In vitro and in vivo anticancer properties of a Calcarea carbonica derivative complex (M8) treatment in a murine melanoma model View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-12

AUTHORS

Fernando SF Guimarães, Lucas F Andrade, Sharon T Martins, Ana PR Abud, Reginaldo V Sene, Carla Wanderer, Inés Tiscornia, Mariela Bollati-Fogolín, Dorly F Buchi, Edvaldo S Trindade

ABSTRACT

BACKGROUND: Melanoma is the most aggressive form of skin cancer and the most rapidly expanding cancer in terms of worldwide incidence. Chemotherapeutic approaches to treat melanoma have had only marginal success. Previous studies in mice demonstrated that a high diluted complex derived from Calcarea carbonica (M8) stimulated the tumoricidal response of activated lymphocytes against B16F10 melanoma cells in vitro. METHODS: Here we describe the in vitro inhibition of invasion and the in vivo anti-metastatic potential after M8 treatment by inhalation in the B16F10 lung metastasis model. RESULTS: We found that M8 has at least two functions, acting as both an inhibitor of cancer cell adhesion and invasion and as a perlecan expression antagonist, which are strongly correlated with several metastatic, angiogenic and invasive factors in melanoma tumors. CONCLUSION: The findings suggest that this medication is a promising non-toxic therapy candidate by improving the immune response against tumor cells or even induce direct dormancy in malignancies. More... »

PAGES

113

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2407-10-113

DOI

http://dx.doi.org/10.1186/1471-2407-10-113

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047926017

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20338038


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Marrow Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HT29 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunophenotyping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Materia Medica", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanoma, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Federal University of Paran\u00e1", 
          "id": "https://www.grid.ac/institutes/grid.20736.30", 
          "name": [
            "Laborat\u00f3rio de Pesquisa em C\u00e9lulas Inflamat\u00f3rias e Neopl\u00e1sicas Depto de Biologia Celular, Setor de Ci\u00eancias Biol\u00f3gicas, Federal University of Paran\u00e1, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guimar\u00e3es", 
        "givenName": "Fernando SF", 
        "id": "sg:person.013332162472.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013332162472.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Paran\u00e1", 
          "id": "https://www.grid.ac/institutes/grid.20736.30", 
          "name": [
            "Laborat\u00f3rio de Pesquisa em C\u00e9lulas Inflamat\u00f3rias e Neopl\u00e1sicas Depto de Biologia Celular, Setor de Ci\u00eancias Biol\u00f3gicas, Federal University of Paran\u00e1, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Andrade", 
        "givenName": "Lucas F", 
        "id": "sg:person.0735742610.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735742610.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Paran\u00e1", 
          "id": "https://www.grid.ac/institutes/grid.20736.30", 
          "name": [
            "Laborat\u00f3rio de Pesquisa em C\u00e9lulas Inflamat\u00f3rias e Neopl\u00e1sicas Depto de Biologia Celular, Setor de Ci\u00eancias Biol\u00f3gicas, Federal University of Paran\u00e1, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martins", 
        "givenName": "Sharon T", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Paran\u00e1", 
          "id": "https://www.grid.ac/institutes/grid.20736.30", 
          "name": [
            "Laborat\u00f3rio de Pesquisa em C\u00e9lulas Inflamat\u00f3rias e Neopl\u00e1sicas Depto de Biologia Celular, Setor de Ci\u00eancias Biol\u00f3gicas, Federal University of Paran\u00e1, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abud", 
        "givenName": "Ana PR", 
        "id": "sg:person.013414154114.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013414154114.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Paran\u00e1", 
          "id": "https://www.grid.ac/institutes/grid.20736.30", 
          "name": [
            "Laborat\u00f3rio de Pesquisa em C\u00e9lulas Inflamat\u00f3rias e Neopl\u00e1sicas Depto de Biologia Celular, Setor de Ci\u00eancias Biol\u00f3gicas, Federal University of Paran\u00e1, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sene", 
        "givenName": "Reginaldo V", 
        "id": "sg:person.0754200117.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754200117.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Paran\u00e1", 
          "id": "https://www.grid.ac/institutes/grid.20736.30", 
          "name": [
            "Laborat\u00f3rio de Pesquisa em C\u00e9lulas Inflamat\u00f3rias e Neopl\u00e1sicas Depto de Biologia Celular, Setor de Ci\u00eancias Biol\u00f3gicas, Federal University of Paran\u00e1, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wanderer", 
        "givenName": "Carla", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur de Montevideo", 
          "id": "https://www.grid.ac/institutes/grid.418532.9", 
          "name": [
            "Cell Biology Unit (CBU), Institut Pasteur de Montevideo (IPMon), Uruguay"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tiscornia", 
        "givenName": "In\u00e9s", 
        "id": "sg:person.01265771657.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265771657.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur de Montevideo", 
          "id": "https://www.grid.ac/institutes/grid.418532.9", 
          "name": [
            "Cell Biology Unit (CBU), Institut Pasteur de Montevideo (IPMon), Uruguay"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bollati-Fogol\u00edn", 
        "givenName": "Mariela", 
        "id": "sg:person.01034422411.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034422411.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Paran\u00e1", 
          "id": "https://www.grid.ac/institutes/grid.20736.30", 
          "name": [
            "Laborat\u00f3rio de Pesquisa em C\u00e9lulas Inflamat\u00f3rias e Neopl\u00e1sicas Depto de Biologia Celular, Setor de Ci\u00eancias Biol\u00f3gicas, Federal University of Paran\u00e1, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Buchi", 
        "givenName": "Dorly F", 
        "id": "sg:person.0732543773.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732543773.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Paran\u00e1", 
          "id": "https://www.grid.ac/institutes/grid.20736.30", 
          "name": [
            "Laborat\u00f3rio de Pesquisa em C\u00e9lulas Inflamat\u00f3rias e Neopl\u00e1sicas Depto de Biologia Celular, Setor de Ci\u00eancias Biol\u00f3gicas, Federal University of Paran\u00e1, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trindade", 
        "givenName": "Edvaldo S", 
        "id": "sg:person.01100535133.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100535133.29"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/1471-2407-9-293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002193200", 
          "https://doi.org/10.1186/1471-2407-9-293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.20602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003229448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.20602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003229448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/002215540305101101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005814302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/002215540305101101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005814302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.24129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006579100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jim.2005.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009268620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-6-62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013454685", 
          "https://doi.org/10.1186/1479-5876-6-62"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.147.5.909", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013505843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/01913120902889153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015608971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.homp.2004.10.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017075745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ecam/nep119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017324854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2006.01.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018146236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/0471142735.im2001s39", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020414913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1369/jhc.4a6353.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021083961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1369/jhc.4a6353.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021083961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jinf.2005.08.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022584805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/canjclin.50.4.215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024183897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2007.12.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025116738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2005.09.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025839394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-005-0155-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028602287", 
          "https://doi.org/10.1007/s00280-005-0155-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-005-0155-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028602287", 
          "https://doi.org/10.1007/s00280-005-0155-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ecam/nem093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030565327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.tcam.2009.06.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031165007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)17951-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031814210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2133.2007.08246.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034607539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.22951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043279632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ecam/neh138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044448271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1081/ddc-43983", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048132255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.micron.2007.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048145819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.21713", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048998517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.2005.032144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049889514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008390-200510000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050881948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008390-200510000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050881948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008390-200510000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050881948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3835(00)00656-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051494234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellbi.2006.06.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052368546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-0182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052371303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3835(00)00633-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053196339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/01913120902889153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058307528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1081/ddc-200043983", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058430258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1389450054863662", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069180291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/3280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070915457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075183198", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076796114", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3727/000000006783981099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077371468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077583269", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082854620", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-12", 
    "datePublishedReg": "2010-12-01", 
    "description": "BACKGROUND: Melanoma is the most aggressive form of skin cancer and the most rapidly expanding cancer in terms of worldwide incidence. Chemotherapeutic approaches to treat melanoma have had only marginal success. Previous studies in mice demonstrated that a high diluted complex derived from Calcarea carbonica (M8) stimulated the tumoricidal response of activated lymphocytes against B16F10 melanoma cells in vitro.\nMETHODS: Here we describe the in vitro inhibition of invasion and the in vivo anti-metastatic potential after M8 treatment by inhalation in the B16F10 lung metastasis model.\nRESULTS: We found that M8 has at least two functions, acting as both an inhibitor of cancer cell adhesion and invasion and as a perlecan expression antagonist, which are strongly correlated with several metastatic, angiogenic and invasive factors in melanoma tumors.\nCONCLUSION: The findings suggest that this medication is a promising non-toxic therapy candidate by improving the immune response against tumor cells or even induce direct dormancy in malignancies.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-2407-10-113", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024632", 
        "issn": [
          "1471-2407"
        ], 
        "name": "BMC Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "In vitro and in vivo anticancer properties of a Calcarea carbonica derivative complex (M8) treatment in a murine melanoma model", 
    "pagination": "113", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e44ed1999cb1a7d7e74b601c40fdeb991b922d49c79ffec131fd22d19d143e62"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20338038"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100967800"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2407-10-113"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1047926017"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2407-10-113", 
      "https://app.dimensions.ai/details/publication/pub.1047926017"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000551.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-2407-10-113"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-10-113'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-10-113'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-10-113'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2407-10-113'


 

This table displays all metadata directly associated to this object as RDF triples.

305 TRIPLES      21 PREDICATES      83 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2407-10-113 schema:about N04debf348ae342fbb38d8bf5a95d1991
2 N1528ae9cad714ca089df63c695665f45
3 N1eb2e47b44af4d0faa608933f37321b6
4 N3f1dff0ecdf4405299d019dfa6327923
5 N454431da0c5741b2aaf867aed6e1ddd6
6 N6fd4106b1c3240658affeb0cdd488a0a
7 N7cc7cad377c04a52a2488523b45a3c5f
8 N873fd97909784eaab2bad7c24e40e894
9 Na25b1bc23f894939822eee1f890c114a
10 Na9fdb90806fa483783d11e4e7e565ab8
11 Nbdafca0c97ab4f1589bc126a31ac4272
12 Nd6717dfe392c4c93aef537f5f6d04c88
13 anzsrc-for:11
14 anzsrc-for:1112
15 schema:author N54d03629a73340b684a2ca8549983823
16 schema:citation sg:pub.10.1007/s00280-005-0155-8
17 sg:pub.10.1186/1471-2407-9-293
18 sg:pub.10.1186/1479-5876-6-62
19 https://app.dimensions.ai/details/publication/pub.1075183198
20 https://app.dimensions.ai/details/publication/pub.1076796114
21 https://app.dimensions.ai/details/publication/pub.1077583269
22 https://app.dimensions.ai/details/publication/pub.1082854620
23 https://doi.org/10.1002/0471142735.im2001s39
24 https://doi.org/10.1002/ijc.22951
25 https://doi.org/10.1002/ijc.24129
26 https://doi.org/10.1002/jcb.20602
27 https://doi.org/10.1002/jcb.21713
28 https://doi.org/10.1016/j.cellbi.2006.06.011
29 https://doi.org/10.1016/j.ejca.2005.09.025
30 https://doi.org/10.1016/j.ejca.2006.01.011
31 https://doi.org/10.1016/j.homp.2004.10.003
32 https://doi.org/10.1016/j.immuni.2007.12.008
33 https://doi.org/10.1016/j.jim.2005.08.005
34 https://doi.org/10.1016/j.jinf.2005.08.017
35 https://doi.org/10.1016/j.micron.2007.02.005
36 https://doi.org/10.1016/s0140-6736(05)17951-3
37 https://doi.org/10.1016/s0304-3835(00)00633-9
38 https://doi.org/10.1016/s0304-3835(00)00656-x
39 https://doi.org/10.1053/j.tcam.2009.06.001
40 https://doi.org/10.1080/01913120902889153
41 https://doi.org/10.1081/ddc-200043983
42 https://doi.org/10.1081/ddc-43983
43 https://doi.org/10.1083/jcb.147.5.909
44 https://doi.org/10.1093/ecam/neh138
45 https://doi.org/10.1093/ecam/nem093
46 https://doi.org/10.1093/ecam/nep119
47 https://doi.org/10.1097/00008390-200510000-00003
48 https://doi.org/10.1111/j.1365-2133.2007.08246.x
49 https://doi.org/10.1136/jcp.2005.032144
50 https://doi.org/10.1158/1078-0432.ccr-04-0182
51 https://doi.org/10.1177/002215540305101101
52 https://doi.org/10.1369/jhc.4a6353.2004
53 https://doi.org/10.2174/1389450054863662
54 https://doi.org/10.2741/3280
55 https://doi.org/10.3109/01913120902889153
56 https://doi.org/10.3322/canjclin.50.4.215
57 https://doi.org/10.3727/000000006783981099
58 schema:datePublished 2010-12
59 schema:datePublishedReg 2010-12-01
60 schema:description BACKGROUND: Melanoma is the most aggressive form of skin cancer and the most rapidly expanding cancer in terms of worldwide incidence. Chemotherapeutic approaches to treat melanoma have had only marginal success. Previous studies in mice demonstrated that a high diluted complex derived from Calcarea carbonica (M8) stimulated the tumoricidal response of activated lymphocytes against B16F10 melanoma cells in vitro. METHODS: Here we describe the in vitro inhibition of invasion and the in vivo anti-metastatic potential after M8 treatment by inhalation in the B16F10 lung metastasis model. RESULTS: We found that M8 has at least two functions, acting as both an inhibitor of cancer cell adhesion and invasion and as a perlecan expression antagonist, which are strongly correlated with several metastatic, angiogenic and invasive factors in melanoma tumors. CONCLUSION: The findings suggest that this medication is a promising non-toxic therapy candidate by improving the immune response against tumor cells or even induce direct dormancy in malignancies.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree true
64 schema:isPartOf N52a42dc3aa634762865e6d4863bc540a
65 Nf06a50eb5fd74c6b971240047a82ba10
66 sg:journal.1024632
67 schema:name In vitro and in vivo anticancer properties of a Calcarea carbonica derivative complex (M8) treatment in a murine melanoma model
68 schema:pagination 113
69 schema:productId N2b6e01946d9d415fb244171db5ea318d
70 N3831972e0b324d8e9daffcf15883c864
71 N3eefcafa4b774517ab89034168e9c057
72 N6f3fa18db3a346bf867b6abeb1037709
73 Na46c14b1b8404610a32d35c50f52d06e
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047926017
75 https://doi.org/10.1186/1471-2407-10-113
76 schema:sdDatePublished 2019-04-10T19:15
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher N67a583c8663a49b0896024c13a3d3fb1
79 schema:url http://link.springer.com/10.1186%2F1471-2407-10-113
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N04debf348ae342fbb38d8bf5a95d1991 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Lung Neoplasms
85 rdf:type schema:DefinedTerm
86 N107008896c0b42fab6edcf94c62725db rdf:first sg:person.013414154114.51
87 rdf:rest N79ea1a7142f34fe284d3df162340f5bd
88 N125f643744294f628850970cb451d9d2 rdf:first sg:person.0735742610.03
89 rdf:rest N762e88a589954edea91c86579c875b38
90 N1528ae9cad714ca089df63c695665f45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Colorectal Neoplasms
92 rdf:type schema:DefinedTerm
93 N1eb2e47b44af4d0faa608933f37321b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Bone Marrow Cells
95 rdf:type schema:DefinedTerm
96 N2b6e01946d9d415fb244171db5ea318d schema:name dimensions_id
97 schema:value pub.1047926017
98 rdf:type schema:PropertyValue
99 N3831972e0b324d8e9daffcf15883c864 schema:name readcube_id
100 schema:value e44ed1999cb1a7d7e74b601c40fdeb991b922d49c79ffec131fd22d19d143e62
101 rdf:type schema:PropertyValue
102 N3eefcafa4b774517ab89034168e9c057 schema:name nlm_unique_id
103 schema:value 100967800
104 rdf:type schema:PropertyValue
105 N3f1dff0ecdf4405299d019dfa6327923 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name HT29 Cells
107 rdf:type schema:DefinedTerm
108 N454431da0c5741b2aaf867aed6e1ddd6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Materia Medica
110 rdf:type schema:DefinedTerm
111 N52a42dc3aa634762865e6d4863bc540a schema:issueNumber 1
112 rdf:type schema:PublicationIssue
113 N54d03629a73340b684a2ca8549983823 rdf:first sg:person.013332162472.66
114 rdf:rest N125f643744294f628850970cb451d9d2
115 N57d51b0d33ab49b8bb8b5d034f185097 rdf:first sg:person.0732543773.66
116 rdf:rest Na802953efd914f96ac1727c02c5399d4
117 N67a583c8663a49b0896024c13a3d3fb1 schema:name Springer Nature - SN SciGraph project
118 rdf:type schema:Organization
119 N6f3fa18db3a346bf867b6abeb1037709 schema:name doi
120 schema:value 10.1186/1471-2407-10-113
121 rdf:type schema:PropertyValue
122 N6fd4106b1c3240658affeb0cdd488a0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Animals
124 rdf:type schema:DefinedTerm
125 N762e88a589954edea91c86579c875b38 rdf:first Nbc8f87c68c994ab28225f8d3cabf2d90
126 rdf:rest N107008896c0b42fab6edcf94c62725db
127 N79ea1a7142f34fe284d3df162340f5bd rdf:first sg:person.0754200117.52
128 rdf:rest N9be19e30b49e476b9bb3978d74677852
129 N7cb6399d20bf4b6ead4fb9d38666c850 rdf:first sg:person.01034422411.10
130 rdf:rest N57d51b0d33ab49b8bb8b5d034f185097
131 N7cc7cad377c04a52a2488523b45a3c5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Immunophenotyping
133 rdf:type schema:DefinedTerm
134 N873fd97909784eaab2bad7c24e40e894 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Melanoma, Experimental
136 rdf:type schema:DefinedTerm
137 N9be19e30b49e476b9bb3978d74677852 rdf:first N9eb5c278675e40618eaf8fd9a85bbdab
138 rdf:rest Nb6264f0b1d5b44a888093d29a15c2c78
139 N9eb5c278675e40618eaf8fd9a85bbdab schema:affiliation https://www.grid.ac/institutes/grid.20736.30
140 schema:familyName Wanderer
141 schema:givenName Carla
142 rdf:type schema:Person
143 Na25b1bc23f894939822eee1f890c114a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Male
145 rdf:type schema:DefinedTerm
146 Na46c14b1b8404610a32d35c50f52d06e schema:name pubmed_id
147 schema:value 20338038
148 rdf:type schema:PropertyValue
149 Na802953efd914f96ac1727c02c5399d4 rdf:first sg:person.01100535133.29
150 rdf:rest rdf:nil
151 Na9fdb90806fa483783d11e4e7e565ab8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Humans
153 rdf:type schema:DefinedTerm
154 Nb6264f0b1d5b44a888093d29a15c2c78 rdf:first sg:person.01265771657.75
155 rdf:rest N7cb6399d20bf4b6ead4fb9d38666c850
156 Nbc8f87c68c994ab28225f8d3cabf2d90 schema:affiliation https://www.grid.ac/institutes/grid.20736.30
157 schema:familyName Martins
158 schema:givenName Sharon T
159 rdf:type schema:Person
160 Nbdafca0c97ab4f1589bc126a31ac4272 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Mice
162 rdf:type schema:DefinedTerm
163 Nd6717dfe392c4c93aef537f5f6d04c88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Mice, Inbred BALB C
165 rdf:type schema:DefinedTerm
166 Nf06a50eb5fd74c6b971240047a82ba10 schema:volumeNumber 10
167 rdf:type schema:PublicationVolume
168 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
169 schema:name Medical and Health Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
172 schema:name Oncology and Carcinogenesis
173 rdf:type schema:DefinedTerm
174 sg:journal.1024632 schema:issn 1471-2407
175 schema:name BMC Cancer
176 rdf:type schema:Periodical
177 sg:person.01034422411.10 schema:affiliation https://www.grid.ac/institutes/grid.418532.9
178 schema:familyName Bollati-Fogolín
179 schema:givenName Mariela
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034422411.10
181 rdf:type schema:Person
182 sg:person.01100535133.29 schema:affiliation https://www.grid.ac/institutes/grid.20736.30
183 schema:familyName Trindade
184 schema:givenName Edvaldo S
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100535133.29
186 rdf:type schema:Person
187 sg:person.01265771657.75 schema:affiliation https://www.grid.ac/institutes/grid.418532.9
188 schema:familyName Tiscornia
189 schema:givenName Inés
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265771657.75
191 rdf:type schema:Person
192 sg:person.013332162472.66 schema:affiliation https://www.grid.ac/institutes/grid.20736.30
193 schema:familyName Guimarães
194 schema:givenName Fernando SF
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013332162472.66
196 rdf:type schema:Person
197 sg:person.013414154114.51 schema:affiliation https://www.grid.ac/institutes/grid.20736.30
198 schema:familyName Abud
199 schema:givenName Ana PR
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013414154114.51
201 rdf:type schema:Person
202 sg:person.0732543773.66 schema:affiliation https://www.grid.ac/institutes/grid.20736.30
203 schema:familyName Buchi
204 schema:givenName Dorly F
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732543773.66
206 rdf:type schema:Person
207 sg:person.0735742610.03 schema:affiliation https://www.grid.ac/institutes/grid.20736.30
208 schema:familyName Andrade
209 schema:givenName Lucas F
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735742610.03
211 rdf:type schema:Person
212 sg:person.0754200117.52 schema:affiliation https://www.grid.ac/institutes/grid.20736.30
213 schema:familyName Sene
214 schema:givenName Reginaldo V
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754200117.52
216 rdf:type schema:Person
217 sg:pub.10.1007/s00280-005-0155-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028602287
218 https://doi.org/10.1007/s00280-005-0155-8
219 rdf:type schema:CreativeWork
220 sg:pub.10.1186/1471-2407-9-293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002193200
221 https://doi.org/10.1186/1471-2407-9-293
222 rdf:type schema:CreativeWork
223 sg:pub.10.1186/1479-5876-6-62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013454685
224 https://doi.org/10.1186/1479-5876-6-62
225 rdf:type schema:CreativeWork
226 https://app.dimensions.ai/details/publication/pub.1075183198 schema:CreativeWork
227 https://app.dimensions.ai/details/publication/pub.1076796114 schema:CreativeWork
228 https://app.dimensions.ai/details/publication/pub.1077583269 schema:CreativeWork
229 https://app.dimensions.ai/details/publication/pub.1082854620 schema:CreativeWork
230 https://doi.org/10.1002/0471142735.im2001s39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020414913
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1002/ijc.22951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043279632
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1002/ijc.24129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006579100
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1002/jcb.20602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003229448
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1002/jcb.21713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048998517
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/j.cellbi.2006.06.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052368546
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/j.ejca.2005.09.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025839394
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/j.ejca.2006.01.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018146236
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.homp.2004.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017075745
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.immuni.2007.12.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025116738
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.jim.2005.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009268620
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.jinf.2005.08.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022584805
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.micron.2007.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048145819
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/s0140-6736(05)17951-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031814210
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/s0304-3835(00)00633-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053196339
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/s0304-3835(00)00656-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051494234
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1053/j.tcam.2009.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031165007
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1080/01913120902889153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058307528
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1081/ddc-200043983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058430258
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1081/ddc-43983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048132255
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1083/jcb.147.5.909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013505843
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1093/ecam/neh138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044448271
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1093/ecam/nem093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030565327
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1093/ecam/nep119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017324854
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1097/00008390-200510000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050881948
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1111/j.1365-2133.2007.08246.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034607539
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1136/jcp.2005.032144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049889514
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1158/1078-0432.ccr-04-0182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052371303
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1177/002215540305101101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005814302
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1369/jhc.4a6353.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021083961
289 rdf:type schema:CreativeWork
290 https://doi.org/10.2174/1389450054863662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069180291
291 rdf:type schema:CreativeWork
292 https://doi.org/10.2741/3280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070915457
293 rdf:type schema:CreativeWork
294 https://doi.org/10.3109/01913120902889153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015608971
295 rdf:type schema:CreativeWork
296 https://doi.org/10.3322/canjclin.50.4.215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024183897
297 rdf:type schema:CreativeWork
298 https://doi.org/10.3727/000000006783981099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077371468
299 rdf:type schema:CreativeWork
300 https://www.grid.ac/institutes/grid.20736.30 schema:alternateName Federal University of Paraná
301 schema:name Laboratório de Pesquisa em Células Inflamatórias e Neoplásicas Depto de Biologia Celular, Setor de Ciências Biológicas, Federal University of Paraná, Brazil
302 rdf:type schema:Organization
303 https://www.grid.ac/institutes/grid.418532.9 schema:alternateName Institut Pasteur de Montevideo
304 schema:name Cell Biology Unit (CBU), Institut Pasteur de Montevideo (IPMon), Uruguay
305 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...