Ontology type: schema:ScholarlyArticle Open Access: True
2010-12
AUTHORSFernando SF Guimarães, Lucas F Andrade, Sharon T Martins, Ana PR Abud, Reginaldo V Sene, Carla Wanderer, Inés Tiscornia, Mariela Bollati-Fogolín, Dorly F Buchi, Edvaldo S Trindade
ABSTRACTBACKGROUND: Melanoma is the most aggressive form of skin cancer and the most rapidly expanding cancer in terms of worldwide incidence. Chemotherapeutic approaches to treat melanoma have had only marginal success. Previous studies in mice demonstrated that a high diluted complex derived from Calcarea carbonica (M8) stimulated the tumoricidal response of activated lymphocytes against B16F10 melanoma cells in vitro. METHODS: Here we describe the in vitro inhibition of invasion and the in vivo anti-metastatic potential after M8 treatment by inhalation in the B16F10 lung metastasis model. RESULTS: We found that M8 has at least two functions, acting as both an inhibitor of cancer cell adhesion and invasion and as a perlecan expression antagonist, which are strongly correlated with several metastatic, angiogenic and invasive factors in melanoma tumors. CONCLUSION: The findings suggest that this medication is a promising non-toxic therapy candidate by improving the immune response against tumor cells or even induce direct dormancy in malignancies. More... »
PAGES113
http://scigraph.springernature.com/pub.10.1186/1471-2407-10-113
DOIhttp://dx.doi.org/10.1186/1471-2407-10-113
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1047926017
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/20338038
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bone Marrow Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Colorectal Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "HT29 Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunophenotyping",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lung Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Materia Medica",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Melanoma, Experimental",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Inbred BALB C",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Federal University of Paran\u00e1",
"id": "https://www.grid.ac/institutes/grid.20736.30",
"name": [
"Laborat\u00f3rio de Pesquisa em C\u00e9lulas Inflamat\u00f3rias e Neopl\u00e1sicas Depto de Biologia Celular, Setor de Ci\u00eancias Biol\u00f3gicas, Federal University of Paran\u00e1, Brazil"
],
"type": "Organization"
},
"familyName": "Guimar\u00e3es",
"givenName": "Fernando SF",
"id": "sg:person.013332162472.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013332162472.66"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Federal University of Paran\u00e1",
"id": "https://www.grid.ac/institutes/grid.20736.30",
"name": [
"Laborat\u00f3rio de Pesquisa em C\u00e9lulas Inflamat\u00f3rias e Neopl\u00e1sicas Depto de Biologia Celular, Setor de Ci\u00eancias Biol\u00f3gicas, Federal University of Paran\u00e1, Brazil"
],
"type": "Organization"
},
"familyName": "Andrade",
"givenName": "Lucas F",
"id": "sg:person.0735742610.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735742610.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Federal University of Paran\u00e1",
"id": "https://www.grid.ac/institutes/grid.20736.30",
"name": [
"Laborat\u00f3rio de Pesquisa em C\u00e9lulas Inflamat\u00f3rias e Neopl\u00e1sicas Depto de Biologia Celular, Setor de Ci\u00eancias Biol\u00f3gicas, Federal University of Paran\u00e1, Brazil"
],
"type": "Organization"
},
"familyName": "Martins",
"givenName": "Sharon T",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Federal University of Paran\u00e1",
"id": "https://www.grid.ac/institutes/grid.20736.30",
"name": [
"Laborat\u00f3rio de Pesquisa em C\u00e9lulas Inflamat\u00f3rias e Neopl\u00e1sicas Depto de Biologia Celular, Setor de Ci\u00eancias Biol\u00f3gicas, Federal University of Paran\u00e1, Brazil"
],
"type": "Organization"
},
"familyName": "Abud",
"givenName": "Ana PR",
"id": "sg:person.013414154114.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013414154114.51"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Federal University of Paran\u00e1",
"id": "https://www.grid.ac/institutes/grid.20736.30",
"name": [
"Laborat\u00f3rio de Pesquisa em C\u00e9lulas Inflamat\u00f3rias e Neopl\u00e1sicas Depto de Biologia Celular, Setor de Ci\u00eancias Biol\u00f3gicas, Federal University of Paran\u00e1, Brazil"
],
"type": "Organization"
},
"familyName": "Sene",
"givenName": "Reginaldo V",
"id": "sg:person.0754200117.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754200117.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Federal University of Paran\u00e1",
"id": "https://www.grid.ac/institutes/grid.20736.30",
"name": [
"Laborat\u00f3rio de Pesquisa em C\u00e9lulas Inflamat\u00f3rias e Neopl\u00e1sicas Depto de Biologia Celular, Setor de Ci\u00eancias Biol\u00f3gicas, Federal University of Paran\u00e1, Brazil"
],
"type": "Organization"
},
"familyName": "Wanderer",
"givenName": "Carla",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institut Pasteur de Montevideo",
"id": "https://www.grid.ac/institutes/grid.418532.9",
"name": [
"Cell Biology Unit (CBU), Institut Pasteur de Montevideo (IPMon), Uruguay"
],
"type": "Organization"
},
"familyName": "Tiscornia",
"givenName": "In\u00e9s",
"id": "sg:person.01265771657.75",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265771657.75"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institut Pasteur de Montevideo",
"id": "https://www.grid.ac/institutes/grid.418532.9",
"name": [
"Cell Biology Unit (CBU), Institut Pasteur de Montevideo (IPMon), Uruguay"
],
"type": "Organization"
},
"familyName": "Bollati-Fogol\u00edn",
"givenName": "Mariela",
"id": "sg:person.01034422411.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034422411.10"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Federal University of Paran\u00e1",
"id": "https://www.grid.ac/institutes/grid.20736.30",
"name": [
"Laborat\u00f3rio de Pesquisa em C\u00e9lulas Inflamat\u00f3rias e Neopl\u00e1sicas Depto de Biologia Celular, Setor de Ci\u00eancias Biol\u00f3gicas, Federal University of Paran\u00e1, Brazil"
],
"type": "Organization"
},
"familyName": "Buchi",
"givenName": "Dorly F",
"id": "sg:person.0732543773.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732543773.66"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Federal University of Paran\u00e1",
"id": "https://www.grid.ac/institutes/grid.20736.30",
"name": [
"Laborat\u00f3rio de Pesquisa em C\u00e9lulas Inflamat\u00f3rias e Neopl\u00e1sicas Depto de Biologia Celular, Setor de Ci\u00eancias Biol\u00f3gicas, Federal University of Paran\u00e1, Brazil"
],
"type": "Organization"
},
"familyName": "Trindade",
"givenName": "Edvaldo S",
"id": "sg:person.01100535133.29",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100535133.29"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1186/1471-2407-9-293",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002193200",
"https://doi.org/10.1186/1471-2407-9-293"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jcb.20602",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003229448"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jcb.20602",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003229448"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/002215540305101101",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005814302"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/002215540305101101",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005814302"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.24129",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006579100"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jim.2005.08.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009268620"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1479-5876-6-62",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013454685",
"https://doi.org/10.1186/1479-5876-6-62"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.147.5.909",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013505843"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/01913120902889153",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015608971"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.homp.2004.10.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017075745"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/ecam/nep119",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017324854"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejca.2006.01.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018146236"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/0471142735.im2001s39",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020414913"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1369/jhc.4a6353.2004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021083961"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1369/jhc.4a6353.2004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021083961"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jinf.2005.08.017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022584805"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3322/canjclin.50.4.215",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024183897"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.immuni.2007.12.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025116738"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejca.2005.09.025",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025839394"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00280-005-0155-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028602287",
"https://doi.org/10.1007/s00280-005-0155-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00280-005-0155-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028602287",
"https://doi.org/10.1007/s00280-005-0155-8"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/ecam/nem093",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030565327"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.tcam.2009.06.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031165007"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(05)17951-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031814210"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2133.2007.08246.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034607539"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.22951",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043279632"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/ecam/neh138",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044448271"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1081/ddc-43983",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048132255"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.micron.2007.02.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048145819"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jcb.21713",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048998517"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/jcp.2005.032144",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049889514"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00008390-200510000-00003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050881948"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00008390-200510000-00003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050881948"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00008390-200510000-00003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050881948"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0304-3835(00)00656-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051494234"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cellbi.2006.06.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052368546"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-04-0182",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052371303"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0304-3835(00)00633-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053196339"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/01913120902889153",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1058307528"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1081/ddc-200043983",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1058430258"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2174/1389450054863662",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1069180291"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2741/3280",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1070915457"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075183198",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1076796114",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3727/000000006783981099",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1077371468"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077583269",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082854620",
"type": "CreativeWork"
}
],
"datePublished": "2010-12",
"datePublishedReg": "2010-12-01",
"description": "BACKGROUND: Melanoma is the most aggressive form of skin cancer and the most rapidly expanding cancer in terms of worldwide incidence. Chemotherapeutic approaches to treat melanoma have had only marginal success. Previous studies in mice demonstrated that a high diluted complex derived from Calcarea carbonica (M8) stimulated the tumoricidal response of activated lymphocytes against B16F10 melanoma cells in vitro.\nMETHODS: Here we describe the in vitro inhibition of invasion and the in vivo anti-metastatic potential after M8 treatment by inhalation in the B16F10 lung metastasis model.\nRESULTS: We found that M8 has at least two functions, acting as both an inhibitor of cancer cell adhesion and invasion and as a perlecan expression antagonist, which are strongly correlated with several metastatic, angiogenic and invasive factors in melanoma tumors.\nCONCLUSION: The findings suggest that this medication is a promising non-toxic therapy candidate by improving the immune response against tumor cells or even induce direct dormancy in malignancies.",
"genre": "research_article",
"id": "sg:pub.10.1186/1471-2407-10-113",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1024632",
"issn": [
"1471-2407"
],
"name": "BMC Cancer",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "10"
}
],
"name": "In vitro and in vivo anticancer properties of a Calcarea carbonica derivative complex (M8) treatment in a murine melanoma model",
"pagination": "113",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"e44ed1999cb1a7d7e74b601c40fdeb991b922d49c79ffec131fd22d19d143e62"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"20338038"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"100967800"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/1471-2407-10-113"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1047926017"
]
}
],
"sameAs": [
"https://doi.org/10.1186/1471-2407-10-113",
"https://app.dimensions.ai/details/publication/pub.1047926017"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T19:15",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000551.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1186%2F1471-2407-10-113"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-10-113'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-10-113'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-10-113'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-10-113'
This table displays all metadata directly associated to this object as RDF triples.
305 TRIPLES
21 PREDICATES
83 URIs
33 LITERALS
21 BLANK NODES