Analysis of factors predicting mortality of new patients commencing renal replacement therapy 10 years of follow-up View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Oliver T Browne, Victoria Allgar, Sunil Bhandari

ABSTRACT

BACKGROUND: The natural history of patients commencing dialysis in East Yorkshire is not well characterised and there is little convincing evidence which has studied the impact of potential factors prior to commencement of renal replacement therapy (RRT) at predicting mortality during dialysis. The aim of this study was to examine the previously published 5-year data on end stage renal disease and co-morbid risk factors for mortality at 10 years. METHODS: An observational cohort study of subjects commencing dialysis in 2001/02 in East Yorkshire with a mean follow up from dialysis initiation of 8.8 years. Predictors of mortality were determined by univariate, multivariate analysis and survival via Kaplan-Meier analysis. Assessment of the utility of the Tangri risk calculator was carried out in addition to slope change in eGFR prior to dialysis commencement. RESULTS: Baseline characteristics and the preferred mode of dialysis remained concordant with the original trial. The mortality rate at the end of the study period was 60% (56/94) with 30% (29) of patients having been transplanted. Highlighted in the 5 year data a significant proportion of mortality was made up of vascular disease and sepsis (71%) but this proportion had decreased (57%) by 10 years. Cardiac disease was the commonest cause of death but notably in 18% of patients, death was related to dialysis or withdrawal of treatment. Vascular disease and diabetes remained independent risk factors and predicative of mortality. Calcium-phosphate product which was associated in the early years with mortality was not in later years. Use of the risk calculator was predictive of commencement of RRT but not mortality but slope change in eGFR was predictive of mortality. CONCLUSIONS: Although diabetes and vascular disease remained predictive of mortality, interestingly calcium-phosphate levels are no longer significant and may be a more specific predictor of early cardiac mortality. Slope eGFR changes prior to RRT are a predictor of mortality. We speculate that aggressive management of cardiac risk factors in addition to early transplantation may be key to influencing the impact of survival in this cohort in addition to possible measures to delay renal progression. More... »

PAGES

20

References to SciGraph publications

  • 2010-02. Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients in KIDNEY INTERNATIONAL
  • 2006-07. Changes in serum calcium, phosphate, and PTH and the risk of death in incident dialysis patients: A longitudinal study in KIDNEY INTERNATIONAL
  • 2007-07. Chronic kidney disease management in the United Kingdom: NEOERICA project results in KIDNEY INTERNATIONAL
  • 2003-06. Traditional and emerging cardiovascular risk factors in end-stage renal disease in KIDNEY INTERNATIONAL SUPPLEMENTS
  • 2003-07. Health-related quality of life as a predictor of mortality and hospitalization: The Dialysis Outcomes and Practice Patterns Study (DOPPS) in KIDNEY INTERNATIONAL
  • 2006-10. Is there a need to optimize glycemic control in hemodialyzed diabetic patients? in KIDNEY INTERNATIONAL
  • 2011-04. Phosphate and Klotho in KIDNEY INTERNATIONAL
  • 2010-02. Blood pressure in chronic kidney disease stage 5D—report from a Kidney Disease: Improving Global Outcomes controversies conference in KIDNEY INTERNATIONAL
  • 2003-05. Cardiovascular risk factors in predialysis patients: Baseline data from the Chronic Renal Impairment in Birmingham (CRIB) study in KIDNEY INTERNATIONAL SUPPLEMENTS
  • 2007-10. Vitamin D levels and early mortality among incident hemodialysis patients in KIDNEY INTERNATIONAL
  • 2005-06. New onset hyperglycemia and diabetes are associated with increased cardiovascular risk after kidney transplantation in KIDNEY INTERNATIONAL
  • 2011-07. Lower estimated GFR and higher albuminuria are associated with adverse kidney outcomes. A collaborative meta-analysis of general and high-risk population cohorts in KIDNEY INTERNATIONAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1471-2369-15-20

    DOI

    http://dx.doi.org/10.1186/1471-2369-15-20

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001356473

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24444187


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cardiovascular Diseases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cohort Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Comorbidity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diabetes Mellitus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Incidence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proportional Hazards Models", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Renal Insufficiency, Chronic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Renal Replacement Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Survival Rate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "United Kingdom", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Hull York Medical School", 
              "id": "https://www.grid.ac/institutes/grid.413631.2", 
              "name": [
                "Hull York Medical School, Hull, East Yorkshire, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Browne", 
            "givenName": "Oliver T", 
            "id": "sg:person.0763424062.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763424062.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Hull", 
              "id": "https://www.grid.ac/institutes/grid.9481.4", 
              "name": [
                "Department of Statistics, Hull York Medical School and University of Hull, Hull, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Allgar", 
            "givenName": "Victoria", 
            "id": "sg:person.01004034176.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004034176.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hull and East Yorkshire Hospitals NHS Trust", 
              "id": "https://www.grid.ac/institutes/grid.417700.5", 
              "name": [
                "Hull York Medical School, Hull, East Yorkshire, UK", 
                "Department of Renal Medicine, Hull and East Yorkshire Hospitals NHS Trust, HU32JZ, Kingston upon Hull, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bhandari", 
            "givenName": "Sunil", 
            "id": "sg:person.0717572411.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717572411.26"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1159/000073708", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003161280"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2215/cjn.05120610", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004746386"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/cs20050025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005483389"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/cs20050025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005483389"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2215/cjn.04780709", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007167491"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ndt/gfr098", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009764798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ki.5001886", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010157937", 
              "https://doi.org/10.1038/sj.ki.5001886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2009121311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011505152"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2009121311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011505152"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.2009.414", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012967333", 
              "https://doi.org/10.1038/ki.2009.414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.atherosclerosis.2009.05.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015629160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/cvr/cvr024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015740725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(09)61969-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017470643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.291.7.844", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017945564"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/ajkd.2000.19928", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018519567"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0706245", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018706980"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(98)07019-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018881858"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.2010.531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020924873", 
              "https://doi.org/10.1038/ki.2010.531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2215/cjn.01891105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021360944"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ndt/gfm839", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021726914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.2009.469", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022076321", 
              "https://doi.org/10.1038/ki.2009.469"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0802743", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022234833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ndt/gfl291", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022706626"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.1523-1755.63.s84.45.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023929031", 
              "https://doi.org/10.1046/j.1523-1755.63.s84.45.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0810177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024168572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2011.451", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026217498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.2011.26", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028416915", 
              "https://doi.org/10.1038/ki.2011.26"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000301159", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029457793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/hypertensionaha.109.144899", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032134157"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/hypertensionaha.109.144899", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032134157"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(09)60212-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032373946"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mnh.0b013e3283435f0e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032792335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mnh.0b013e3283435f0e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032792335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(10)60674-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033235001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2215/cjn.00470111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033626953"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2010010125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033840302"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2010010125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033840302"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0806470", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034293538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.ajkd.2007.12.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034597422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.ackd.2007.07.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038773946"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ki.5001542", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039685860", 
              "https://doi.org/10.1038/sj.ki.5001542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ahj.2003.07.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041333626"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.1523-1755.2003.00072.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042869291", 
              "https://doi.org/10.1046/j.1523-1755.2003.00072.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1523-1755.2003.00072.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042869291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4065/80.10.1270", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043494252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2215/cjn.03160906", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043554607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ki.5002451", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044432540", 
              "https://doi.org/10.1038/sj.ki.5002451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.1523-1755.63.s85.25.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044932656", 
              "https://doi.org/10.1046/j.1523-1755.63.s85.25.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1523-1755.63.s85.25.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044932656"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1523-1755.2005.00349.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045326880", 
              "https://doi.org/10.1111/j.1523-1755.2005.00349.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ki.5002273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045656059", 
              "https://doi.org/10.1038/sj.ki.5002273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/ajkd.1998.v31.pm9506677", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047123469"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/qjmed/hcp164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047867424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/qjmed/hcp164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047867424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ahj.2003.12.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050067239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.ajkd.2010.12.027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050832374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.ajkd.2008.10.047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051362124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.300.6720.297", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052338335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2741/3794", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070915955"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2014-12", 
        "datePublishedReg": "2014-12-01", 
        "description": "BACKGROUND: The natural history of patients commencing dialysis in East Yorkshire is not well characterised and there is little convincing evidence which has studied the impact of potential factors prior to commencement of renal replacement therapy (RRT) at predicting mortality during dialysis. The aim of this study was to examine the previously published 5-year data on end stage renal disease and co-morbid risk factors for mortality at 10 years.\nMETHODS: An observational cohort study of subjects commencing dialysis in 2001/02 in East Yorkshire with a mean follow up from dialysis initiation of 8.8 years. Predictors of mortality were determined by univariate, multivariate analysis and survival via Kaplan-Meier analysis. Assessment of the utility of the Tangri risk calculator was carried out in addition to slope change in eGFR prior to dialysis commencement.\nRESULTS: Baseline characteristics and the preferred mode of dialysis remained concordant with the original trial. The mortality rate at the end of the study period was 60% (56/94) with 30% (29) of patients having been transplanted. Highlighted in the 5 year data a significant proportion of mortality was made up of vascular disease and sepsis (71%) but this proportion had decreased (57%) by 10 years. Cardiac disease was the commonest cause of death but notably in 18% of patients, death was related to dialysis or withdrawal of treatment. Vascular disease and diabetes remained independent risk factors and predicative of mortality. Calcium-phosphate product which was associated in the early years with mortality was not in later years. Use of the risk calculator was predictive of commencement of RRT but not mortality but slope change in eGFR was predictive of mortality.\nCONCLUSIONS: Although diabetes and vascular disease remained predictive of mortality, interestingly calcium-phosphate levels are no longer significant and may be a more specific predictor of early cardiac mortality. Slope eGFR changes prior to RRT are a predictor of mortality. We speculate that aggressive management of cardiac risk factors in addition to early transplantation may be key to influencing the impact of survival in this cohort in addition to possible measures to delay renal progression.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/1471-2369-15-20", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1024626", 
            "issn": [
              "1471-2369"
            ], 
            "name": "BMC Nephrology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "15"
          }
        ], 
        "name": "Analysis of factors predicting mortality of new patients commencing renal replacement therapy 10 years of follow-up", 
        "pagination": "20", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "0676167c8435e23ddf57c87839b76e7eb47eb1d3dc18779e670bc2fd56bc5321"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24444187"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100967793"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/1471-2369-15-20"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1001356473"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/1471-2369-15-20", 
          "https://app.dimensions.ai/details/publication/pub.1001356473"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T10:00", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89819_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1186%2F1471-2369-15-20"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2369-15-20'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2369-15-20'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2369-15-20'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2369-15-20'


     

    This table displays all metadata directly associated to this object as RDF triples.

    324 TRIPLES      21 PREDICATES      98 URIs      37 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/1471-2369-15-20 schema:about N0d2f70eef5964214911748acb43955a0
    2 N0eb3e06ccace4980a74654cc64147e95
    3 N58ab2279043d4b1eb3e2ec9346da5321
    4 N5c9ee7266b484fd58d4774be438a5e7a
    5 N5fddf38943b64a5f944164b04f59e8cf
    6 N710ec1d6760345a2adea0e99ae2bc7d0
    7 N74512f2e73ec49fab95f585ad3db5db8
    8 N843d858f6c334b26a24855d1e1a47a18
    9 N899dcf2f14de46638cf8611b756bb353
    10 N9b09b75372094db3aa29ad0831eea99d
    11 Nc469af6bf37c41cca951ade1228698d5
    12 Nccb1eaf831e04b7ea6a91b38f9c16e50
    13 Nce96c12a984f440c848619efabb1059e
    14 Nd78200f295cb4653bfb7d0533703c87b
    15 Ndc4a2cb0a4834260a47cbdaeb83fca3b
    16 Ne7ee3b1a587c4896b2c5ac064371116b
    17 anzsrc-for:11
    18 anzsrc-for:1103
    19 schema:author Nb6c300ead7424b6dbb5e5eee5d47c0bd
    20 schema:citation sg:pub.10.1038/ki.2009.414
    21 sg:pub.10.1038/ki.2009.469
    22 sg:pub.10.1038/ki.2010.531
    23 sg:pub.10.1038/ki.2011.26
    24 sg:pub.10.1038/sj.ki.5001542
    25 sg:pub.10.1038/sj.ki.5001886
    26 sg:pub.10.1038/sj.ki.5002273
    27 sg:pub.10.1038/sj.ki.5002451
    28 sg:pub.10.1046/j.1523-1755.2003.00072.x
    29 sg:pub.10.1046/j.1523-1755.63.s84.45.x
    30 sg:pub.10.1046/j.1523-1755.63.s85.25.x
    31 sg:pub.10.1111/j.1523-1755.2005.00349.x
    32 https://doi.org/10.1001/jama.2011.451
    33 https://doi.org/10.1001/jama.291.7.844
    34 https://doi.org/10.1016/j.ahj.2003.07.029
    35 https://doi.org/10.1016/j.ahj.2003.12.025
    36 https://doi.org/10.1016/j.atherosclerosis.2009.05.013
    37 https://doi.org/10.1016/s0140-6736(09)60212-9
    38 https://doi.org/10.1016/s0140-6736(09)61969-3
    39 https://doi.org/10.1016/s0140-6736(10)60674-5
    40 https://doi.org/10.1016/s0140-6736(98)07019-6
    41 https://doi.org/10.1042/cs20050025
    42 https://doi.org/10.1046/j.1523-1755.2003.00072.x
    43 https://doi.org/10.1046/j.1523-1755.63.s85.25.x
    44 https://doi.org/10.1053/ajkd.1998.v31.pm9506677
    45 https://doi.org/10.1053/ajkd.2000.19928
    46 https://doi.org/10.1053/j.ackd.2007.07.008
    47 https://doi.org/10.1053/j.ajkd.2007.12.013
    48 https://doi.org/10.1053/j.ajkd.2008.10.047
    49 https://doi.org/10.1053/j.ajkd.2010.12.027
    50 https://doi.org/10.1056/nejmoa0706245
    51 https://doi.org/10.1056/nejmoa0802743
    52 https://doi.org/10.1056/nejmoa0806470
    53 https://doi.org/10.1056/nejmoa0810177
    54 https://doi.org/10.1093/cvr/cvr024
    55 https://doi.org/10.1093/ndt/gfl291
    56 https://doi.org/10.1093/ndt/gfm839
    57 https://doi.org/10.1093/ndt/gfr098
    58 https://doi.org/10.1093/qjmed/hcp164
    59 https://doi.org/10.1097/mnh.0b013e3283435f0e
    60 https://doi.org/10.1136/bmj.300.6720.297
    61 https://doi.org/10.1159/000073708
    62 https://doi.org/10.1159/000301159
    63 https://doi.org/10.1161/hypertensionaha.109.144899
    64 https://doi.org/10.1681/asn.2009121311
    65 https://doi.org/10.1681/asn.2010010125
    66 https://doi.org/10.2215/cjn.00470111
    67 https://doi.org/10.2215/cjn.01891105
    68 https://doi.org/10.2215/cjn.03160906
    69 https://doi.org/10.2215/cjn.04780709
    70 https://doi.org/10.2215/cjn.05120610
    71 https://doi.org/10.2741/3794
    72 https://doi.org/10.4065/80.10.1270
    73 schema:datePublished 2014-12
    74 schema:datePublishedReg 2014-12-01
    75 schema:description BACKGROUND: The natural history of patients commencing dialysis in East Yorkshire is not well characterised and there is little convincing evidence which has studied the impact of potential factors prior to commencement of renal replacement therapy (RRT) at predicting mortality during dialysis. The aim of this study was to examine the previously published 5-year data on end stage renal disease and co-morbid risk factors for mortality at 10 years. METHODS: An observational cohort study of subjects commencing dialysis in 2001/02 in East Yorkshire with a mean follow up from dialysis initiation of 8.8 years. Predictors of mortality were determined by univariate, multivariate analysis and survival via Kaplan-Meier analysis. Assessment of the utility of the Tangri risk calculator was carried out in addition to slope change in eGFR prior to dialysis commencement. RESULTS: Baseline characteristics and the preferred mode of dialysis remained concordant with the original trial. The mortality rate at the end of the study period was 60% (56/94) with 30% (29) of patients having been transplanted. Highlighted in the 5 year data a significant proportion of mortality was made up of vascular disease and sepsis (71%) but this proportion had decreased (57%) by 10 years. Cardiac disease was the commonest cause of death but notably in 18% of patients, death was related to dialysis or withdrawal of treatment. Vascular disease and diabetes remained independent risk factors and predicative of mortality. Calcium-phosphate product which was associated in the early years with mortality was not in later years. Use of the risk calculator was predictive of commencement of RRT but not mortality but slope change in eGFR was predictive of mortality. CONCLUSIONS: Although diabetes and vascular disease remained predictive of mortality, interestingly calcium-phosphate levels are no longer significant and may be a more specific predictor of early cardiac mortality. Slope eGFR changes prior to RRT are a predictor of mortality. We speculate that aggressive management of cardiac risk factors in addition to early transplantation may be key to influencing the impact of survival in this cohort in addition to possible measures to delay renal progression.
    76 schema:genre research_article
    77 schema:inLanguage en
    78 schema:isAccessibleForFree true
    79 schema:isPartOf N07e678f75fb94318aaaa268eac7385cd
    80 Ncce274e24b9e48a3bbb00649f52d43af
    81 sg:journal.1024626
    82 schema:name Analysis of factors predicting mortality of new patients commencing renal replacement therapy 10 years of follow-up
    83 schema:pagination 20
    84 schema:productId N0d1c8dbe58c046398d8584a082f732b0
    85 N8209c1bfcf3d40b5b83fe2d4a3ec3e19
    86 N91ff5ef0abc94db6a8f5a2c27199bce4
    87 Nc4321f90bf5b4e61b2bdbe49f6ff172c
    88 Nc7a5b7395b1b4ca4a3086a2760dd60fb
    89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001356473
    90 https://doi.org/10.1186/1471-2369-15-20
    91 schema:sdDatePublished 2019-04-11T10:00
    92 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    93 schema:sdPublisher N9187ff88d09f49b6b9261b8ceee9b947
    94 schema:url https://link.springer.com/10.1186%2F1471-2369-15-20
    95 sgo:license sg:explorer/license/
    96 sgo:sdDataset articles
    97 rdf:type schema:ScholarlyArticle
    98 N07e678f75fb94318aaaa268eac7385cd schema:issueNumber 1
    99 rdf:type schema:PublicationIssue
    100 N0d1c8dbe58c046398d8584a082f732b0 schema:name readcube_id
    101 schema:value 0676167c8435e23ddf57c87839b76e7eb47eb1d3dc18779e670bc2fd56bc5321
    102 rdf:type schema:PropertyValue
    103 N0d2f70eef5964214911748acb43955a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Renal Insufficiency, Chronic
    105 rdf:type schema:DefinedTerm
    106 N0eb3e06ccace4980a74654cc64147e95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name United Kingdom
    108 rdf:type schema:DefinedTerm
    109 N20765e6d2f254bd08fa120806c97245d rdf:first sg:person.0717572411.26
    110 rdf:rest rdf:nil
    111 N58ab2279043d4b1eb3e2ec9346da5321 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Female
    113 rdf:type schema:DefinedTerm
    114 N5c9ee7266b484fd58d4774be438a5e7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Diabetes Mellitus
    116 rdf:type schema:DefinedTerm
    117 N5fddf38943b64a5f944164b04f59e8cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Incidence
    119 rdf:type schema:DefinedTerm
    120 N710ec1d6760345a2adea0e99ae2bc7d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Risk Factors
    122 rdf:type schema:DefinedTerm
    123 N74512f2e73ec49fab95f585ad3db5db8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Comorbidity
    125 rdf:type schema:DefinedTerm
    126 N8209c1bfcf3d40b5b83fe2d4a3ec3e19 schema:name dimensions_id
    127 schema:value pub.1001356473
    128 rdf:type schema:PropertyValue
    129 N843d858f6c334b26a24855d1e1a47a18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Humans
    131 rdf:type schema:DefinedTerm
    132 N899dcf2f14de46638cf8611b756bb353 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Survival Rate
    134 rdf:type schema:DefinedTerm
    135 N9187ff88d09f49b6b9261b8ceee9b947 schema:name Springer Nature - SN SciGraph project
    136 rdf:type schema:Organization
    137 N91ff5ef0abc94db6a8f5a2c27199bce4 schema:name nlm_unique_id
    138 schema:value 100967793
    139 rdf:type schema:PropertyValue
    140 N98d7428431ca4314b46960293caeab8e rdf:first sg:person.01004034176.43
    141 rdf:rest N20765e6d2f254bd08fa120806c97245d
    142 N9b09b75372094db3aa29ad0831eea99d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Male
    144 rdf:type schema:DefinedTerm
    145 Nb6c300ead7424b6dbb5e5eee5d47c0bd rdf:first sg:person.0763424062.41
    146 rdf:rest N98d7428431ca4314b46960293caeab8e
    147 Nc4321f90bf5b4e61b2bdbe49f6ff172c schema:name pubmed_id
    148 schema:value 24444187
    149 rdf:type schema:PropertyValue
    150 Nc469af6bf37c41cca951ade1228698d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Treatment Outcome
    152 rdf:type schema:DefinedTerm
    153 Nc7a5b7395b1b4ca4a3086a2760dd60fb schema:name doi
    154 schema:value 10.1186/1471-2369-15-20
    155 rdf:type schema:PropertyValue
    156 Nccb1eaf831e04b7ea6a91b38f9c16e50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Middle Aged
    158 rdf:type schema:DefinedTerm
    159 Ncce274e24b9e48a3bbb00649f52d43af schema:volumeNumber 15
    160 rdf:type schema:PublicationVolume
    161 Nce96c12a984f440c848619efabb1059e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Proportional Hazards Models
    163 rdf:type schema:DefinedTerm
    164 Nd78200f295cb4653bfb7d0533703c87b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Cohort Studies
    166 rdf:type schema:DefinedTerm
    167 Ndc4a2cb0a4834260a47cbdaeb83fca3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Renal Replacement Therapy
    169 rdf:type schema:DefinedTerm
    170 Ne7ee3b1a587c4896b2c5ac064371116b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Cardiovascular Diseases
    172 rdf:type schema:DefinedTerm
    173 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    174 schema:name Medical and Health Sciences
    175 rdf:type schema:DefinedTerm
    176 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    177 schema:name Clinical Sciences
    178 rdf:type schema:DefinedTerm
    179 sg:journal.1024626 schema:issn 1471-2369
    180 schema:name BMC Nephrology
    181 rdf:type schema:Periodical
    182 sg:person.01004034176.43 schema:affiliation https://www.grid.ac/institutes/grid.9481.4
    183 schema:familyName Allgar
    184 schema:givenName Victoria
    185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004034176.43
    186 rdf:type schema:Person
    187 sg:person.0717572411.26 schema:affiliation https://www.grid.ac/institutes/grid.417700.5
    188 schema:familyName Bhandari
    189 schema:givenName Sunil
    190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717572411.26
    191 rdf:type schema:Person
    192 sg:person.0763424062.41 schema:affiliation https://www.grid.ac/institutes/grid.413631.2
    193 schema:familyName Browne
    194 schema:givenName Oliver T
    195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763424062.41
    196 rdf:type schema:Person
    197 sg:pub.10.1038/ki.2009.414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012967333
    198 https://doi.org/10.1038/ki.2009.414
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1038/ki.2009.469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022076321
    201 https://doi.org/10.1038/ki.2009.469
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1038/ki.2010.531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020924873
    204 https://doi.org/10.1038/ki.2010.531
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1038/ki.2011.26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028416915
    207 https://doi.org/10.1038/ki.2011.26
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1038/sj.ki.5001542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039685860
    210 https://doi.org/10.1038/sj.ki.5001542
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1038/sj.ki.5001886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010157937
    213 https://doi.org/10.1038/sj.ki.5001886
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1038/sj.ki.5002273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045656059
    216 https://doi.org/10.1038/sj.ki.5002273
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1038/sj.ki.5002451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044432540
    219 https://doi.org/10.1038/sj.ki.5002451
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1046/j.1523-1755.2003.00072.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042869291
    222 https://doi.org/10.1046/j.1523-1755.2003.00072.x
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1046/j.1523-1755.63.s84.45.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023929031
    225 https://doi.org/10.1046/j.1523-1755.63.s84.45.x
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1046/j.1523-1755.63.s85.25.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044932656
    228 https://doi.org/10.1046/j.1523-1755.63.s85.25.x
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1111/j.1523-1755.2005.00349.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045326880
    231 https://doi.org/10.1111/j.1523-1755.2005.00349.x
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1001/jama.2011.451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026217498
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1001/jama.291.7.844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017945564
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1016/j.ahj.2003.07.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041333626
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1016/j.ahj.2003.12.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050067239
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1016/j.atherosclerosis.2009.05.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015629160
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1016/s0140-6736(09)60212-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032373946
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1016/s0140-6736(09)61969-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017470643
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1016/s0140-6736(10)60674-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033235001
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1016/s0140-6736(98)07019-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018881858
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1042/cs20050025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005483389
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1046/j.1523-1755.2003.00072.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042869291
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1046/j.1523-1755.63.s85.25.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044932656
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1053/ajkd.1998.v31.pm9506677 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047123469
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1053/ajkd.2000.19928 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018519567
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1053/j.ackd.2007.07.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038773946
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1053/j.ajkd.2007.12.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034597422
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1053/j.ajkd.2008.10.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051362124
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1053/j.ajkd.2010.12.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050832374
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1056/nejmoa0706245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018706980
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1056/nejmoa0802743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022234833
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1056/nejmoa0806470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034293538
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1056/nejmoa0810177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024168572
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1093/cvr/cvr024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015740725
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1093/ndt/gfl291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022706626
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1093/ndt/gfm839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021726914
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1093/ndt/gfr098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009764798
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1093/qjmed/hcp164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047867424
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1097/mnh.0b013e3283435f0e schema:sameAs https://app.dimensions.ai/details/publication/pub.1032792335
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1136/bmj.300.6720.297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052338335
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1159/000073708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003161280
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1159/000301159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029457793
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1161/hypertensionaha.109.144899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032134157
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1681/asn.2009121311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011505152
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1681/asn.2010010125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033840302
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.2215/cjn.00470111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033626953
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.2215/cjn.01891105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021360944
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.2215/cjn.03160906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043554607
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.2215/cjn.04780709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007167491
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.2215/cjn.05120610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004746386
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.2741/3794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070915955
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.4065/80.10.1270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043494252
    314 rdf:type schema:CreativeWork
    315 https://www.grid.ac/institutes/grid.413631.2 schema:alternateName Hull York Medical School
    316 schema:name Hull York Medical School, Hull, East Yorkshire, UK
    317 rdf:type schema:Organization
    318 https://www.grid.ac/institutes/grid.417700.5 schema:alternateName Hull and East Yorkshire Hospitals NHS Trust
    319 schema:name Department of Renal Medicine, Hull and East Yorkshire Hospitals NHS Trust, HU32JZ, Kingston upon Hull, UK
    320 Hull York Medical School, Hull, East Yorkshire, UK
    321 rdf:type schema:Organization
    322 https://www.grid.ac/institutes/grid.9481.4 schema:alternateName University of Hull
    323 schema:name Department of Statistics, Hull York Medical School and University of Hull, Hull, UK
    324 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...