Clostridium perfringens enterotoxin carboxy-terminal fragment is a novel tumor-homing peptide for human ovarian cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-12

AUTHORS

Emiliano Cocco, Francesca Casagrande, Stefania Bellone, Christine E Richter, Marta Bellone, Paola Todeschini, Jennie C Holmberg, Han Hsuan Fu, Michele K Montagna, Gil Mor, Peter E Schwartz, Dan Arin-Silasi, Masoud Azoudi, Thomas J Rutherford, Maysa Abu-Khalaf, Sergio Pecorelli, Alessandro D Santin

ABSTRACT

BACKGROUND: Development of innovative, effective therapies against recurrent/chemotherapy-resistant ovarian cancer remains a high priority. Using high-throughput technologies to analyze genetic fingerprints of ovarian cancer, we have discovered extremely high expression of the genes encoding the proteins claudin-3 and claudin-4. METHODS: Because claudin-3 and -4 are the epithelial receptors for Clostridium perfringens enterotoxin (CPE), and are sufficient to mediate CPE binding, in this study we evaluated the in vitro and in vivo bioactivity of the carboxy-terminal fragment of CPE (i.e., CPE290-319 binding peptide) as a carrier for tumor imaging agents and intracellular delivery of therapeutic drugs. Claudin-3 and -4 expression was examined with rt-PCR and flow cytometry in multiple primary ovarian carcinoma cell lines. Cell binding assays were used to assess the accuracy and specificity of the CPE peptide in vitro against primary chemotherapy-resistant ovarian carcinoma cell lines. Confocal microscopy and biodistribution assays were performed to evaluate the localization and uptake of the FITC-conjugated CPE peptide in established tumor tissue. RESULTS: Using a FITC-conjugated CPE peptide we show specific in vitro and in vivo binding to multiple primary chemotherapy resistant ovarian cancer cell lines. Bio-distribution studies in SCID mice harboring clinically relevant animal models of chemotherapy resistant ovarian carcinoma showed higher uptake of the peptide in tumor cells than in normal organs. Imunofluorescence was detectable within discrete accumulations (i.e., tumor spheroids) or even single chemotherapy resistant ovarian cancer cells floating in the ascites of xenografted animals while a time-dependent internalization of the FITC-conjugated CPE peptide was consistently noted in chemotherapy-resistant ovarian tumor cells by confocal microscopy. CONCLUSIONS: Based on the high levels of claudin-3 and -4 expression in chemotherapy-resistant ovarian cancer and other highly aggressive human epithelial tumors including breast, prostate and pancreatic cancers, CPE peptide holds promise as a lead peptide for the development of new diagnostic tracers or alternative anticancer agents. More... »

PAGES

349

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2407-10-349

DOI

http://dx.doi.org/10.1186/1471-2407-10-349

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014348122

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20598131


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma, Clear Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Papillary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Squamous Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cercopithecus aethiops", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Claudin-3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Claudin-4", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clostridium perfringens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cystadenocarcinoma, Serous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Resistance, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enterotoxins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Flow Cytometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, SCID", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ovarian Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptide Fragments", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spheroids, Cellular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Distribution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation, Heterologous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Uterine Cervical Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vero Cells", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cocco", 
        "givenName": "Emiliano", 
        "id": "sg:person.01364015242.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364015242.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Casagrande", 
        "givenName": "Francesca", 
        "id": "sg:person.01025004771.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025004771.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bellone", 
        "givenName": "Stefania", 
        "id": "sg:person.01244366775.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244366775.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Richter", 
        "givenName": "Christine E", 
        "id": "sg:person.01300611442.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300611442.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bellone", 
        "givenName": "Marta", 
        "id": "sg:person.01346724642.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346724642.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Todeschini", 
        "givenName": "Paola", 
        "id": "sg:person.0710225445.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710225445.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Holmberg", 
        "givenName": "Jennie C", 
        "id": "sg:person.01001102657.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001102657.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fu", 
        "givenName": "Han Hsuan", 
        "id": "sg:person.01315072061.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315072061.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Montagna", 
        "givenName": "Michele K", 
        "id": "sg:person.0626217232.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626217232.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mor", 
        "givenName": "Gil", 
        "id": "sg:person.010561742344.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010561742344.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schwartz", 
        "givenName": "Peter E", 
        "id": "sg:person.01207015645.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207015645.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arin-Silasi", 
        "givenName": "Dan", 
        "id": "sg:person.01005662342.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005662342.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Azoudi", 
        "givenName": "Masoud", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rutherford", 
        "givenName": "Thomas J", 
        "id": "sg:person.01017553075.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017553075.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Internal Medicine & Oncology, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abu-Khalaf", 
        "givenName": "Maysa", 
        "id": "sg:person.01141233371.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141233371.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Brescia", 
          "id": "https://www.grid.ac/institutes/grid.7637.5", 
          "name": [
            "Division of Gynecologic Oncology, University of Brescia, Brescia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pecorelli", 
        "givenName": "Sergio", 
        "id": "sg:person.01065666275.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065666275.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Santin", 
        "givenName": "Alessandro D", 
        "id": "sg:person.01134001475.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134001475.57"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00428-007-0448-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010071782", 
          "https://doi.org/10.1007/s00428-007-0448-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-007-0448-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010071782", 
          "https://doi.org/10.1007/s00428-007-0448-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/gyno.2002.6797", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011554474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/gyno.2002.6797", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011554474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.2001.27124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013102286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajog.2009.02.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014276923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-1314", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017504907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/367630a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020802188", 
          "https://doi.org/10.1038/367630a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.20006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022825825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-3472", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023511958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.136.6.1239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027081156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.20408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029743777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.98.3.1176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045705996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mc.10098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047238641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0041-0101(96)00101-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047888288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-540-35280-8_884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049545842", 
          "https://doi.org/10.1007/978-3-540-35280-8_884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074708115", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074735181", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074739253", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074815977", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074856841", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074949032", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074976751", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075108940", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075314241", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077263641", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078807057", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-12", 
    "datePublishedReg": "2010-12-01", 
    "description": "BACKGROUND: Development of innovative, effective therapies against recurrent/chemotherapy-resistant ovarian cancer remains a high priority. Using high-throughput technologies to analyze genetic fingerprints of ovarian cancer, we have discovered extremely high expression of the genes encoding the proteins claudin-3 and claudin-4.\nMETHODS: Because claudin-3 and -4 are the epithelial receptors for Clostridium perfringens enterotoxin (CPE), and are sufficient to mediate CPE binding, in this study we evaluated the in vitro and in vivo bioactivity of the carboxy-terminal fragment of CPE (i.e., CPE290-319 binding peptide) as a carrier for tumor imaging agents and intracellular delivery of therapeutic drugs. Claudin-3 and -4 expression was examined with rt-PCR and flow cytometry in multiple primary ovarian carcinoma cell lines. Cell binding assays were used to assess the accuracy and specificity of the CPE peptide in vitro against primary chemotherapy-resistant ovarian carcinoma cell lines. Confocal microscopy and biodistribution assays were performed to evaluate the localization and uptake of the FITC-conjugated CPE peptide in established tumor tissue.\nRESULTS: Using a FITC-conjugated CPE peptide we show specific in vitro and in vivo binding to multiple primary chemotherapy resistant ovarian cancer cell lines. Bio-distribution studies in SCID mice harboring clinically relevant animal models of chemotherapy resistant ovarian carcinoma showed higher uptake of the peptide in tumor cells than in normal organs. Imunofluorescence was detectable within discrete accumulations (i.e., tumor spheroids) or even single chemotherapy resistant ovarian cancer cells floating in the ascites of xenografted animals while a time-dependent internalization of the FITC-conjugated CPE peptide was consistently noted in chemotherapy-resistant ovarian tumor cells by confocal microscopy.\nCONCLUSIONS: Based on the high levels of claudin-3 and -4 expression in chemotherapy-resistant ovarian cancer and other highly aggressive human epithelial tumors including breast, prostate and pancreatic cancers, CPE peptide holds promise as a lead peptide for the development of new diagnostic tracers or alternative anticancer agents.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-2407-10-349", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2478916", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438823", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1024632", 
        "issn": [
          "1471-2407"
        ], 
        "name": "BMC Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "Clostridium perfringens enterotoxin carboxy-terminal fragment is a novel tumor-homing peptide for human ovarian cancer", 
    "pagination": "349", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "445a6cffd8ba4d4c4316f83dccea2b6f861beb9212b2b682436acdf2ec3c0dc9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20598131"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100967800"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2407-10-349"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1014348122"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2407-10-349", 
      "https://app.dimensions.ai/details/publication/pub.1014348122"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000549.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-2407-10-349"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-10-349'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-10-349'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-10-349'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-10-349'


 

This table displays all metadata directly associated to this object as RDF triples.

370 TRIPLES      21 PREDICATES      83 URIs      50 LITERALS      38 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2407-10-349 schema:about N00658d032f1c4e248aa08b30f5357eed
2 N07dbed4ff52a4bada289ac967e9ef6b4
3 N0ba8ed76f4c04c57b96831b24e387d77
4 N0ce93066272448f0b98c142e569b901d
5 N13cc0aa2616946e18283ab74db48c4ca
6 N2118fb8c14f146e591bab24ef3222213
7 N245d1d2ba127476998b2d17d4abbd146
8 N26cacf674eb4416e9d79be6b172d13d0
9 N30c4fbbede944a02b604903c731cea72
10 N34b9c86215b14638a9969a34f9a71a6d
11 N3a1eeaa98d534064b934c0b8ce950e87
12 N3d0991938ad0435796c449e181676307
13 N4cd6036a3c2b4f2ea99d1c5e55098c0b
14 N51d305c6abd943a5b0557ecd783e749f
15 N52ba2797433a4f6894c8bb6be6ffc7d5
16 N7066de8beda44ca6a6f5b17c9916d6b6
17 N7e25387bc5414e3da11f0c2dc3ae5d96
18 N7f4973b78d4f40d787742b1ade3bdc2a
19 N98e68f39331a4269981b0b96df366a66
20 Na11a01ce98ea4cc7a2d8a2ac0d78b881
21 Nb132f850a710414d82353d1be0888670
22 Nb6f967b2852043acbdf13f7229c320ba
23 Nd07ffdfc61b5494f93b108a792379ca9
24 Nd299ed04ba384356a273cde654976884
25 Nd2d2a98d88cb47f389ff50fe2ba9ae74
26 Nd4d60b53443f4539b31f394f43e02dad
27 Ndf929e8ee5da41e4872cb53449898810
28 Ne6ece24a86c74d71b52272c76e4831b5
29 Nf3a94ffb52d84d2a85e8e99983cacb6f
30 anzsrc-for:11
31 anzsrc-for:1112
32 schema:author Ncb5878d6972042cca2736d53a0f02cb7
33 schema:citation sg:pub.10.1007/978-3-540-35280-8_884
34 sg:pub.10.1007/s00428-007-0448-x
35 sg:pub.10.1038/367630a0
36 https://app.dimensions.ai/details/publication/pub.1074708115
37 https://app.dimensions.ai/details/publication/pub.1074735181
38 https://app.dimensions.ai/details/publication/pub.1074739253
39 https://app.dimensions.ai/details/publication/pub.1074815977
40 https://app.dimensions.ai/details/publication/pub.1074856841
41 https://app.dimensions.ai/details/publication/pub.1074949032
42 https://app.dimensions.ai/details/publication/pub.1074976751
43 https://app.dimensions.ai/details/publication/pub.1075108940
44 https://app.dimensions.ai/details/publication/pub.1075314241
45 https://app.dimensions.ai/details/publication/pub.1077263641
46 https://app.dimensions.ai/details/publication/pub.1078807057
47 https://doi.org/10.1002/ijc.20408
48 https://doi.org/10.1002/mc.10098
49 https://doi.org/10.1006/gyno.2002.6797
50 https://doi.org/10.1016/j.ajog.2009.02.010
51 https://doi.org/10.1016/s0041-0101(96)00101-8
52 https://doi.org/10.1053/gast.2001.27124
53 https://doi.org/10.1073/pnas.98.3.1176
54 https://doi.org/10.1083/jcb.136.6.1239
55 https://doi.org/10.1158/0008-5472.can-04-3472
56 https://doi.org/10.1158/0008-5472.can-07-1314
57 https://doi.org/10.3322/caac.20006
58 schema:datePublished 2010-12
59 schema:datePublishedReg 2010-12-01
60 schema:description BACKGROUND: Development of innovative, effective therapies against recurrent/chemotherapy-resistant ovarian cancer remains a high priority. Using high-throughput technologies to analyze genetic fingerprints of ovarian cancer, we have discovered extremely high expression of the genes encoding the proteins claudin-3 and claudin-4. METHODS: Because claudin-3 and -4 are the epithelial receptors for Clostridium perfringens enterotoxin (CPE), and are sufficient to mediate CPE binding, in this study we evaluated the in vitro and in vivo bioactivity of the carboxy-terminal fragment of CPE (i.e., CPE290-319 binding peptide) as a carrier for tumor imaging agents and intracellular delivery of therapeutic drugs. Claudin-3 and -4 expression was examined with rt-PCR and flow cytometry in multiple primary ovarian carcinoma cell lines. Cell binding assays were used to assess the accuracy and specificity of the CPE peptide in vitro against primary chemotherapy-resistant ovarian carcinoma cell lines. Confocal microscopy and biodistribution assays were performed to evaluate the localization and uptake of the FITC-conjugated CPE peptide in established tumor tissue. RESULTS: Using a FITC-conjugated CPE peptide we show specific in vitro and in vivo binding to multiple primary chemotherapy resistant ovarian cancer cell lines. Bio-distribution studies in SCID mice harboring clinically relevant animal models of chemotherapy resistant ovarian carcinoma showed higher uptake of the peptide in tumor cells than in normal organs. Imunofluorescence was detectable within discrete accumulations (i.e., tumor spheroids) or even single chemotherapy resistant ovarian cancer cells floating in the ascites of xenografted animals while a time-dependent internalization of the FITC-conjugated CPE peptide was consistently noted in chemotherapy-resistant ovarian tumor cells by confocal microscopy. CONCLUSIONS: Based on the high levels of claudin-3 and -4 expression in chemotherapy-resistant ovarian cancer and other highly aggressive human epithelial tumors including breast, prostate and pancreatic cancers, CPE peptide holds promise as a lead peptide for the development of new diagnostic tracers or alternative anticancer agents.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree true
64 schema:isPartOf N2e6414e1e4fc44fea84a0c2687498c17
65 N58d6510c49994a57bc29f64c0358bfd6
66 sg:journal.1024632
67 schema:name Clostridium perfringens enterotoxin carboxy-terminal fragment is a novel tumor-homing peptide for human ovarian cancer
68 schema:pagination 349
69 schema:productId N6f5534bd7135408e9f1a3e51048a7b59
70 N88b056e8bb51441a91b14739f0c98696
71 N89420322f2fe42059dd218b45ebb4ada
72 N9bb3661750844ebfa62b353eb36759d6
73 Nc9ca1e60882043848dfb5b571c2423f6
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014348122
75 https://doi.org/10.1186/1471-2407-10-349
76 schema:sdDatePublished 2019-04-10T19:15
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher Nb68718fe57604fc1b02f999d3d1f6122
79 schema:url http://link.springer.com/10.1186%2F1471-2407-10-349
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N00658d032f1c4e248aa08b30f5357eed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Adenocarcinoma
85 rdf:type schema:DefinedTerm
86 N024957d71e64440cbdc7f4f5dec20cf8 rdf:first N0bdd0a52e4eb49e68bbff59e9225e3db
87 rdf:rest N836a1ed079b041a3b258cb11f6a05528
88 N07dbed4ff52a4bada289ac967e9ef6b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Drug Resistance, Neoplasm
90 rdf:type schema:DefinedTerm
91 N0ba8ed76f4c04c57b96831b24e387d77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Adenocarcinoma, Clear Cell
93 rdf:type schema:DefinedTerm
94 N0bdd0a52e4eb49e68bbff59e9225e3db schema:affiliation https://www.grid.ac/institutes/grid.47100.32
95 schema:familyName Azoudi
96 schema:givenName Masoud
97 rdf:type schema:Person
98 N0c2211c084554985af5d69ca853c5582 rdf:first sg:person.01207015645.37
99 rdf:rest Nac9cc4c7f5be4151a6a98ea1c74f8151
100 N0ce93066272448f0b98c142e569b901d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Tissue Distribution
102 rdf:type schema:DefinedTerm
103 N13cc0aa2616946e18283ab74db48c4ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Fibroblasts
105 rdf:type schema:DefinedTerm
106 N1d8a2fe86ea347328d334013eb378451 rdf:first sg:person.01244366775.56
107 rdf:rest Ncc913e45c4324d4ca544d9be4cdd9622
108 N20d897c45f234fcf814c5e3de04ebcbf rdf:first sg:person.01134001475.57
109 rdf:rest rdf:nil
110 N2118fb8c14f146e591bab24ef3222213 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Female
112 rdf:type schema:DefinedTerm
113 N245d1d2ba127476998b2d17d4abbd146 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Reverse Transcriptase Polymerase Chain Reaction
115 rdf:type schema:DefinedTerm
116 N25ab6ac37ad84925ab023d23fe91082b rdf:first sg:person.0626217232.19
117 rdf:rest Nd3e79b8b772c46878ca225d9bbd78d9d
118 N26cacf674eb4416e9d79be6b172d13d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Clostridium perfringens
120 rdf:type schema:DefinedTerm
121 N2e6414e1e4fc44fea84a0c2687498c17 schema:issueNumber 1
122 rdf:type schema:PublicationIssue
123 N30c4fbbede944a02b604903c731cea72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Enterotoxins
125 rdf:type schema:DefinedTerm
126 N34b9c86215b14638a9969a34f9a71a6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Claudin-3
128 rdf:type schema:DefinedTerm
129 N3a1eeaa98d534064b934c0b8ce950e87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Ovarian Neoplasms
131 rdf:type schema:DefinedTerm
132 N3d0991938ad0435796c449e181676307 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Claudin-4
134 rdf:type schema:DefinedTerm
135 N430ab72d747e4b91976e8a5f4884fb8e rdf:first sg:person.01346724642.81
136 rdf:rest N6094f64499944fa28d00ec76b84d5d73
137 N4cd6036a3c2b4f2ea99d1c5e55098c0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Humans
139 rdf:type schema:DefinedTerm
140 N51d305c6abd943a5b0557ecd783e749f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name RNA, Messenger
142 rdf:type schema:DefinedTerm
143 N52ba2797433a4f6894c8bb6be6ffc7d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Cercopithecus aethiops
145 rdf:type schema:DefinedTerm
146 N58d6510c49994a57bc29f64c0358bfd6 schema:volumeNumber 10
147 rdf:type schema:PublicationVolume
148 N6094f64499944fa28d00ec76b84d5d73 rdf:first sg:person.0710225445.16
149 rdf:rest Ndee3e77f8fac4ff78290a27e52397333
150 N6f5534bd7135408e9f1a3e51048a7b59 schema:name pubmed_id
151 schema:value 20598131
152 rdf:type schema:PropertyValue
153 N7066de8beda44ca6a6f5b17c9916d6b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Vero Cells
155 rdf:type schema:DefinedTerm
156 N748cca9fa2094e48a2355ca09570a541 rdf:first sg:person.01315072061.83
157 rdf:rest N25ab6ac37ad84925ab023d23fe91082b
158 N7e25387bc5414e3da11f0c2dc3ae5d96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Cystadenocarcinoma, Serous
160 rdf:type schema:DefinedTerm
161 N7f4973b78d4f40d787742b1ade3bdc2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Uterine Cervical Neoplasms
163 rdf:type schema:DefinedTerm
164 N836a1ed079b041a3b258cb11f6a05528 rdf:first sg:person.01017553075.00
165 rdf:rest N933fa8b172e14868a6e4991b230a2758
166 N88b056e8bb51441a91b14739f0c98696 schema:name doi
167 schema:value 10.1186/1471-2407-10-349
168 rdf:type schema:PropertyValue
169 N89420322f2fe42059dd218b45ebb4ada schema:name nlm_unique_id
170 schema:value 100967800
171 rdf:type schema:PropertyValue
172 N933fa8b172e14868a6e4991b230a2758 rdf:first sg:person.01141233371.32
173 rdf:rest Ne60ea39c8ac7494782e7da5b79c347a3
174 N98e68f39331a4269981b0b96df366a66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Flow Cytometry
176 rdf:type schema:DefinedTerm
177 N9bb3661750844ebfa62b353eb36759d6 schema:name dimensions_id
178 schema:value pub.1014348122
179 rdf:type schema:PropertyValue
180 Na11a01ce98ea4cc7a2d8a2ac0d78b881 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Animals
182 rdf:type schema:DefinedTerm
183 Nac9cc4c7f5be4151a6a98ea1c74f8151 rdf:first sg:person.01005662342.41
184 rdf:rest N024957d71e64440cbdc7f4f5dec20cf8
185 Nb132f850a710414d82353d1be0888670 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Carcinoma, Papillary
187 rdf:type schema:DefinedTerm
188 Nb68718fe57604fc1b02f999d3d1f6122 schema:name Springer Nature - SN SciGraph project
189 rdf:type schema:Organization
190 Nb6f967b2852043acbdf13f7229c320ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Peptide Fragments
192 rdf:type schema:DefinedTerm
193 Nbce1e628e6984429b20a948bf21ba038 rdf:first sg:person.01025004771.31
194 rdf:rest N1d8a2fe86ea347328d334013eb378451
195 Nc9ca1e60882043848dfb5b571c2423f6 schema:name readcube_id
196 schema:value 445a6cffd8ba4d4c4316f83dccea2b6f861beb9212b2b682436acdf2ec3c0dc9
197 rdf:type schema:PropertyValue
198 Ncb5878d6972042cca2736d53a0f02cb7 rdf:first sg:person.01364015242.73
199 rdf:rest Nbce1e628e6984429b20a948bf21ba038
200 Ncc913e45c4324d4ca544d9be4cdd9622 rdf:first sg:person.01300611442.63
201 rdf:rest N430ab72d747e4b91976e8a5f4884fb8e
202 Nd07ffdfc61b5494f93b108a792379ca9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Carcinoma, Squamous Cell
204 rdf:type schema:DefinedTerm
205 Nd299ed04ba384356a273cde654976884 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Transplantation, Heterologous
207 rdf:type schema:DefinedTerm
208 Nd2d2a98d88cb47f389ff50fe2ba9ae74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Spheroids, Cellular
210 rdf:type schema:DefinedTerm
211 Nd3e79b8b772c46878ca225d9bbd78d9d rdf:first sg:person.010561742344.27
212 rdf:rest N0c2211c084554985af5d69ca853c5582
213 Nd4d60b53443f4539b31f394f43e02dad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Tumor Cells, Cultured
215 rdf:type schema:DefinedTerm
216 Ndee3e77f8fac4ff78290a27e52397333 rdf:first sg:person.01001102657.54
217 rdf:rest N748cca9fa2094e48a2355ca09570a541
218 Ndf929e8ee5da41e4872cb53449898810 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Membrane Proteins
220 rdf:type schema:DefinedTerm
221 Ne60ea39c8ac7494782e7da5b79c347a3 rdf:first sg:person.01065666275.46
222 rdf:rest N20d897c45f234fcf814c5e3de04ebcbf
223 Ne6ece24a86c74d71b52272c76e4831b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
224 schema:name Mice
225 rdf:type schema:DefinedTerm
226 Nf3a94ffb52d84d2a85e8e99983cacb6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
227 schema:name Mice, SCID
228 rdf:type schema:DefinedTerm
229 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
230 schema:name Medical and Health Sciences
231 rdf:type schema:DefinedTerm
232 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
233 schema:name Oncology and Carcinogenesis
234 rdf:type schema:DefinedTerm
235 sg:grant.2438823 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2407-10-349
236 rdf:type schema:MonetaryGrant
237 sg:grant.2478916 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2407-10-349
238 rdf:type schema:MonetaryGrant
239 sg:journal.1024632 schema:issn 1471-2407
240 schema:name BMC Cancer
241 rdf:type schema:Periodical
242 sg:person.01001102657.54 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
243 schema:familyName Holmberg
244 schema:givenName Jennie C
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001102657.54
246 rdf:type schema:Person
247 sg:person.01005662342.41 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
248 schema:familyName Arin-Silasi
249 schema:givenName Dan
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005662342.41
251 rdf:type schema:Person
252 sg:person.01017553075.00 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
253 schema:familyName Rutherford
254 schema:givenName Thomas J
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017553075.00
256 rdf:type schema:Person
257 sg:person.01025004771.31 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
258 schema:familyName Casagrande
259 schema:givenName Francesca
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025004771.31
261 rdf:type schema:Person
262 sg:person.010561742344.27 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
263 schema:familyName Mor
264 schema:givenName Gil
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010561742344.27
266 rdf:type schema:Person
267 sg:person.01065666275.46 schema:affiliation https://www.grid.ac/institutes/grid.7637.5
268 schema:familyName Pecorelli
269 schema:givenName Sergio
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065666275.46
271 rdf:type schema:Person
272 sg:person.01134001475.57 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
273 schema:familyName Santin
274 schema:givenName Alessandro D
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134001475.57
276 rdf:type schema:Person
277 sg:person.01141233371.32 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
278 schema:familyName Abu-Khalaf
279 schema:givenName Maysa
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141233371.32
281 rdf:type schema:Person
282 sg:person.01207015645.37 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
283 schema:familyName Schwartz
284 schema:givenName Peter E
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207015645.37
286 rdf:type schema:Person
287 sg:person.01244366775.56 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
288 schema:familyName Bellone
289 schema:givenName Stefania
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244366775.56
291 rdf:type schema:Person
292 sg:person.01300611442.63 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
293 schema:familyName Richter
294 schema:givenName Christine E
295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300611442.63
296 rdf:type schema:Person
297 sg:person.01315072061.83 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
298 schema:familyName Fu
299 schema:givenName Han Hsuan
300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315072061.83
301 rdf:type schema:Person
302 sg:person.01346724642.81 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
303 schema:familyName Bellone
304 schema:givenName Marta
305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346724642.81
306 rdf:type schema:Person
307 sg:person.01364015242.73 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
308 schema:familyName Cocco
309 schema:givenName Emiliano
310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364015242.73
311 rdf:type schema:Person
312 sg:person.0626217232.19 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
313 schema:familyName Montagna
314 schema:givenName Michele K
315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626217232.19
316 rdf:type schema:Person
317 sg:person.0710225445.16 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
318 schema:familyName Todeschini
319 schema:givenName Paola
320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710225445.16
321 rdf:type schema:Person
322 sg:pub.10.1007/978-3-540-35280-8_884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049545842
323 https://doi.org/10.1007/978-3-540-35280-8_884
324 rdf:type schema:CreativeWork
325 sg:pub.10.1007/s00428-007-0448-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010071782
326 https://doi.org/10.1007/s00428-007-0448-x
327 rdf:type schema:CreativeWork
328 sg:pub.10.1038/367630a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020802188
329 https://doi.org/10.1038/367630a0
330 rdf:type schema:CreativeWork
331 https://app.dimensions.ai/details/publication/pub.1074708115 schema:CreativeWork
332 https://app.dimensions.ai/details/publication/pub.1074735181 schema:CreativeWork
333 https://app.dimensions.ai/details/publication/pub.1074739253 schema:CreativeWork
334 https://app.dimensions.ai/details/publication/pub.1074815977 schema:CreativeWork
335 https://app.dimensions.ai/details/publication/pub.1074856841 schema:CreativeWork
336 https://app.dimensions.ai/details/publication/pub.1074949032 schema:CreativeWork
337 https://app.dimensions.ai/details/publication/pub.1074976751 schema:CreativeWork
338 https://app.dimensions.ai/details/publication/pub.1075108940 schema:CreativeWork
339 https://app.dimensions.ai/details/publication/pub.1075314241 schema:CreativeWork
340 https://app.dimensions.ai/details/publication/pub.1077263641 schema:CreativeWork
341 https://app.dimensions.ai/details/publication/pub.1078807057 schema:CreativeWork
342 https://doi.org/10.1002/ijc.20408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029743777
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1002/mc.10098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047238641
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1006/gyno.2002.6797 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011554474
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1016/j.ajog.2009.02.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014276923
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1016/s0041-0101(96)00101-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047888288
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1053/gast.2001.27124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013102286
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1073/pnas.98.3.1176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045705996
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1083/jcb.136.6.1239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027081156
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1158/0008-5472.can-04-3472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023511958
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1158/0008-5472.can-07-1314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017504907
361 rdf:type schema:CreativeWork
362 https://doi.org/10.3322/caac.20006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022825825
363 rdf:type schema:CreativeWork
364 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
365 schema:name Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
366 Internal Medicine & Oncology, Yale University School of Medicine, New Haven, CT, USA
367 rdf:type schema:Organization
368 https://www.grid.ac/institutes/grid.7637.5 schema:alternateName University of Brescia
369 schema:name Division of Gynecologic Oncology, University of Brescia, Brescia, Italy
370 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...