/10.1016/j.coph.2005.03.006
35 https://doi.org/10.1016/j.ygyno.2005.10.034
36 https://doi.org/10.1016/s0140-6736(02)08270-3
37 https://doi.org/10.1016/s0165-4608(03)00003-7
38 https://doi.org/10.1016/s1097-2765(00)80035-0
39 https://doi.org/10.1016/s1097-2765(00)80202-6
40 https://doi.org/10.1016/s1097-2765(00)80466-9
41 https://doi.org/10.1016/s1097-2765(01)00174-5
42 https://doi.org/10.1016/s1097-2765(03)00424-6
43 https://doi.org/10.1017/s146239940800077x
44 https://doi.org/10.1046/j.1525-1438.2000.010004289.x
45 https://doi.org/10.1056/nejmoa0900212
46 https://doi.org/10.1073/pnas.091062498
47 https://doi.org/10.1073/pnas.95.25.14863
48 https://doi.org/10.1086/318787
49 https://doi.org/10.1093/jnci/94.13.990
50 https://doi.org/10.1097/pap.0b013e3181b4fffa
51 https://doi.org/10.1097/pgp.0b013e3181c042b6
52 https://doi.org/10.1146/annurev.pathol.3.121806.151422
53 https://doi.org/10.1158/0008-5472.can-03-2451
54 https://doi.org/10.1158/0008-5472.can-09-2842
55 https://doi.org/10.1158/1078-0432.ccr-07-4959
56 https://doi.org/10.1158/1940-6207.capr-09-0078
57 https://doi.org/10.1371/journal.pone.0007314
58 https://doi.org/10.3322/caac.20006
59 schema:datePublished 2010-12
60 schema:datePublishedReg 2010-12-01
61 schema:description BACKGROUND: BRCA1 gene inactivation causes chromosomal instability, leading to rapid accumulation of chromosomal rearrangements and mutations. The loss of BRCA1 function due to either germline/somatic mutation or epigenetic silencing is observed in most high-grade serous carcinomas of the ovary. METHODS: DNA ploidy and gene expression profile were used in order to compare gross genomic alteration and gene expression pattern between cases with BRCA1 loss through mutation, BRCA1 epigenetic loss, and no BRCA1 loss in cases of high-grade serous carcinoma with known BRCA1 and BRCA 2 status. RESULTS: Using image cytometry and oligonucleotide microarrays, we analyzed DNA ploidy, S-phase fraction and gene expression profile of 28 consecutive cases of ovarian high-grade serous adenocarcinomas, which included 8 tumor samples with BRCA1 somatic or germline mutation, 9 samples with promoter hypermethylation of BRCA1, and 11 samples with no BRCA1 loss. None had BRCA2 mutations. The prevalence of aneuploidy and tetraploidy was not statistically different in the three groups with different BRCA1 status. The gene expression profiles were also very similar between the groups, with only two genes showing significant differential expression when comparison was made between the group with BRCA1 mutation and the group with no demonstrable BRCA1 loss. There were no genes showing significant differences in expression when the group with BRCA1 loss through epigenetic silencing was compared to either of the other two groups. CONCLUSIONS: In this series of 28 high-grade serous carcinomas, gross genomic alteration characterized by aneuploidy did not correlate with BRCA1 status. In addition, the gene expression profiles of the tumors showed negligible differences between the three defined groups based on BRCA1 status. This suggests that all ovarian high-grade serous carcinomas arise through oncogenic mechanisms that result in chromosomal instability, irrespective of BRCA status; the molecular abnormalities underlying this in the BRCA intact tumors remains unknown.
62 schema:genre research_article
63 schema:inLanguage en
64 schema:isAccessibleForFree true
65 schema:isPartOf N0cb0b15dcb23493aab67cc1add3f3bb6
66 N8dd1ed96503146cd9a89d8c8323a0f6e
67 sg:journal.1024632
68 schema:name Gross genomic alterations and gene expression profiles of high- grade serous carcinoma of the ovary with and without BRCA1 inactivation
69 schema:pagination 493
70 schema:productId N49c0cef19fb1431ab38da85ceea94328
71 N6580281643d341edad4371d1cb5486bf
72 Na7986289f71649e5ad9e9df912371a01
73 Nee82eaaa239d4d3bb3261ac66f894b68
74 Neeae186f134a4bd3b0d99613833101f8
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021183604
76 https://doi.org/10.1186/1471-2407-10-493
77 schema:sdDatePublished 2019-04-11T01:07
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N61efaefaae124ce3b2079f5a3e948445
80 schema:url http://link.springer.com/10.1186%2F1471-2407-10-493
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N01d8d0c81179440ca6c28bc61a97ab9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Cystadenocarcinoma, Serous
86 rdf:type schema:DefinedTerm
87 N0cb0b15dcb23493aab67cc1add3f3bb6 schema:volumeNumber 10
88 rdf:type schema:PublicationVolume
89 N0db321220949410eb169ed189f25721e rdf:first sg:person.01356130201.26
90 rdf:rest Ncf49eccf54f94b428fc8f7d7a66f7241
91 N1ae78627aa85443b81ae4ce6d873c9fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Epigenesis, Genetic
93 rdf:type schema:DefinedTerm
94 N455bb8445cc64b6daa8bdd067fd82ba0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Gene Expression Regulation, Neoplastic
96 rdf:type schema:DefinedTerm
97 N46d01e4c434e406c951fa06e3bae6518 rdf:first sg:person.01120560217.98
98 rdf:rest N4d20986680fa4279a883f2b3466c5d52
99 N49c0cef19fb1431ab38da85ceea94328 schema:name doi
100 schema:value 10.1186/1471-2407-10-493
101 rdf:type schema:PropertyValue
102 N4d20986680fa4279a883f2b3466c5d52 rdf:first sg:person.0777615543.62
103 rdf:rest rdf:nil
104 N560c0076cd084c3684cf427a217f6052 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name BRCA1 Protein
106 rdf:type schema:DefinedTerm
107 N61efaefaae124ce3b2079f5a3e948445 schema:name Springer Nature - SN SciGraph project
108 rdf:type schema:Organization
109 N6580281643d341edad4371d1cb5486bf schema:name readcube_id
110 schema:value 64edb0d7117ea8842891a4fccdbe780117e2c4a645f023fa6de6d9a6ea68f823
111 rdf:type schema:PropertyValue
112 N67c217a29c9546f486b3bb446b1d5ec1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Ploidies
114 rdf:type schema:DefinedTerm
115 N724bcd81728446e4a5ca86e70e1e76ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name S Phase
117 rdf:type schema:DefinedTerm
118 N7f3f1afde2f540008926e62c42bc1296 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name DNA Methylation
120 rdf:type schema:DefinedTerm
121 N8dd1ed96503146cd9a89d8c8323a0f6e schema:issueNumber 1
122 rdf:type schema:PublicationIssue
123 N97d71fa8681548fdbb3f86a8e0d3a1d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Cohort Studies
125 rdf:type schema:DefinedTerm
126 N9fbe7e2e2d444da8842f6ce0018601eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name BRCA2 Protein
128 rdf:type schema:DefinedTerm
129 Na4239784cc474b56859e2aba0ee80bf7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Humans
131 rdf:type schema:DefinedTerm
132 Na7986289f71649e5ad9e9df912371a01 schema:name nlm_unique_id
133 schema:value 100967800
134 rdf:type schema:PropertyValue
135 Nae1695d21dd44193b5e0aa032c602b85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Gene Expression Profiling
137 rdf:type schema:DefinedTerm
138 Nb2c2926541b84ac9b9fe722cacce747a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Promoter Regions, Genetic
140 rdf:type schema:DefinedTerm
141 Nba99e8ccb2094687add37525049f7cd4 rdf:first sg:person.0756710342.30
142 rdf:rest N0db321220949410eb169ed189f25721e
143 Nbc1e08bf1d044b4e8df0083ac0e62363 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Genomic Instability
145 rdf:type schema:DefinedTerm
146 Ncf49eccf54f94b428fc8f7d7a66f7241 rdf:first sg:person.01131314301.23
147 rdf:rest Nd3a8b4e962364c78a25d1df123b9c947
148 Nd3a8b4e962364c78a25d1df123b9c947 rdf:first sg:person.0737427052.58
149 rdf:rest N46d01e4c434e406c951fa06e3bae6518
150 Nd4f04674908f485db3d263facd55e09e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Biomarkers, Tumor
152 rdf:type schema:DefinedTerm
153 Nde44bf2efd5c4d19985a3dffa2946bf3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Ovarian Neoplasms
155 rdf:type schema:DefinedTerm
156 Ne0ad09982aeb4ac7a63c498f55c5eda7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Germ-Line Mutation
158 rdf:type schema:DefinedTerm
159 Ne287edca90004fed946f27a51178cc00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Oligonucleotide Array Sequence Analysis
161 rdf:type schema:DefinedTerm
162 Nee82eaaa239d4d3bb3261ac66f894b68 schema:name dimensions_id
163 schema:value pub.1021183604
164 rdf:type schema:PropertyValue
165 Neeae186f134a4bd3b0d99613833101f8 schema:name pubmed_id
166 schema:value 20843305
167 rdf:type schema:PropertyValue
168 Nf0958c69ae2146f1920a2425f8bd2309 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Female
170 rdf:type schema:DefinedTerm
171 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
172 schema:name Biological Sciences
173 rdf:type schema:DefinedTerm
174 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
175 schema:name Genetics
176 rdf:type schema:DefinedTerm
177 sg:journal.1024632 schema:issn 1471-2407
178 schema:name BMC Cancer
179 rdf:type schema:Periodical
180 sg:person.01120560217.98 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
181 schema:familyName Gilks
182 schema:givenName C Blake
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120560217.98
184 rdf:type schema:Person
185 sg:person.01131314301.23 schema:affiliation https://www.grid.ac/institutes/grid.55325.34
186 schema:familyName Tropé
187 schema:givenName Claes G
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131314301.23
189 rdf:type schema:Person
190 sg:person.01356130201.26 schema:affiliation https://www.grid.ac/institutes/grid.55325.34
191 schema:familyName Risberg
192 schema:givenName Björn Å
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356130201.26
194 rdf:type schema:Person
195 sg:person.0737427052.58 schema:affiliation https://www.grid.ac/institutes/grid.240952.8
196 schema:familyName van de Rijn
197 schema:givenName Matt
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737427052.58
199 rdf:type schema:Person
200 sg:person.0756710342.30 schema:affiliation https://www.grid.ac/institutes/grid.55325.34
201 schema:familyName Pradhan
202 schema:givenName Manohar
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756710342.30
204 rdf:type schema:Person
205 sg:person.0777615543.62 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
206 schema:familyName Lee
207 schema:givenName Cheng-Han
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777615543.62
209 rdf:type schema:Person
210 sg:pub.10.1007/s00428-009-0778-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1028591112
211 https://doi.org/10.1007/s00428-009-0778-y
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/modpathol.3800641 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044883893
214 https://doi.org/10.1038/modpathol.3800641
215 rdf:type schema:CreativeWork
216 sg:pub.10.1038/nature03443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036499081
217 https://doi.org/10.1038/nature03443
218 rdf:type schema:CreativeWork
219 sg:pub.10.1038/nature03445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039649759
220 https://doi.org/10.1038/nature03445
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/nrm2718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024297992
223 https://doi.org/10.1038/nrm2718
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/sj.onc.1203334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005228794
226 https://doi.org/10.1038/sj.onc.1203334
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/sj.onc.1208056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042100427
229 https://doi.org/10.1038/sj.onc.1208056
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/sj.onc.1209874 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041645442
232 https://doi.org/10.1038/sj.onc.1209874
233 rdf:type schema:CreativeWork
234 sg:pub.10.1186/1471-2407-8-17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003338054
235 https://doi.org/10.1186/1471-2407-8-17
236 rdf:type schema:CreativeWork
237 https://app.dimensions.ai/details/publication/pub.1075087966 schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1083071638 schema:CreativeWork
239 https://doi.org/10.1006/gyno.2002.6646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042896670
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/j.coph.2005.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006121543
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/j.ygyno.2005.10.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011600196
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/s0140-6736(02)08270-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036340611
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/s0165-4608(03)00003-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029863262
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/s1097-2765(00)80035-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045196719
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/s1097-2765(00)80202-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047827768
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s1097-2765(00)80466-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023088089
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/s1097-2765(01)00174-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018212723
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/s1097-2765(03)00424-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048378076
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1017/s146239940800077x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042317114
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1046/j.1525-1438.2000.010004289.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1056744084
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1056/nejmoa0900212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036199013
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1073/pnas.091062498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001631710
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1073/pnas.95.25.14863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020882317
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1086/318787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058622528
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1093/jnci/94.13.990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008897588
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1097/pap.0b013e3181b4fffa schema:sameAs https://app.dimensions.ai/details/publication/pub.1019505999
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1097/pgp.0b013e3181c042b6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049244574
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1146/annurev.pathol.3.121806.151422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024864484
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1158/0008-5472.can-03-2451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004918539
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1158/0008-5472.can-09-2842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048542747
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1158/1078-0432.ccr-07-4959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037188385
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1158/1940-6207.capr-09-0078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030626163
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1371/journal.pone.0007314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007427601
288 rdf:type schema:CreativeWork
289 https://doi.org/10.3322/caac.20006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022825825
290 rdf:type schema:CreativeWork
291 https://www.grid.ac/institutes/grid.17091.3e schema:alternateName University of British Columbia
292 schema:name Department of Pathology and Laboratory Medicine, University of British Columbia and Vancouver General Hospital, Vancouver, British Columbia, Canada
293 rdf:type schema:Organization
294 https://www.grid.ac/institutes/grid.240952.8 schema:alternateName Stanford Medicine
295 schema:name Department of Pathology, Stanford University Medical Center, Stanford, CA, USA
296 rdf:type schema:Organization
297 https://www.grid.ac/institutes/grid.55325.34 schema:alternateName Oslo University Hospital
298 schema:name Department of Gynecologic Oncology, Oslo University Hospital, Oslo, Norway
299 Division of Pathology, Oslo University Hospital, Oslo, Norway
300 Faculty Division the Norwegian Radium Hospital, University of Oslo, Oslo, Norway
301 Institute for Medical Informatics, Oslo University Hospital, Oslo, Norway
302 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...